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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Van A Gene for Intestinal Bacteria Enterococcus faecium (E. faecium) Resistant to Vancomycin Venus H. Al-Saffar
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Out of 100 enterococcal strains clinical samples, a total of 59 (59%) Enterococcus faecium (E. faecium), 32 (32%) E. faecalis, 3 (3%) each of  E. casseliflavus, and E. avium, and 1 (1%) each of E. gallinarum, E. flavescens, and E. raffinosus  isolates were recovered, from burn, wound, and urine samples in Al-Hilla teaching hospital were identified to species level with a VITEK-2 system. For detection vancomycin resistance, all of enterococcus spp. isolates were tested by using multiplex PCR for (VanA, VanB, and Van C) genes. Results showed that only 5 isolates were resistant to vancomycin; 2 (VanA) genes were from E. faecium, 2 (VanB) genes were from E. faecalis, 1 (VanC) gene was from E. gallinarum.Keywords: VITEK-2, PCR.
The Development of Nursing Diagnosis Based on Indonesian Nursing Diagnosis Standard of Patient with Schizophrenia in Hospital Rizki Fitryasari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Abstract Objective: Schizophrenia is the common diagnosis for the patient in the hospital who care for mental illness and need several weeks for hospitalization. An accurate nursing diagnosis must be a part of the clinical pathway for patients in a hospital setting to deliver the effective intervention of nursing care. This study aimed to develop a nursing diagnosis based on an Indonesian nursing diagnosis Standart on patients with a diagnosis of schizophrenia in the Surabaya Menur Mental Hospital. Methods: A research and development (R&D) design was employed in this study with a descriptive approach. The sample was 98 medical records documents obtained by purposive sampling. The respondents were selected by inclusion criteria: patients with schizophrenia who had been hospitalized and had experienced a recurrence. The instrument used an observational sheet. The data were analyzed using univariate analysis. Result: The results showed that six nursing diagnoses were formulated during the implementation of nursing care. They were violent behavior (41.8%), hallucinations (36.7%), social isolation (11.2%), self-care deficits (7%), delusions (2%), and risk of suicide (1%). Conclusion: The nursing diagnoses developed based on Indonesian Nursing Diagnosis Standart which were classified as a psychological, behavioral, relational, and environmental category. The nursing diagnoses can be developed in the clinical pathway as a result of evidence-based so they can improve the quality of nursing care. Keywords: schizophrenia nursing diagnosis, clinical pathway, Indonesian Standard of Nursing Diagnosis
Enhancing Some Physical Properties of Cosmetic Face Powders Karar Abdali
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

In present paper, calculation of refractive index values at different temperature ranges of some cosmetics face powders before and after adding polyethylene glycol (PEG) polymer have been measured. The temperatures range values were (30, 35, 65) °C. The results show that, the index of refraction values decreased with increasing of temperatures in that thermal range, that is lead to decrease the transparency of medium and make it more burnish. By mixing method a blend solution have been prepared and tested on face powders and taking a best result of absorbing UV-rays all colloidal diagnosed by (FTIR) spectrums.Keywords: Cosmetics, Face Powders, PEG and Refractive Index.
The Effectivity of Porous Hydroxyapatite loaded with Gentamycin on Chronic Tibial Osteomyelitis in Rabbit Models Ismail Dilogo
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Introduction. Osteomyelitis management with debridement, guttering, and systemic antibiotics often do not give satisfactory results due to the inability of antibiotics to reach the infection site. Another method of antibiotic delivery in the form of beads are deemed ineffective as it requires two separate surgeries. Combination of local antibiotics with absorbable porous hydroxyappetite scaffolding  and antibiotic carriers have not been studied. Methods. We conducted pre-test and post-test control group in a rabbit model of osteomyelitis. Ten rabbits divided in control group and the treatment group (n=5). We injected Staphylococcus aureus in the rabbit tibia, forming the osteomyelitis model, and subsequently performed treatment for osteomyelitis. In the control group, we performed debridement and administered ceftriaxone injection for 4 weeks, whereas in the treatment group, we added the combination of porous hydroxyapatite and gentamicin. Afterwards, we performed clinical assessment, x-ray examination, culture, and histopathology.Results. Radiologically, tibia cortical thickening scores improved in the treatment group compared to the control group (p=0.48) as well as histopathological osteomyelitis evaluation score (p=0,009). Clinically, there were improvements in the swelling scores (n=5) of the treatment group compared to control group, but no significant statistically (p=0.053). In culture, there were no significant difference between the two groups (p=1.00).Conclusion. Combination of porous hydroxyapatite and gentamicin as a local treatment of osteomyelitis of the rabbit tibia osteomyelitis models improved radiological and histopathological scores and also clinically compared to existing standard treatment procedures for chronic osteomyelitis
Evaluation of Drug Pre¬scription Pattern among Iraqi Dentists in Babylon City Mohammed Abdul-Hassan Jabarah Al-Zobaidy
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Background: Drugs that are commonly prescribed by dentists include analagesics and antibiotics. However, the frequency of antibiotics prescription by dentists, whether for treatment or prvention of bacterial infections, is relatively lower than that by physicians. Also, the pregressive development of bacterial resistance to antibiotics called for seeking best-evidence on antibiotics ptrescription by practicing dentists to prevent the emergence of life-threatening antibiotic-resistant bacterial strains. Methods: Descriptive cross-sectional questionnaire-based study conducted in Babylon City, Iraq from August 2017 to January 2018. Data expressed as absolute numbers and proportions and presented using descriptive statistics. Results: In Babylon City, practicing dentists preferred amoxicillin as the first choice antibiotic for patients not allergic to penicillin; otherwise, macrolides and cephalosporins are recommended alternatives. In addition, mefenamic acid and ibuprofen were the preffered analgesics for pain relief. Also, participants often utilize clinical and scientific justifications for prescription of drugs in question. Conclusions: Dentists need to apply best-evidence concerning treatment of dental infections. And to actively participate in continuing professional development activities regarding antibiotics prescription. Keywords: Dentists, Antibiotics, Analgesics, Prescription for dental conditions, Pharmacology.
Using of Whey Proteins as Antioxidant in Some Food Products Nahla Tariq Khalid
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Oxidation of foodstuffs has become an issue concerning with food quality and consumer health, specifically in dairy products which contain a percentage of fat. The present study aimed to use whey proteins concentration (WPC) as additive to some samples of dairy products selected from local market. Adding WPC to these products with different concentration demonstrated a good activity of whey proteins concentration as antioxidant. Lipid oxidation measured on the basis of malondialdehyde by determining thiobarbaturic acid (TBA). Results obtained show differences in TBA value before and after adding WPC. Adding WPC reduced the TBA value about half in collected samples, and that led us that the period of lipid oxidation with adding WPC will be longer than these samples used without adding WPC. Using this method to protect food products from lipid oxidation by adding WPC has been proved the activity of whey proteins as antioxidant in this research.Keywords: Whey proteins, Antioxidant activity, Foods products. 
Incidence of Cryptosporidiasis in Human of Al-Hilla City/Iraq Fatima HA
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

During one year period from 2nd January till 31st December 2017 A prospective study was conducted in the children and maternity hospital in Al-Hilla city on the admitted patients. The aim was to identify if cryptosppridial infection exist in this locality, its incidence course of the disease and its treatment. Results showed that Cryptosporidiasis was present, the disease incidence was high and its course is more severe in patients with malnutrition. There was no difference in response of all patients to different lines of treatment.Keywords: Cryptosporidiasis, Malnutrition, Watery diarrhea, Cryptosporidium.
DNA- Drug Binding and Uric Acid Concentrations Relationship in Renal Failure Mohsin O. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Kidney diseases are recognised as a significant health problem affecting approximately 188 million peoples in low- and middle-income countries. In this study, investigation of the relationship between DNA and UA concentrations and the interaction of DNA and drug in renal failure patients was studied. DNA was extracted from serum and whole blood by two methods, kit and manual to find the best way, by comparison, the results. Nanodrop and electrical migration technique were used to measure the obtained concentration of DNA. The interaction between DNA and drug (Allopurinol) in the presence of UA was done by using ultraviolet and infrared spectroscopies. The study included 80 healthy and 80 patients samples with chronic renal impairment with ages rang (20-80) of both genders. The result showed a significant increase in the concentration of UA, urea and creatinine in renal failure patients compared to control a significant reduction in DNA concentration in patients with high UA concentration, the DNA extracted by manual method was higher compared to the results of the kit. The type of interference between DNA and Allopurinol is intercalative binding.Keywords: Kidney disease, Allopurinol, DNA, Uric acid and renal failure.
The Effect of Nimodipine to Reactive Oxygent Species (ROS) in SHSY-5Y Cell-Line Culture Expressed by Chronic Hyperglycemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Diabetes mellitus is a metabolic disease with a chronic hyperglycemia condition. Diabetic peripheral neuropathy is a condition that arises from long-term damage due to chronic and hyperglycemia combination of various factors and pathways. One of them is the occurrence of oxidative stress caused by an increase in ROS intracellular. The accumulation of ROS can activate other pathways and result in an ion imbalance Ca2+. Nimodipine is a type L calcium channel blocker which has neuroprotective properties. Therefore, nimodipine is expected to reduce the expression of ROS in neurons that occur due to chronic hyperglycemia conditions. Objective: To determine the effect of nimodipine on ROS in culture of SH-SY5Y-induced cell-line neurons chronic hyperglycemia. Methods: Experimental research with in vitro methods using the exposed SH-SY5Y neuronal cell line chronic hyperglycemia. The study sample was divided into 9 groups, the control normoglycemic group, hyperglycemia control 25 mM and 50 mM, normoglycemia with nimodipine 10 nM and 100 nM, hyperglycemia 25 mM with nimodipine 10 nM and 100 nM, and 50 mM hyperglycemia group with nimodipine 10 nM and 100 nM. Nimodipine is given for 30 minutes on Sh-Sy5Y cells that have previously been exposed to hyperglycemia conditions chronic for 6 days. The intensity of intracellular ROS was observed by immunohistochemical methods on the sixth day. Results: In comparison of normoglycemic conditions (5 mM) and hyperglycemia 25 mM, normoglycemic conditions 5 mM resulting in a significantly higher ROS intensity (p <0.05). Whereas in comparison normoglycemia (5 mM) and hyperglycemia 50 mM had a significant increase in ROS intensity (p <0.05). Expose glucose 5 mM can increase ROS expression due to a series of processes due to hypoglycemic conditions. Exposure to high doses of glucose (50 mM) can increase ROS formation. Giving nimodipine to cells able to reduce the intensity of ROS on glucose exposure 5 mM, 25 mM and 50 mM significantly (p <0.05). Conclusion: Chronic hyperglycemia conditions can increase the formation of ROS in SH-SY5Y and cell cultures nimodipine can significantly reduce ROS levels.Keywords: Nimodipine, SH-SY5Y, ROS, Hyperglycemia, Neuropathy. 
Improving the Efficiency of Cloud Computing Services Using Cuckoo Search and Bee Colony Algorithms Mojtaba Aliabadian
Journal of Global Pharma Technology .
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Abstract

Nowadays, the tendency of organizations to use service-orientation instead of using applications is being increased day by day. Existence of port for the organizations and providing organizational services in frame of web services has enables users to use organizational services rapidly and easily via internet. The basic and initial services of the organization are provided for the users in frame of web services and through the organizational port. Cloud computing as a common computing model for the organizations and firms and even individuals is based on two types of servicing: the deployment location and the type of service provided. In order to meet needs of applicants in best way and to adjust the services rapidly with changed requirements, the services are combined to utilize capability of several available services within the organization or other organizations. In the issues of combining cloud services, one of the most important challenges is the issue of implementation time. As various services are existed in the cloud distributed space, the pace of the problem is large and selecting the optimal option is complicated and time-consuming in most cases. In this study, a new approach is presented for combination of services in cloud computing. The main objective of the proposed method is improvement of efficiency and reduction of implementation time for optimal selection of services available in cloud and consequently, combination of these services. Combination of the services in proposed method is done using combination of Cuckoo Search and Bee Colony Algorithms as the most important meta-heuristic in field of optimization. The way of using these algorithms in frame of proposed method to combine the services in cloud computing is presented in details and practical evaluation is also presented. The simulation results show that the proposed method could provide considerable improvement in field of efficiency criteria compared to similar algorithms.Keywords: Cloud computing, Cloud services combination, Cuckoo Search Algorithm, Bee Colony Algorithm.

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