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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Alternative Current Electrical Conductivity of Octaphynyl Tetrapyrrazino Porphrazine Cobalt (II) Hasan Sabeeh Jabur
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

The alternative current (Ac) conductivity of octaphynyl tetrapyrrazino porphrazine cobalt (op Tp Pz Co) was measured at rate of frequency of 5 X I03to 5 X103 Hz of and temperature rate (303 to 423) k. The dc conductivity was carry out in the same temperature rate, which consists of frequency independent (Dc conductivity) and frequency dependent part. This type of conductivity results from hopping of cargo carriers between localized sites around Fermi levels. The jump position is indication of the degree of imperfection in the crystal. Crystallization degree the number of the jump position was calculated using Web band William equation which is estimated to be l x l020ev-1cm3.Keywords: Octaphenyl Tetrapyrazino Porphrazine cobalt, Temperature rate (303 to 423) k Frequency dependent, Conductivity Ac, Conductivity.
A Model to Evaluate Content Dimensions in Educational Institutes in order to establish a Knowledge Management System Dorsa Didehvar
Journal of Global Pharma Technology .
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Abstract

Organizational knowledge is one of the most important assets of every organization; thus, its optimal management will lead to a comprehensive organizational improvement. Knowledge management is a powerful tool to achieve competitive advantages and it has been experienced that its use in academic environment has many advantages. However, the important issue prior to establishing a knowledge management system is to identify and determine the effective factors on the readiness of organizations to implement this project. Therefore, the main goal of this research is to provide a model to evaluate the readiness level of content dimension of educational centers in order to establish the knowledge management system. This research is a combination of quantitative and qualitative methods; and after exploratory studies, exploratory interviews with experts of knowledge management have been carried out. The data were coded and classified using the methods of grounded theory. As a result, four hundred and ninety two codes were obtained and the main model consisted of 7 main components and 18 sub-components. A questionnaire consisted of 54 questions was used in this research and its validity and reliability was calculated 0.929 through content method and Cronbach’s alpha coefficient respectively. Data were analyzed through confirmatory factor analysis and the final model consisted of six main content dimensions. These dimensions are as follows in terms of importance and priority: Development of educational departments in accordance with environmental knowledge estimated as 1.193, senior management supportive strategies estimated as 0.469, institutionalization of processes and technology knowledge estimated as 0.461, evident and caching technologies estimated as 0.344, knowledge-oriented behaviors estimated as 0.297, participative culture in knowledge creation estimated as 0.237. Furthermore, twenty-eight sub-problems will be extracted in terms of importance and priority.Keywords: Modeling, Content Dimensions, Educational Centers, Knowledge management system’s establishment.
Genotypic and Phenotypic Detection of Mutant Thrombolytic Enzyme (staphylococcal fibrinolysin) Expressed by Mutant Staphylococcus aureus Vancomycin Sensitive S.aureus (VSSA) and Methicillin Sensitive S.aureus (MSSA) by Hydroxylamine Chemical Mutagen Nebras Rada Mohammed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The aim of this study in order to determine mutagenesis of virulence S.aureus MRSA, VRSA then make it non virulent VSSA, MSSA by Hydroxylamine (HA) chemical mutagen. The study design of cases are Cross-sectional study so as to  limit types of epidemiologic studies including descriptive study of 500 isolates collected  from different sources of human infections from Tonsils, Nose, Tumors, Urine, Blood and Skin(Acne), all identification by Vitek2-GP. The  antimicrobial sensitivity test done of all 500 isolates against 14 antibiotics, the resistance of antibiotics including Vancomycin 475(95%), Methicillin 500(100%), Imipenem 475(95%), Erythromycin 175(35%), Cloxacillin 225(45%), Azithromycin 275(55%), Ceftazidine 125(25%), Ceftriaxone 75(15%), Cephalexin 75(15%), Norfloxacin 50(10%), Cefoxitin 25(5%), Gentamycin 25(5%), Oxacillin 25 (5%) and Clindamycin25 (5%)  compared with CLSI(2013).The expression of fibrinolytic enzyme (Staphylokinase) done on plasma agar plate to locate hydrolysis around well of plasma on medium, the result showed 180 (69%) isolates of Vancomycin resistance S.aureus (VRSA) and Methicillin resistance S.aureus (MRSA) produces Staphylokinase. The chemical mutagenesis was done by exposure VRSA S.aureus  and MRSA S.aureus  to different doses of chemical mutagen including Hydroxylamine(HA).The study of antibiotics after chemical mutagenesis accomplished on Muller Hinton Agar plate and in vitro to human serum to Vancomycin , Methicillin that have high resistance before mutagenesis, the result showed after chemical mutagenesis by Hydroxylamine (HA) of S.aureus (VRSA) and S.aureus (MRSA) become  sensitive to Vancomycin called Vancomycin Sensitive S.aureus (VSSA) and  sensitive to Methicillin called Methicilline Sensitive S.aureus  (MSSA) with possess higher productivity of Staphylokinase (thrombolytic enzyme).The genetic analysis of sak gene of mutant VSSA, MSSA S.aureus done by genotypic PCR after DNA extraction with  amplification of mutant VSSA, MSSA S.aureus sak gene to determine each isolates possess sak gene of VSSA ,MSSA  S. aureus   with high expression  of staphylokinase, the results showed all isolates of mutant VSSA MSSA S.aureus possess sak gene with 420bp compared with DNA Ladder Marker.  Key words: Fibrinolytic enzyme, Mutagenesis, Mutagenic specificity.
Different Parameters Affecting to Production of Curcumin-Dry-Salted Frog (Hoplobatrachus Rugulosus) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Frog (Hoplobatrachus rugulosus) meat is an attractive food choice in international market. Frogs are mainly collected from nature and with the rising human activities. Consumption of frog meat has increased in the last few years. Frog production has been growing up and down many times due to the spontaneous development of farmers. Meanwhile frog processing is not developed in Vietnam thus the export volume of this product is limited. Most of frogs are supplied directly to the market for consumers. It’s necessary having post-harvest management including the processing of this species into the value-added foodstuff. From that, commercial frog value chain can be enhanced. Most traditional sun dried frogs do not meet the expected standard for human consumption due to the infestation of the products by the fly, insect larvae, contaminants and spoilage. The simplicity of the salting process, the low cost of production and the easy combination with curcumin could be considered as a preservative. Objective of this research focused on the processing of frog into the curcumin-dry-salted product by salting and drying method. Different technical experiments were investigated such as the effect of salt, curcumin ratio during soaking, temperature of drying, and packaging storage to chemical, microbial and sensory characteristics of the finished product. Results revealed that dry salting was better than wet salting. With addition of 0.75% of curcumin, drying at 50oC in 3 hours, the curcumin-dry-salted frog products had the good physicochemical, microbiological and sensory characteristics. By preserving under vacuum at 4oC, the curcumin-dry-salted frog could be maintained shelf-life for 12 months without any deterioration.Keywords: Frog, Hoplobatrachus rugulosus, Curcumin, Salting, drying, Vacuum, Shelf-life.
Prevalence of Tuberculosis in Nasiriyah City from 2010-2015 Kadhim Mohan Manhil
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Tuberculosis deployed in Nasiriyah City this study aimed to prevalence of Tuberculosis in Nasiriyah City, It is during visit to the health centers in the first and second Nasiriyah sector and updating us on the data found where the number of total infections in Nasiriyah from a year 2010 and 2015 to 2821 cases distributed among different age groups where the infection rate among children 5% and women 25% and men 70% and through study and observation of the database and the number of cases. low that number infection case in 2015 than it was in 2010 where the number of people with tuberculosis in 2010 in 628 infection case in 2015 was 260 cases and this shows a lower incidence gradually The study was conducted in Nasiriyah City, said the number of infected men more than women and children, and this goes back several reasons in men and through the study also found Variation in infection to the health center. Some centers recorded the highest cases of infection from tuberculosis during this year’s, some did not score in three years, an infection in Nasiriyah, the second sector is generally more than the infection in the first sector.It is during our visit to the health centers in the Nasiriyah to first and second Nasiriyah sector and updating us on the data found Also, the percentage fixed in Nasiriyah, from 2010 to 2015 among children, women and men, but the disparity in number by every year.Keywords: Tuberculosis, Nasiriyah city, Iraq.
Pharmacogenetic Testing: Effectiveness of the Use of the Indirect Anticoagulant Warfarin Oxana Bogaevskaya
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

There are some particularities of managing patients who have been taking anticoagulants for a long time and who need dental treatment. People who regularly receive oral anticoagulant therapy are at increased risk of bleeding during and after surgery in the oral cavity. Clinicians must constantly weigh the risk of postoperative bleeding with continued therapy, as well as the risk of thromboembolic complications when the drug is discontinued. The purpose of this study is to study the effectiveness and safety of the indirect anticoagulant Warfarin in patients with diseases of the cardiovascular system undergoing dental treatment. In 2017-2018, based on the Moscow dental clinic No. 2 (Russian Federation), studies were conducted in which 350 patients participated, of which 5 were excluded from the sample. Moscow cardiological dispensary No. 1 patients who applied for dental care were involved. The first group consisted of 30 people with a diagnosis of severe diseases of the cardiovascular system (coronary heart disease, etc.), the second - 65 people with an average risk of thrombosis, the remaining 250 people of the 3rd group are patients with a low risk of thrombosis. Instead of Warfarin, the first two groups received low molecular weight heparin, the third - continued the course of Warfarin. In addition to general clinical methods (ECG, maintaining the INR level (international normalized ratio), etc.), examinations used a selection of local anesthetics and vasoconstrictors. Significant differences in the INR level before and after the operation between the three groups were not found - all of them were within normal limits. The maximum number of bleeding cases in patients from the 1st group is 2.1 times higher than in the 2nd group (p ≤ 0.01), and 3.5 times higher than in the first (p ≤ 0.001). Between the 2nd and 3rd group the difference was 1.6 times (p ≤ 0.05). Regardless of the use or rejection of Warfarin, the maximum number of bleeding cases during dental procedures occurs in patients with severe cardiovascular diseases. Refusal from Warfarin is justified in case of severe diseases of the cardiovascular system, but in the case of a low level of thrombosis, therapy with Warfarin is possible. The risk of bleeding is evenly distributed within each group, regardless of the combined use of a vasoconstrictor and anesthetic or only anesthetic, while maintaining the difference between the groups. We have shown that the severity of diseases of the cardiovascular system can also influence the number of cases of bleeding during dental interventions. The complexity of the dental intervention determines the likelihood of bleeding. In the first group, for patients who had one tooth removed, bleeding was observed 5 times less compared with removal of the cyst (p ≤ 0.001), and 4 times less - compared with operations on the pulp (p ≤ 0.001). Pearson's correlation between the type of dental intervention and the number of bleeding in this group is the highest (0.91), 0.82 in the 2nd group, 0.56 in the 3rd. The type of dental intervention, regardless of the use of Warfarin, has a direct relationship with the number of bleeding. The maximum number of bleeding is observed in patients with severe pathologies of the cardiovascular system.Keywords: Effectiveness and safety of dental treatment, Warfarin, INR, Anticoagulants, Anesthetics, vasoconstrictors, Injection pain relief, Pharmacogenetic testing.
Photo Catalytic Removal of Paraquat Dichloride Herbicide in Aqueous Solutions by Using TiO2 Nanoparticle Ayad F. Alkaim
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Abstract In this work treatment of paraquat dichloride herbicide in wastewater using TiO2 nanoparticle as catalyst has been investigated.  Different parameters also investigated such as the effect of catalyst loading, the influence of initial dye concentration, and the effect of intensity of light in order to reach to the optimum operational conditions in which the best treated  of  paraquat dichloride herpicide. The highest removal efficiency of paraquat dichloride herbicide was indicated at 0.17 gm/100cm3 mass of aluminum oxide and 100 ppm of paraquat dichloride herbicide. photocatalytic degradation of paraquat dichloride herbicide was favorable in the 7.33 mW/cm2 light intensity. The percentage efficiency of removal paraquat dichloride herbicide equal 94. 77 %.Keywords: TiO2 nanoparticle, Paraquat dichloride herbicide, Photoefficiency.
The Effect of a Learning Program According to the Felder and Silverman Model Using Assistive Aids to Develop Reflective Thinking and Learning Some of Basic Skills for Students in Tennis Makarim Aliawi Nasser
Journal of Global Pharma Technology .
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The importance of the research is the need for the teacher to search for the best method that is appropriate to the nature of the student and his educational environment in a manner that motivates the student and to achieve the best performance, and this through the preparation of an educational program using the model Feldder and Silverman aims to develop their thinking and learn some basic skills in tennis as well as use The aids that contribute to and accelerate the acquisition of skills and facilitate their performance because they give a clear impact in learning the basic skills that represent the ultimate goal of the learning process. The purpose of the research is to: Prepare an educational program according to the Felder and Silverman model using the aids in the development of intellectual thinking and learning some basic skills for students, to know the effect of the educational program according to the Feldder and Silverman model in the development of thinking and learning some basic skills for students. According to the model of Felder and Silverman using the aids in the development of intellectual thinking and learning some basic skills in tennis for students.The Research HypothesesThere are statistically significant differences in the development of reflective thinking and learning some basic skills for students between the tests of pretest and posttest, there are significant statistical differences between the groups research in posttest tests. The researchers used the experimental program to design the equivalent groups with pre and remote testing because it fits in with the research problem. The research community determines the students of the third stage - the College of Physical Education and Sports Sciences / Karbala University for the academic year 2017-2018 (96) (A-B-C-D) The research sample was selected by lot. The sample of the research was the students of the (A-B) division, where the number of A (23) students and (B) (27) The Feldder and Silverman scale applied to the research sample of the students of the two divisions, and the researchers reached the following conclusions: The educational program developed according to the model of Felder and Silverman for learners has had a clear and effective effect in the development of intellectual thinking and learning some basic skills of tennis for students, the educational program helped to master each part of the skills and the emergence of development of the skill level of the two experimental groups in the development of contemplative thinking and skills. The recommendations were as follows: The need to focus on the use of methods Felder and Silverman through the use of teaching aids because it accelerates the process of learning, the need to rely on the principle of classification of students according to the model Felder and Silverman before embarking on any research, the need to conduct similar studies and the use of samples and other skills.Keywords: Learning program, Felder and Silverman model, Reflective thinking and tennis.
Antibacterial Activity of Nisin-Silver Nanoparticles on Staphylococcus epidermidis and Therapeutic Effects in Experimental Skin Infection in Mice Ahmed Qassim Al-Awadi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Today technology using nanoparticle when treatment pathogentic microorganism and we focused on this here .It was found that the species of Staphylococcus epidermidis used in present study were sensitive to Levofloxacin .The aim of report effect (Nisin-Silver Nanoparticles) on ability of complete healing injury comparing using Nisin only. In vivo study revealed that silver nanopasrticles treatment of S. epidermidis contaminated injured skin showed good healing process contain complete regeneration of the epithelial cells of the epidermis and good prognosis and increase of cellulartiy of the dermal content compared with untreated group. In conclusion, treatment of skin infected with S.epidermidis using silver nanoparticles at different concentration may limit the skin damage, localized the lesion to the incision site and enhance the healing process.Key words: Staphylococcus epidermidis, Nisin A, silver nano particles.
The Recurrence of Stricture in Postoperative Patients at Dr. Soetomo Hospital from 2013-2017: A Case-Control Study I Dewa Gede Reza Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Background: Urethral stricture is one of urology disease that commonly occurs in men with the incidence increase above 54 years old. Urethroplasty was an effective management option for almost all types of stricture and remained as the gold standard. Recurrence of stricture is one of complication that can occur after operative treatment. Methods: A case-control study with secondary data of all patients treated and undergoing operative management of the anterior-posterior urethral stricture in Dr. Soetomo Hospital from January 2013 to December 2017. Diabetes mellitus, hypertension, urine culture, and previous history of sachse were as independent variables. The data described by the distribution table and continued by Chi-square test using the SPSS application. P-value

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