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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Post-exercise hypotension phenomenon in elderly after aerobic exercise Agha Bhargah; Made Muliarta; I Putu Yuda Prabawa; Ida Bagus Amertha Putra Manuaba; Varennia Bhargah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Post-exercise hypotension (PEH) which means the occurrence of changes in blood pressure after a physical exercise to a lower blood pressure level after the start of physical exercise. The incidence of PEH can be concluded as a benefit when viewed regarding people who experience a state of hypertension, but if in people with normal blood pressure circumstances can cause the risk of a state of hypotension. The purpose of this study was to determine the magnitude of the decrease in post-exercise hypotension in elderly. Study model using a quasi-experimental model with pre-test and post-test group design involving 28 elderly as a research subject. Aerobic exercise in this study was performed through a healthy heart gymnastics exercise with a duration of 45 minutes. Blood pressure measurements were performed before exercise (baseline value), immediately after exercise, 15 minutes, 30 minutes, 45 minutes, and 60 minutes after exercise was done. Statistical analysis using normality and homogeneity test, ANOVA test, and paired sample t-test to compare differences in blood pressure parameter between period of measurement. There are differences in systolic, diastolic, and Mean Arterial Pressure (MAP) blood pressure between time measurements (p<0.001). The systolic blood pressure was significantly lower at 60 minutes post exercise (121.96±1.43 mmHg) compared with baseline (141.35 ± 8.76) (p<0.001). Diastolic blood pressure was significantly lower at 60 minutes post exercise (121.96 ±1.43 mmHg) compared with baseline (91.75 ± 1.48) (p<0.001). MAP was significantly lower at 60 minutes post exercise (93.89 ± 1.15 mmHg) compared with baseline (108.39±1.34) (p<0.001). Aerobic exercise through a healthy heart gymnastics session on elderly provides a post-exercise hypotension phenomenon. The lowest reduction of blood pressure was found at 60 minutes after aerobic exercise.Keywords: Systolic, Blood Pressure, Hypotension, Diastolic.
Epidemiology of Human Rabies Deaths in Babylon Province, Five Years Descriptive Epidemiologic Study Hasan Alwan Baiee
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Human rabies is a fatal zoon tic diseases, it was endemic in Iraq since 4000 BC, poor passive surveillance and lack of educational awareness of public in Iraq lead to the end emicity and outbreaks of the disease especially in the central governorates including Babylon province. The objective of this study was to evaluate the epidemiologic features and the incidence of deaths of human   rabies   in Babylon province during the years 2012 to 2016.Nine human rabies deaths were reported during this period. Diagnosis is majorly carried out by clinical presentation coupled with history of exposure to rabies infected dog. This number of human deaths due to rabies gotten from this review is a far cry to the number of human death due to the diseases. This study showed that this disease is endemic in Babylon governorate, an epidemic took place in the province during the year 2016, the victims were mainly males; male to female ratio was 8: 1, fatal human rabies affect mainly children and young age males, most of victims didn’t receive post exposure vaccine (88.9%).Human rabies in Babylon province still a public health problem, strategic plan for elimination of human rabies is strongly needed. Keywords: Epidemiology, Human rabies, deaths, Babylon, Iraq.
Histological Effects of Saccharomyces Boulardii Probiotic in Some Mice Organs Infection with Salmonella Typhimurium Hanan Abdullah Ali Al-Shammary
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Background and Objective: Saccharomyces Boulardii, Eukaryotic probiotic it was unable to proven therapeutic efficacy. This study leads to evaluate the protective effect of three types of probiotic yeast Saccharomyces Boulardii in the tissues of some internal organs of laboratory mice before and after infection with pathogenic bacteria Salmonella Typhimurium. Materials and Methods: Three types of yeasts  were used ,Local Iraqi Isolate (Local Saccharomyces Boulardii) LSb ,Mutant Iraqi Isolate (Mutant Saccharomyces Boulardii) MSb and commercial strain (Commercial Saccharomyces Boulardii) CSb. Forty  male white mice were divided into 4 groups , Each group included 10 mice: control, MSb, CSb and LSb ,dosed with 0.2 ml/day for 28 days  of yeast  inoculums except control treatment fed on the standard diet, half number of animals in each group were sacrificed for histological examination of some organs (liver, spleen and intestine),the remaining mice were infected with 0.2ml of S. Typhimurium daily for 8 days , and sub-treated  have been derived: Control + St, MSb + St, CSb + St and LSb + St. the histological examination of the indicated organs was performed .Results: Histological indicators of internal organs (liver ,spleen  and  intestine) of the groups MSb, LSb and CSb, shown that no necrosis or clear lesion or inflammatory sign in those organs .In addition  ,histological examination of infected St +control group shown necrosis of hepatocytes , congested central  vein and dilated  of sinusoids of the liver  , necrosis in the lymphoid tissue and inflammatory cells infiltration in the white  pulp of the spleen , while the changes in the intestine shown inflammation cells infiltration in the lamina properia and erosion of  epithelial cells , compared with the positive effects  of MSb + St, CSb + St, and LSb + St in reducing necrosis ,inflammation and cytotoxic effects of  S. typhimurium, but the MSb + St group was the best .Conclusion: Mutant Iraqi isolate was the efficient in protective the tissues of (liver, spleen and intestine of animals after infections with S. Typhimurium bacteria .Keywords: Probiotics, Saccharomyces Boulardii, Mutagenesis, Salmonella Typhimurium, Histopathological changes.
Adsorption and Photocatalytic Degradation of Crystal Violet Dye by using Cadmium Sulfide in Aqueous Solutions Aseel M. Aljeboree
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Chemical methods were used to synthesized cadmium sulfide thin films in a mixed phase which testing for wastewater treatment through the photocatalytic degradation. Specific region of light (UV) was used to remove the organic pollutant which commonly destroy the environmental such Crystal violet dye forming what we could it wastewaters. The testing solutions were degraded under visible-light irradiation using the CdS thin films. Structural studies of the CdS photocatalyst refer to the hexagonal and cubic phases with good crystallinity and uniformly and homogenous distributed over all the sites of support with less agglomerations.  The morphology analysis mostly shown induces porosity, which mostly enhance intercalating dyes. The optical band-gap energy of sample within film was 2.35 eV, which explained the high photcatalytic behavior in the degradation of the non-biodegradable Crystal violet dye. As accepted the semiconductor/ UV-light were succeed to declaration of day which shows good acceptable results. The surprised was the efficiency of degradation or deceleration was rises very high as compare with the same conditions of reaction in room temperature in addition to increases with raises of concentration from 0.5 to 4 g/L. Keywords: Cadmium sulfide, Photcatalytic degradation, Adsorption, Crystal Violet dye.   
Synthesis, Antioxidant, and Preliminary Antitumor Activities of New Curcumin Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Curcumin is a molecule gifted from nature to improve human health by its multiple biological activities. However, the application of curcumin in therapeutics is limited mainly due to its poor aqueous solubility, insignificant chemical stability, and low cellular uptake. To address some of these drawbacks, eight analogues of curcumin were synthesized starting from simple molecules. Characterization of the chemical structures of these analogues was documented by interpretation of their IR, 1H-NMR, and 13C-NMR spectra. Biological activities of the synthesized analogues were studied by comparing their activities with those of curcumin. This biological assessment included examining the antioxidant capacity via DPPH and hydroxyl radical scavenging activity tests, and screening the preliminary antitumor activity against MCF-7 and HeLa cancer cell lines by MTT test. Depending on the resulted data, it was found that these analogues have the comparable biological activities but with better stability and water solubility in comparison with curcumin. It is postulated that such analogues may be useful clues to improve the therapeutic applications of curcumin.Keywords: Curcumin, Synthesis, Analogues, Antioxidant, Antitumor.
A Review on Polymeric Nanoparticles: A Promising Novel Drug Delivery System Anup Naha
Journal of Global Pharma Technology Volume 10 Issue 04: (2018) April 2018
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Abstract

Polymeric nanoparticles[PNPs] has been considered as a promising drug delivery system for a variety of drugs, anticancer agents, biological macromolecules and vaccines.These nanoparticles are a novel approach and plausible solution for conventional therapeutics, prophylactic and diagnostic options. Polymeric nanoparticles (PNPs) are Nano sized solid particles orparticulate dispersions with size ranging from10nm to 1000nm. With its enormous potential PNPs offers vast scope for researches in this field. This article covers properties of polymeric nanoparticles, its therapeutic applications, polymers used in preparation, method of preparation and characterization.Keywords: Polymeric nanoparticles (PNPs), Polymerization, Drug delivery system.
The Effect of Existential Therapy on Divorced Women's Existential Anxiety Abdollah Aliesmaieli
Journal of Global Pharma Technology Volume 08 Issue 07
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Abstract

The aim of the present study is to investigate the effectiveness of existential therapy on divorced women’s existential anxiety. The study is the result of a quasi-experimental research conducted at Babol Islamic Azad University. The sample size included 22 people assigned to experimental and control groups. To do the study, 22 female university students were selected and after carrying out a pre-test were then randomly assigned to two groups, namely, experimental and control. Then, 12 (at maximum) therapy sessions were held for the experimental group. Finally, both the experimental and control groups were evaluated by a post-test. The data was analyzed by using the covariance test analysis (ANCOVA). The results showed that existential therapy decrease existential anxiety (p<0/01). The post-test scores of existential anxiety for the subjects in the experimental group were significantly lower than the pre-test of the same group and the post-test of the control group. According to the results of the study it is predicted that existential therapy can be used as an effective method for treating the problems of divorcee women. The results of this study were in line with the findings about the treatment of cancer, diabetes and traumatic and post-traumatic stress disorder patients.Keywords: Existential Anxiety, Existential Therapy, Good & Good Test.
Effects of Different Doses of Aspartame on Some Biochemical Parameters of Kidney Rats Marwa Amer Ali
Journal of Global Pharma Technology .
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Abstract

This study aims to determine the effect of aspartame on the biochemical parameter, and its influence on the kidney tissues in rats. Thirty adult male rats and 30 adult female rats, with age of 60-65 day are used in this study, almost on an average live weight between (165-200) gm. The experiment concentrates on the daily dose, where the animals are randomly divided into four groups, each group contains 15 animals (five males & ten females), three experiment groups treated and control group. The first group treatment A gavage with concentrated aspartame of (250 mg / kg/ per day), the second group treatment B gavage with concentrated aspartame (500mg/kg/per day) and the third group treatment C dosage of (1000mg/ kg/ per day), while the control group dosed with 1ml physiologic solution daily. All the groups had their daily dosages orally for 90 days, and the study continued from 29 October 2017- 26 January 2018. After the end of experiment , blood sample was collected for estimate this serum of urea ,uric acid  and creatinine .The results of this study showed that there is non- significant differences (P> 0.05)  in urea concentration between control group and group A,B and C.  Also there is non-significant differences (p>0.05) between treatment groups .The result showed there is a significant differences (p<0.01)in creatinine concentration in group A in comparison with control group .But group B showed non- significant differences (p>0.05) in creatinine concentration compared with control group .while group C has a significant increase (p<0.05) in creatinine concentration in compared with control increase (p<0.05) in creatinine concentration in compared with control group. When the treatment groups the results showed that the group A high significant difference (p<0.01) when compared with B group .whereas non -significant differences (p>0.05) between A and C groups. Also there is non- significant differences (p>0.05) between B and C groups. In uric acid showed non- significant differences (p>0.05) compared with group A and control group, Also there is a non-significant decreased (P>0.05) compared with the B group and control group. While showed in the C group has a high significantly differences (p<0.01) compared with the control group .when compared the treatment groups the results showed there is non- significant differences (p>0.05) between group A and B, C groups .Also there is non- significant differences (p>0.05) between B group and C.Keywords: Aspartame and effect on kidney.
Influence of Silver Nanoparticles on Optical Properties for (PS-PMMA) Blend Saba Salim Nemah
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The optical properties of poly (methyl metha acrylate) (PMMA) with polystyrene (PS) blend films doped with silver nanoparticles were studied. The blend films were prepared using solution casting technique different weight ratio (0, 2.0, 4.0, and 6.0 wt %) of the Ag nanoparticles, the optical properties of the prepared films were investigated. The optical absorption spectra of these films in the wavelength range from (320-1100 nm) were measured to investigate the influence of Ag nanoparticles on the optical properties of (PS-PMMA) blend. The results showed that energy gap of the blend films decreases with increasing Ag nanoparticles weight ratio. The absorbance, absorption coefficient, extinction coefficient, refractive index, parts dielectric constant (real and imaginary) of the prepared (PS- PMMA) blend films were found to be increased with increasing the weight ratio of Ag nanoparticles.Keywords: Nanoparticls, Optical properties, (ps-pmma) polymer.
Dietary Diversity among Children Aged 12-23 Months in Urban Area Eka Mishbahatul Marah Has; Nursalam .; Yuni Sufyanti Arief
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

This study aimed to describe the dietary diversity among 12-23 months old children living in an urban area. A cross-sectional survey which involved 146 mothers who had children aged 12-23 months, living in Surabaya City, East Java, was conducted. Mother's, child's, household's characteristics, and child's dietary diversity were collected by using a questionnaire. Then, the frequency distribution and percentage analysis were performed. The result showed that most children (96.6%) met the minimum dietary diversity as recommended by WHO. The food groups which mainly consumed were vitamin A-rich fruits and vegetables (100%) and grains, roots, and tubers (96.6%). In reverse, the food groups which less consumed were other fruits and vegetables, and legumes and nuts. Integrated health promotion is needed to ensure low socioeconomic status household who lived in the urban area met the appropriate infant and young child feeding practice. Keywords: Dietary diversity; Children aged 12-23 months; Urban area.

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