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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Prevalence and Some Associated Factors of Stunting Among Under-Five Children in Hilla City-Babylon Province, Iraq Alwan Baiee
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

Stunting among children  under five years of age  is a serious  health problem especially in middle and low income countries including Iraq, it is associated with high morbidity and mortality among infants and young children the objective of this study was to identify the prevalence and  some correlates of  stunting  among children under 5 years of age.A cross-sectional descriptive study was conducted, to collect primary information from  mothers  of 1000 children attending  ten randomly selected primary health care centers(five rural and five from city center) in Babylon province- AL-Hilla city during the period from  Octobar,2015 through June 2016 a pre tested questionnaire, anthropometric measurements ( length/height for age) were used  to assess children's stunting  according to -2SD length/ height for age of the World Health Organization Standard Median .The results revealed that the prevalence rate of stunting among 1000 under five children included in this study were 20.6%. Significant statistical associations were found between stunting and the following independent variables; age groups: more in the age group 24>60 months, gender: highly prevalent in boys, maternal education: highly distributed in children with poorly educated mothers, breast feeding: peaked among mixed breast feeders and among children of low family income p<0.05. In conclusion Stunting ( chronic malnutrition) in the study area is still a  concern that needs intervention by governmental and non-governmental organizations, improvements in child feeding, and better maternal education are needed to maintain the children's nutritional status to prevent and control this serious health problem .Keywords: Under weight, Stunting, Children. Under-fives, Babylon, Iraq.
Evaluating the Reality of University Sports from the Point of Players View in Iraqi Universities Hassanine Juma Assery
Journal of Global Pharma Technology .
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Abstract

The current study objectives at following:To identify the reality of sports university from the perspective of players of Iraqi universities.Evaluation of the reality of university sports from the perspective of players of Iraqi universities.The researchers used the descriptive method in the survey method. The research community identified the 156 Iraqi players in the Iraqi universities and then selected a sample of 70 randomly selected players. The researchers then selected and applied the measure of the reality of university sports on the research sample. Results and the use of appropriate statistical treatments to reach the results after the results were presented analyzed and discussed the researchers reached the most important conclusions of the following:Ability of the measure of the reality of Sports University, which researchers applied in measuring the reality of university sports in Iraqi universities.The reality of university sports in Iraqi universities is at the acceptable level.There is weakness in the reality of university sports in Iraqi universities.Keywords: Evaluating, University sports and Iraqi Universities.
Protective Role of Propolis against Iron Overload Induced Genotoxicity and Oxidant/Antioxidant Status Mjida A.J. Al-Qayim
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The current study designed to investigate the protecting role of propolis in DNA damage  and oxidaant / antioxidant imbalance caused by  iron overload. 24 adult male wister rats divided in to 3 equal groups and handled as following: 1st group(C) as control, 2nd group, IO) group IP iron dextran 100mg/ kg BW each 72 hr. 3rd (IOP) given IP iron dextran 100mg/ kg BW each72 hr. and orally Propolis crude extract (50 mg /kg body weight) daily for two months. Results revealed that administered rats with propolis showed enhancement in oxidant/anti-oxidant indicators, categorized by raise of GSH, and MDA reduction on the contrast with IO group. Propolis adiminstration to IO  rats  decreased the  DNA damage and fragmentation. Conclusion, the present results are established for the first time a new role for the Propolis, in counter and reduce the iron overload harmful effects on DNA mainly via modulation of oxidant status in IO.
Why Focusing on Traditional Medicine is too important- Interesting Facts with Evidence Gopalasatheeskumar K; Kalaichelvan VK
Journal of Global Pharma Technology Volume 13 Issue 03 (2021) March 2021
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Abstract

In 2000 BC people ate the part of plants to the treatment of disease, 1850 AD drunk the portion (traditional medicine) of the plants. And after 1940 AD they start swallow the synthetic drugs for treatment because scientists discover the exact mechanism of drug action. However now days (2000 AD) people again start eat the herbal for the treatment diseases. So that this review is focused on the reasons for why people again going back to herbal medicine. From leading data bases such as Science Direct, PubMed and Google scholar, this review collected the literatures. The herbal and herbal drugs are having phytochemicals such as alkaloids, flavonoids, terpenoids, steroids, glycosides, saponins, triterpenoids etc., for their therapeutic activity. And also some of the herbal medicines are produce good therapeutic action than synthetic drugs as well as produce safer treatment for example Silymarin for hepatoprotective, Vinca alkaloid for cancer, Digoxin glycosides for cardio protective, Curcumin polyphenol for anti inflammatory, Quercetin flavonoid for antioxidant and Nilavembu for viral fever. The 2000 AD people may didn’t know the exact mechanism of herbal treatment but 2000 BC peoples started the research on herbal medicine and findout exact mechanism of herbal medicine. And also they are isolated the active principles from the traditional herbal medicine and developed the formulation and sale into the market. In future herbal medicine will play the important role in treatment of diseases. Keywords: Herbal medicine; Indian medicine; Folk medicine; Phytoconstituents.
Correlation of Depressive Disorder among Patients with Diabetes Mellitus Type 2 and its Complications in Al- Nasiriya City/Iraq Hussain Hlial Wdaa Al-Sayyad
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Background: Diabetes mellitus and depression are so prevalent diseases, when diabetes comorbid depression, it results in insufficient control of blood sugar with severe complications that increase prevalence and severity of depression. Aims of study: To reveal the prevalence of depression among patients with type two diabetes and to Identify the association of depression with complications of diabetes in comparison with non-depressed patients.   Patients and methods: Cross sectional random sample of diabetic patients in AL-Nasiriya diabetic center and AL-Hussein hospital and private clinic at duration of months from May 2017 to April 2018 were exposed for (Zung self-rating depression scale) with supervision of specialist psychiatrist and physician, physical examination and investigations were achieved by senior physician. Results: (51) patients of sample were males (42) patients were female (37.1%) were single, (37.6%) were illetrant and non-employed. most common complications were (ischemic heart disease (39%) cerebral vascular accident (42%), diabetic foot were (25.8). They were treated in different hypoglycemic drug (oral hypoglycemic, insulin and both). Ethic: All patients were given oral consent, their relative also agree to achieve the screening test, physical examination. Conclusion: Diabetes type 2 and its complications were positively correlated to depression with moderate of high severity in comparison with normal patients.Keywords: DT2, Depression, Complication Nasiriya center of diabetes, Iraq, Zung-self ratting scale.
A REVIEW ON THE APPLICATION OF NANOTECHNOLOGY IN THE TREATMENT OF HYPERTENSION Vamshi Krishna Tippavajhala
Journal of Global Pharma Technology Volume 9 Issue 07
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Abstract

Hypertension or elevated blood pressure is a common chronic disease. It is associated with severe symptoms like aneurysms, chronic kidney disease, amnesia, improper speech, blindness, peripheral artery disease, brain stroke, heart attack etc. Pathophysiology for hypertension involves the role of autonomous nervous system, cardiac output and renin-angiotensin aldosterone system. This review article mainly deals with the application of nanotechnology and nanoparticulate drug delivery systems in the formulation of various antihypertensive drugs for the treatment of hypertension. Applications of various nanoparticulate drug delivery systems like solid lipid nanoparticles, polymeric nanoparticles, nanosuspensions and self-nanoemulsifying drug delivery systems for antihypertensive drugs have been reviewed and discussed in this article which indicate that the bioavailability of various poorly soluble and permeable antihypertensive drugs can be improved using these nano carriers.
Effect of Mineral Acids (H3PO4) on Rooting Response of Aging Mung Bean (Phaseolus aureus Roxb.) Cuttings via Indole Acetic Acid Level Ahmed Habeeb Al-Mamoori
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Phosphoric acid (H3PO4) effect on the rooting that is response of aging mung bean cuttings as a weak mineral acid calculated on level of Indole-3-Acetic Acid (IAA). significant increase in rooting response of aged cuttings is  shown in the data (for 3days in d/H2O) with (0.01, 0.001, 0.0001%,) of H3PO4 concentrations solution and with (% 0.01 and 0.001%) concentration show extremely significant  increase in rooting response of aged cuttings (for 3days in solution of H3PO4 ), while extremely significant decrease in rooting response compared to control (d/H2O) with  extremely concentration (0.5%) . a extremely significant increase of IAA content in hypocotyls of aged cuttings in optimum concentration of H3PO4verified by Quantitative estimation of IAA by spectrophotometric method as indicators for oxidative processes that occurrence during aging phenomenon.Keywords: Aging, IAA biosynthesis, Rooting response, Mineral acids, Macronutrients, Stem cuttings, Mung bean.
Low Glutathione Peroxidase Plasma Levels Related to the Severity Degree of Vitiligo I Gusti Ayu Agung Praharsini
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Introduction: Vitiligo is a pigmentation disorder caused by damage to melanocytes which causes loss of pigment production on the skin and mucosal surfaces. The etiology of vitiligo is still unknown, but there are several theories regarding the occurrence of damage and death of melanocytes in vitiligo. One is a widely known theory is the theory of oxidative stress. The body has a defence mechanism against free radicals through the formation of antioxidants, one of which is glutathione peroxidase (GPx). Increased free radicals will result in decreased levels of glutathione peroxidase. This study aims to prove the correlation between plasma glutathione peroxidase and an increase in the severity of vitiligo. Method: The study design using an analytical study with a cross-sectional approach in vitiligo patients at Sanglah Hospital Denpasar. Sampling were done with consecutive sampling technique involving 40 vitiligo patients and 20 non-vitiligo controls that met the inclusion and exclusion criteria. Venous blood sampling was performed to measure GPx plasma levels and physical examination to measure the severity of vitiligo based on VASI scores. The collected data were analysed using SPSS version 23.0 with normality test, unpaired T test, correlation test and chi-square to get the prevalence ratio (PR).Result: The results showed a lower level of GPx plasma in vitiligo patients (72.3 ± 82.5 ng/mL) compared to non-vitiligo (160.63 ± 124.33 ng/mL) subjects (p<0.05), low GPx levels were a risk factor for vitiligo with a prevalence ratio (PR 1.57; CI 95% = 1.89-2.776; p<0.05) and plasma GPx levels have a strong negative correlation with the degree of vitiligo severity based on vitiligo area severity index (VASI) scores in vitiligo subjects (r=-0.60; p <0.05) Conclusions in this study there is a negative correlation between plasma GPx levels with vitiligo severity and low GPx levels are risk factors for vitiligo.Keywords: Glutathione peroxidase, Vitiligo, Vasi score.
Synthesis, Structural Study and Biological Activity Evaluation of Cr (III), Mn (II), Zn (II), Cd (II) and Hg (II) Complexes with New Schiff Base Ligand Derived from Isatin Wurood Ali Jaafar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The New Schiff base [3E-3-((1,5-dimethyl-3-((4-nitrophenyl)imino)-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)indolin-2-one][L] was prepared by two steps, 4-aminoantipyrine was reacted with isatin in the first step to produce the precursor [A], then [A] was reacted with p-nitroaniline to give a new tridentate ligand [L]. this ligand[L] was reacted with some metal ions in Cr (III), Mn(II), Zn(II), Cd(II) and Hg(II)to give a series of new metal compexes of the general molecular formula [M(L)2]Cln , where: M=Cr(III), n=3; M=Mn(II),Zn(II),Cd(II) and Hg(II), n=2. All compounds were have been characterized by spectroscopic methods [ IR, UV-Vis, atomic absorption],elemental microanalysis, chloride content, magnetic susceptibility, conductivity measurements along with 1H,13C-NMR and mass spectroscopy for ligand [L] only. According to the results of the above techniques, the suggested geometrical structures for all prepared complexes were octahedral formula.Keywords: Schiff base, Isatin, 4- amino antipyrine.
Biofilm Formation in Imipenem-Resistant Acinetobacter baumannii from the Intensive Care Unit Mohammed F. Al- Marjani
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Acinetobacter baumannii is emerging as an important hospital pathogen, which can persist in the environment for extended periods of time. It is known to produce biofilms, a community of bacteria enclosed within a protective polymeric matrix. One hundred A. baumannii isolates were collected from patients from the intensive care unit (ICU). Antimicrobial susceptibility test was performed by disk diffusion method and MICs of imipenem were determined. Biofilm formation was assayed by micro titer plate and then PCR was performed for detection of ompA and bap genes. The results show that the imipenem-resistance was seen in 80% of A. baumannii isolates, and all these isolates were inferred to be (MBLs) producers. Among these isolates, 91.25% formed biofilms, 32.5% of isolates were categorized as moderately biofilm-producing isolates, 11.25% formed strong biofilms, and 8.75% of the isolates were non-biofilm producers. All isolates simultaneously carried the ompA gnes, whereas 70% of isolates harbored bap gene. Our results revealed a high prevalence of Metallo Beta-Lactamase and biofilm formation in Imipenem -resistant A. baumannii isolates from ICU.Keywords: Acinetobacter  baumannii, Imipenem -resistance, Biofilm, Iraq.

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