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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis of New Derivatives of Cephalexin with Isatin and Glycine Schiff Bases Shayma l. Abdulhadi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Objectives: Two derivatives of cephalexin were synthesized by reaction with isatin-glycine Schiff base and bromoisatin-glycine Schiff base separately. Methods: Cephalexin was linked through the amine group to isatin glycine and bromoisatin glycine Schiff bases by amide bond formation. Results: These derivatives were characterized by FT-IR, H-NMR, elemental CHN analysis and then tested for their antimicrobial activity compared to cephalexin against gram-positive, gram-negative bacteria and Candida albicans fungi. Conclusion: The two compounds showed better activity against Staphylococcus aureus, compound 3b is more active against Escherichia coli, and compound 3a is more active against Klebsiella pneumonia.Keywords: Isatin, Bromoisatin, Cephalexin, Schiff base, Antimicrobial activity.
Isolation and Characterization of Antihyperglycaemic Triterpenes from the Flowers of Calotropis gigantea Naveen K. Choudhary
Journal of Global Pharma Technology Volume 10 Issue 12 (2018) December 2018
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Abstract

Calotropis gigantea, Akda, belonging to family Asclepidaceae, is a medicinal plant distributed widely throughout the India. In our previous study, chloroform extract of Calotropis gigantean showed potent anti-diabetic activity. Hence our main aim is to isolate the active compounds present in chloroform extract which might be responsible for anti-diabetic activity. Bioactivity guided isolation was performed to isolate the active compounds. Three phytoconstituents,  β-sitosterol, Stigmasterol and α- amyrene have been isolated from the flowers of Calotropis gigantea. The structures of these phytoconstituents have been established by spectroscopic methods.Keywords: Calotropis gigantea, β-sitosterol, Asclepidaceae, chloroform extract, anti-diabetic activity.
Behavioral Factors Affecting Patient's Compliance in Consuming Anti-diabetic Oral Drugs Liza Pristianty
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Treatment compliance is a major problem in overcoming diabetes mellitus. This case inhibits the achievement of optimal levels of health for people with diabetes mellitus. However, various types of factors that enable patients to be disobedient to treatment have not been widely studied in terms of pharmacy. Objective: This study aimed to identify behavioral factors that influence diabetes mellitus patient compliance in taking oral antidiabetic drugs. Methods: This study was observational analysis using cross-sectional design. Sampling was obtained by accidental sampling method. The independent variables in this study were the knowledge and attitudes of patients; availability of health care facilities, and behavior of pharmaceutical officers. Whereas, the dependent variable was the compliance of the patients with diabetes mellitus taking antidiabetic drugs. Data were collected using valid questionnaires then analyzed using correlational analysis. Results: The results of this study indicated that the support of pharmacists had significant effect on patient compliance (p = 0.006). Whereas, knowledge, behavior, and availability of health service facilities had no significant effect on patient compliance in taking oral antidiabetic drugs (results in sequence: p = 0.642; p = 0.379; p = 0498). Conclusion: The role of pharmacist is very important in efforts to provide information and motivation for the treatment of diabetes mellitus, especially the consumption of oral antidiabetic drugs. This research is expected to improve pharmacy services related to the accuracy of providing information to patients. It will also have an impact on improving the quality of life of patients and providing quality services.Keywords: Behavioral factors, Diabetes mellitus, Patient compliance.
Effectiveness of Gac Aril Extract to Stickiness, Retrogradation and Staling of Glutinous Rice Cake Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Gac fruit (Momordica cochinchinensis Spreng) is a popular fruit in rural area of Vietnam. Its aril contain high amount of β-carotene, lycopene, α-tocopherol and fatty acid. Its bright red color attracts consumers besides phytochemical constituents. It is very important to utilize these valuable constituents in Gac aril for multiple food processing applications. Glutinous rice cake is a kind of folk cake, very rustic, was present very early in the cuisine of Vietnam, also the specialty cakes of the local countryside, quite familiar and impressed in the hearts of people, products with aromatic fatty flavor, tasty, sweet flowing with delicate. Nowadays consumers require glutinous rice cake with superior appearance, texture, taste and flavor while stabilizing its nutritional value. Therefore in this present research, we examined the supplementation of Gac aril extract in different concentrations (2.0, 3.0, 4.0, 5.0%, 6.0%) to the physico-chemical, sensory and shelf-life of the glutinous rice cake. Our results showed that 5.0% Gac aril extract was adequate to supplement into glutinous rice cake making to extend its shelf-life for 5 days. Consumers have more chance to enjoy glutinous rice cake in good appearance and high functional properties.Keywords: Gac aril extract, Glutinous rice cake, Supplementation, Physico-chemical, sensory, Shelf-life.
Treatment of Children with Immune Thrombocytopenia by High Dose Intravenous Dexamethasone: A Window for Improvement Ali Hadi Mahdi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Introduction Immune thrombocytopenia is a hematological disorder Characterized by platelet destruction caused by auto antibodies resulting in reduction in platelet count to lower than normal range and increased bleeding tendency. Corticosteroids are considered one of the most appropriate treatment options for pediatric ITP. Methods: In this study 16 pediatric patients with acute ITP had been enrolled to evaluate their response to high pulsed dose of dexamethasone given as a 4-day course every 14 days for 4 courses by measuring their platelet counts before and after each course and along 14 months after completing the 4 courses. Results: There was a significant (p<0.0001) increase in platelet count after each cycle in comparison with platelet count before the same cycle. All the patients, at the end of fourth cycle, showed either partial or complete response and no one showed minimal or no response. Conclusion: High dose dexamethasone can be proposed as a first-line treatment for children with ITP. Repeated cycles of therapy seem to be more efficient than only one cycle to achieve a long-term response. 
Technology of Cognitive and its Effect on the Level of the Enzyme (Acetyl cholinesterase) and (Lactic Acid) and the Performance of most Important Offensive Skills in Fencing for Female Students Hayder Naji Habash Alshawi
Journal of Global Pharma Technology .
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Abstract

The importance of research to the study of cognitive technology and its effect with the formulation of acetylcholinesterase and lactic acid for female students in the fencing, the problem of research was that the game of fencing of games of relatively small space requires the player to have positive qualities, so the researchers studied the effect of the enzyme acetylcholinesterase in technology of cognitive plus and lactic acid to achieve the best results, the objectives of the research were to identify the level of cognitive technology (Cogni Plus), acetylcholinesterase, lactate acid level, and the level of some physiological variables for female students in fencing, to identify the correlative relationship between the (Cogni Plus) level and the acetylcholinesterase and lactic acid in the fencing for female students, the researchers used the descriptive method in a survey and correlative method to suit the nature of the problem. The sample of the research included the players of the Middle and South Euphrates clubs in the youth fencing participating in the premier league for the 2016-2017 sports season, the nine clubs (Basra, Maysan, Muthanna, Wasit, Dhiqar, Rafidain, Solidarity, Babil and Karbala). The sample was selected in a simple random way, (20) players (10) for Al-Tadamon Sports Club and (10) for Al-Rafidain Sports Club. The researchers used the following tests: First: Cognitive Level of Cognitive Plus, Biochemical Variables, Lactic Acid concentration, and acetylcholinesterase concentration. The researchers concluded that cognitive cognition technology increased in players due to psychological effect they have. Decreased action of the enzyme acetylholinesterase due to the concentration of lactic acid in the muscle, which leads to slow work and send instructions, Increase the proportion of lactic acid in the muscles as a result of the high level cognitive technology (Cogni Plus) and recommended the adoption of the results of research and use by the trainers of the fencing to see the psychological effects of physiological fencing players. Attention to the psychological preparation of the players during the training process along with the physical, skill and plan numbers because of its importance in the reflection on the physical and physiological aspects of the performance. To establish a department of sports medicine in the faculties of physical education and sports sciences and provide all specialized devices in order to facilitate the task of carrying out research and studies. Conducting research and similar studies by researchers to standardize and define standard levels of cognitive technology scale (Cogni Plus) on individual and group games.Keywords: Cognitive technology, Acetyl cholinesterase, Lactic acid and fencing.
Tetanus Combined Immunization with Tetraxim and Pentaxim in Children from 3 Months to 4 Years Alla Philippova
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The causative organism of tetanus is the Clostridium tetani. Immunization is one of the effective methods of disease prevention, which is carried out from the first 2 months of life. Further vaccination continues, in combination with the measles vaccine. Thus, tetanus in modern medicine is one of the elements of the combined vaccinations. 300 children were vaccinated hosted by the Department of Infectious Diseases of the Hospital № 2 in Moscow (Russian Federation) during the first six months of 2017. The age interval of children is from 3 months to 4 years. 2100 vaccinations were carried out, 1810 of which were vaccinations with Pentaxim, and the rest with Tetraxim.  255 children (85% of all), immunization program with Tetraxim was prolonged after the Pentaxim vaccinations. This is due to the fact that the first immunization occurs in half of a year. The reasons for this are in the social incompetency of the most parents as they begin immunization from 6 months, not from 3. The proposed drugs showed high-potency in children of different age groups and in state of health. Tetraxim and Pentaxim are applicable for children with allergies, as well as with CNS involvement. Moreover, they can be included in combination vaccines against such diseases as whooping cough, diphtheria, tetanus, poliomyelitis, Haemophilus influenzae b. It is due to the same components used, namely DTwP, IPV.
Model of Physical Activity (Gambo Rasa) on Type-2 Diabetes Mellitus Glucose Level in Working Area of Bolo Health Center Abdul Haris
Journal of Global Pharma Technology Volume 12 Issue 07 (2020) July 2020
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Abstract

Introduction: The principle of managing diabetes mellitus consists in setting management goals, modifying diet and exercise, medication, monitoring blood glucose levels, monitoring complications regularly, and evaluating laboratories. In addition to these principles, four main pillars of diabetes mellitus management were more concise to understand, which include education, diet, exercise, and medicine. Exercise was considered important for diabetes mellitus management because it can cause physiological effects such as lowering blood glucose levels, lowering fat levels the body, decreases blood lipid levels, lowers blood pressure, and improves fitness. Methods: The research design used was "one group pretest-posttest design", researchers examined changes that occur after an intervention. Data were analyzed using paired sample t-test. Results: The results showed that there was an influence of the physical activity model (Gambo Rasa) on blood glucose levels of type-2 diabetes mellitus. Keywords: Model of Physical Activity, Gambo Rasa; Type-2 Diabetes Mellitus; Blood Glucose
Anti-Leishmanial Activity of the Leaves of Hyoscyam using Extraction Promastigotes of Leismania Major In-Vitro Mahmoodreza Behravan
Journal of Global Pharma Technology .
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Abstract

Background and aim Protozoan of Leishmaniasppisaagent of disease of cetaceous leishmaniasis (or tropical sore) and kala-azarworldwide. Due to the prevalence of leishmaniasisin different parts of the world and in Iran, and considering that pentavalent antimony compounds for the treatment of disease has severalside effects, the use of medicinal plants is emphasized. By increasing drug resistance in the treatment of diseases especially parasitic diseases, as well as the existence of the side effects of chemical compounds, the use of herbal medicines has been increased in the treatment of parasitic diseases worldwide. Method and Material In this experimental study, first the alcoholic and hydro extract of the fresh, dried and powdered plant was provided by the method of distillation with water vapor and then various concentrations of 0.25, 0.5, 1, 2, 4 mg/ml of the extract were added to the culture environment containing promastigotes of Leis mania major. After adding extract at 6, 12, 24, 48 and 72 hours the number of live parasites was evaluated and numeratedby MTT colorimetric method and using the Neuberger slide. Results The results of the research showed there isa significant reduction in the number of parasites of Leishmaniain terms of time; that has been created in response to extract Hyoscyamusniger. So in investigating the effect of plant extract of Hyoscyamusnigeronpromastigotes of Leis mania major in concentration 4theparasite existing in vitro was almost equal to zero. All examined concentrations (0.25, 0.5, 1, 2, 4 mg/ml) of this extract have caused to reduce the number of parasites of leis mania. Conclusion This extract has had very favorable effect on extract promastigotesofLeishmania major and could destroy almost all parasites present in the culture environment and therefore this plant can be used as the successor of the Glucan time drug in the treatment of leishmaniasisdisease.Keywords: Leishmania major, Hyoscyamusniger, MTT, In-vitro.
The Role of Antibodies Lipids in Antiphospholipid Abortion Occurred in Women with Toxoplasmosis in Kirkuk City Bafreen Mohamad Raza
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In the study the level of antiphospholipin (APL) antibodies with T. gondii in 160 abortion women who clinically diagnosed with recurrent miscarriage their aged between 15– 45 years, attending to Kirkuk hospital and 20 pregnant women with good health had not been subjected to previous abortion were included as control in the study which extended from April 2017 to October 2017. Blood samples and the required information regarded with maternal age and number of previous miscarriage were collected from both patients and healthy. Shown from the results that 21 (13.13 %) cases of abortion women with previous miscarriage were positive in APL- IgG and 10 (6.25 %) cases of abortion women with recurrent previous miscarriage give for APL+ and T.gondii IgG +IgM, all test results give negative in healthy women. An obvious significant ant differences at probability level (P < 0.05) found when make comparison between (APL IgG, IgM) with T.gondii+ APL IgM, IgG in both patient and healthy. The highest percentage of abortions was in the age (15-25) group. The lowest number of abortions was within the age group (25-35) years. The overall rate was 31%. It was the proportion of antiphospholipin IgG+ 21% and%10 of (IgG+ IgM) for antiphospholipin with antibodies T.gondii. There was no case of acute infection IgM+ antibody.Keywords: Recurrent Abortion, Toxoplasma gondii, Antiphospholipid.

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