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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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A Review on Manufacturing Operations of Solid Dosage Forms: Design and Implementation on GMP Systems in the Manufacturing Facility Alex Joseph
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Manufacturing of solid dosage forms which should be performed accordance with the Good Manufacturing Guidelines as per the local regulatory requirements, Product quality cannot be adequately ensured only by inspecting and testing a finished product because finished-product testing cannot detect all defects, quality must be built into a product with processes that are well-controlled during design and manufacturing. Manufacturers need to establish and implement the quality design that controls each step in manufacturing process to ensure that the product meets predetermined specification. This study is anticipated to provide guidance which includes all the operations starting with procedure for obtaining the manufacturing license, procurement of raw materials and packing materials, handling in warehouse, production planning, dispensing, line clearance, in-process quality control tests, storage, sampling, analysis, approval and batch release.Keywords: Good manufacturing practice, Manufacturing license, IPQC.
The Effectiveness of Different Teaching Methods According to the Kolb Theory in Performance Accuracy of Some Basic Skills and Neuralgic Inhibition in Tennis Aqeel Yahya Hashim Abdulaziz; Zainab Nadhim Shakir Al. Gburi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

In an attempt to use modern techniques in learning skills and believing that there is a need to re-examine the method used and provide the potential for the student to obtain information from them to ensure the process of education and to change the methods that are widespread based on memorization and conservation and literal application and replace them with modern methods to ensure the development of thinking and creativity capabilities of teachers and students And to benefit from modern information and techniques , And experimenting through the effectiveness of different teaching methods in accordance with the patterns of the theory of the circle Kolb in the performance of the accuracy of some basic skills in tennis. The aim of the research was to identify the classification of students according to the Kolb theory and the different teaching methods suitable for each classification, and to identify the best groups that were used according to Kolb's theory of performing some basic skills in tennis. The researchers hypothesized that the use of various teaching methods according to "Kolb theory is positively effective in learning some basic skills in tennis. he fields of research were the human field: students of the Department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa, class III / for the academic year (2016 - 2017) .The period field from 1/11/2016 until 1/8/2017, and the spatial field ,in the internal gymnasium of the department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa . The researchers used the experimental method in the two groups (experimental) method. On this basis, the researchers selected the sample of the students from the third stage of the Department of Physical Education and Sports Sciences / Faculty of Education for Girls / University of Kufa with (25). After excluding (7) female students from the original society for their participation in the exploratory experiment, the sample was selected by 18 female students in the simple random way , Which was divided into two experimental groups according to the classification form of the theory of Kolb, which classified the sample to the practical and theoretical and according to the qualifications of each student, the first experimental group (the practical) (10) students and applied the method of solving problems in teaching basic skills in tennis , And the second experimental group (theorists) (8) students. The method of mental training in teaching was applied to the basic skills of the tennis game. The special units were prepared for each group after presentation to the experts and the preparation of the tools for experimental procedures such as computer use , video clips and strips educational, rackets and tennis balls, and form evaluating the performance of accuracy, was applied (8) educational units on the two sets of research experimental, by one unit for each week, as it has been implementing the teaching style of solving problems with the first experimental group (practically) and the style of mental training with the second experimental group (theorists), and the conclusions obtained between the results of tribal tests and dimensionality and there is a significant moral differences and in the interest posteriori tests and both sets, and either posteriori tests results were the absence of significant differences between the two groups differences The pilot, and the researchers recommended that the need to use Kolb's theory circle in teaching. Keyword: Methods and methods of teaching, Kolb theory, Learning patterns, Tennis and precision performance.
Starch/Gum Arabic Blends for Controlled Drug Delivery and Cancer Therapy: Synthesis and Characterization Ismaeel Moslam Alwaan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Cancer is one of the most mortal diseases in the world .This work was planned to prepare a new chemical cross linking starch/gum Arabic hydrogel system in the presence of potassium persulfate(K2S2O8)as initiator, to describe the characteristic of the new material , and to investigate its potential utilizations in controlled drug delivery and cancer therapy. Crosslinked starch /gum Arabic hydrogel will be manufacture with changeable levels of starch and gum Arabic then were loaded with hydroxyurea. The structure of the native starch and starch/gum Arabic blends was characterized by FTIR, SEM. The starch and starch/gum Arabic blends were analyzed for in vitro drug release studies by using UV-vis spectroscopy. The swelling test, MTT assay were also investigated. The drug release and swelling test was monitored at pH 4 and pH7.4. The experimental results proved that the production of starch/gum Arabic blends was reduced the swell ability which lead to slow release of hydroxyurea,  and the rate of hydroxyurea release was significantly higher at pH 7.4 than pH4, at constant incubation time. The swelling ratio and drug release of the blends was decreased with increasing gum Arabic levels. In vitro cytotoxicity study show the killing of 14∼"> 63% colorectal cancer cells at 500µg/ml of hydroxyurea concentration while the 14∼"> 49% destruction of cells require for the starch/gum Arabic/hydroxyurea blends at the same concentration and  after 24hr of incubation. The sustained released of hydroxyurea-loaded starch/gum Arabic blend shows much better anticancer efficacy thereby, revealing a novels vehicle for the treatments of cancer.Keywords: Starch, Gum Arabic, Hydroxyurea, Controlled release drugs.
Effect of Trimetazidine on Myocardial Disorders in Rats Hadeel Jabar Neama Almuoswi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Cardiac muscle anemia affects the functions of mitochondria that results in ion disparity. The condition called cardiac arrhythmia. The research aims to study the effect of antianginal medication of trimetazidine on myocardial disorders in rats. The study was conducted on the rats. They were fed with 10 mg trimetazidine per Kg weight of mice each day for seven days. Tests were done for the effect of the moderator on mitochondrial metabolism in severe cardiac muscle anemia affected rats. Acute cardiac muscle anemia results in an injury to mitochondrial functions. So, when anemia cluster without trimetazidine treatment was observed, a major reduction within the infarction range was ascertained in trimetazidine-treated anemia cluster (31±3% vs. 52.8±4.89%). Trimetazidine maintained the mitochondrial organization. And, thus, better the metabolic process management, magnitude relation, and sophisticated activity. Moreover, the mitochondrial biosynthesis and division or fusion of the cells improved. The indubitable Promote the activated receptor gamma peroxisome proliferators (PPARγ), the Joint Co-1α (PGC-1α), mitofusins one (Mfn1), dynamin-related super molecule one (Drp1), Optic nerve atrophy one (OPA1) emerge in rats with acute cardiac muscle anemia. Therefore, the incontestable heart defending effects of trimetazidine was shown to preserve mitochondrial metabolic process, increased biogenesis, and split/union of cells. And, thus, this rat model of cardiac muscle anemia may be effectively used along with other cardio protective agents.Keywords: Trimetazidine, Myocardial disorders, Rats.
Efficiency of 3,4- dihydropyrimidin -2 (1H) Derivative Compounds in Inhibition Fungi Associated with Wheat Seeds Ahmed Ihsan Flayyih Al-Jawhari
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

This  study  conducted  to  synthesis  and  identification  of  3,4 - dihydropyrimidin  -2 (1H)  derivative  compounds  , and  also  study  the  efficiency  of  these  compounds  in  inhibition    fungi  associated  with  wheat  seeds . The  results  showed  that  three  compounds  were  synthesis  and identificate  by  using  Infrared  spectroscopy  (IR)  ,  H-MMR and  Mass  spectroscopy .  The  result  showed  that  three  species  of  fungi  were  isolated  from  wheat  seeds  , these  fungi  were  Rhizoctoniasolani  ,  Trichodermalignorum  and  Aspergillusniger.  The  results  obtained   that  compound  ( 3a )  was  more  efficiency  to  inhibition  all  fungi  isolated  , and  the  statistical  methods  showed  no  significant  between  different  concentrationsof compounds . Keywords: Dihydropyrimidin, Monastrol, Fungi, Fungicides, Wheat, Seeds.
Natural Outbreaks of Infectious Bursal Disease in Brahma and Aseel Chicken in Iraq Qayssar Ali Kraidi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The infectious bursal disease (IBD) represents one of the most severe poultry diseases and is responsible for marked economic losses in poultry populations in Iraq. Backyard chicken with different breeds have been recently raised successfully in a rural area for hobby and household consumption, however, the status of the disease in free-ranging backyard chickens in Iraq is not documented, for this reason, the objective of the present study was to determine the disease in free-range poultry naturally infected with IBDV currently circulating in Iraq. A tentative diagnosis of IBD was conducted based on clinical findings, gross lesions besides the histopathology and lesion scoring analysis and was confirmed by identification of IBDV antigen in AGPT. Typical IBD clinical signs and lesions were observed in all types of birds with a high mortality rate (30% & 25%) reported in Aseel and Brahma breeds, respectively. Histopathological lesion scores analysis for IBDV characterized by a high lesion score of (+5) observed in the studied birds of all breeds. Based on the results of high mortality rate and high histopathological lesion scores we can suggest the occurrence of the disease in backyard chicken in Iraq associated with pathogenic field IBD virus. The present study provides first background document on the current status of IBD in free-range poultry in Iraq.Keywords: Aseel, Brahma, IBD, Iraq. 
The Microwave-assisted Extraction of Anthocyanins, Total Phenolic Compounds and the Antioxidant Activity in Morus nigra L. (Black mulberry) Grown in the Da Lat City, Lam Dong Province, Vietnam Nguyen Hong Khoi Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Morus nigra L. (Black mulberry) is a nutritious fruit that contains many bioactive compounds such as anthocyanins, polyhenol and antioxidant activity. The microwave-assisted extraction method (MAE) is an advanced method with due to its advantages of short extraction time and lower  solvent consumption. The objective of this research is to find the appropriate conditions to extract the highest contents of anthocyanin, polyphenol and antioxidant activity in black mulberry by MAE method. The pH-differential method is used to determine the anthocyanin content, the polyphenol content is determined by the Folin-Ciocalteu method and the antioxidant activity is determined by the DPPH method. The highest contents of these coumponds were obtained as follows anthocyanin contents 128.07 mg/L, polyphenol contents 4305.38 mg/L and antioxidant activity 2715.68 μmol/L when extracted under conditions of concentration of ethanol 60o, solid to solvent ratio 1:30, microwave power 600W, microwave-assisted extraction time 2 minutes.Keywords: Black mulberry, Anthocyanin, Polyphenol, Antioxidant activity, Microwave-assisted extraction.
Nuclear Co-Localization of Expressional Products of CDK4&CDK6 and Human T Cell Lymphtropic Virus Type-1- Genes: An in Situ Hybridization and Immunohistochemical Study of Hodgkin’s Lymphoma Tissues from a Group of Iraqi Patients Noor Sami AL- Lebawy
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infects 15-20 millions individuals worldwide. This on co retrovirus can be transmitted through 3 ways: horizontally, vertically (mother to child) and via blood transfusion. HTLV-1 causes 2 major diseases: Adult T-cell leukemia/lymphoma (ATLL) and tropical spastic par paresis/HTLV-1-associated myelopathy [1]. Although tumor cells exhibit rather infrequent mutations of cdk genes with the exception of G1 kinesis Cdk4 and Cdk6 amplification, over expression or hyper activation of basic cell cycle regulators is a general feature of human tumors [2]. Objective: To analyze the impact of concordant expression of cdk4, cdk6 and HTLV-1 infection on a group of tissues with Hodgkin’s lymphoma (HL). Patients and methods Eighty formalin-fixed, paraffin- embedded lymph node tissues were enrolled in this study; (40) biopsies from Hodgkin’s lymphoma (HL), and (40) lymph nodes with (unremarkable pathological changes) as apparently healthy controls. Detection of HTLV-1was done by ultra-sensitive version of in situ hybridization method whereas immunohisto chemistry detection system was used to demonstrate the expression of cdk4and cdk6 gene expression Results: The HBZ gene of HTLV-1positive – CISH reaction was detected in (22.5%: 9 out of 40 cases) of Hodgkin lymphoma tissues.NoHTLV-1 positive –CISH reaction was detected in healthy lymph nodes tissues of the control group. The differences between the percentages of HTLV-1 detection in HL tissues and control groups were statistically highly significant (P value = < 0.05). The positive cdk4&cdk6-IHC reactions were detected in 35% (14 out of 40 cases) and 57.5% (23 out of 40 cases) of Hodgkin lymphoma cases, respectively. A strong positive correlation was found between the detection, scores and intensity of cdk6 and cdk4markers. Conclusions: Significant expressions of both cdk6 and cdk4markersas well as HTLV-1 genes in Hodgkin’s lymphoma could indicate for their possible roles both in lymph node pathogenesis and carcinogenesis.Keywords: HTLV-1,Hodgkin’s lymphoma (HL), CDK6, CDK4, ISH, IHC.
Synthesis of a New Bicyclicgamma Lactam and Evaluation of their Anticancer Activity Husam M. Kredy
Journal of Global Pharma Technology .
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Abstract

Highly diastereoselective synthesis of γ-lactams 5(a-b) based on the reaction of imines 3(a-b) with phenylsuccinic anhydride is described in this study in moderate yields. The synthesized compounds were tested in vitro for their antioxidant activity. The prepared compounds showed an antioxidant activity. Anticancer activity of the compounds 3(a-b) were tested against breast cancer cells (MCF7), which showed high efficiancy against MCF7 cell lines . The compounds were determined on the basis of the spectral studies using IR, 1H-NMR and13C-NMR.Keywords:  γ-lactams, Antioxidant, Anticancer, MCF7.
Photocatalytic Oxidation of 2-Butanol over Co3O4-Al2O3 Spinel Catalyst Hussein I. Ismael
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The catalyst Co3O4-Al2O3 was prepared by co precipitation methods in different ratios (40: 60, 50: 50, 60: 40,70:30) for the mixed oxides respectively, these ratios were calcinated at 550 °C for 4hours and characterized by using powder X-Ray Diffraction, Fourier transform Infrared spectroscopy. These catalytic activity were investigated in photo oxidation of 2-butanol by using 0.2g.of Co3O4-Al2O3 in different times (0, 15,30,45,60 and 75 min). The result showed that the best ratio gives high activity was 40:60 at 25 °C.  The resultant 2-butanone was measured spectrophotometrically at λ maximum=285nm and estimate this concentration depending on the calibration curve of 2-butanone.Keywords: Cobalt Oxide, Photooxidation of 2-butanol.

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