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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Application of Surgical Safety Checklist (WHO) at Al- Diwaneyah Teaching Hospital Ali Jawad Hamza Al-Shammari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Surgery have been considered as one of the global health care important part, however the surgical complications are still common, but can be prevented. Till now, surgery is an essential component of public health and its role is increasing rapidly. Aims: Present study aims to use a safety checklist items to improve team surgical care which will reduce complications and deaths associated with surgery. Patient and Methods: This prospective study enrolled 162 patients using checklist of surgical safety consist of 19 items with different types of operations at Al-Diwaneyah Teaching Hospital in Iraq during the period 1st of February 2018 until 1st of February 2019. We follow the patients until 30 days after surgical intervention. Results: After applying the 19 items of surgical safety checklist to 162 patients, the risk of the surgical site infection(SSI), respiratory complications, missed gauze and risk of blood loss (3.7%, 2.4%, 0.6% and 1.85%) respectively were comparable to the results of the World Health Organization. Pulse oximeter was used in 92.5% and site marking in 65.4%. In 61.73% of patients received antibiotic prophylaxis in which just 3.7% developed surgical site infection, while the extended regime in 38.27%, there is 9.8% with SSI. No mortality reported during the collection of the data. Conclusions: The surgical checklist is a simple and effective method in reducing surgical complications. WHO recommends use of the checklist in all surgical operations and encourages clinicians to modify the list for different specialty and hospitals. Keywords: Safety check list, Surgical site infection, Surgical complications, Basic surgical care.
Molecular Investigation of E.dispar in Terms of Virulence Factors CP1, CP5 Khalid Thamir Mattar AL-Shaibani
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The current study included the detection of  existence the Parasite E.dispar in 180  samples of feces  for  stricken patients with diarrhea from revisers  to  public hospital of Al -Shamia  and three primary health centers in the district of Al- Shamia which is subsidiary to Al- Qadisiyah governorate  for period of  July 2016 till the end of December 2017, only 48 samples containing the Parasite of amoeba with it nourished  ,sacked  state  or both out of 180 sample of  feces for stricken   patients with diarrhea, the incidence rate of the Parasite of amoeba recorded 26.22%, and the obligation results are submitted to microscopic examination for  Molecular examination  to Real Time PCR (Taq Man Probe) to specific  investigate  to the   E. dispar and indicate the existence this kind in 31 samples ,with  64.58% rate  of the total of 48 obligation samples, after then the obligation samples  underwent to  molecular testing for E. dispar to investigate  about each of  the two the predation virulence factors, CP1 and CP5 using SYBER Green Real Time PCR. the current study has shown that  the possession E. dispar  for the virulence factors malign factor  of CP1 using  the initiators  concern the genes,  then proved existence of the CP1 factor  in  18 samples of total  31 positive   samples for parasite with 58.06% rate . While did not prove existence the gene of the CP5 in the type of E. dispar. Some studies to be positive about  that E. dispar coexisted  in the intestines  of human , while other studies pointed to a lack of clarity about the  fact  of  this type has   pathogen or no , because of  its ability to bring about (causation ) some focal lesions and harming  and make damage in the laboratory  living tissues . from this standpoint, the current study  come to investigate about two virulence factors of the virulence factors   as a step  of steps the  study  which consider the most comprehensive study of the Species E. dispar to show  the reality of living of this kind.Keywords: E. dispar, CP1, CP5.
A Review on Role of miRNA in Kidney Diseases Priyadarshini .
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

micro RNA or miRNA are short non-coding RNAs species that inhibit target gene expression by blockingprotein translation or by mRNA degradation. Several studies have shown that miRNAs regulatethousands of gene expressions throughout the genomic machinery and play important roles in thephysiological and pathological events. In addition, miRNA play important role in pathogenesis of variousrenal diseases, including diabetic nephropathy, renal carcinoma, polycystic kidney diseases, allograftrejection etc. miRNA as a biomarker has been an area of intensive researches, as it has been discoveredto be potential therapeutic tools to manage several diseases. Therapeutic potential of miRNA-basedtreatment though promising but various challenges such as target specificity is still to be explored.Identification of miRNA and their target can provide a novel therapeutic candidate for curing variouskidney diseases. In this review, we have stated the role of various miRNAs in the development of variousrenaldiseases.
Variables Factors in Wax Apple (Syzygium Samarangense) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Wax apple (S. samarangense) fruit is crispy, juicy and tasty with apple aroma. Fruit flesh contains spongy tissue. It represents potential benefits for human health because they are rich source of polyphenolic antioxidants. This fruit is also highly perishable. Its economic potentials have never been exploited. During its harvesting season, a considerable percentage of the fruits are not harvested due to lack of demand and inadequate storage facilities, therefore leading to wastage. The surplus could be used for fruit wine. Effect of primary fermentation duration (4, 6, 8, 10 days), sugar to pulp ratio (5, 10, 15, 20% w/w), Saccharomyces cerevisiae inoculation (2.0 x 106,4.0 x 106, 6.0 x 106, 8.0 x 106 cfu/g) on anthocyanin (mg/ 100 mL), total phenolic content (mg GAE/ 100 mL) and total flavonoid (mg CE/ 100 mL) content of fermented wax apple fruit drink were thoroughly investigated. The secondary fermentation (1, 2, 3, 4 weeks) was also examined to improve the turbidity (mJ/cm2) and sensory score of the final fermented drink. The optimal conditions for fermentation of wax apple juice should be conducted at 8 days of primary fermentation with 15% of sugar supplementation inoculated with 6.0 x 106 cfu/ml of Saccharomyces cerevisiae and 4 weeks of secondary fermentation (aging) to get pleasant physico-chemical characteristics of fermented wax apple drink. Fermented Syzygium samarangense drink was red-pink, clear and transparent. This present study revealed that horticulture farmers would get more added values from wax apple fruits not only by local commerce but also processing. It could be processed by fermentation and conversion into high valued wineKeywords: Wax apple, Wine, Fermentation, Sacchromyces cerevisiae, Anthocyanin, Phenolic, flavonoid
Effect of Doped Nickel on the Structural and Electrical Properties of Alumina Prepared by the Chemical Co-precipitation Method Omer H. Abas
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Pure α-Al2O3 compound and its nickel (Ni) composites were prepared with different weight ratios according to the formula ((NiO) x (Al2O3)1-x), where (x = 0, 0.125, 0.25, 0.375, 0.50 g) through the chemical co-precipitation method. These were calcined at 1300 ͦC, and the prepared samples were characterized using different techniques such as XRD and FT-IR spectroscopy. The investigation by X-ray diffraction (XRD) showed that the prepared α-Al2O3had only one pure phase of α-Al2O3 with a crystallite size of 33nm, while the NiAl2O4 composites were formed in different phases according to the weight ratios of the NiO used (NiO/NiAl2O4, NiAl2O4, Al2O3 / NiAl2O4). In addition, the crystallite sizes of the phases of the resulting composites ranged from 35 – 50nm, and increased with increasing NiO content. The best result was obtained for the NiAl2O4 composite at x = 0.25g, where the characterization by FT-IR spectroscopy showed that the pre-calcined composites at 500 ̊C initially formed the spinal phase of the doped composites, but the composites prepared at the final sintering temperature of 1300 ͦC formed the pure and spinal phases. The effective NiO4group was formed at the tetragonal sites and a part of it was formed in the octahedral sites, while the effective group (AlO6) was formed at the octahedral sites, thereby indicating that the material was in the spinal inverse and spinal phases. The A.C. conductivity indicated that the highest value of the dielectric constant was at a minimum frequency and decreased with increasing frequency at low frequencies as a result of the effect of a vacuum charge and ionic polarizations. However, at high frequencies, it was found that the dielectric constant did not depend on the frequency, thereby indicating that the dipole moments followed the electric field only at low frequencies. In addition, the A.C. conductivity showed that the conductivity increased with increases in the frequency according to the correlated barrier hopping model (CBH), where the charge carriers jump up from one site to another causing the A.C. conductivity to increase with increasing frequencyKey terms: Nickel Alumina, Alumina, Dielectric, Precipitation method.
Study the Effect of Ceylon Cinnamon (Cinnamomum Zeylanicum) Powder on Some Physiological Parameters in Broiler Chicks Sura Safi Obayes Khafaji
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

The current study aimed to investigate the effects that could be caused by ceylon cinnamon (Cinnamomum  zeylanicum) powder addition to diet of broileron some physiological parameters. A total of 150 one-day-old mixed-sex broiler chicks were distributed into 3 treatments, comprising 5 replicates per treatment, with 10 chicks for each replicate. 1st group (control) fed on the standard diet during the experimental period (42 days), 2nd group (T1) and 3rd group (T2) fed on standard diet mixed with 500&1000 mg/kg of CNP, respectively. On 1st and 42nd day of experiment, body weight was recorded. As well as, blood samples were collected at the end of experiment, for assessment of RBC and WBC counts, PVC, Hemoglobin concentration (Hb) and heterophils/lymphocytes ratio (H/L). Total protein, Albumin, globulin, Triiodothyronine (T3) and Tetraiodothyronine (T4) concentrations in blood serum were determined. The statistical analysis registered the significant (P<0.05) elevation in the body weight on 42nd day of experiment inT1 and T2 groups comparing with the control. The results revealed that the second and third groups recorded significant (P<0.05) increase in RBC and WBC counts, as well as, PVC and HB concentration. While H/L significant (P<0.05) decline in T1 and T2 groups comparing with the control. At the same time, the result of total protein, globulin, T3 and T4concentrations revealed a significant increment (P<0.05) in two treated groups when compared with control. Therefore, it was concluded that the use of cinnamon powder can affected positively on some physiological traits and broiler performance.Key words: Cinnamon powder, Physiological parameters, Broiler chicks.
Study MetheletetraHydrofolatredctase (MTHFR) Gene Polymorphism in Myocardial Infarction Patients in Babylon Province/ Iraq Mona Al-Terehi
Journal of Global Pharma Technology .
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Abstract

The present study was aimed to investigate MetheletetraHydrofolatredctase (MTHFR) gene which related to acute myocardial infarction (MY) patients using restriction fragment length polymorphism (RFLP-PCR) technique, the results show that the homozygote TT genotype was (23.3%) in patients and (30.0%) in control with non-significant variation (OR 1.41). while CT genotype was (30.0%) and (33.03%) in patent and control respectively  with not significantly with OR (14.414) , CC genotype was (46.7%) in patients and (36.70%) in control. The allelic frequency was T patient vs. controls; 38% vs. 47% while allelic frequency was C in the patient vs. controls; 62% vs. 53%. we have concluded that  the MTHFR 677T allele hasn’t  been contributed as a risk factor for myocardial infarction .Our findings raise the possibility that novel genetic defects and/or environmental  factors  may  influence  homocysteine  metabolism  in  this  ethnic  group.Keywords: MetheletetraHydrofolatredctase, Acute myocardial infarction, RFLP-PCR.
GC-MS Analysis of Main Chemical Constituents and Antioxidative Potential of Propolis from Meghalaya, India Ibanrikynti Turnia; Rajesh Prasad; Surya Bali Prasad
Journal of Global Pharma Technology Volume 12 Issue 03 (2020) March 2020
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Abstract

Objective: Propolis or bee glue is a complex resinous honey bee product known to possess several useful pharmacological properties.Propolis is becoming increasingly popular because of its potential role in contributing to human health. The chemical composition and biological characteristics of propolis depend upon plant sources accessible to bees, bee species, geographical region and seasons. Method: In the present study, the main chemical constituents of propolis sample from Meghalaya were analyzed using gas chromatography-mass spectrometry (GC-MS) technique. The antioxidant properties of the same propoliswere also determined by chemical assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical scavenging activity, and metal chelating activity. Results: GC-MS analysis identified twenty different groups of compounds, out of which eight compounds along with their biological activity were recorded. The main constituents of propolis from Meghalaya were N-hexadecanoic acid (34.88%), oleic acid (26.37%), tetradecanoic acid (4.90 %), 2-furancarboxaldehyde,5-(hydroxymethyl) (3.21%) and 3,7,11,15-tetramethyl-2-hexadecene-1-ol (1.95%). The propolisshowed significant antioxidant activity in all the assays. The antioxidant activity of the propolis may also include other chemical constituents not detected through GC-MS analysis. Conclusion: The findings demonstrate thatpropolis from Meghalaya is a rich source of natural antioxidants and should be very useful in the preventionof various free radicals related diseases.Keywords: Propolis, GC-MS, antioxidant activity
Color Stability of Coated Stainless Steel Arch wires Measured by Visible Spectrophotometer (An In-Vitro Study) Abeer Basim Mahmood
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Background: Aesthetic archwires are used to overcome the aesthetic problems of stainless steel wires but the color of the coating layer can be changed with time when exposed to oral environments. The aim of this study was to evaluate the degree of color change of different aesthetic archwires from different companies and under different coloring solutions.  Materials and Methods: 150 samples of coated archwires from 3 companies (Highland, G&H and Dany) were immersed 5 solutions (artificial saliva, turmeric, tea, coffee and Miranda) to evaluate the degree of color changes after 7, 14 and 21 days using visible spectrophotometer. Data were collected and analyzed using ANOVA and post hoc Turkey’s tests. Results: Turmeric solution caused high color change in contrast to Miranda solution. Aesthetic archwires from Highland company showed the highest degree of color change than archwires from other companies. Conclusions: Turmeric solution produced more discoloration than other solutions and the effects of these solutions are related to different chemical compositions of those solutions.Keywords: Aesthetic arch wires, Staining drinks, Turmeric, Tea, Coffee, Miranda.
The Validity Assessment of E-Cadherin Expression to Differentiate Ductal and Lobular Type Invasive Breast Carcinoma I Gusti Ayu Sri Mahendra Dewi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Currently, breast cancer is one of the leading causes of cancer related death in women worldwide. The diagnosis of breast cancer still depends on biopsy to determine the histopathological subtype and the nature of the cancer. However, the subtypes alone could not differentiate between lobular and ductal carcinoma. Therefore, this study aimed to evaluate the validity of E-cadherin expression as biomarker to differentiate ductal and lobular invasive breast carcinomas. Methods: An analytic observational cross sectional study was conducted using 47 biopsy samples of ductal and lobular type invasive breast carcinoma examined at Anatomical Pathology Laboratory Faculty of Medicine, Udayana University/ RSUP Sanglah Denpasar in 2017. The samples were evaluated using H & E staining while E-cadherin expression was examined by using Immunohistochemistry technique (IHC). Pearson chi-square was performed to analyze the data with p-value less than 0.05 was considered significant or valid. Result: Descriptive statistics showed that the samples were homogeneous in term of age between ductal and lobular types (p=0.668). Breast cancer was found to be more prevalent on the left breast compared to the right one in both in ductal and lobular types. IHC staining showed that E-cadherin expression was significantly lower in lobular types (9.1% positive) compared to ductal (60.0% positivity) and, thus, can be used to differentiate them (p=0.000). Conclusion: E-cadherin expression was a valid biomarker to differentiate ductal and lobular type invasive breast carcinoma. More comprehensive study with larger number of samples is required to assess the generality of this findingKeywords: E-cadherin, Breast carcinoma, Ductal type, Lobular type.

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