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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 156   157   158   159   160 
Optimization of the Simultaneous Determination of Sitagliptin and Metformin, in Human Plasma by A Rapid HPLC Method Balamurugan K; Kirtimaya Mishra; Suresh R
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Simple, rapid and reproducible methods were established for quantitative determination of Sitagliptin (SIT) and Metformin (MET) spiked with plasma using an Onyx C18 Monolithic column  connected with an Onyx C18 guard cartridge.  and PDA detection at 210 nm. The mobile phase was MeOH, ACN, 0.01mM KH2PO4 (pH 3.5±0.5), adjusted with freshly prepared 10% orthophosphoric acid.  was pumped at 0.492 mL/min. The method was linear between 0.5-2.5 µg/mL, statistically validated for its linearity, precision and accuracy. The precision was found to be less than 1% showing high precision of the assay method. It was found that the excipients in the commercial tablet did not interfere with the method. Developed method can routinely use for the estimation of SIT and MET related compounds from the dosage form spiked with plasma.
The Association Between the Severity of Diabetic Peripheral Neuropathy and Diabetic Risk Factors in Diabetic Patients Type I and II. Sarah Ali Alkindy
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Back ground: The diabetic risk factors can effect on the severity of diabetic peripheral neuropathy (DPN). The most risk factors have an effect on the peripheral nervous system are duration of diabetic disease, glycocelated hemoglobin (HbA1C) and type of diabetes (DM type). Objectives: To determine the association between severity of DPN and duration of diabetes, HbA1C, the type of diabetes, age and sex of diabetic type I and II patients. Patients and Methods: Three hundred individuals were participated in cross sectional study. They divided to two groups labeled as A and B. Group A regarded as diabetic patients with abnormal neurological examination. Group B regarded as diabetic patients with normal neurological examination. About 68 male and 82 female were participated in this study for each group.  The age of participant are grouped as <18, 18-30 and 31-60 year. The full history was taking from participants including socio demographic data and duration of disease with type of diabetes. All participants with type I and II underwent clinical assessment and biochemical investigation. The clinical assessment used Toronto clinical scoring system (TCSS) for screening diabetic peripheral neuropathy (DPN). The biochemical investigation was done for determining the level of HbA1C. The study was carried out at Marjan teaching hospital and Al Sadeq teaching hospital in Babylon province during the period from Aug.2017 to Sep.2018.Results:TCSS used for scoring the DPN to mild, moderate and severe. The severity of DPN show significant association with duration of DM disease,  type of diabetes , the level of HbA1C and age of diabetic patients, the P value about o.oo1, 0.02 , 0.001 and 0.001respectively. The sex of  diabetic patients showed no significant association with severity of DPN, the P value 0.45.Conclusions: There is higly association between severity of DPN and DM duration, HbA1C , type of DM and age of diabetic patients. There is no association between sex of diabetic patients and severity of DPN.
Evaluation of the Efficiency of the Isolated Fungi from Some Insect Species on White Fly Larvae: Bemisia Tabaci (Hemiptera: Aleyrodidae) H.D. Abdal-Jabar
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The study was carried out inorder to isolation and identification of fungi associated with Formicidae pp, Pyrrhocois apterus and Coccenilla septempunctata L. and evaluate of the pathogenic ability of fungi isolated from adult bodies. Isolated fungi represented by Penicillium compactum, Penicillium janczwskii, Aspergillus terreus, Alternar of black adult ants, while the fungi were isolated penicillium chrysogenum, Beauveria bassiana, Aspergillus parasticus, Aspergillus campestris. From firebug insect, the fungi were isolated Alternaria chlamydospora, Aspergllus niger, Penicillium compactum, Ulocladium atrum of beetle insect. The results showed that the highest incidence was for fungi. Aspergllus niger and Penicillium janczwskii with equal percentage % 24.6, while the lowest incidence was for the two Aspergillus terreus Ulocladium atrum 1.5, 3.07 Respectively. The results indicated the superiority of the fungus Alternaria chlamydospora Aspergillus terreus to the rest of fungi in attracting adults Bemisia tabaci with the highest rate of affint for adults 48.0, 49.0 respectively while the lowest rate of attraction was treated with fungi Penicillium janczwskii was 0.3 adult. After five minutes later. The results clear that the highest mortality percentage of white fly was killed in the treatment of fungi Aspergillus parasticus and Ulocladium atrum the transaction amounted to% 57.17, 58.32 Respectively, while the lowest mortality percentage in the treatment of fungi Aspergillus sterreus amounted to% 38.92, It was found that the mortality percentage increased with increasing exposure time as it reached after passing 48, 70, 96,120 hours of treatment. Keywords: Isolation, Biological control, Diagnosis, Effect, Fungi, White fly, Mortality percentage.
In Vitro and In Vivo Effects of Silver Nanoparticles Biosynthesized By Serratia Marcescens Khawlah Jebur Khalaf
Journal of Global Pharma Technology .
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Abstract

Biosynthesis of silver nanoparticles by Serratia marcescens was demonstrated using the supernatant for extracellular biosynthesis. The formation of AgNPs was characterized by UV-Vis spectrophotometry, atomic force microscopic (AFM) and fourier transform infrared spectroscopy (FTIR).Antimicrobial activity of silver nanoparticles was performed by use well diffusion method and show that these AgNPs can be used as growth inhibitors against pathogenic isolates:  Salmonella sp. , Staphylococcus aureus. Staphylococcus epidermedis,   E. coli, Klebsiella sp, Candida albicans   .Antibiotic susceptibility of Salmonella sp. was determed by used disk diffusion method and found the most susceptible for amoxicillin, chloramphenicol, azithromycin, ampicillin and cefotaxime and resistance to flurmequine neomycin and colistin. The present study was designed to assess the effect of silver nanoparticles wich synthesized by serratia marcescens in modulating the salmonellosis in BALB/C mice. we found that in vivo the histological study for liver it was damage when compared with mice's liver treated with antibiotic  (amoxicillin ) .Keywords: Serratia marcescens, silver nanoparticles, pathogenic bacteria, liver.
Risk Detection and Assessment in Wood and Metal Products Industries using HAZAN Method Hamed Biglari
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

Developing and advancing technology in the industries has increased the number of risks at work environment and the number of workers at risk as well. These risks and the risk factors need to be managed, assessed, and controlled using systematic methods. Therefore, the present study is aimed at assessing and detecting risks in wood and mental products industries using HAZAN method. Data gathering was done using HAZAN worksheet, observation, walking and talking method, risk detecting checklists, technical documents, and plots available. The findings represented 137 risks at workshop, out of which 2.92% were 1st rank (unacceptable), 2.92% were 2nd rank (undesirable), 85.4% were 3rd rank (acceptable if controlled), and 8.76% were 4th rank (acceptable). Most of the risks were found at MDF section (n 30), metal assembly (n 28), metal works (n 27), and MDF assembly (n 23). In addition, high risks jobs were bending, electrical welding, PVC work, and guillotine work. The results showed that 3rd rank risks were the largest group of risks and this showed that great improvement could be made in cutting the number of accidents and financial and life loss by controlling these risks. It is notable that 1st rand risks should be controlled immediately using engineering and administrative controls and 2nd rank risks shall be turned into 3rd rank risks in a reasonable time frame. With regard to 3rd rank risks, we need to make sure of availability of controls; and the 4th rank risks were acceptable. Taking measures such as safety training and permanent supervision by the safety authorities were also effective to minimize the risks.Keywords: Risk, assessment, HAZAN method, industrials products, workers risk 
Optical Nonlinearity of Thiazine Dyes Doped With Nanoparticles of Liquid Crystals Ban A. Naser
Journal of Global Pharma Technology .
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Abstract

The optical nonlinearity of several thiazine dyes such as(azure A and azure B) organic dyes doped with nanoparticles of liquid crystals in ethanol solvent has been studied using diode pump solid state laser at wavelength(457 nm) and power (56 mW) as the source of excitation. The optical responses were characterized by measuring the intensity dependent refractive index (n2) of the medium using the Z-Scan technique. The results indicate that the samples of organic dyes doped with nanoparticles of liquid crystals possess very large linear and nonlinear optical properties as compared with samples of pure organic dyes. This result showed that these organic doped dyes are very suitable for applications in optical devices and can be available for applications as active laser medium.Keywords: Organic laser dyes, Z-Scan technique, Nonlinear optical properties, Liquid crystals.
A Survey of the Aquatic Insects in Shatt Al-Arab River, Iraq Sadek J.T.
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The study on survey of aquatic insects was done covering the zone of Basra city to Shatt A-Arab River, south of Iraq. The aquatic insects were collected using a plankton net method from three stations. There were varieties of aquatic insects belonging to 2 orders in the study sites. The orders of insect were Hemiptera and Coleoptera. During the study period, there is range from total of 26 to 58 individuals of aquatic insect trapped and collected in to Shatt A-Arab River from May to July 2018. Some species of aquatic insects (Berosus spinosus and Paracymus relaxus) were found significant (P<0.05) different compared with Plea leachi, Hydaticus histrio and Ochthebius kermanicus. This shows the richness and various species of aquatic insects in the study area. The quality of non-harmful habitats is most suitable for aquatic insects to reproduce under a natural ecosystem with abundant diet source.Keywords: Shatt Al-Arab River; Aquatic insects; Hemiptera; Coleoptera
Reconstruction of A Huge Soft Tissue Deffect in Flank Region Using Rectus Femoris Flap Meirizal Hasan; Rahadyan Magetsari; Rezky Saraswaty
Journal of Global Pharma Technology Volume 13 Issue 04 (2021) April 2021
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Abstract

Introduction:Coverage of full-thickness large flank defect is a challenging procedure for surgeons. The rectus femoris (RF) muscle flap is an excellent donor muscle for many reconstructions. The vascularized rectus femoris (RF) muscle flap has been proved to be effective to cover infected vascular grafts in the flank region. Outcome of the treatment can be evaluated by evaluating the patient daily activity. Case Report:This was a case report conducted on patient with huge soft tissue deffect in flank region. A 62 years old male with large defect of the right flank region due to infection of the abdominal cavity after appendectomy 2 months ago. The wound size 15 x 7 x 7 cm, with the base is bowel, with serohemoragic discharge. Then perform debridement and rectus femoris flap. A month after operation, the patient came to the Sardjito General Hospital with defect of the right hypogastric region and then VAC was performing in this patient. Two month after VAC, the wound was covered by granulating tissue and then the patient underwent FTSG. A month after the second operation, the patient came to outpatient clinic, able to walk, with the condition of the wound was good, no visible sign of infection. Conclusion:From this case report shows that rectus femoris flap has a good result to coverage the huge soft tissue defect in flank region. The patient can perform a simple daily living. Keywords: Rectus femoris, Flank defect, Flap.
Sequencing of Zona Pellucida 4 (ZP4) Gene in Patients with Polycystic Ovary Syndrome Infected with Toxoplasmosis Hanaa N. Abdullah
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Polycystic ovary syndrome  is an endocrine disorder in women which leads to reproductive and metabolic abnormalities. The zona pellucida 4 gene is a glycoprotein which is a part of the extracellular matrix of an ovum. Twenty blood samples were taken from women with PCOS. Also, 20 blood samples were taken from the infected women, polycystic ovary with toxoplasmosis and healthy women groups. Whole blood samples were used to perform a polymerase chain reaction, while was ELISA used to measure Anti- Toxoplasma IgG antibody levels in the sera of both the studied and control groups. The biochemical test was used to determine the follicle-stimulating hormone, luteinizing hormone, and Testosterone.  There is a highly significant difference regarding the levels of anti- Toxoplasma IgG antibody among PCOS patients who were infected with Toxoplasma gondii (1.5865±.42295), Toxoplssmosis control group (1.4097±.46171) and healthy control (6380±.33308). The hormones levels of PCOS showed a highly significant difference (P<0.01) FSH; (22.260±3.8692) compared with healthy control (8.362±1.1149) and Toxo. Control group LH; (32.080 ±2.7523), compared to Toxo. Control group (9.939±1.3910) and healthy control (9.445±1.8159) and Testosterone; (2.0470±.55663) compared to Toxo. The control group (.6580±.13575) and healthy control (.6365±.12512) respectively. Single nucleotide polymorphism T6235C indicated that T to C conversion was observed at nt 6325 in the ZP4 gene, and this evolution was experiential in one PCOS. This SNP is a synonymous substitution, which occurred in the fifth position of the proline codon, changing the codon ATA to ACA.
Some Biochemical Tests of Broiler Chickens As Affected by Different Levels of Sodium Bicarbonate Kadhim S. Kadhim
Journal of Global Pharma Technology .
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Abstract

The objective of this research to investigate the effect of supplementation of sodium bicarbonate on some biochemical parameters of broiler chickens.  At 42 day-old, broiler chickens were randomly allotted to three dietary treatments, 50 chickes in each fed on diet contain (0%, 0.5% and 1%) of sodium bicarbonate. Then each group was divided in to sub groups, 25 animals in each. At day 42 (the end of the experimental period), chickes were given 5h fasting period and  blood plasma of chicks were collected  without anticoagulant and plasma were separated by centrifugation at 3000 rpm for ten minutes and stored in a deep freez (-20) until analysis serum Carietenini , HDL , Globulins , ALP , ALT , AST , cholesterol , Glucose and total protein were determined by full auto biochemistry technique . As a result , in broiler chickens supplementation of different levels of sodium bicarbonate caused important changes in some biochemical parameters .Significantly positive correlations (P ≤ 0.01) were detected for  HDL ,  ALP , ALT ,and  AST , while (P ≤ 0.05 ) for  Glucose and total protein . It seems, different levels of sodium bicarbonate were no Significant effect on blood Carietenini, Globulins and Cholesterol.Keywords: Sodium bicarbonate, Biochemical traits, Broiler chickens.

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