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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Investigation of Star Fruit (Averrhoa Carambola) Juice Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Star fruit (Averrhoa carambola) is widely grown in Vietnam. It is a good source of natural antioxidants especially proanthocyanidins, epicatechin and vitamin C. It is quite a popular fruit usually consumed fresh or made into fruit juice or juice beverage. In order to utilize this good source as a healthy food drink, we attempted to produce star fruit juice. We focused on investigation of dilution ratio of star fruit juice with water, soluble dry matter, and pasteurization to product quality. Our results showed that dilution ratio 40:60 (juice: water), 20 oBrix, pasteurization at 90 oC in 5 minutes gave the best star fruit juice.Keywords: Star fruit, Averrhoa carambola, Juice, Pasteurization, Soluble dry matter, dilution ratio.
Eco Friendly Synthesis, Characterization and Antibacterial Activity of ZnO Nan particles using Bacillus Subtilis against Multi-Drug Resistant Bacteria Ayad F. Alkaim
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Zinc oxide nanoparticles have received likely attention due to their immense uses. For such purpose, the improvement of innovative and biological methods is in significant request for raising these materials in industrial field. This document describes a unique way for the biosynthesis of ZnO nanoparticles using abacillus subtilis. The morphology structure and stability of the synthesized ZnO nanoparticles were studied using XRD, FTIR, FE-SEM and TEM. The results showed that the synthesized nanoparticles are stable, hexagonal phase, spherical with extreme particles in size range within 7–19 nm in diameter and has antibacterial activity against MDR bacteria from different sources.Keywords: Eco friendly Synthesis.
Nano - Structured Hesperidin: Evaluation the Antioxidant Activities In Vitro Ghassan M. Sulaiman
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Hesperidin from citrus peels is known to have anti-inflammatory, vaso-protective, hypo-lipidemic, anti-allergic, anti-carcinogenic and antioxidant actions. Current study was designed to evaluate the antioxidant capacity of hesperidin and hesperidin nanoparticles by using simple in vitro free radical scavenging system including, DPPH free radical-scavenging, hydrogen peroxide scavenging and Resazurin dye scavenging activities. Hesperidin nanoparticles showed strong scavenging effects against DPPH, hydrogen peroxide and Resazurin dye, and this effect was more potent than pure hesperidin. The scavenging activity of hesperidin nanoparticles was concentrations dependent, in the range of 100-400 µg mL-1showing a maximum activity of 80% at 400 µg mL-1in similar way to Vit.C which was used as positive control. In conclusion, this work displayed that hesperidin exhibited antioxidant activity and could be considered as a source of antioxidants from nature.Keywords: Hesperidin nanoparticles, Antioxidants, Resazurin, DPPH, Hydroxyl.
ART in Indonesia: A Current Review of Ethics cinta ayu abutari
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Currently, Assisted Reproductive Technology (ART) programs such as intrauterine insemination (IUI) and in vitro fertilization (IVF) are developed in Indonesia. As a religious country, the implementation of ART programs raises a variety of ethical issues and religion reactions such as sperm or oocyte donor was haram, sperm from the deceased husband, a sinful masturbation, surrogate mother was Zina, gender selection by human, man assumption as God to decide which embryo be transferred and to create life. Some specific religious organizations provide statements regarding this matter based on scriptural studies and the opinions of their respective religious leaders. Confucianism allows sex selection, while other religions refuse. Hindu and Buddhist allow all ART program, while Catholic declare rejection to all ART program. Islam allows ART programs, without sperm and oocyte donor or surrogate mother. This difference in views is mediated by government regulations that support ART programs but are still limited by legal marital status. The state provides government rules on the implementation of the ART program in Indonesia, although every spouse is allowed to follow their beliefs. In conclusion, ART programs were allowed by most of the religions in Indonesia, as long as not involve the third party as the donor.
α-Glucosidase Inhibitory Activity of Ethanol Extract Obtained from Dillenia suffruticosa and Pycnarrhena cauliflora Dzul Fadly
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The objective of the study was to find out the inhibitory of α-glucosidase activity and the antioxidant properties of an ethanol extract derived from leaves and stems of Dillenia suffruticosa and Pycnarrhena cauliflora. Dried powder of them was macerated with 96% ethanol solvents. α- Glucosidase inhibitory property was significantly demonstrated by the leaves and stems of D. suffruticosa. Antioxidant activity was found high in D. suffruticosa leaves and stems. The results indicate that D. suffruticosa stem may potential being antioxidant and antidiabetic compounds.Keywords: Dillenia suffruticosa, Pycnarrhena cauliflora, diabetes mellitus, α-glucosidase, ethanol extract.
ANALYSIS OF UKRAINIAN PHARMACEUTICAL MARKET RETAIL SEGMENT DEVELOPMENT Natalia Bogdan
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The pharmaceutical market is an important part of the system of pharmaceutical provision of the country. In modern conditions, the pharmaceutical market performs many functions, among which the social function is one of the most important. The aim of our study was to analyze the dynamics of the development of the Ukrainian pharmaceutical market in the conditions of the socio-economic and financial crisis in the country. We conducted dynamics analysis of pharmacy sales development in retail sector of pharmaceutical market (2011-2017). We used historical, comparative, logical, graphical, and mathematical-statistical methods of scientific search. As a result of studies we have found that during 2011-2017 the retail segment of Ukrainian pharmaceutical market had zigzag-shaped development dynamics. We distinguished three main stages of its development. So, during the first stage (2011-2013), we observed positive growth dynamics of pharmacy sales expressed in hryvnia, U.S. dollar, and package pieces. What is more, increase of pharmacy sales' indicators, expressed in hryvnia and U.S. dollar, did not differ significantly. The second, the most difficult, period lasted for two years (2014-2015). This period was characterized with decrease of sales' volume, expressed in U.S. dollar and in natural indexes (package pieces). In 2015 the lowest indexes of pharmacy sales, expressed in U.S. dollar (22.75 million U.S. dollars), and in natural indexes (1507.1 million of package pieces), were observed. Increase (38.0%) of sales' volumes, expressed in hryvnia, which was observed in 2015, was due to devaluation of national currency. The third stage of market development started in 2016 and is continuing still. In the retail segment an increase in volume of pharmacy sales, expressed in hryvnia – by 22.0%, in U.S. dollar – by 4.0%, and in package pieces – by 6.0%, has been observed from2016. Inthe conditions of relative stabilization of U.S. dollar rate in 2017, growth of sales' volume in U.S. dollar was 17.0%, and in natural indexes – only 5.0%. Gradual slowdown of one sale weighted average cost growth, beginning in 2016, is an important positive characteristic of pharmacy sales market development. For example, in 2015 this index grew by 41.0%, in 2016 – by 16.0%, and in 2017 – only by 10.0%. Of special note is the fact of gradual increase of sales' volume per capita, expressed in U.S. dollar. For example, in 2015 this index was 36.04, in 2016 – 37.24, and in 2017 – 44.09 U.S. dollars.Retail segment of Ukrainian pharmaceutical market, in the conditions of political and social-economical crisis in the country, has shown the complex nature of its development. Devaluation of national currency in the conditions of high dependence of Ukrainian pharmaceutical market on import significantly influenced the dynamics of pharmacy sales. In these conditions Ukrainian consumers of pharmaceutical services should not be left alone with the problem of significant increase of prices of medical products. Implementation of systemic reforms in health protection, and development of consistent state policy of Ukrainian pharmaceutical market development and medicines' consumption regulation provide the real way out of this situation.
Optimal Capacitor Placement Using ICA and comparison with PSO Method; Case Study in KERMAN Mahdi Mozaffari Legha
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

Increasing application of capacitor banks on distribution networks is the direct impact of development of technology and the energy disasters that the world is encountering. Line loss reduction is one of the major benefits of capacitor, amongst many others, when incorporated in the power distribution system. The quantum of the line loss reduction should be exactly known to assess the effectiveness of the distributed generation. In this paper, a new method is proposed to find the optimal and simultaneous place and capacity of these resources to reduce losses, improve voltage profile too the total loss of a practical distribution system is calculated with and without capacitor placement and an index, quantifying the total line loss reduction is proposed. This results in saving substantial amount of energy. To reduce our objective function, we find optimized type of conductor by taking use of Imperialism Competitive Algorithm (ICA) method and comparison with PSO method. To demonstrate the validity of the proposed algorithm, computer simulations are carried out on actual power network of Kerman Province, Iran and the simulation results are presented and discussed.Keyword: Distribution systems, Loss reduction index, Capacitor placement, Imperialist Competitive Algorithm
Phytochemical Evaluation of Ethanolic Extract of Cassytha Filiformis (Linn) Through GC-MS Analysis P. Sudha Kesavarthini
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
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Abstract

Medicinal plants have had a crucial role in human culture and civilization. The present study was carried for the preliminary phytochemical analysis of the ethanolic extract of the plant Cassytha filiformis (Linn) belongs to the family Lauraceae. Bioactive constituents in the ethanolic extract of Cassytha filiformis (Linn) was analysed by GC-MS analysis. In GC-MS analysis, around one hundred and fifty eight compounds were present, in which many compounds where not reported for their biological properties. The presence of various bioactive compounds confirms the application of Cassytha filiformis (Linn) for various diseases by traditional use.Keywords: Cassytha filiformis (Linn); Lauraceae; GC-MS analysis.
Shock and Flexural Strength of Composite Materials Reinforced by Kevlar Fiber Mustafa A. Rajab
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Composite materials in this regard represent nothing but a giant step in the ever-constant endeavor of optimization in materials.  The research aims to study the mechanical properties (shock strength and Flexural strength) of composite materials (epoxy resins with phenolic formaldehyde resin) supported by graphite or silica particles or both, and reinforced with Kevlar fibers.
In Vitro Dissolution Enhancement of Curcumin by Melt Dispersion and Solvent Casting Technique Aided by Molecular Modelling Approach Anindya Jana; Subrata Kumar Biswal; Rudra Narayan Sahoo; Partha Niyogi; Subrata Mallick; Rajaram Mohapatra
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
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Abstract

Purpose: The oral bioavailability of curcumin is low due to its lipophilic nature. The drug also tends to degrade in alkaline pH. This inherent character of curcumin limits its stability and oral bioavailability. Use of polymeric carriers to alter the physicochemical nature of the drug is one of the favoured techniques of drug formulation. Aim of this study was to improve the in-vitro dissolution and solubility of curcumin by using hydrophilic carriers such as polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) of different grades and to check the effect of the different excipients used in the formulation of curcumin by solid dispersion technique. Methods: Solid dispersions of curcumin have been prepared by the solvent evaporation and melting method by using carriers in suitable ratios. In this experiment, ethanol was used as an organic solvent for solvent evaporation. The presence of different release rate modifiers such as croscacamellose sodium, kollidon CL and sodium and lauryl sulphate (SLS) in the SD formulation were also studied. In-silico approach has been applied to quantify the curcumin and carrier interaction. Results: The solubility of the solid dispersion prepared by the solvent evaporation and the melting method was found to be 13.5 and 78.9 fold to that of the pure curcumin respectively. Physical characterization by FTIR and DSC studies advocated that the physical state of crystalline drug has been modified in solid dispersions due to its dispersion in the polymer matrix. Conclusion: Dissolution studies revealed that all the formulations were having better drug release profile compared to the physical mixture. The lowering of binding energy in in-silico ducking study indicated towards possible molecular drug carrier interaction. Keywords: Curcumin, Solubility, Dissolution, Solid dispersion.

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