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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Case History of Severe Toxicoallergic Dermatitis in Patient with Acute Leukemia Igor Y. Gadaev
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Adverse drug reactions are a serious problem in practical healthcare since they can have a significant impact on the patients’ quality of life while the global prevalence of morbidity and mortality caused by drug after-effects is increasing every year. Among the most common adverse drug reactions are skin reactions. They have described a case history of severe furosemide-induced toxicoallergic dermatitis in a 62-year-old man with acute myeloid leukemia taking saluretic due to comorbid cardiac pathology. Furosemide was withdrawn due to of severe toxicoallergic dermatitis onset while the glucocorticosteroids therapy with a 40 mg qd dose of prednisolone was prescribed. Secondary to furosemide withdrawal and due to glucocorticosteroid therapy, the following amelioration was registered: there were no new lesions, bullae and anabrosis disappeared, edema decreased and the patient’s general state of health improved. The described case of severe furosemide-induced toxicoallergic hemorrhagic vasculitis is associated not only with the direct allergenic action of the drug being the sensitization reaction trigger, but is also associated with the aberrant immunoreactive status of a particular patient due to his hematologic malignancies (acute myeloid leukemia). Such severe toxicoallergic reactions are rare enough, but it is extremely important to draw the clinicians’ attention to this problem, since these are the timely diagnosis of mentioned conditions, the identification and elimination of the trigger drug, timely and adequate treatment that guarantee a favorable prognosis for patients. That is why clinicians should not only aim for the verification and treatment of the underlying disease, but also consider the patient's comorbid conditions. Keywords: Drug-induced dermatitis, furosemide-induced severe toxicoallergic dermatitis, Delayed-onset allergy, Toxicoallergic dermatitis in acute leukemia.
Environmental Awareness Among the Students of the Faculty of Education Buthaina Shaheed
Journal of Global Pharma Technology .
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Abstract

Student search slice represents the extract of the most important components of society which can play a big role in addressing the various problems and obstacles in order to follow the technological development that the purpose of this study: identify the environmental awareness among the students of the Faculty of education. Detect indications of differences to environmental awareness among students depending on the variable gender (male, female) 3. detect indications of differences to environmental awareness due to the variable competence (knowledge, human) research has been determined by the College of education for the academic year 2017 research goals requests creation of a tool to measure the level of awareness Ecosystem then ascertain its truthfulness and consistency through displayed on a group of experts in psychology and ecology researchers applied the scale on a sample of (400) then the data were analyzed using statistical case for Social Sciences (SPSS) results: environmental awareness among students Average education. No statistical differences in the level of environmental consciousness according to heterosexual (male, female). There are differences in the level of environmental awareness due to the variable competence (knowledge, human). Based on these results, we offer a number of al astenta. 1. to adopt environmental sciences department at Faculty of science scientific strategies to promote environmental awareness through many seminars and set up seminars and awareness and educational lectures for all cadres in the University as well as the various strata of society. 2. Activate the role of the media, working on achieving compliance with laws and regulations and avoid all illegal means to be environmentally friendly. From: numerous studies and researches on this subject have great importance on individual and community health.
Studying the Effect of Some Organic Sulfur Compounds as Flame Retardants for Polyester and Epoxy Resins Hanan Qais Al-Masoudi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

In this work, five additives were used, namely; Pentane -2,3,4-trione3-[(5,6-diphenyl-6H-1,3,4-thiadiazin-2-yl)hydrazine]) (Additive I).(5-[(z)-(5,6-diphenyl-6H-1,3,4-thiadiazin-2-yl)diazenyl]-4,6dimethyl-2H-1,3-thiazin-2-amine)(AdditiveII).( (4Z,6E)-6-((Z)-(5,6-diphenyl-6H-1,3,4thiadiazin-2-yl)diazenyl)-5,7-dimethyl-2,3-dihydro-1,4-thiazepine-3 carboxylic acid)(Additive III).(6-[(5,6-diphenyl-6H-1,3,4-thiadiazin-2yl)diazenyl]-5,7dimethyl-1,3,4-thiadiazepin-2-amine) (Additive IV). (2,2- (1,4-phenylene)bis (4,5-dihydro1,thiazole-4-carboxylicacid) (Additive V).The effects of these additives on flammability of unsaturated polyester and epoxy resins have been studied. Sheets of the resins with weight percentages of (0.2, 0.4, 0.6 & 0.8 %) of the additives in dimensions (150×150×3) mm were used. Two standard test methods used to measure the flame retardation are: (ASTM: D-2863) and (ASTM: D-635).Results are obtained from these tests indicated that, additive IV has high efficiency as flame retardant, self–extinguishing (S.E.) at the percentage (0.2 %) for unsaturated polyester resin and the percentage (0.4 %) for epoxy resin. Also self- extinguishing (S.E.) at the percentage (0.4%) for additives II in unsaturated polyester resin and the (0.6%) for additives II in epoxy resin Additive V show low effect on flammability in both resinsKeywords: Sulfur compounds; Organic sulfur compounds; Additives; Flame retardants; Flammability; Unsaturated polyester resin; Epoxy resin; Thermosetting polymer.
Effect of HPLC Separated Flavonoids Extracted from Centraurea Cineraria to Some Species of Bacterial Pathogenicity Zeinab Hashim Mohammed
Journal of Global Pharma Technology .
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Abstract

The research included the separation and determination of flavonoids from the extract of Centraurea Cineraria gray using the high-performance liquid chromatography technique. Cirsilineol, Jaceosidin, Melitensin, Apigenin and Prunasin were found to be identical to the standard compounds used in chromatography analysis. The flavonoids found in the extract were detected using qualitative chemical analyzes. The effect of the gray catheter extract containing the flavonoids mentioned above was studied in five bacterial species (Escherichia coli, Streptococcus pneumonia, Klebsiellaspp Staphylococcus aureus, Pseudomonas aeruginosa) using Agar well diffusion method and then added concentrations (100,75,50,25 mg / Ml of the extract and the measuring sieve. The transparent zone of the bacterial growth inhibitor showed a concentration of 100 mg / ml inhibitory capacity with a zone of 17 mm inhibition for Klebsella.
Synthesis and Spectroscopic Study of 3-Hydroxy-2-(3-(4-Nitrobenzoyl) Thiouriedo) Propanoic Acid with their Metal Complexes Abbas M. Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

A new ligand 3-hydroxy-2-(3-(4-nitrobenzoyl) thiouriedo) propanoic acid (NTP) where synthesized by reaction of 4-nitro benzoyl isothiocyanate with serine amino acid. The ligand was characterized by FT-IR, NMR spectra and the elemental analysis. The transition metal complexes of this ligand where synthesize and characterized by UV-Visible spectra, FT-IR, magnetic suscpility, conductively measurement, The general formula [M (NTP) 2] where M+2= (Mn, Co, Ni, Cu, Zn, Cd, Hg,), the form of molecular for these complexes as tetrahedral except Cu has square planer.Keywords: Serine, 4-nitrobenzoyl isothiocyanate, Transition metals.
Development of Extemporaneously Prepared Captopril Oral Dosage Forms - A Comprehensive Chronological Study Ayman M. Al-Qaaneh
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Captopril is an Angiotensin-converting enzyme inhibitor, its effectiveness as an antihypertensive agent and in the treatment of several cardiovascular conditions in neonates and children has been proved clinically. Unfortunately, in many countries, it is available as a solid dosage form only. As this does not satisfy the needs of these patients in terms of dosage and pharmaceutical formulations, extemporaneously prepared formulations represent the only available solution for this situation. Many attempts have been made to study the different factors that may affect the stability of captopril in oral liquid formulations, aiming to design a formula with maximum stability profile. Although there is still debate about the effect of some factors on captopril stability, other factors have a clear role. Low storage temperature, acidic media (up to pH 4), use captopril powder, absence of heavy metals, increase drug concentration, sugar-free vehicle, decrease oxygen contents in the formulation, and excipients such as chelating agents and antioxidants are well known to increase captopril stability. Varies type of extemporaneously prepared dosage forms (liquid, powder, or tablet) with different formulations have been prepared and studied. Unfortunately, the stability of captopril in these preparations has been highly variable and sometimes conflicting results obtained, reflecting the sensitivity of captopril to a variety of factors that have not yet been completely identified. This review discusses these factors and extemporaneously prepared formulations in a comprehensive chronological way. Keywords: Captopril, extemporaneous preparation, Drug stability, Pharmaceutical formulation, Drug compounding.
Impact of Metabolic Factors on the Incidence and Intensity of Knee Osteoarthritis in a Sample of Iraqi Patients Mohammed Mahmood Mohammed
Journal of Global Pharma Technology .
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Abstract

Background: Osteoarthritis (OA) is a leading cause of physical disability, morbidity and lessened quality of life, mainly in elderly people. It characterized by inflammation, breakdown, and consequent loss of cartilage of the joints. OA usually associated with obvious risk factors, like obesity, age, inflammation and joint injury, in addition to quality of diet and some metabolic factors. Purpose: To evaluate the role of obesity and different metabolic factors on the incidence and severity of symptoms in patients with knee osteoarthritis. Methods: Fourth patients with painful knee OA were randomly selected at the outpatient clinic of Baghdad teaching hospital. All patients diagnosed with OA in one or both knee joints. The patients were allocated into two groups: Group A: Include 20 non-obese patients diagnosed with knee OA. Group B: Include 20 overweight and obese patients diagnosed with knee OA. A validated, self-administered questionnaire method known as Western Ontario Mac Master Osteoarthritis Index (WOMAC) which includes evaluation of pain, stiffness and physical function, were done. FBG, TC, LDL, TG, HDL cholesterol, in addition to serum leptin, IL-1β and TNF-α were measured for both groups to be statistically evaluated. Results: The results showed a significant differences (P<0.05) between group A and group B regarding to BMI, serum leptin, TG, LDL, IL-1β and TNF-α (less values in group A), in addition to WOMAC score and serum HDL (more values in group A). However, no significant differences (P<0.05) seen for FBG and TC between both groups.  Conclusion: This study clearly demonstrated that increasing body weight with the presence of other metabolic factor can strongly enforce and accelerate many process involved in the pathogenesis of OA, including inflammatory response, cartilage degradation and bone remodeling.Keywords: Osteoarthritis, Obesity, Metabolic syndrome, inflammation, WOMAC.
Evaluation of Chemical Chaperones on the Transient Expression in Chinese Hamster Azam Rahimpour
Journal of Global Pharma Technology Volume 08 Issue 07
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Abstract

Recombinant proteins play an important role in biomedical and basic science researches. In this regard, mammalian cells have widely use in monoclonal antibodies. Improper aggregation complex recombinant proteins have been known as a bottleneck in successful production of active bio-therapeutics. Anti-CD52 is efficient immunosuppressive agents of therapeutic applications especially in autoimmune diseases. In this study, effects of four chemical Chaperones including DMSO and 4-phenyl butyrate (4-PBA) on transient of a recombinant evaluated during six days. Analysis of the expression level showed up to 2 fold in DMSO treated cells, while 4-PBA treatment improved antibody expression up to 50%, 30% and 10%, respectively. Keywords: Monoclonal antibody, Transient expression, Chemical chaperone.  
Equilibrium and Thermodynamic Study of Malachite Green & Phenol Red Dyes Adsorption from Aqueous Solution by Use Algae Biomass Ahmed Mohammed Abbas
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Recently the focus has been on using the surfaces of the adsorbent economically cheaper and technologically more efficient technology in treatment environmental pollution problems the biomass of Algae was applied for the adsorption of Malachite Green (MG) and Phenol Red (PhR) dyes from aqueous solution. The prepared adsorbent was characterized by FT-IR and SEM Technique .The adsorption of (MG) and (PhR) dyes onto algae biomass from aqueous phase were taken as a function of the absorbed weight, dye concentration, temperature and contact time. . The equilibrium data of (MG and PhR) adsorption onto biomass of Algae was analyzed by different isotherms models and it follows Langmuir adsorption isotherm model for the (MG) dye while (PhR) dye it follows the Freundlich isotherm. The evaluation of thermodynamics functions such as the Gibbs free energy negative for (MG) dye adsorption, positive for (PhR) dye adsorption and positive enthalpy values indicated respectively the different spontaneous and endothermic behavior of the reaction and the chemisorption of the sorption process.Keyword: Biomass, Algae, Adsorption, Malachite Green, Phenol Red.
Efficacy of Edible Coating to Extend the Post-harvest Shelf-life of Shallot (Allium ascalonicum) Bulb N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Shallot or violet onion (Allium ascalonicum) bulbs are well known for their biological activity resulting from the presence of sulphur compounds. The health and nutritional benefits of shallot have led to their increased demand and hence production. Shallot harvest handling must be done immediately after harvest because these commodity are easily damaged. Plastic food packaging causes serious environmental problems. Edible coatings offer various physicochemical advantages for fruit and vegetable in preservation. Objective of this study focused on the effectiveness of different coating materials such as chitosan, CMC, xanthan gum, carrageenan, sodium alginate to the quality of shallot bulbs. Results showed that after 6 month storage by 3.0% chitosan at ambient temperature, shelf-life of shallot bulbs remained its stability. Edible coating could maitain shallot quality by controlling respiration rate as well as decay. It’s not only as an effective strategy for the product but also friendly environment.Keywords: Shallot bulb, Allium ascalonicum, Chitosan, Coating, Storage, Shelf-life.

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