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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Carbonic Anhydrase Inhibitor Combination on Fertility Male Rats Anmar Shukr Mahmood
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Carbonic anhydrase inhibitors are many drugs, the main usage in epilepsy and raised intracranial pressure and the most commonly used are acetazolamide and topiramate. Twenty healthy adult males Wistar rats After acclimatization three weeks and divided to two groups randomly (10 rats/group) and treatment for 60 days as follows: high dose (Hd) group administrated 30 mg/kg/B.W of Acetazolamide and 9mg/kg/B.W of Topiramate and low dose (Ld) group received 5mg/kg B.W of Topiramate and 30 mg/kg B.W of Acetazolamide orally/day. Serum Hormones concentration tested are testosterone (ng/ml) and follicular stimulation hormones (FSH), Serum luteal hormones (LH) mlU/ml. The histological section showed the pathological changes in the Hd group while in the Ld have semi normal changes, the results confirm that the rats received of low dose more safety than the high dose of these  drugs combination.
Phytosterol Composition in Various Kinds of Red Beans Processing (Vigna angularis) Sugijanto Kartosentono
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The high level of blood cholesterol can be overcome by consuming phytosterols obtained from plants, especially nuts. One of the leading beancommodity in the society is red beans (Vignaangularis). This study aims to identify the content of phytosterols in red beans and the processing effect of phytosterols. Red beans sample which has been processed, was extracted with n-hexane, acetone, and hydrolyzed. The results of sample extraction were analyzed using the 6890 Series Agilent Gas Chromatography instrument with a Flame Ionization Detector (FID) and HP-5 column (5% Phenyl, 95% Methyl Siloxane). Phytosterol content in the form of campesterol, stigmasterol, and sitosterol was found in red bean samples. The most composition of stigmasterol was found in baked samples and significantly different from boiled samples (p
Reticulocyte Hemoglobin Equivalent (RET-HE) As A Predictor and Early Marker for Oral Iron Response in Iron Deficiency Anemia Patients Ketut Suega; I Made Bakta
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was aimed to determine whether Ret-He has a role for early detection and as a predictor factor for treatment response in iron deficiency anemia patient after oral iron therapy in 4 weeks. Iron deficiency anemia (IDA) patient were diagnosed based on hypochromic microcytic anemia with ferritin level < 20 ng/ml. All patients were taking oral iron pill for 4 weeks. Hemoglobin serum, absolute reticulocyte count (ARC), Ret-He, MCV, MCH, MCHC, and hematocrit were measured. Responders are defined as patients who reach total changes of their hemoglobin level > 2 g/dl in 4 weeks. Data analysis was done by SPSS. There were 26 IDA patients consisted of 15 (57.7%) female and 11 (42.3%) male patients with mean of age was 47.31. Before treatment, level of Ret-He, absolute reticulocyte count, HB, HCT and MCV were 18.16 pg (SD 4.43), 0.67 (SD 3.02), 7.94 g/dl (0.74), 26.5 % (SD 2.48), 64.9 fl (SD 0.51) respectively. There was 18 (69.2%) patient considered as responders and 8 (30.8%) patients considered as non-responders. The evaluation showed all markers were increased except for absolute reticulocyte level. On adjusted multiple logistic regression, the only variable that found statistically significant was Ret-He at week 1 with p= 0.031; 95% CI 0.349-0.950. It is suggested that reticulocyte hemoglobin equivalent (Ret-He) proved to be an early and sensitive predictor for oral iron therapy response in patients with iron deficiency anemia. Keywords: Ret-He, Treatment response, Iron deficiency anemia.
The Effect of Cognitive Interventions with Drug Control on Emotional-Behavioral Problems in Adolescents Mohsen Saeid Manesh
Journal of Global Pharma Technology .
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Abstract

The purpose of this study was to investigate the effect of cognitive intervention with drug control on emotional-behavioral problems in Adolescents. Being a quasi-experimental study, the research employed a pretest, posttest and follow-up (one month) design. The statistical population included bereaved Adolescents in yazd city in 2016. Of them, 30 students were selected via access sampling method, and were then randomly assigned into experimental and control groups. The measurement instrument was Goodman Strengths and Difficulties Questionnaire (Goodman, 1997). Experimental group received 8 sessions of cognitive intervention (each a 90-minute session). The results of analysis of covariance (with SPSS21) showed that cognitive intervention had significantly reduced emotional-behavioral problems in both in posttest and follow-up (P ≤ 0.05). Results also showed a significant difference between groups in all subscales including emotional problems, conduct problems, hyperactivity and peer problem in posttest and follow-up (P ≤ 0.05).Keywords: Cognitive interventions, Drug control, Emotional-behavioral problems, Adolescents.
Quantitative Analysis of Lutein from Iraqi Tagetes erecta Zainab Aziz Ali
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Tagetes erecta is a plant belongs to the genus Tagetes and family Asteraceae. Phytochemical studies show that tagetes erecta leafs and flowers are rich in alkaloids, flavonoids, tannins and essential oils. Lutein which is an oxycarotenoid and phenolic compounds was found to be the major secondary metabolite. [1]The name lutein comes from the Latin word, lutea, meaning yellow. At normal concentrations in food, it is a yellow pigment, but can appear orange or red at high concentration [2].The tetraterpene Lutein and zeaxanthin are found in high concentrations in the macula of the human eye, giving the macula its yellowish color. In fact, the macula also is called the "macula lutea" (from the Latin macula, meaning "spot," and lutea, meaning "yellow") have an important role in reducing the oxidation and reduce the incidence of cataracts. It is believed that lutein and zeaxanthin in the macula block blue light from reaching the underlying structures in the retina, thereby reducing the risk of light-induced oxidative damage that could lead to macular degeneration (AMD) [3]. In this study lutein was isolated from Tagetes erecta by column chromatography. The isolated lutein was identified by TLC, HPTLC. Structure elucidation was performed using UV, FTIR, 1H-NMR and 13C- NMR. The quantity of lutein was measured in the Iraqi plant.Keywords: Tagetes; Lutein; Isolation.
Study the Association of CYP3A5 Polymorphism on the Risk of Breast Cancer in Some of the Iraqi Women Israa Hussein Hamzah
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Cytochrome P450 enzymesare involved in activation of numerouspro carcinogenic compounds such as polycyclic aromatic hydrocarbon as well as plenty of endogenous compounds including testosterone and estrogen. The CYP3A isoenzymes represent the predominant cytochrome P450 enzymes in the human liver and gastrointestinal tract.  CYP3A  subfamily have four members  (CYP3A43, CYP3A7, CYP3A5 and CYP3A4). The aim of the present work is to investigate whether the CYP3A5 polymorphism modifies the risk of breast cancer in the Iraqi population. A total of eighty women were recruited in the present study divided into fifty breast cancer patients aged 25-65 years who visit the Oncology Teaching Hospital, Baghdad, Iraq, as well as 30 healthy sex and age matched controls. The sequence analysis of CYP3A5 fragment with molecular weight 349bp resulted in two distinct genotypesin the breast cancer group, with 96% (n=48) had the CYP3A5*3/*3 homozygote genotype and 4% (n=2) had the CYP3A5*1/*3 heterozygote genotype. In the control group, 100 %( n=30) had the CYP3A5*3/*3 homozygote genotype. No significant differences between breast cancer patients and control were observed with respect to genotype distribution (P>0.05). Our results revealed that there is no association between risk of the breast cancer and CYP3A5 polymorphism in Iraqi women.Keywords: Cytochrome, CYP3A5, Iraq, Breast cancer, Polymorphism
Identification and Association Polymorphisms of TGF-β and IFN-y Genes with Schizophrenia Risk in Iraqi Patients Anwar Abed Nasser Dhabaan
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Genetics study for IFN-γ (Interleukin-γ) T/A +874 and TGF-β1(Transforming growth factor-beta) +869*C/T genes polymorphisms for schizophrenia patients with mean age 49.95±1.6 was studied by using ARMS-PCR (Amplification refractory mutation system technique). The results revealed the presence of two alleles A and T with three genotypes (TT, TA and AA) for IFN-γ (+874 T/A) gene, and two alleles C and T with three genotypes (CC, TT and CT) for TGF-β1 (+869*C/T). The result show that high frequency for allele A of IFN-γ +874 T/A as compare with T allele in schizophrenia patients samples (n=38) and associated with etiological fraction (EF) of schizophrenia, dependent on values of odds ratio (OR) and confidence intervals (CI), while T allele associated with preventive fraction (PF) of schizophrenia. The ARMS-PCR analysis results present AA and TT homozygotes genotypes of IFN-γ T/A +874 gene was more than in schizophrenia patients as compared with control and showed that AA and TT genotypes associated with EF in schizophrenia risk, while TA heterozygote genotype present in high frequency in control as compared with schizophrenia patients and associated with (PF). The T allele for TGF-β1 (+869*C/T) gene exist in high frequency for schizophrenia patients and associated with (EF) schizophrenia, while C allele associated with (PF) schizophrenia. The TT homozygote genotype frequency of TGF-β1 (+869*C/T) gene was more than in schizophrenia patients and associated with (EF) of schizophrenia, while CC homozygote and CT heterozygotes genotypes present more than in control as compared with schizophrenia patients and associated with (PF).Keywords: Polymorphism, Schizophrenia, IFN-γ T/A +874 and TGF-β1 (+869*C/T) genes.
Assessment the Aurora a Kinas Overexpression among Colorectal Adenocarcinoma in Iraqi Patients Ali A. Majeed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In the worldwide the colorectal carcinoma is  represented the most common gastrointestinal malignancy The cancer represent one of major causes of death after cardiovascular diseases in Iraq. Aurora Kinase a (AURKA) is a member of the serine/threonine kinas family as well refers as (STK15) or (BTAK) regulates the function of centrosome, spindles, kinetochores in mitotic and chromosomal instability. AURKA overexpression is observed in various cancers including colon cancer and depended on our knowledge there is no in our country about the expression of AURKA colorectal carcinoma patients. This study included fifty five blocks embedded in paraffin was 31 (56.36%) males and 24 (43.63%) females which were obtained from colorectal adenocarcinoma patients and all samples composed of 25 (45.45%), 20 (36.36%) had moderate differentiated and (18.19%) had poorly differentiated colorectal carcinoma. The ages of patients had ranged from 20 to 80 years, with a mean of (7.44±50.6  SE).In this study, Iraqi patients showed that the protein overexpression of AURKA by immunohistochemical technique was significantly difference among these grades (p=0.0001,r=552) with high expression in well-moderate than poor differentiated while the AURKA protein overexpression was non- significant difference among different stage tumor sizes (P value =0.1746, r=0.254) as well as, the results showed there were no significant differences between AURKA protein overexpression with the gender, age and lymph-vascular and perinural invasions (P value =0.613,r=0.078), (P value 0.812, r=0.356), (p=0.711,r=0.192) respectively. Conclusion: The AURKA biomarker may be used as prognostic factor of tumor initiation in Iraqi patients with colorectal adenocarcinoma.  Keywords: Iraqi patients, Colorectal Adenocarcinoma, AURKA.
Study of Histological and Histochemical Changes of Primary Visual Cerebral Cortex with Aging Process Rajaa Ali Moheiseen Al-Taee
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Aging has been defined as the sum of all changes produced with the passing of time, lectins are specific carbohydrate-binding proteins; they can be employed as specific probes to localize defined monosaccharide and oligosaccharides on cell surface and on cytoplasmic structures, and in an extracellular matrix. Understanding of ocular changes with aging is based on knowledge of normal ocular structure and histochemistry. For this purpose  , this study aimed : to study age-dependent histological and ultrastructural (glycoconjugates) changes in the primary visual cerebral cortex with light and fluorescence microscopy by using routine and five lectin stains  to illustrate the patterns of glycoconjugates materials during aging . This study was conducted in the department of biology /college of science, department of anatomy and histology /college of medicine of Babylon University and College of Medicine /Al-Nahrain University, with a total of 40 albino rat  .Our finding suggested: an aging appears to alter the carbohydrates components of visual cerebral cortex , The histochemical study during the preceding of age (3 , 8, 24 ,48) weeks revealed variable tempo-spatial variability of lectin bindings to the primary visual cerebral cortex  tissue, and referred that different cerebral layers have similar patterns of distribution in some aspect   , but dissimilarity in another. In conclusion, The finding of the present study clearly indicate that the lectin bindings could be an indicator for the glycoconjucate changes that play an essential role in aging process by marking cellular differentiation, cellular migration, and cellular interactions.Keywords: Aging, Lectin, Primary Visual Cerebral Cortex, Histology, Histochemistry.
Cultural-psychological Alienation and its Effect in Teaching the Ability to Stand on the Head in the Gymnastics for Students in College of Physical Education and Sports Sciences AWS Yousif Khelfa
Journal of Global Pharma Technology .
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Abstract

The basic ground-based movements in learning skills on all other devices, not without these skills difficulties. The problem of research is that there is a weakness in the orientation towards learning skills. The problem of research is summarized by the following question: Is psycho-cultural alienation the reason for the weak tendency towards learning skills or other reasons? What is the relationship between psycho-cultural alienation in the performance of this skill? To achieve the objectives of research will conclude the researcher to the actions achieved, including the identification of psychological alienation levels - cultural at the College of Physical Education and Sports Science students, and to know the relationship between psychological alienation - cultural and learn the skill of standing on the head. Is there a relationship of statistical significance between psychological and cultural alienation and the ability to stand on the head and the researcher used the descriptive method to suit the nature of the problem. The study sample was randomized to 30 students from the second stage of the Faculty of Physical Education and Sports Sciences, Thi-Qar University. It was found that there is a significant correlation between psychological and cultural alienation and learning the ability to stand on the head. So as not to attract second-stage students to practice skill. The teacher's failure to use the principle of reinforcement and correction of errors that may occur during performance leads to a poor approach to learning skills. The researcher recommended the use of a good method in the gymnastics to clarify and absorb the skill technique. And the need to use the principle of reinforcement. And the need to provide the appropriate educational environment.Keywords: Cultural-psychological alienation, gymnastics and Sports Sciences.

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