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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Self Care Behavior As An Indicator Of Psychological Adaptation In Patients Undergoing Chemotherapy Awatiful Azza
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Chemotherapy is one of the medical actions taken to treat cancer and kill cancer cells using cytostatic drugs. This treatment not only has positive effects but also the negative effects of sufferers. This study aims to analyze the relationship of self-care behavior with the psychological adaptability of patients undergoing chemotherapy Methode: This study used a cross-sectional design. The Sample was 120 patients in the chemotherapy treatment unit at the hospital in Jember-Indonesia district, with purposive sampling. The independent variables were self-care behavior (include self-care confidence, self-care management, Self-care maintenance). The dependent variable was a psychological adaptation. Data were obtained through a modified Self Care Heart Failure In-dex (SCHFI) instrument which has been modified for patients undergoing chemotherapy. Data were analyzed by using Chi-square with a significance level of p < 0, 05. Results: of this study indicate there was a relationship between self-care behavior with the psychological adaptability of patients with chemotherapy, the p-value was 0.00 <0.05. Conclusion: Self-care behavior is one form of nursing service that can be applied to patients undergoing chemotherapy. The ability to engage patients independently during chemotherapy can increase patient self-esteem and will help improve patient adaptation due to the side effects of chemotherapy. Further study recommends developing the intervention to improve the adaptation of patients undergoing chemotherapy.Keywords: Adaptation, Self Care Behavior, Chemotherapy.
Hemopoietic Activity of the Beetroot Ethanolic Extract of Beta Vulgaris (Shamandar) in Albino Rats Shahbaa M. Al-Khazraji
Journal of Global Pharma Technology .
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Abstract

Beta vulgaris known locally as shamandar, the aim of this study is to demonstrate the hem biotic effect of the ethanolic extract of beetroot of the plant, The study was prepared to investigate the effect on hemoglobin (Hb), red blood cell count (RBC) “, packed cell volume (PCV) “, mean corpuscular hemoglobin (MCH) “, mean corpuscular volume (MCV)”, and mean corpuscular hemoglobin concentration (MCHC) “by using 50 albino Swiss rats. Five groups of rats (each 10) were fed orally with different doses of beetroot extract of Beta vulgaris (200, 400, 800, 1600 mg/kg body weight and control), for sixteen days. Blood samples were collected from the rats by ocular bleeding, and analyzed for the determination of the hem biotic parameters. It is concluded from the study , that the beetroot ethanolic extract of beta vulgaris elevate the blood parameters in a dose dependant  manner , which support the folklore  use of the juice of the shamandar to treat anemia.Keywords:  Beta vulgaris, Shamandar,   Beetroot, Albino Rats, Blood Picture, anemia.
Excitation of Λ - type three Level System by Pulsed Radiation as a Model of Radiology Tissue Response Saddam Flayeh Haddawi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

In several biomedical applications, it is desirable to transfer an electron in an atom from one energy level to another. This may be a direct transfer, involving only two atomic levels, or may involve some intermediate levels which the electron must pass through before coming to its final state. The model dealt with here incorporates one such intermediate level, and so we consider three atomic levels in all. Also, our model allows for the possible loss of the electron, via collisional excitation, spontaneous emission, or some other process. We have to de ne a parameter, in units of frequency, which is proportional to the loss rate. The purpose of the thesis is description of the interaction of a three level with pulsed radiation in the Λ scheme. And also we will consider the scheme of excitation whereas two neatly diverged long-term stayed ground states  and, are connected by two nearly resonant laser fields to a third distant short lived state b.
Analytical Method Validation for the Determination of Tetrabutylammonium Bromide Content in Daclatasvir Dihydrochloride by LC-Ms/Ms Suresh Reddy. Yellampalli
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
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Abstract

Objective: A rapid, sensitive and selective analytical method was developed and validated for the determination of Tetrabutylammonium bromide content in Daclatasvir dihydrochloride. Method: Chromatographic separation was achieved on a Kinetex biphenyl 150X 4.6 mm, 5µm column using isocratic elution with the mobile phase consisting of acetonitrile and ammonium formate buffer with flow rate was 0.7 mL/min. Results: The retention time of Tetrabutylammonium bromide was found 4.65 min. The method was validated according to ICH [1] guidelines. The calibration curve was linear over the concentration range of 0.0310–0.1530 % (r = 0.9999). The intra- and inter-day precision (RSD %) was 3.8 % and the accuracy (%) was LOQ (91.8 %) to 150 % (101.6 %). Conclusion: The proposed method was simple, precise and accurate. The method can be used for the testing of content of Tetrabutylammonium bromide in Daclatasvir dihydrochloride API during routine quality control and stability testing.Keywords: LCMS/MS, Tetrabutylammonium bromide, Method validation, ICH guidelines and Daclatasvir dihydrochloride.
Autonomic Function in Peripheral Nerve Regeneration Especially in Radial and Ulnar Nerve Injuries after Microsurgery: A Systematic Review Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

This literature review seeks to understand the difference in autonomic function of radial and ulnar nerve injuries after microsurgery. During this surgery, additional damage to nerves is also experienced. This research focused on peer-reviewed articles from Pubmed-NCBI database. This is a medical database which features medical peer-reviewed articles on various illnesses treatments and outcomes. The eligibility criteria used were that the article must be full text, published within the past 10 years, written in English language, and featured the keywords-radial nerve injury, ulnar nerve injury and microsurgery. There was no specific characteristic for participants as all individuals with injury were considered. The search from the database yielded 121 initial articles. Of this number, 33 were excluded for being editor comments and no full texts. This had led to 88 remaining articles which were further screened to remove articles written in other languages and those which were older than 10 years. This featured a total of 43 articles. Of this remaining total, only 30 articles were used. The other 15 were excluded as a result of research reliability issues. The procedures used in the articles featured a lot of limitations which questioned the validity of their results. This paper concludes with a summary of the analysis of the difference in autonomic function of the radius and ulna after microsurgery.Keywords: Autonomic function, Radial nerve, Ulnar nerve, Microsurgery.
Nanogels as Next Generation Drug Delivery Systems Sri Sruthi K; Satya Lakshmi S; Srinivasa Rao Y; Kamala Kumari P.V
Journal of Global Pharma Technology Volume 12 Issue 07 (2020) July 2020
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Abstract

Nanogels are the innovative drug delivery systems which plays an integral part in pointing out many issues related to old and modern courses of treatment, such as nonspecific effects and poor stability. Nanogels are the highly cross linked nanosized hydrogels ranges from 20-200 nm. These can also be administered through various routes, including oral, pulmonary, nasal, parenteral, intraocular etc. Nanogels have high degree of drug loading capacity and it also shows better permeation capabilities due to a smaller size. These are also release the drug by pH responsive, thermosensitive, volume transition, photochemical internalization and photo-isomerization mechanism.Withemerging field of polymer sciences it has now become an inevitable to prepare smart nanosystems which can prove effective for treatment as well asclinical trials progress. The present review providing the comprehensive illustrations on novel applications, drug loading technique, mechanism of the drug release from nanogels. Further, current status, clinical trial status, and future perspective of the nanogels have been summarized.
Purification and Characterization of Tracp from sera of Patients with Chronic Renal Failure Hathama R. Hasan
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background and Objective Tartrate Resistant Acid Phosphatase (TRACP) also known as type 5 acid phosphatase is a glycoprotein with basic pI , and occurring as two similar isoforms 5a and 5b with different carbohydrate content. This study aims to characterize both TRACP isoforms physico-chemically and spectrophotometrically Materials and Methods: Ion exchange chromatography was applied in order to purify TRACP isoforms (5a and 5b) from sera of control and patients with End Stage Renal Disease (ESRD). Results: The results indicated different specific activities of TRACP 5a and 5b and their proportional amounts in sera of patients with ESRD were different from that of the control group, they had approximate molecular weight of (36.8-39.3 KDa) and a basic isoelectric point equal to9.6 incontrol and patients with ESRD. The optimal pH for 5b is relatively higher than for 5a, the heparin (23 KU/L) had an inhibitory effect only on the activity of TRACP 5a, the iron content of isoform 5b was found to be one mole per one mole of enzyme, and UV spectrum of TRACP 5a was found to be different from that of TRACP 5b in both control and patients with ESRD. Conclusion: We conclude that there are differences in the characterization of both isoform TRACP 5a and 5b in sera of end stage renal disease.Keywords: TRACP, Purification, Isoform, Characterization.
Effect of Oxymetholone by the Mother Treatment During Pregnancy and Lactation in the Testicular Tissue in Mature Male Rats Mohammad Pourahmadi
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

Introduction: Oxymetholone is an active nutritional anabolic - androgenic steroid which is used as a performance-enhancing drug in high dose and may result in the lung cancer, mineral deposits in the lungs, irregular cycles, ovarian and liver cancer. Unfortunately, some athletes take oxymetholone as a performance-enhancing drug for its anabolic effects and muscle growth in high doses. The aim of this study is to investigate oxymetholone induced complications in the testicular tissue in immature male rats, whose mothers were treated by oxymetholone during different pregnancy and lactation periods. Materials and Methods: In this study, we used fifty six female rats and fourteen male rats aged 110-120 days, weighing were approximately 200 ±20g. The animals were divided into groups including control, solvent 1 (pregnancy- 21 days), solvent 2 (pregnancy- lactation- 42days) solvent 3 (lactation - 21 days), experimental 1 (pregnancy 21 days) experimental 2 (pregnancy- lactation- 42 days), and experimental 3 (lactation-21 days). Solvent groups used DMSO with 99.5% concentration and experimental groups used oxymetholone with 10 mg/kg concentration by the intra peritoneum method. Results: The rate of spermatocyte cells in the experimental group of pregnancy-lactation and spermatid cells in the groups of pregnancy and pregnancy - lactation indicated a significant decrease compared to control. Conclusion: Oxymetholone in high doses or long-term influences on tissues and physiological activities in the reproductive system. Keywords: Oxymetholone, Spermatogenesis, Rats.
Isolation and Identification of Bacterial Causes of Acute Tonsillitis Frial Gemeel Abd
Journal of Global Pharma Technology .
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Abstract

Acute tonsillitis was an inflammatory process of the tonsillar tissues and was usually infectious in nature. Acute tonsillitis starts suddenly and usually goes away again within one to two weeks. This infection was often bacterial, or sometimes viral.   A hundred of blood and swabs specimens were collected from patients who were suffering from tonsillitis whose did not take any drugs for both sex with age ranging from 1-60 years in AL-Hilla-Teaching hospital and hospital Babylon for birth and children during a period from October 2017 through January 2018 . The causative agent for tonsillitis was   isolated and diagnostic of microorganism according to morphological and biochemical test  by using VITEK compact 2 .The results  appeared the number of gram positive bacteria about 100 and 23 isolate from  gram negative bacteria .The most common causative agent was Streptococcus pyogenes and Staphylococcus aureus. The sensitivity of bacterial to antibiotic was appeared most of bacterial resistance to amoxicillin, Cefotaxime and Aztreonam) but sensitive to other antibiotic such as Gentamycin, Chloramphenicol and Ciprofloxacin kit. Qualitative and semi quantitative ASO determination was done using the ASO latex agglutination kit. 24%of patient was ASO positive and 67% was ASO negative The level of ASO in patients that tested positive for the presence of ASO ranged from 1600IU/ml to 25600IU/ml. 12 sample were the highest concentration of 25600IU/ml .The conclusion of this study found that Streptococcus pyogenes was most common causative agent for tonsillitis and the bacteria resist amoxicillin.Keywords: Tonsillitis, Amoxicillin, Streptococcus, ASO.
Adsorption Thermodynamic Study of Congo Red Dye on Electrospun Nanofibers Mat of Polyacrylonitrile Juman A. Naser
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present study intends to prepare nanofibers mat of polyacrylonitrile by electrospinning technique and investigates their adsorption capacity to Congo red dye from the aqueous solution, after characterize it by different techniques such as FTIR, SEM, EDA, XRD and BET. The influence factors on adsorption were studied including adsorbent dosage, initial concentration, contact time, pH and ionic strength. The results confirmed that the increasing in pH decreases the adsorption capacity. So, the optimum adsorbent dosage, initial concentration and contact time were 0.006 g, 25 mg/L and 150 min respectively. The isotherm models of Freundlich and Langmuir were applied on the experimental adsorption data to evaluate the maximum capacity and energy of adsorption. The experimental data was founded more fitted with Langmuir model. Additional, the thermodynamic parameter changes such ∆G, ∆H and ∆S of adsorption were estimated. The results explained that the adsorption process was exothermic and non-spontaneous.Keywords: Electrospinning, Congo red dye, Polyacrylonitrile, Nanofiber, Adsorption.

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