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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Parasitological and Immunological study of the Effect of Chitosan and Chitosan Nanoparticles Loaded with Spiramycin on Toxoplasmosis Hanaa Kamil Hamad
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was carried out to evaluate parasitological and   immunological of the effect of chitosan and chitosannanoparticles loaded with spiramycin on toxoplasmosis infected mice. After injection intra peritoneal with 103viable tachyzoites for acute infection, treatments given for seven days. Peritoneal fluid examination revealed a significant decrease in the number of Toxoplasmagondiitachyzoites in all treated infected mice compared with infected non-treated. The combined therapy gave better results than single. The best effect was observed in group of mice treated with spiramycin combined with chitosan nanoparticles. Also immunoglobulin Ig Manti body and gamma Interferon (INFγ), Tumor Necrosis Factor alpha (TNF-α) cytokines responses against T. gondii antigens were assessed by enzyme linked immunosorbent assays (ELISA) kits after treatment. In this study the findings indicated improvement of immune status after treatment.Keywords: Toxoplasma gondii, Nanochitosan, Spiramycin, Cytokines, ELISA.
The Correlation between Metacognitive Knowledge with Mathematics Anxiety in the First Grade High School Female Students Farhad Karimi
Journal of Global Pharma Technology .
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Abstract

The aim of this study was to investigate the relationship between control source and role-personality conflict the purpose of this study is to investigate the correlation between met cognitive knowledge and math anxiety. The population of the study consists of 1950 female students in the first grade of high school in Tehran 8th district. 323 female students were selected using cluster sampling. The instrument consisted of two standardized questionnaires designed by Swanson to assess problem-solving met cognitive knowledge and Math Anxiety Scale constructed by Chiu and Henry. Using factor analysis and Cranach’s alpha, both validity and reliability of the questionnaires were attained. Analyzing the data in the descriptive statistics area was conducted by frequency and percentage and in inferential statistics with the Pearson correlation showed that the relationship between met cognitive knowledge and problem solving with math anxiety is negatively significant at 99%confidence level (r=-0/454).The relationship between the components of met cognitive knowledge (person, task and strategy) with math anxiety is significantly negative. In other words, the more the learner informed and aware of the cognitive system, task, and strategy, the less he/she will feel math anxiety. The index of knowledge of strategies demonstrates the most significant negative relationship with students' math anxiety while the two other indexes, knowledge of self and task, are in the next levels respectively. The results generally indicate that more students are aware of problem-solving met cognitive knowledge, less they suffer from math anxiety.Keywords: Math Anxiety, Met cognitive knowledge, The first grade high school.
Synthesis, Structural Characterization, Thermal properties and Biological Activity of New Complexes Derived from Ligands with N, O Donor Atoms Nihad Kadhum Hasan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The study includes preparation and characterisation of  a new tridentate  Mannich -β-amino carbonyl ligand and its metal complexes are reported. The formation of  the ligand (R)-2-((4-(dimethylamino)phenyl) ((2-nitrophenyl)amino)methyl)-5,5-dimethylcyclohexane-1,3-dione (HL) was achieved from the reaction of 4-dimethylaminobenzaldehyde, 2-nitroaniline and dimedone in a 1:1:1 mole ratio, respectively.The reaction of the ligand with Co(II), Ni(II) and Cu(II) metal ions in a 2:1 (L:M) mole ratio resulted in the  isolation of monomeric complexes. The ligand and its metal complexes were characterised using a range of analytical and spectroscopic techniques including; elemental microanalysis, magnetic susceptibility, conductance, TGA, FT-IR, electronic spectra and 1H, 13C-NMR spectra. The  characterisation data indicated the isolation of six coordinate monomeric complexes with the general formula; [M(HL)2] (where M= Co(II), Ni(II) and Cu(II)). The ligand and its complexes were screened against several bacterial strains and fungi species. The obtained data indicated that the complexes are more active against several kind of organism, under survey, compared with the free ligand.Keywords:  Dimedone;  Mannich -β-amino carbonyl  ligand; Monomeric metal complexes; Thermal properties; Structural study.
Effect of Candesartan, Atenolol and Amlodipine on Oxidative Stress in Kerbala Patients with Hypertension Mohammed Talat Abbas
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Hypertension is a heterozygous disorder in which patients can be stable according to pathophysiological characteristics that have a direct effect on the effectiveness of specifically targeted antihypertensive drugs on detecting recoverable forms of hypertension and the risks of cardiovascular complications. This study was performed to compare the effect of anti-hypertension drug with etenolol, amlodipine and candesartan on oxidative stress in kerbala patients with primary hypertension. A total of 60 hypertensive patients (20 patients with etenolol, 20 patients on amlodipine and 20 candersarten) and 20 health components in the study. In conclusions Treatment with etenolol, amlodipine and candesartan reduces SBP, DBP, and MDA and improves the antioxidant system (SOD, CAT).Keywords: Hypertension, Etenolol, Amlodipine, candesartan, Oxidative stress.
Technical Factors Influencing to Instant Powder from Strawberry (Fragaria) Juice N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Strawberry (Fragaria), a rich source of phytochemicals (ellagic acid, anthocyanins, quercetin, and catechin) and vitamins (ascorbic acid and folic acid), has been highly ranked among dietary sources of polyphenols and antioxidant capacity. Bioactive compounds in strawberry revealed high abundance of anthocyanins, flavonols, flavanols, and cinnamic acid.  To increase strawberrys popularity and expand their use in the food industry, it’s neccesary to explore the appropriate postharvest handling and storage.The aim of this work was to study the feasibility of spray drying of strawberry juice juice. Various characteristics of spray-dried fruit juice powders are well affected by spray-drying conditions including inlet air temperature, out let air temperature, feed flow rate, drying carrier agent. Results revealed that inlet/ outlet spray drying temperature (155oC: 85oC), speed flow rate (12 ml/ min), γ‐cyclodextrin: maltodextrin (4: 6 % w/v) were appropriated for spray drying of dried strawberry powder from its juice. The spray-dried product of γ‐cyclodextrin-maltoxetrin-strawberry juice was considered to be the good technique to dry strawberry juice on the result of phytochemical determination, physical and chemical properties and antioxidant activity. Value addition of strawberry juice has been created by changing in the physical form of the agricultural produce which leads to its greater acceptability, extended availability, enhanced market viability and increased cost to benefit ratio for the grower of the strawberry produce.Keywords: Strawberry juice, Spray drying, Dried powder, Inlet air, Out let air, Speed flow rate, γ‐cyclodextrin, maltodextrin.
Post Reconstitution Stability of Co-Amoxiclav Injection for Multiple Usages in Developing Countries Mazlina M Said
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

OBJECTIVE: Co-amoxiclav injections are stored after reconstitution by healthcare givers for multiple usage contrary to manufacturer’s instructions in pediatric patients to reduce the cost of treatment in developing countries. The purpose of this study is to determine the percentage content of amoxicillin and clavulanic acid in co-amoxiclav injections at the point of administering of second dose after reconstitution.METHODS: Samples were reconstituted according to manufacturers’ instructions and stored in a refrigerator (2-5°C) and at tropical temperature (30°C and 75% RH). The samples were assayed immediately and then 8 hours after reconstitution. The assay was carried out using HPLC according to the USP monograph for amoxicillin-clavulanic acid suspension and the percentage content during the administration of the second dose was calculated in reference to a freshly prepared samples.RESULTS: The percentage content of amoxicillin and clavulanic acid in refrigerated samples was <70% and <35% of the freshly prepared samples respectively, While at simulated tropical room temperature, it was <45% and <15% of the freshly prepared samples respectively.CONCLUSION: The study showed that storage of reconstituted co-amoxiclav injection will lead to administering of lower dose at the point of admistration of the second dose; this will lead to treatment and antibiotic resistance.
New Azo-Thiadiazole Ligands (Preparation, Spectral, Thermal, Biochemical, Physical properties) - Studying Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Azo-Thiadiazole  dyes  were  prepared  as  a new  ligands  from  aminothiazole  compound. The  reaction  started  with  coupling  step  of  hydroxyl  benzoic  acid , then  cyclization  step  of  thiosemicabazide  to  produce  thiadiazole  derivative ,  flowed  by  reaction  with   dicarbonyl compounds  to  yield   azo- thiadiazol  ligands. Our new  azo ligands  investigation  by many  chemical  techniques  represented   by  ( I.R,  H.NMR, Mass )- spectra  and  studied   their   behavior  (Thermal , Biochemical  )  with  Physical  properties .  Keywords: Thiazole, Thiadiazol , Cyclization , Esterification , Azo , Sulphobenzoic  acid.
Fundamental Aspects of Superdisintegrants: A Concise Review. Training According to Kinetic Energy Index and its Impact on Flow and Motor Transport for the Moment of Elevate and Achievement of Long Jump for Youth Hashem Ali Hassan
Journal of Global Pharma Technology .
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Abstract

The world has witnessed a dramatic development in the different areas of life nowadays, and this development has been caused by the application of the scientific and modern technological foundations in the sporting field, and despite this development, further research and studies are to be conducted to reveal the best methods and methods for the development of events Sports. Thus, the importance of research is illustrated by the development of the most important scientific solutions through the kinetic Energy index training and its impact on cruise and motor transport at the moment of advancement to achieve the best achievement.  The researchers noted that the preparation of the kinetic energy index exercises did not take place in the application area during the training programs because it has a significant impact on speed development and the kinetic energy index works by determining the intensity of the training according to the mass and speed of the jumper, and that this requires new solutions to help develop Achievement during the technical performance. Therefore, the researchers have developed a motor energy marker exercise and will take into consideration in its flowchart and motor transport at the moment of upgrading for achievement.The Research ObjectivesPreparation of motor energy index drills for young long-jump players.To identify the impact of the exercises with the kinetic energy index in the cruise and motor transport at the moment of upgrading and the long jump to the youth. The Research HypothesisThere is a positive impact of the exercises according to the kinetic energy index in the cruise and motor transport at the moment of upgrading and the long jump to the youth.As for the second chapter, the researchers referred to the training with the kinetic energy Index and its impact on the flow and motor transport at the moment of advancement and the achievement of the long jump of young people, as well as the previous studies that were relevant to the subject matter of the research. The researchers used the training curriculum with the design of the two equal groups (Control and Experimental), which were designed to fit the nature of the research, where the research community, the players of the governorate of Al- Qadisiyah, identified the youth group for the effective long jump of the sports season (2017 – 2018), which number (15) And they are scattered over seven clubs that will officially participate in the championships of the central athletics Federation, selected in the random manner and in the (10) of the shares, which accounted for (66.7%). From the research community, they were evenly distributed to two female officers and experimental groups, and the remaining (5) were selected as a sample of the pilot study. The most important findings were mentioned in conclusions, which showed the moral differences between the pretest and combined tests of the two groups.The Conclusions are followingThere is a positive impact in the use of motor energy marker training in the technical performance and delivery of long jump effectiveness.Kinetic energy Marker training is instrumental in improving the linkage between proximity and elevation to long-term jump.The use of the kinetic energy index in training during training modules leads to the evolution of motor flow of the final step of proximity and preparation for the advancement of Long jump.Keywords: Training, kinetic energy, motor transport, elevate and achievement and long jump.
Effect of Special Exercises for the Development of Some Biochemical Variables and the Level of Performance of Diagonal Spike Skill in the Volleyball Hamida Obaid Abdulamir
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Volleyball is one of the sports activities that need to apply the modern scientific methods through the development of the sport training science, which aims to improve the player's physical and functional abilities through careful planning of training courses for the development of its efficiency in the performance of all requirements for volleyball, The importance of research in the study of some chemical components of blood and the changes obtained by the training using special exercises because of its importance in developing the skill of beating overwhelming in the players the researchers used the experimental method to suit the nature of the problem on the players of the Kufa youth sports club for the season of 2018 (12) players, and was adopted a cohesive method of selection in the selection of the sample, the tests used in the research biochemical tests: measuring variables (cholesterol, sugar, And the test of the skill of beating the overwhelming country, after which the researchers carried out the tribal test, and then the exercise and then the post-test The researchers concluded that the exercises used, which were specialized exercises of the type of skill and complex exercises and exercises. The researchers recommended to emphasize the importance of speed of performance and stress on exercise. Specialization in the skill type especially in the volleyball game, the interest in training the ability to develop the strength of the chemical variables and the level of skill performance of volleyball players, and benefit from the measurement of the activity of enzymes and the proportion of sugar and cholesterol contribute to the processes energy and muscular construction in the training of volleyball players at all levels, and conducting similar research in the use of explosive force training exercises to develop muscle strength in the non-oxygen system and identify the biochemical variables of volleyball players.Keywords: Special exercises, Biochemical variables, Spike, Volleyball.
The Role of Growth-Associated Protein-43 (GAP-43) and Superior Cervical Ganglion-10 (SCG-10) mRNA and Protein Levels in Dorsal Root Ganglion Neurons of Lumbar Spinal Cord Segments (L4-L5) Associated with Sciatic Injured Nerve Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

The analysis focuses on the role of growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein levels not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with sciatic injured nerve. The objective of the research study is to unearth the role of growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein level not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with sciatic injured nerve. The sources were past scientific papers that were published and obtained from google scholar and other sites with open source access. The research review is an original work. The analysis will be centered on a review article that focused on analysis on advantages and disadvantages GAP 43 as neuroregeneration marker examination in rat sciatic nerve injury. The study eligibility criteria was articles that are not older than fifteen years, are written in English and are published. Key words: Sciatic nerve injury, GAP-43, SCG-10 and DRG neurons of L4-L5.

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