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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Various Anticoagulants on Ethinyl Estradiol and Levonorgestrel Analysis in Human Plasma in Vitro by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry Yahdiana Harahap
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: This research objective is to evaluate the different types of anticoagulant to ethinyl estradiol and levonorgestrel analysis in plasma using ultra performance liquid chromatography tandem mass spectrometry. Method: Chromatography condition was obtained with Acquity® UPLC BEH C18 column (1.7 µm; 50 x 2.1 mm); mobile phase consisting 0.1% formic acid in water – acetonitrile under gradient elution ; flow rate of 0.3 mL/minute; column temperature of 40ºC; injection volume of 10.0 µL; 5-minute analysis time and prednisone as internal standard. Sample preparation used protein precipitation followed by liquid-liquid extraction. Results: There was a linear result ranging from 5-500 pg/mL concentration of ethinyl estradiol and 100-10,000 pg/ml concentration of levonorgestrel. There was no significant difference for stability and recovery of ethinyl estradiol and levonorgestrel in citrate, heparin, and EDTA plasma (p > 0.05; ANOVA). However, significant difference for peak area ratio (p < 0.05; Kruskal Wallis), between citrate, EDTA, and heparin plasma was observed. Conclusion: Citrate and heparin plasma analysis had better result than EDTA plasma analysis.Keywords: Ethinyl estradiol, Levonorgestrel, Prednisone, EDTA, Heparin, Citrate.
Serum Levels of Zinc, Selenium and Homocystine among Iraqi Patients with Type-2 Diabetes Mellitus Aqeel Abbas Noaman
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background  and Objectives: ( The disease of  Diabetes  Mellitus ) is  a  main  medical,  economic and social   big problem,  because  the  high  pervasion  and increment incidence (of this depilating disease with )subsequent cascading of (several disabling complications) and it needs for special medical care. High prevalence of this disease) occur in Middle East.Its prevalence in Iraq increased from 5% in 1978 to19.7%in 2012). The current study initially focuses on the investigation of serum micronutrients [zinc (Zn), selenium (Se)] and homocystin (Hcy)] levels as well as their relatedness with (type 2 Diabetes Mellitus) in Iraqi patients. Subjects and Methods: This study was designed as a case - control investigation and conducted at diabetic center in Baquba General Hospital in Diayla, Iraq. This study involves 50 patients with type 2 DM and 25 apperently healthy, age and sex matched subjects for that represent as control group. The patients were classified into two sub-groups including, type 2 DM with nephropathy (33 patients) and type 2 DM without nephropathy (17 patients). (Fasting blood sugar, creatinine as well as some selected serum levels including two important micronutrients (Se, Zn) with addition and all of them were measured in each group. Results: The prevalence of DM Type2 was at age of 60 to ≥ 70 years. (Diabetes was more prevalent) in males than in females (58 % ,  42 % consecutively)  .The mean level of blood glucose  and creatinine (were  typically higher in  both diabetic groups) as compared to the control group (p = .000). Selenium level was lower in diabetic patients with a significant difference when it compared with healthy control. Study groups according to zinc level (p-value= 0.149) did not indicate a significant difference. In this study homocysteine levels was)higher in DM patients with nephropathy than diabetes without nephropathy (17.09±1.942 vs 16.72±2.323)  with statistically significant differences comparing  with the control group (6.74±0.946) No significant correlation  was  found among Zn , Se and Hcy with plasma glucose and creatinine. Conclusion: (The findings of the current research show obvious decreased in the serum Se among Type2 DM patients with and without nephropathy comparing with control. Additionally, serum homocystine levels were elevated regarding to the occurrence of diabetic nephropathy so it could be an indicator for observed DM and progression of DM nephropathy.Keywords: Type 2 Diabetes, Zinc, Selenium, Homocysteine.
Effect the Magnetic Water on Physiological Traits of Callus the Fenugreek (Trigonella foenum graecum L.) Basheer Abdulhamza Alalwani
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The experiment was conducted in the tissue culture lab. Biology Dept., Babylon University. Callus induction was achieved by culturing the seeds of (Fenugreek) Trigonella foenum-graecum (L.) on MS medium supplemented with 1.0 mg/lˉ¹ 2, 4-D and BA which combination with all study treatments'. The magnetic water effected by improving the growth of callus, physiological and biochemical characteristics of callus. This study aimed to investigate the effects of magnetic water on some characteristics of growth and chemical constituent in Fenugreek. To this end callus formation was allowed to take place for 45 days in the dark at 25±2 °C from Fenugreek seeds were grown as two experimental groups. A group of seeds were irrigated with distilled water and in parallel the other group with magnetic water at three gausses 1000, 2000 and 3000 gauss. Results revealed that in comparison to control plants, irrigating with magnetic water increases the growth parameters. The treatments 1000 and 2000 gauss showed significant increase in fresh and dry weight, but decline was at 3000 gauss overcome of all treatments including control (Distilled water). From the results obtained it can be said that Physiological Traits outperformed on control by gave the highest values of CAT and SOD by using of magnetic water. Keywords: Fenugreek (Trigonella), Tissue cultures, Magnetic water.
Synthesis and Spectral Study of mono-ligand Complexes for Acriflavine with Some Metalions and Evaluation Their Antibacterial Activity Haya H. Abdul. Hameed
Journal of Global Pharma Technology .
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Abstract

In this study, a new seven complexes have been prepared from acriflavine (LCl) with metal ions VO (II),Co (II),Ni (II),Cu (II) ,Cd (II), Zn (II) and Hg (II) with mole ratio (M:L) (2:2) all complexes have general composition [M2(L1)Cl4(H2O)4]Cl2, [(VO)2(L1)2(SO4)2(H2O)2]Cl2in ethanol. The ligand and all complexes were characterized by modern spectroscopic(IR, UV_Vis , Mass, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements and molar conductance. In addition to evaluated their antibacterial activity against two type of bacterial. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry, the value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligandKeywords: Acriflavine, Acridine, Acriflavine metal complexes, Biological activity.
Arsenic Removal from Aqueous Solutions by Raw and Incinerated Pine Bark Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

In this research, raw and incinerated pine barks were evaluated as absorbents for the removal of pentavalent arsenic As(V), from aqueous solutions. After preparing artificial wastewater samples containing different concentrations of arsenic, the impact of the parameters including pH, adsorbent dosage, contact time and initial arsenic concentration was assessed on arsenate adsorption level by both of the absorbents. The results showed that the pine bark ash could remove arsenic from aqueous solutions better than the raw pine bark in optimum conditions of contact time of 60 minutes, pH 7, absorbent dosage of 1 g/l and initial arsenic concentration of 1000 µg/l with absorption efficiency of 95.86%. Considering the high efficiency of absorbent at neutral pH as well as the availability and low cost of the pine barks, the use of pine bark ash is suggested as an effective absorbent for removing arsenic from aqueous solutions.Keywords: Pine Bark, Arsenic, Aqueous Solutions
Antibiotic Susceptibility Patterns of Uropathogens Isolated From Catheterized Patients in Al-Imam Hussein Medical City in Holy Karbala Zahra M. Al-Hakak
Journal of Global Pharma Technology .
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Abstract

Objective: Indwelling urinary catheters (IUCs) are commonly used in hospitalized patients. Catheter-associated urinary tract infections (CAUTIs) are a major source of nosocomial infections in the worldwide. The present study was conducted to the etiological Bacterial pathogens of the UTI and to determine the antibiotic sensitivity pattern of pathogens isolated.  Methods: This study was carried out in AL- Imam Hussein Medical in holly Karbala city from (1st March, 2017) to (30st June, 2017).Total (300) urine samples were tested bacteriologically and for antibiotic susceptibility using standard procedures. Results: A total (300) patients,(111) by(37%) were female and (189) by (63%) were male with indwelling urinary catheters were studied divided into four groups according to hospital ward. The highest percentage of age group was seen in (36-45) years group. Uropathogens were isolated from (244) patients sample only. The bacterial isolates included E. coli (53), Pseudomonas aeruginosa (99), Klebseillapneumonia  (22), Staphylococcus aureus (20), Coagulase negative Staphylococcus (16), Candida albicans (14), Enterococcus faecalis (8), B hemolytic  Streptococci (6) and Serratiamarcesens (6). All isolated bacteria display variation in sensitivity and resistance pattern. Conclusions: This study observed that Pseudomonas aeruginosais the main organism which isolated from Catheterized patients caused UTI. In addition, the study showed that E. coli isolates were the predominant pathogens and showed increasing resistance pattern to the commonly drugs which used in present study.Keywords: Urinary Catheter, Urinary Tract, Infection, Antibiotic, Patterns, Holy Karbala.
Hepatoprotective Effect of Zingiber Officinale Roscoe against Anti-Tubercular Drug-Induced Liver Toxicity in Albino Rats Babul Kumar
Journal of Global Pharma Technology Volume 11 Issue 11 (2019) November 2019
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The present study was aimed to investigate the hepatoprotective effect of ethanolic extract of Zingiber officinale Roscoe against hepatotoxicity induced by antitubercular drugs in Wistar albino rats. The ethanolic extract of rhizomes of Zingiber officinale was prepared using a Soxhlet apparatus. 24 Wistar albino rats were randomly divided into four groups (n=6). Except Group 1, all the other groups were treated with antitubercular drugs [isoniazid (I) (7.5mg/kg), rifampicin (R) (10mg/kg) and pyrazinamide (P) (35mg/kg)].  Group 2 and group 4 were treated with Silymarin (100mg/kg) and Zingiber officinale (500mg/kg) respectively, one-hour prior administration of antitubercular drugs for 30 days. At the end of the study, blood was collected and the two animals from each group were sacrificed and the liver was sent for histopathological examination. Data calculated by mean ± standard error of the mean and by unpaired t-test. Any p-value less than 0.05 have been considered as statistically significant. Antitubercular drugs significantly increased the Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), Alkaline Phosphate (ALP), Total bilirubin (TB), unconjugated bilirubin (UB) and Total protein (TP) levels as compared to the control group. Treatment with Z. officinale extract (500mg/kg) significantly (P<0.05-P<0.001) reduces the antitubercular drugs induced hepatic toxicity and biochemical elevations towards normal. Zingiber officinale extract was hepatoprotective against antitubercular drugs induced hepatotoxicity in albino rats.Keywords:  Zingiber officinale extract, Isoniazid, Rifampicin, Pyrazinamide, Liver enzymes.
Pharmacognostic Studies on Tradescantia Zebrina Gouri Kumar Dash; Mohamad Nur Aiman Fadrul; Allan Mathews
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
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Tradescantia zebrina Heynh. ex Bosse (Family- Commelinaceae), is an important medicinal plant with several traditional medicinal uses. In Malaysia, the plant is recommended to be a remedy to improve kidney function. In the present paper, we report some pharmacognostic studies on the leaves since there are no standard parameters available for this plant in the literature. Presence of typical epidermis with multiple hypodermis layers, few chloroplasts scattered in the spongy parenchyma and red color in most parts of the upper and lower epidermis are some of the key features for the identification of the species. Preliminary phytochemical screening of leaves showed presence of sterols, saponins, flavonoids, tannins, carbohydrates, and proteins and amino acids respectively. The above findings together with physicochemical parameters can be useful in establishing pharmacognostic standards for the plant.
Inhibitory Effect of Silver Nano Particles (AgNPs) Against Biofilm Formation in Multidrug Resistance P. aeruginosa Isolated from Burn infections Huda H. Al-Hasnawy
Journal of Global Pharma Technology .
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P. aeruginosa is an opportunistic pathogen that display uncommon phenomena of antimicrobial resistance. It is important to reminder that more than (80 %) of bacterial infections are caused by biofilms. Disruption and inhibition of preformed biofilms can be accomplished using silver nanoparticles. Out of 40, 22 (55%)  P. aeuroginosa isolates were recovered isolated pathogen was subjected to antibiotic susceptibility test using disc diffusion test. Screening of silver resistance using silver nitrate also done by agar dilution method using different concentrations (100µglml-400µglm). Formation of biofilm was detected. Silver nano particles were prepared and tested for anti-biofilm activity using different concentrations ranging from (2.5µg/ml-20µg/ml) employing tissue culture plate method. P. aeruginosa isolates were recovered from burn unit at a percent (55%), those isolates were found to be multidrug resistance and silver resistance as following: (100%) for each of piperacillin, imipenem and Cefotaxime. While (88%), (65%), (62%) for amikacin, ceftriaxone and gentamicin respectively. Biofilm production was detected quantitatively by microtiter plate method (100%), qualitatively via congo red agar method (44%) in multidrug resistant P. aeruginosa isolates. The inhibitory effect of silver nano particles in formation of biofilm was estimated using tissue culture plate method using different concentrations ranging from (2.5µg/ml -20µg/ml) and show high inhibition rate at 20µg/ml. This study concluded that silver nano particles have good antibiofilm activity with small concentration that could be used as an alternative therapy in those opportunistic pathogen.Keywords: Silvernanoparticles, P.aeruginosa, Biofilm Inhibition, Biofilm Formation.
Clinical and Pharmacological Approaches to Optimize Outpatient Treatment of Bronchial Asthma Olga Pashanova
Journal of Global Pharma Technology Volume 12 Issue 01
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Asthma is a common chronic disease. There is no age-related predisposition to the disease, occurring in both adults and children. The study presents clinical trial of ANAFERON FOR CHILDREN® effect on URTI remission process in combination with mild and moderate bronchial asthma in children. The studies were based on a sample of 150 children (age 3-6 years, average age 4.1 ± 0.1), conducted during 2017-2019 in Moscow, the Russian Federation. The first group included 89 children taking ANAFERON once a day for 3 months; the second (control) group included the remaining 61 who took a placebo-treatment during the same time period. The presence of an autoimmune disease was an exclusion criterion. Significant difference of 2.5 times less occurring of the disease (p = 0.0002) was found between the average number for the experimental group compering to the control. Children from the experimental group were 2.2 times less likely to have exacerbations of bronchial asthma (p = 0.013). 3 days is the duration and maintenance period of symptoms for the experimental group, that’s 3 times lower comparing to the control group-9 days (p = 0.041). The Mean Neutrophil Volume (MNV) was significantly reduced (p = 0.001), in a month, Squamous Epithelium Index (SEI) (p = 0.009) in the experimental group. The experimental group maintained significantly low values of MNV and DRE at the end of ANAFERON therapy (p = 0.001). Current management of bronchial asthma includes a Treatment Effectiveness Assessment (TEA) and Patient Safety with medications prescribed, as well as improving of therapeutic cooperation and the patients’ quality of life. The use of ANAFERON reduces the frequency of URTI by 2.4 times in the 3-6-year-old children with bronchial asthma. Additionally, ANAFERON is well tolerated for children. The use of ANAFERON (as a preventive drug) reduces 1) occurring of mild and moderate bronchial asthma by 1.5 times; 2) the number of cases of bronchial asthma exacerbation by 2.2 times; 3) the duration of asthmatic attacks by 3 times. This is associated with cytoprotective effect of the drug on the olfactory epithelium, as well as its influence on reducing the number of children with low IFNƛ (by 3.4 times in 3 months of therapy). Keywords: Bronchial asthma, Prevention, ANAFERON, Placebo, Cytological indicators.

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