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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
Effect of Adding Flax Seed to Bread Flour which Produced in the Laboratory and Study its Quality Properties Ibtihal I. M
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The aim of this current research was to Knowledge effect of addition of Flax seed at different percentages to bread flour and pop loaf bread was prepared that addition 10 % from Flax seed flour to bread flour resulting in increasing the percentages of moisture, ash, fat, fiber and protein. The result showed no significant differences in the moisture content, low value of gluten content and falling number. Was noticed in all treatment. Specific volume, it is the same for all treatments. Sensory evaluations of loaf bread appear no significant difference between control 100 % wheat flour and 10 % Flax seed. And found that the bread of both types was acceptable. Therefore this conclusion we can point out that the Flax seed can be used with the flour to prepare the flat bread. To improve the deffency of gluten.Keyword: Bread, Flax seed, Gluten, Fiber.
Synthesis and Characterization of Zinc Sulphide (ZnS) Thin Film Nanoparticle for Optical Properties Abdullah Hasan Jabbar
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

ABSTRACT. In this paper, we studied the synthesis and optical features of non-conventional energy have led us to this work. Neat Zinc sulfide (ZnS) powder was hired for synthesizing ZnS thin films. 0.5 µm thickness thin films of the ZnS was deposited by a thermic volatility system onto oxidized Si substrates at the cool temperature (T cold = –50ºC) and at the temperature (T ambient = 25ºC). An individual substrate possessor with a thermo-electric cooler was used to cool the substrates, these deposited ZnS thin films were subjected to air annealing at temperatures 100 oC, 200 oC and 300 oC for one hour in a furnace. ZnS synthesis by precipitation technique. UV-Vis spectroscopy and (SEM) scanning electron microscopy used for the study of optical features. Optical features of ZnS thin films were perfected by measuring the absorbance of ZnS films on glass substrates in the range of wavelength 200–900 nm by subtracting the glass substrate as a reference. ZnS thin films used for optical applications.
Molecular Identification of Two Species of Saprolegnia that Predominant in Diwaniyah River/Iraq and Studying Them Nutrition Preference Majid Kadhim Alshibly
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

This study including isolation and identification the Saprolegniaspp from Diwaniyah river waters via baiting method, waters samples were collected during September and November of 2016, the identification was confirmed by polymers chain reaction (PCR). The nutrition preference of isolated fungi was tested by using standard bites (seeds of millet) which compared with other nutrients such as yellow and red corn seeds, sesame seeds, mung bean seeds and alfalfa seeds, the nutrition preference test were experimented by baiting method and also on solid and liquid cultures. The results showed that two species of Saprolegnia were isolated from waters of Diwaniyah River S. ferax and S. parasitica the first one appeared in 14 isolates (61%) and the second appeared in 8 isolates (39%). The nutrition preference test showed that the red corn was the best in attraction and growing Saprolegnia spp., this results indicate that the ability to use it in preparation media to isolate this fungi.Keywords: S. ferax , S.prasitica , PCR, Nutrition preference, Seeds.
Investigation of Macadamia Flour Fortified to Wheat Flour in Bread Making Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Bread is one of the most important staple foods in the world. Macadamia nut contains bioactive components and high levels of monounsaturated fatty acids that are beneficial to human health. It would be of therapeutic advantage if wheat flour could be replaced with phytochemical functional nuts other than wheat flour such as macadamia in bread-making. This research has been tried in the application of composite flour through the incorporation of macadamia flour into wheat flour to improve nutritional quality of bread. In this study, macadamia flours were used to substitute refined wheat flour in bread-making doughs at 2%, 4%, 6%, 8%, 10% substitution levels. Significant variations in physicochemical, biological and organoleptic attributes were thoroughly noticed. The substituted bread-making with 8% macadamia flour had enhanced firmness, rich in total phenolics, flavonoids but low in peroxide value. During 8 days of preservation in paper- aluminum foil polyethylene laminate pouch at ambient temperature, the physico-chemical, microbial and sensory characteristics of bread still conformed to overall acceptability.Keywords: Bread, Macadamia, Firmness, Phenolic, Flavonoid, Peroxide value.
Comparison between Some Bacteria and Fungi for Biodegradation of Glyphosate Herbicide in some Agriculture Soil in Iraq Faiza Kadhim Emran
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Glyphosate is a compound used as herbicide in the control and killing of grasses and herbaceous plants. It can be used in agriculture to prepare fields before planting during crop development and after crop harvest. Because of its toxicity to non-target organisms, there is need to decontaminate glyphosate from contaminated soils and bioremediation is a very useful alternative to conventional cleanup methods. The success of this will depend on isolating bacteria and fungi with the ability to degrade glyphosate in a changing environment. The abilities of two bacterial species Aeromonassobraia and Acinitobacter hemolyticus and three fungal species Aspergillu niger, penicilium notatum and Rhizopus sp. to degrade glyphosate herbicide under varying environmental conditions were evaluated in this study. The isolates were screened for glyphosate utilization using mineral salt medium containing glyphosate as carbon source. Two bacterial isolates were tested for their ability to biodegradation of glyphosate in liquid medium identified by Vitek compact system. Three fungal isolates were tested for their ability to biodegradation of glyphosate in liquid medium CzapekDox  and  Potato Dextrose agar (PDA).The two bacterial isolates, Aeromonassobraia and Acinitobacter hemolyticus and three fungal isolates, Penicillium notatum, Aspergillus niger, and Rhizopus sp., showed the capacity to utilize glyphosate efficiently and were therefore used for further biodegradation studies. The optimum conditions (incubation period, temperature) for biodegradation of glyphosate were examined. The obtained results indicated that the best incubation period was after 7 days for Aeromonassobraia while the best incubation period was after 9 days for Acinitobacter hemolyticus in mineral salt medium.  Favorite temperature was 450C for both bacterial isolates. Microbial growth during the study was monitored by measuring the optical density at 660 nm. This study showed that Aeromonassobraia and Acinitobacter hemolyticus exhibited a high capacity to efficiently degrade glyphosate under the environmental conditions studied. The obtained results indicated that the best growth was Aspergillus niger after 15 days while the weak growth was Penicillium notatum after 15 days in Czapek Dox and Potato Dextrose agar (PDA).  Fungal growth during the study was monitored by observed rang density growth. This study showed that Aspergillusniger best capacity to efficiently degrade glyphosate under the 50,100 mg/l. Other concentrations (200,300mg/l) inhibit growth for all fungal isolate. Thus, the organisms can be exploited for biodegradation of glyphosate.Keywords: Bacteria, Fungi, Biodegradation, Glyphosate, Herbicide.
Determination of Parents Burnout for Child with Type 1 Diabetes Mellitus in Endocrine and Diabetes Center at Al-Nasiriyah City Amer Muhasin Naser
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objectives: To assess level of parents’ burnout   for child with type 1 diabetes mellitus (T1DM). Also to find out the association between parents burnout, and demographic characteristics (child age at diagnosis, gender of parents’, parents' level of education).Methodology: A descriptive cross-sectional study design was conducted in Endocrine and Diabetes Center at AL-Nasiriyah city to assess level of parents' burnout for child with T1DM and find out the association between parents burnout, and demographic characteristics (child  age at diagnosis ,gender of parents' , parents' level of education). The study was conducted on 200 parents' who have child with type T1DM. The data were collected using the interview and the questionnaire form, which was designed to contain (44) items containing the form of personal and demographic characteristics and parents'' burnout, as followed by Maslach burnout interview after modification (Maslach, 2001). This part involves (34) distributed into three sub-domains, which are (Emotional exhaustion, Personal accomplishment and Depersonalization). The data were analyzed using descriptive statistics method (frequency, percentages, Chi Square). Results: The study shows that the parents' are moderately burned out and there is no statistically significance between parents' bournut and parents' demographic characteristics. Recommendations: Study recommended establishing educational program should be done for parents' to decreases burnout level. Instructional class or folder given for parent's for increase their knowledge toward effects of burnout on their daily physical and emotional functionsKeywords: Parents', Burnout, T1DM.
Synthesis and Preliminary Antibacterial Effects of New 1, 3, 4-Oxadiazoles Zeid Hassan Abood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

4-aminobenzoyl hydrazide [I] was reacted with carbon disulfide in the existence of potassium hydroxide in ethyl alcohol to give 5-(4-aminophenyl)-2-thiol-1,3,4-oxadiazole [II]. The initiator aldehyde [III] was prepared via coupling reaction of 2-hydroxybenzaldehyde with the corresponding diazonium salt of compound [II]. Aldehyde [III] was condensed with some anilines including (3-bromoaniline, 4-aminophenol, 3-aminophenol, 2-aminophenol, 4-methoxyaniline, 2, 4-dimethylaniline and 4-acetamidoaniline) utilizing microwave irradiation technique in ethyl alcohol to yield seven imines [IV] a-g. Treatment of imines [IV]a-g with phthalic anhydride in microwave oven gave seven 1,3-benzoxazepine-4,7-diones derivatives of 1,3,4-oxadiazole [V]a-g. The antibacterial activities for the desired compounds were investigated on bacteria, Staphylococcus aurous and Escherichia coli. The results showed that the synthesized 1, 3, 4-oxadiazoles (compounds [V]a, [V]b, [V]c, [V]d and [V]e expressed better activity to gentamycin athwart positive bacteria. On the other hand, the 1,3-oxazepine-4,7-diones [V]a, [V]b, [V]c, [V]d, [V]f and [V]g exhibited greater effect against negative bacteria in comparison with that of the control drug (Gentamycin).Keywords: 1, 3, 4-Oxadiazoles, Benzoxazepines, Imines, Cycloaddition, Antibacterial action.
Study Effect of Kinetin, Bio-fertilizers and Organic Matter Application in Lettuce under Salt Stress Zaahra. Z. Majid
Journal of Global Pharma Technology .
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Abstract

Salinity causes cellular damage and limits crop productivity, by reduces water availability of plant roots via negative osmosis potential, salinity affects. The present study aims to mitigate the adverse effects of soil salinity in lettuce through organic composts like Plam fronds and Rice wastes   with exogenous applications like Kinetin and Bio-fertilizers. field experiment designed  to study the effect of irrigation water quality ,organic composts  ,kinetin and Bio-health application in N.P and K contents in leaves and anti-oxidant enzymes activity  of lettuce  , The experiment included 54 treatments with three factors  The first factor represents the salinity of irrigation water (W) at two  levels (1.2,  6.1) ds m-1 ), The second factor represents the kinds of organic composts (Palm fronds and Rice wastes) 20 ton /hectare to each one. The third factor represented the kinetin application (50 mg.L-1) and Bio-Health fertilizers (5kg/ hectare). The results show elevated water salinity levels led to elevation in activity of POX ,CAT, MDA,SOD enzymes and proline contents in leaves, while resulting decrease in leave contents of ( N.P.K) and the total yield, marketing yield and marketing head weight, Organic composts , kinetin and bio-health applications alleviated from the negative effects of saline water by increasing the total yield, marketing yield and marketing head weight and  (NPK) contents in leaves ,reduced POX ,CAT, MDA,SOD and proline ,except bio-health applications increased POX ,CAT, MDA,SOD  activities, That possible to mitigation the negative effect of salt stress by some application like exogenous plant growth Regulators , bio fertilizers and decomposed organic matter to solve the disruption of endohormons and lack of available nutrients under salt stress, and elevation of osmotic stress in soil solution in roots area, the study applications improved the growth and it has increased the lettuce tolerance to the salt  stress.Keywords: Salt stress, lettuce, Kinetin, Organic composts, Bio-heath, bio-fertilizers.
Optimization of Factors Affecting Iontophoretic Drug Delivery of Diltiazem Hydrochloride Using Factorial Design Jasmin Jayantilal Garala
Journal of Global Pharma Technology .
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Abstract

Gel formulation of Diltiazem hydrochloride was prepared using hydroxy propyl methyl cellulose polymer and Dimethyl sulfoxide as a permeation enhancer. Ethanol was added as a co-solvent for proper mixing of Dimethyl sulfoxide in gel. Four factors related to iontophoretic delivery like drug concentration, permeation enhancer concentration, quantity of applied electric current and area of application were optimized using fractional factorial design (24-1). Twelve formulations of Diltiazem hydrochloride gel were prepared and evaluated for in-vitro drug release study using modified diffusion cell. Steady state flux (Jss) for all prepared formulations were calculated as a response and data was evaluated using Design-Expert® software. Based on optimization results final optimized formulation was prepared by using drug concentration of 2.56 % w/w, permeation enhancer concentration of 5% w/w, 0.49 mA current and 1.50cm2 of application area and evaluated for in-vitro iontophoresis using diffusion cell. Steady state flux was found to be 296 μg/h cm2 which was closer to the targeted theoretical Jss (300 μg/h cm2). Desired therapeutic concentration of Diltiazem hydrochloride was achieved by optimizing various factors affecting iontophoretic drug delivery. Iontophoretic drug delivery of Diltiazem hydrochloride using gel formulation is possible. Keywords: Permeation enhancer, Iontophoresis, Factorial design, Steady state flux.
Synthesis, Characterization and Study Some Thermal Properties of New Maleimide Polymers from Sulfadiazine Ehab Kareem Obaid
Journal of Global Pharma Technology .
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Abstract

Series homo  and  copolymers  of  N-substitution  maleimides  by convert Sulfadiazine to chloroacetyl sulfadiazine (compound G) by mixture  Sulfadiazine  and  chloroacetyl chloride in presence triethylamine in DMF as solvent, and then substitution of chloro group in compound G by hydrazine to prepare hydrazinyl chloroacetyl sulfadiazine (compound H), then amic acid derivative (I)  were prepared by reaction malic anhydride with (compound H). This compound convert to N-substitution maleimide by closed the ring to preparation the (monomer) compound (J) by use access of acetic anhydride and sodium acetate. Finally preparation of homopolymers (K) by reaction the monomer carried out with Azobisisobutyronitrile (AIBN) as a free radical initiator in DMF as a solvent, and preparation of two different copolymers by reaction (I) compound with (acrylamide and maleic anhydride) carried out with AIBN as initiator and DMF as a solvent, and then study thermal properties of prepared polymers by TGA and DSC. All synthesized compounds were identified by many spectroscopy methods including   FT-IR, 1H-NMR, 13C-NMR, and Mass spectroscopy.Keywords: Sulfadiazine, Amic acid, Maleimide, AIBN, homopolymaleimide, copolymaleimide.

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