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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Impact of the Design of Cooled Suit in the Recovery and Get Rid of Lactic Acid in the Handball Players in Karbala Club Hassim Abdul Jabbar Saleh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

The game of handball rely heavily on anaerobic energy production system, and many of the sediments produced when working within the system to produce the necessary muscular contraction of energy, the most important (lactic acid), so the return of the player natural state has become one of the important things to familiarity with them from Before coaches and sports workers. Here lies the importance of research in the design of the suit refrigerated and their impact in the process of healing, which helps restore the player to its natural state, and as soon as possible. The research aimed to design suit refrigerated, and to identify the extent of the efficiency of the suit cooled in the speed of recovery and get rid of lactic acid after the first half and the game players Karbala club handball, and to identify the advantage experimental and control groups in the speed of recovery and get rid of lactic acid after the first half and the game players club Karbala handball. It was the use of the experimental method with the two groups equalizers experimental and control, and select the research community my players Karbala Sports Club handball category of applicants and the number 16 player, "was chosen as a sample of them-style comprehensive inventory after excluding (4) players who are goalkeepers and injured, were divided into Two equal groups Each group includes (6) players. The researchers concluded that the cooled suit is suitable for the recovery process and the elimination of the accumulation of lactic acid. The use of the cooled suit after the first half and the second run hastened the elimination of the accumulation of lactic acid and the healing, and the use of cooled formula is much better than the procedures used by the players and trainers in the process of recovery quick.Keywords: Design, Cooled suit, Recovery, Lactic acid and handball.
Investigation on Light Structural View by Using of Reinforced Concrete with Nanoparticles Seyyedeh Fatemeh Khoshkalam Soleymandarabi; Raheleh Rostami
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The fibrous concrete is widely used in the construction industry, especially physical appearance industry. In this technical paper has been investigated concrete contained with nanomaterial and their properties.Spraying and pre-mixing techniques for the production have been introduced. If the fiber content is high then trapped air will increase and the density will decrease and thus the weight of parts will reduce. The dimensions of nanoparticles can play the role of filling cavities. Nano crystalline formation can also improve concrete strength. In this paper are introduced self-cleaning concrete, self-monitoring concrete, Nano-reinforced concrete and concrete Nano-coatings and glass Nano-fibers. Finally, in this paper has been paid to the application of fibrous concrete at the international conferences center of Esfahan in Iran and feature of Marriott hotel in San Francisco and the view of the Jubille church in Roma, Italy.Studies have shown that fiber concrete has use in the construction industry because of high-speed production, installation and high flexibility. Kiywords: Fibrous concrete, Nanoparticles, architecture, Self-cleaning concrete, Self-healing concrete, self-monitoring concrete.
Pharmacological Action of Aloe Vera and Linseed Oil on Experimentally Induced Hemorrhoid in Rats Noor D. Aziz
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Objective:-Hemorrhoids is recognized as one of the most common medical conditions in general population. It is clinically characterized by painless rectal bleeding during defecation with or without prolapsing anal tissue. This study designed to investigate the in vivo preclinical effect of aloin from aloe vera and linseed oil on experimentally induced hemorrhoid in rats by croton oil. Materials and Methods:  Twenty five albino rats (150-310 gm.) involved in this study. The animals were separated into five groups (5 animals / each).The first and second groups represent negative and positive control, the third one treated with alovera ointment (10 %), the fourth group was treated with linseed oil and the last one treated with proctoheal® cream as a standard treatment. The latter four groups was induced experimentally with hemorrhoid by applying croton oil via rectoanal region. Twenty-four hours after the induction, animals of the respective groups were treated for 5 days. On the fifth day, 1 hour after the relevant treatment, blood samples were collected by cardiac puncture technique for estimating the complete blood picture and C-reactive protein. Rectum is surgically removed (2 cm) to detect macroscopically lesions, histopathological findings and evaluate rectoanal coefficient (RAC). Results:-The cytoarchitecture of rectoanal portion of the animals treated with linseed oil was near to normal, so the response rate of linseed is higher to other treatment (aloe vera ointment). Conclusion:  linseed oil has a priority for alovera extract (Aloin) as well as has a beneficial effect on edema and inflammatory signs.Keywords: Hemorrhoid, Aloe vera, Linseed oil, Rat, Croton oil.
Amphetamine Drug Analysis Using Raman Spectroscopy Yaser Zuhair Tawfiq
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The main concept of this work is to analyze the illegal amphetamine drug by Raman spectroscopy. The samples of amphetamine were obtained from the drug control office in Iraq. Two different forms of amphetamine samples (a full tablet 167mg, and powder167mg) were chosen to investigate the sensitivity of Raman spectroscopy. The spectral of the two samples show no difference, and the amount of material does not constitute an obstacle in the way of measurements. The Raman shift spectrum of two forms has been reported in the region 2969.2 cm-1 for the powder form and 3009 cm-1 for the tablet form.Keywords: Raman spectroscopy, Amphetamine, Drugs.
Evaluation of Disincentive Effects of 70% Isopropyl Alcohol and 10% povidone-iodine Safety Antimicrobial Agents of Skin Iman Fadhil Abdul-Husin
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Background: Many disinfectants were used clinically in both single and mixture applications, however there had been few research on disincentive electricity according to sterilization series when the use of an aggregate of disinfectants. Aim: the purpose of present study was to evaluate the antimicrobial of two disinfectants each one alone and when the usage of a combination of them on skin isolates bacteria. Methods: One hindered and eight healthy volunteers were recruited. first groups were treated with a70% isopropyl alcohol on forearm, second groups were treated with 10% povidone-iodine on forearm and third groups were treated with  combination of 70% isopropyl alcohol and 10% PVP-I on forearm included disinfections on the both forearm with isopropyl alcohol first followed by 10% PVP-I. Skin cultures have been acquired the usage of cotton swabs three minutes after application of each disinfectant, and then had been inoculated on blood agar plates for bacterial lifestyle Result: There was no significant difference in the number of positive cultures between subject treated with single disinfect  (first groups, 150bacterial isolates for subject  treated with a 70% isopropyl alcohol; while in the second group 108bacterial isolates for subject  treated with10% povidone-iodine (P < 0.01)).Third groups was more effective than disinfection with a single agent  since there were only 48 bacterial isolates  suggesting that there is relationship between disincentive power of mixed two disinfectants that  used in present study. Conclusion: The combination of 70 % isopropyl alcohol and 10% PVP-I was more effective than disinfection with a single disinfects of them with either 70% isopropyl alcohol or 10% PVP-I disinfect.Keywords: Antimicrobial agents, 70% isopropyl alcohol, and 10% povidone –iodine.
Effect of Costus Specious Extract on Some Types of Pathogenic Bacteria Hanan Shihab Ahmad
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The present study aimed to investigate the effect of different concentrations of cold water extract, hot water extract, and alcohol extract of Costus specious plant with concentrations of 25, 50, 100, 150, 200, 250, 300, 350 micro liters / ml tested on eight pathogenic bacteria Staphylococcus aureus, Proteus Klebsiella Bacillus, Entrobactera, Serratia Pseudomonas aeruginosa Escherichia coli, Was obtained from the laboratories of the hospital of the city of medicine in Baghdad. The method of spread across the cattle. There was an effect on the bacteria at different concentrations in the cold water extract Costus specious where there is no effect of the extract on the bacteria enterobacteria. The results of the measurement of the diameter of the inhibition are clear. There is an effect on the bacteria species with the hot water extract of the Indian variety with different concentrations and the alcoholic extract of the Costus specious plant which had an effect on the bacteria species with different concentrations. The difference in the effect of the extract on the growth of the bacteria depends on the type of bacteria and concentration of the extract The effect of cold water extract at a concentration of 5 g / mL was more effective on Staphylococcus aureus. The effect of the hot water extract at a concentration of 5 g / 3 ml had an effect on Klebsiella and E. coli bacteria. The alcohol extract had the highest effect of 2 g / 5 ml on E. coli and the 5 g / mL alcohol extract was more effective on Serratia and Enterobacteria and no effect on bacteria Klebsiella.
Nursing Students Interests to Work Overseas: A Mixed Methods Study Pepin Nahariani
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: Opportunities for nurses to work abroad are extensive. But in-fact 60% of nurses work in the country, 35% work outside of their competence and only 5% work abroad. The study aimed to analyze the interest of nursing students to work overseas. Methods: a mixed-methods design was conducted. The totals samples were 395 respondents of Diploma Nursing, Bachelor of Nursing, and Profession of Ners programs. The sample was taken using totals sampling. The data collection was taken by a nursing migration questionnaire, a statistical test using linear logistic regression. The qualitative approach used by an in-depth interview. Eight Participants who were from the Bachelor of Nursing students.  Results: The results showed that almost 62.5% (247) of respondents indicated an intention to work overseas. Whereas the most significant influence of a plan to work abroad was gender, 43% of females, the academic of nursing bachelor programs were 49%, English language skills were 29%, and income is less than 3 million 61%. The country chosen had the highest probability (OR 3.5), thus the planned future overseas (OR 1.47), the information (OR 1.26), and the study program (OR 1.25). But the lower grades of intention working abroad were income (OR 0.6). Conclusion: Based on this research showed that most students interest in working abroad in Kuwait (83.5%), Japan (15.7%) dan Arab Saudi (0.3%). Besides, the few students’ interests work in another country that has a foreign language from English. The implementation of increasing career paths and improving the quality of human resources through foreign language skills will provide excellent opportunities to work overseas.Keywords: Student; Nursing; Interest; Intention; Working overseas.
Simultaneous Analytical Method Of 6-Mercaptopurine and 6-Methylmercaptopurine In-vitro Study With Bio-Sampling Venipuncture and Dried Blood Spot Yahdiana Harahap
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Objective: 6-Mercaptopurine (6-MP) is a cancer chemotherapeutic agent. Metabolic pathway by thiopurine S-methyltransferase (TPMT) to become 6-methylmercaptopurine (6-MMP).Bio-sampling is required to obtainbiological sample, using two technique; invasive (venipuncture) and minimum invasive(dried blood spot). This study aims to obtain an optimization and validation analysis 6-MP and 6-MMP in vitro study with bio-sampling venipuncture and dried blood spot (DBS). Method: Plasma from venipuncture method extraction was done using dichloromethane. Separation was performed using Waters HPLC, C18 SunfireTM column (5μm, 250 x 4.6 mm), with gradient elution, flow rate 1 mL/min and detected at UV-PDA wavelength of 303 nm. Bio-sampling dried blood spot with DBS CAMAG® paper diameter of 8 mm and extracted with acetonitrile-methanol (1:3). Separation was performed with Waters LC-MS/MS UPLC C18 column (1.7 μm, 2.1 x 100 mm) with gradient elution, flow rate 0.2 mL/min. 5-fluorouracil (5-FU) was used as internal standard.Result: The method venipuncture was linear at concentration range of 2-200 ng/mL for 6-MP and 20-2000 ng/mL for 6-MMP. The method dried blood spot using Waters Xevo TQD for mass detection with positive electrospray ionization (ESI) for 6-MP, 6-MMP and negative ESI for 5-FU in Multiple Reaction Monitoring mode. Linear with the range 26-1000 ng/mL for 6-MP and 13-500 ng/mL for 6-MMP.Conclusion: The developed method is valid for 6-MP and 6-MMP simultaneously in vitro from venipuncture using HPLC and from dried blood spot using LC-MS/MS and showed good selectivity, linearity, accuracy and precision, matrix effect and stability.Keywords: 6-mercaptopurine, 6-methylmercaptopurine, Venipuncture, Dried blood spot.
Liquisolid Lipid Based Liquisolid Compacts of Olmesartan Medoxomil with Improved Oral Bioavailability: In Vitro and In Vivo Evaluation Dhiraj Chopra
Journal of Global Pharma Technology Volume 11 Issue 02 (2019) Feb. 2019
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Abstract

The main objective of the current research work is to evaluate the potential of lipid based liquisolid compacts (OLC) to enhance oral bioavailability of Olmesartan Medoxomil (BCS Class II molecule).OLC have been prepared using Capmul MCM and Captex as non-volatile vehicles, Pearlitol SD 200, Avicel PH 102 and Flowlac 90 as carrier’s materials and Syloid® 244FP as a coating material. Liquisolid compacts were prepared by premixing the non-volatile liquid and drug in equal ratio, converting the resulting wet mass into free flowing powder using carrier and coating material (5:1 ratio). Prepared LBLC’s were evaluated for their micromeritics properties, solubility, dissolution and in vivo bioavailability in selected rats. Among the formulations prepared, formulation (OLC1) containing Capmul MCM as vehicle, Pearlitol SD 200 as carrier has shown enhanced drug release (99.7 ± 5.4 release in 30 minutes) and solubility (72.54mg/mL) compared to other formulations. Hence, this formulation is evaluated for comparative in vivo bioavailability in rats along with pure drug and marketed formulation (Olmezest). It was found that relative bioavailability of OLC 1 was increased by 4.86 times compared to pure drug and increased by 1.42 times compared to marketed formulation. Hence, the study demonstrated that lipid based liquisolid technology can lead to improve the bioavailability of poorly soluble drugs like olmesartan medoxomil significantly.
Investigation of Antibacterial Activity and Cytotoxicity of ZnO nanoparticles Synthesized by a Novel Biological Method Shurooq S. Mahmood
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This research explains the biosynthesis, characterization, evaluation of the antibacterial activity and cytotoxicity of zinc oxide nanoparticles (ZnO NPs) prepared by a low-cost and simple procedure. Bio-inspired ZnO NPs were synthesized with the aid of a novel, non-toxic, ecofriendly biological material namely; Banana peels extract (BPE). Qualitative phytochemical screening of the aqueous fruit peels extract of Banana revealed the presence of many phytocomponents in it. The structural, morphological and optical properties of the synthesized nanoparticles have been characterized by using UV–Vis spectrophotometer, XRD, FE – SEM with EDX analysis, AFM, and FTIR. The synthesized ZnO NPs were characterized by a peak at 373 nm in the UV–Vis spectrum. The XRD of the sample revealed the hexagonal wurtzite structure with an average grain size 11.98 nm. Particle shapes and sizes were determined by FE-SEM. Surface morphology of the sample was studied by AFM. FT-IR confirmed the presence of functional groups of both leaf extract and ZnO NPs. The results showed the antibacterial activity of the ZnO NPs against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). The cytotoxicity of ZnO NPs was tested against vero101 normal cell line and skin A431 cancer cell line by Crystal violet (CV) assay. Banana peels mediated ZnO NPs showed no evidence of toxicity against normal cell line, the nanoparticles are biocompatible and are non-toxic and effective cytotoxic effect against cancer cell line. These results clearly support the benefits of using a biological method for synthesizing ZnO NPs with anticancer activities.Keywords: Zinc Oxide NPs; Biosynthesis; Banana peels extract (BPE); Phytochemical; Antibacterial; Cytotoxicity

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