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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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DFT Study of Alkyl-Substituted Morphine Molecules Vahid Moeini
Journal of Global Pharma Technology Volume 08 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

In this paper, (5α,6α)-7,8-didehydro- 4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) as well as alkyl-substituted morphines are studied using density functional theory (DFT) at B3LYP/6-311++g(2d,p) level. The calculated Hartree-Fock (H-F) energies ranged as -1018.0049 to -939.3950 kJ mol-1. Among the three studied molecules, C16H16NO3-CH2CH2CH3 system represents the minimum vibrational frequency, H-F energy as well as the minimum highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) energy gap with 49.939×1010 Hz, -1018.0049 kJ mol-1 and 0.11257, respectively. Keywords: DFT, Hartree-Fock, Morphine, HOMO-LUMO.
Effects of Thiopurine Methyltransferase (TPMT) Polymorphism on Red Blood Cells and Plasma Concentration of 6-Mercaptopurine: Clinical Study Mohammed Khudair Hasan
Journal of Global Pharma Technology .
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Abstract

Objective: This study was  aimed to find out the proper dosing strategy for patients with ALL treated with 6-mercaptopurine with possible genotype polymorphisms and the relationship between genotype and toxicity.  Material and Methods:  Sixty ALL patients and sixty healthy subjects were enrolled. The subjects involved two groups; group A Includes 60 patients with acute lymphoblastic leukemia on maintenance (continuation) phase (2:1 Male: Female ratio); group B Includes 60 healthy subjects' adults and children without any medical illnesses (2:1 Male: Female ratio). DNA was isolated from whole blood and genetic polymorphism in thiopurine S-methyltransferase (TPMT) coding genes were detected by polymorphism chain reaction-restriction fragment length (PCR-RFLP) assay. Complete blood count, liver function tests, renal function tests and blood sugar concentration obtained at the same day of blood sampling for patient and control subjects were done. Results: TPMT polymorphisms were seen in 14 (23.33%) of the total study population. The number of patients with TPMT*2 was 8 (13.33%), whereas, patients with TPMT*3B was 6 (10.00%). As a comparison between patients with TPMT polymorphism to patients without TPMT polymorphism, Hepatotoxicity and nephrotoxicity increased significantly in patients with TPMT polymorphism. Random blood sugar was significantly higher in patients with TPMT polymorphism (p = 0.02894). Bone marrow suppression was significantly higher in patients with TPMT polymorphism. 6-TGNs concentrations were increased significantly in the patients with TPMT polymorphisms using 6-MP (p = 0.00667). A significant positive relationship was founded between 6- TGNs RBC concentration and serum creatinine concentration (r= 0.9340), serum concentration of ALT, AST, ALP plasma concentration and TSB (r= 0.7428, 0.6250 0.6509 and 0.435) Conclusions: In this study, we report a presence of the TPMT2 and TPMT 3B polymorphism in Iraqis population. Therefore, TPMT variants monitoring is important to avoid the development adverse effects in patients treated with thiopurine drugs.Keywords: TPMT gene, 6- Mercaptopurine, Thiopurine drugs, Polymorphisms, Acute lymphoblastic leukaemia.
Extracellular Biosynthesis of TiO2 Nanoparticles Using Supernatant Culture of Lactobacillus crispatus Kawther H. Ibrahem
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this study, titanium dioxide nanoparticles were synthesized biologically using isolated L.crispatus from vagina of healthy women. The formation of TiO2 nanoparticles was characterized by atomic force microscope (AFM) using supernatant culture of L.crispatus .Extracellular biosynthesized TiO2 nanoparticles occurred with the average size (87.88) nm. For further characterization, the x-ray diffraction (XRD), energy dispersive x –ray spectroscopy (EDX), and scanning electron microscope (SEM) were used. XRD Confirmed the formation of crystallographic plane of anatase of TiO2 nanoparticles indicating that nanoparticles corresponded to anatase crystalline, while the EDX analysis of TiO2 nanoparticles indicated that the synthesized nanoparticles were anatase form and not frutile or brookite form. The SEM images of the synthesized TiO2 nanoparticles were showed spherical or oval in shape. The effect of independent variables, including different incubation times and storage condition on the biosynthesis of TiO2 nanoparticles was investigated. The average size (70.98)nm of TiO2 nanoparticle was observed after 72 h .The stability of the synthesized TiO2 nanoparticles for (1,2,3)months under cooling condition was studied and the result revealed that the synthesized TiO2 nanoparticle remained stable without change in color even after storage for three months under cooling conditions.Keywords: TiO2 nanoparticles; Biosynthesis; Lactobacillus Crispatus; Incubation time; Storage time.
Development of the Potential of Extrak Lidah Mertua (Sansevieria sp) and Lemongrass (Cymbopogon Nardus) in Lowering the Number of Air Germs of Space through Humidifier Modification AT Diana Nerawati
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

According to Regulation of the Minister of Health No.1077 of 2011, indoor air pollution especially houses are very dangerous to human health, because in general people spend more time doing activities indoors so that the house becomes very important as a micro environment related to the risk of air pollution. Efforts to deal with indoor air pollution caused by germs need to be carried out, especially indoor air pollution the danger level is greater than outdoors. The goal is to test the decrease in germ rate in the air of the room with humidifier modification using sansevieria and lemongrass extrak. The experimental design used in the study is One Group Pretest Posttest Design. As a humidifier modification material to lower the Air Germ Number of the Room. The achievement of this goal was done using pre-experiments with the form of One Group Pre- Post Test Design. The free variables are Sansevieria extraks with concentrations of 30%, 40% and 50% and the bound variables are germ numbers. Analysis of the data used in the form of a paired t test and Anova test. The results showed that the average extrak air germs of Sansevieria and Lemongrass concentrations were 30% before treatment of 15.6 CFU/dm3 and after treatment of 3.4 CFU/dm3, while the concentration of 40% of space air germs before treatment is 19.8 CFU/dm3 and after treatment 5.6 CFU/dm3 and the concentration of 50% of space air germs before treatment is 17.2 CFU/dm3 and after treatment is 6 CFU/dm3. The result of the paired t test showed that p < 0,05, means there is a significant difference in the decrease in the number of germs before and after treatment at all conditions. Extrak Sansevieria and Lemongrass are able to lower the number of air germs of space. at extrak concentrations Sansevieria 30% and lemongrass 0.1 % the average decrease in the germ rate is 78.2%, while for concentrations 40% the average decrease in germ rate is 74.24% and the average 50% concentration decrease in the germ rate is 65.11%. Anova test results obtained that tongue in-laws extract (Sansiviera,sp) concentrations of 30% 40% and 50%, have a p value of > 0.05, which means there is no meaningful or insignificant difference.The results of this study are extrak Sansevieria sp and Cymbopogon Nardus as humidifier fluid modification at concentrations of 30%, 40% and 50% have the same effectiveness in lowering indoor air germs. Recommendations for development and trials modify sansievera and lemongrass extrak solutions with other oceans that can also absorb air pollution. Keywords: Germ numbers, Humidifier, Extrak sansieveira and cymbopogon nardus, air spaces.
Religiosity and its Impact on the Family Life Framework According to Imam Reza (Peace Be Upon Him) Ayatollah Zarmohammadi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Those who are familiar with religion and its evolutionary teachings endorse its extraordinary effect on individual and social life of human being; although there is difference of opinion regarding the scope of this influence. Some believe in the maximal role of religion and some believe in its minimal role, but what has been accepted by both groups is the very involvement of the religion in all human affairs. The current essay deal with human expectation of religion and at the same time discusses the influence of religiosity on the family life according to Imam Reza (peace is upon him). Moreover, it also debates the necessity of formation of family and its functions in the production and preservation of generation, providing peace, sense of integration and purity of generation and also such factors strengthening family foundation as generosity, good manner, adornment, and satisfaction of sexual instinct.Keywords: Life Framework, Religiosity.
The Effect of Organizational Cynicism and Injustice on Counter Productive Behaviors of Staff Considering Demographic Factors Rahim Rouzbahani
Journal of Global Pharma Technology .
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Abstract

In recent years, scientists have sought to show a decreasing trend in civil and citizenship behaviors; whereas, unfair and counterproductive interactions and behaviors are increasing. Counterproductive behaviors of a collection include a various range of behaviors such as rudeness, being carefree, robbery and aggressive behaviors towards colleagues and other clients. Meanwhile, counterproductive behaviors are increasingly rising in staff's organizational life. The present research aims to study the effect of organizational cynicism and injustice on counterproductive behaviors of staff in a public hospital considering demographic factors. This is an applied research in terms of objective and a descriptive-survey in terms of nature. Lisrel software and path analysis model were used to test the research hypotheses and to obtain results. According to the hypotheses testing results, the increase of employees' organizational cynicism increases their counterproductive behaviors in a public hospital; the increase of organizational injustice increases employee's counterproductive behaviors; as well as, the increase of organizational injustice increases staff's organizational cynicism in a public hospital.Keywords: Organizational cynicism, Organizational injustice, Counterproductive behaviors, Hospital.
Synthesis and Characterization of New Imines-Imides Functionalized Compounds Derived from Trimethoprim moiety Supplemented with Aminothiazole Mohammad F. Mesher Al-Dulaymmi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Imides, Imines, five- and six- membered heterocyclic rings are among the compounds that have attracted a considerable attention of work due to their versatile biological activities. Therefore including these functional in the same compound perhaps enhancing the whole activity of the synthesized compounds. Trimethoprim moiety which is antibacterial drug possessing a pyrimidine ring and diamine groups, was selected as a starting material for this purpose. Mono imides (B1-B5) were prepared by treatment of the corresponding amic acids (A1-A5) (obtained by the reaction of equimolar amount of selected anhydrides and trimethoprim), with a suitable dehydrating agents. The remaining amino group was converted to the aminothiazole via the ring closure of the corresponding acetyl chloride amides (C1-C5) with thiourea in refluxing DMF. The target new imines (D1-D5) were synthesized by reaction of certain aldehydes and ketones with the new thiazoleamines. The structures of all the synthesized compounds were elucidated by considering the data of the FTIR, 1H-NMR, and other physical properties.Keywords: Trimethoprim, Imines, Imides, Cyclic anhydrides.
GC/MS Analysis of Terpenes of Boswellia Serrata Resin Found in Iraq Noor S Jaafar
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Objective: The aim of this work was to detect terpenes other than boswellic acid derivatives in olibanum of Boswellia Serrata found in Iraq. Methods: The olibanum of Boswellia Serrata was macerated in methanol for one day, then filtration.  Filter at was concentrated till reddish brown syrupy residue was gained, (3%) potassium hydroxide was added till basification. This basic solution was stirred continuously until a uniform emulsion was formed, then extracted with chloroform in a separatory funnel; the chloroform fraction was analyzed by GC /MS spectrometry. Results: GC /MS analysis reveal the presence of terpenes and non-terpenes constituents.  Conclusion: Most of the detected terpenes were sesquiterpenes and the least one was di-terpenes.Keywords: Boswellia Serrata, Olibanm, Terpenes, Gas Chromatography- Mass Spectrometry.
Influence of Staphylococcus Aureus on the Oral Candida Albicans Mouna Akeel Hamed Al-Oebady
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Candida albicans is that the most current isolated from the human body and it consider as a natural part of the commensal microorganisms. The mouth is colonized by many of bacterial species, and it also the relationship between these oral bacteria and C. albicans has been a subject of interest in understanding the event of candidiasis. Many studies have tried to explain the bacteria-fungal relationship within the oral environment; however, few have targeted on the single bacterial species inhibiting growth of C. albicans. Staphylococcus aureus and Candida albicans were isolated and purified from the samples of 50 patients with the fixed orthodontic appliances and PCR was performed to identify this isolated. The microscopic examination and qPCR were carried out to determine the inhibitory impact of S. aureus on C. albicans. This study demonstrated Staphylococcus aureus displayed the strongest inhibitory effect on the growth of Candida albicans. By qPCR assay, all isolated C. albicans were inhibited on the growth by S. aureus in the various periods. Mixed culture experiments also demonstrated inhibitory of C. albicans by S. aureus.Keywords: PCR, Staphyloccous, Candida, Oral cavity.
The Investigation of the Stability of the Granules Based on Arginine and Tincture of Ginseng Katerina Romas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The article presents the stability studies of the granules based on arginine and tincture of ginseng with neuroprotective (nootropic) action for the treatment of various disorders of the functional activity of the brain. For determining stability and shelf life of the developed medicine, several series of granules were stored at a temperature 15-25 °C in a dark, light protected place. Based on the research, it can be concluded that within 24 months from the date of manufacture, granules remain stable in all respects that have been studied.

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