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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Comparison of Age-Related Hearing Loss in Diabetics and Non-Diabetics Patients Nader Saki
Journal of Global Pharma Technology .
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Abstract

Background and Objectives Presbycusis refers to symmetrical and bilateral hearing loss which occurs with aging. Diabetes mellitus affects multiple systems of the body and causes conditions that are often irreversible. The aim of this study was to compare age-related hearing loss in diabetic patients and non-diabetics. Methods & Materials In this study, 42 diabetic patients who visited the Diabetes Center of Ahvaz were randomly selected. Forty-two non-diabetics who visited the otolaryngology center not complaining of hearing problems were randomly selected as the control group. Audiometry (AZ26 interacoustic Co. Denmark)  is done for all subjects. Independent t-test was used to compare the two groups. The Mann-Whitney test was used for ordinal variables, while the chi-square test was used for qualitative variables. The analyses were conducted using SPSS version 20 Results The findings showed an increased prevalence of hearing loss in patients with diabetes.  The bilateral hearing loss was observed in both diabetics and non-diabetics but its prevalence was significantly higher in the diabetic group (P value<0.05). Conclusion Hearing loss was more prevalent in diabetics than non-diabetics, while hearing thresholds were affected in all frequencies of audiometry.Keywords: Diabetes; Age-related hearing loss; Presbycusis; Audiometry.
In Vivo Assessment the Anti-obesity Potentials of Enteric Lactobacillus spp Al-Wendawi S.A
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Consumption of probiotics impacted gut microbiota and have potential effects on chronic diseases, such as obesity. This study investigated the anti-obesity potentials of two putative probiotics, Lactobacillus fermentum L1 (Ll) and Lactobacillus paracasei L2 (L2), individually and in combination (L1+L2) against diet-induced obese rats model. The Lactobacillus suspensions were orally administered, to experimental rats, at a daily level, with two consecutives of approximately 1×108 CFU/rat for up to ten weeks. Feeding rats with a combination of L1+L2 was more effective in improvement some of obesity related biomarkers. Rats supplementation with a combination of L1+L2 attenuated the body weight gain in rats that shifted Lee index towered normal value (0.294±0.05).The L1+L2 combinations exhibited hypoglycemic activity, represented by amelioration of glycemic parameters significantly (P<0.05), where, they reduced the levels of; fasting blood glucose (80.43±2.46mg/dl), fasting serum insulin (0.29±0.03ng/dl), and improved insulin resistant disorder (1.05±0.04) comparison with positive control group rats. Concurrently, lactobacilli combinations (L1+L2) pronounced anti- dyslipidemia and improved serum lipid profile of experimental rats, hat the level of blood lipids were significantly (p<0.05) dropped; total cholesterol (TC) to 80.0±2.56 mg/dl, triglycerides (TG) to 79.2±2.07 mg/dl, and low-density lipoproteins cholesterol (LDL-C) to 52.71±2.56 mg/dl. The satiety-related hormones (leptin and adiponectin) levels in rat sera also were altered by supplementation of rats with L1+L2, leptin level was reduced to 1.12±0.05 ng/ml, while adiponectin level was rose to 2.35±0.04 ng/ml.Keywords:  Probiotics, Lactobacillus fermentum, Lactobacillus paracasei, Anti-obesity potentials, Dyslipidemias, Glycemic parameters, Leptin and adiponectin.
Impact of Folic Acid and Cyanocobalamin on Growth, Milk Yield and its Components of Awassi Ewes and their Lambs Mozhir K.K. Almahdawi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

The aim is to knowledge of vital role of folic acid and B12 vitamin on growth, milk production, milk components of Awassi sheep and their lambs.This experiment was carried out on 24 head of pregnant Awassi ewes with lambing of them in one of the private farms at Altagia village in southern of Hilla city. The experiment was included two phases, the first phase were dosage to Awassi ewes with two vitamins by mouth during experiment periods through estrus, gestation and parturition. The animals were randomly distributed into four treatments, the first treatment (control) without vitamins, second treatment was daily treated by 5mg/ewe of folic acid and third treatment was dosage of cyanocobalamin (B12 vitamin) with 225 μgm per ewe at twice time every week and fourth treatment were combination treated of folic acid and B12 vitamin as the same concentrations above. The second phase of the experiment, which began from birth of lambs and lasted weaning age ( 90 days).The lambs were dosage with two vitamins by mouth method after four hours of their born as the same mentioned of ewes in the first phase of experiment .The lambs were randomly distribution into four treatments, the first treatment was called control treatment without treated any vitamins and the second treatment were dosage with 1mg of folic acid to twice time per week, as well as the third treatment were treated with 125 μgm of B12 vitamin for twice time per week, As either fourth treatment the animals were mixture dosage of two vitamins (folic acid, cyanocobalmine) in the same concentrations. The results of statistical analysis of the first phase indicated the existence of significant differences (P≤0.05) on the averages of ewe’s weights at parturition and weaning, amount of daily feed intake, proportion of milk sugar, total protein and triglycerides of blood. As well as the results indicated high significant differences (P≤0.01) on the average of weights of ewes at the end of gestation, feed conversion , daily milk production , moisture, crude protein, crude fat non fats , total solids of milk and concentrations of cholesterol and albumin in blood of ewes. As for the second phase the results were shown significant differences (P≤0.05) on average amount of daily feed intake, total protein, albumin, triglycerides and cholesterol in the blood of lambs and another beside ,the results indicated high significant differences (P≤0.01) on average of live weight of lambs at birth and weaning, amount of daily feed intake and daily and total weight gains, and cholestrol concentration in the blood of Awassi lambs. We conclude that animals were dosages of folic acid with B12 vitamin were improving of health status and to improve significantly in most of traits of productive performance, growth and blood characteristics of ewes and their lambs as compared to the control treatment. Keywords: Folic acid, B12 vitamin, Milk yield, Milk components, Blood proteins.
Invention and Description of p-CuO /n-Si (200 oC) Heterojunction for Photodiode Applications Ahmed N. Abd
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

P-CuO /n-Si was prepared and studied with respect to Drop casting method  at  200°C temperature, it was concluded that energy band gap of CuO films is (1.6)eV calculated from optical properties. AFM reveal that the generated CuO Films have ball-shape with perfect homogeneity, the measurements of the XRD revealed that the CuO were of cubic crystal structure, the responsively photo detector after deposited CuO showed an increase in response.Keywords: CuO, Structure properties, AFM, Optical properties, Solar cell.
The Study of all the Optical, Electrical and the Performance Coefficients for the (Rhodamine B - Acriflavine) Laser Dyes Solar Cells Doped with Nanoparticles Mithaq M. Mehdy Al- Sultani
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

In this study of the effect of nanomaterials on the performance of Solar cells with laser dyes. The study included visual measurements of the dye solutions with different concentrations on the optical properties such as absorption and transmittance (A, T), the absorption coefficient, refractive index, reflectivity and optical conductivity at the wavelengths (400-800) nm. Using the UV-visible spectrum device, the value of the energy gap was calculated. The changing in the values of the previous variables the focus. The electrical properties as ( dielectric constant 14ε "> , the permittivity of  14ϵ "> , medium impedance 14Z">  , electrical conductivity 14 σE ">  were also calculated. the electrical response time 14tE">   dielectric time 14tdie "> ,  and the permeability 14μ">  were also calculated, and the solar cells Parameters ( 14Voc"> ), ( 14Isc"> ), ( 14Rsh"> ), ( 14Rs"> ), ( 14Pin"> ), (ŋ), F.F) with silver nanoparticles of higher efficiency than the cell coated with zinc oxide particles Zno is 16.9%.Keywords: Rhodamine B dye, Acriflavine dye, Ag,Zno nanoparticles, Solar cell, laser dyes.
The Reconstruction Procedure Using Osteocutaneous Vascularzed Fibula Graft in Limb Salvage Surgery for Recurrence Adamantinoma of Tibia Ade Martinus
Journal of Global Pharma Technology .
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Abstract

Introduction Adamantinoma is a very rare malignant bone tumor. The recurrence case seems to have more rapid enlarges and more aggressive invasion of surrounding soft tissue. Recently limb salvage has become the primary method of bone tumor treatment due to oncologist orthopaedic surgical advancement and more accurate imaging techniques. The osteocutaneous fibula graft is one of the advance option for intercalary reconstruction of the defect after bone tumor resection. The objectives of this case report are to present the reconstruction procedure of recurrence primary bone tumor using osteocutaneous fibular graft. Case Report.22 year’s old male with mass on right leg that gradually increased in size. He was previously diagnosed to have an adamantinoma, excised in other hospital 5 years ago. Radiograph and MRI examination support a recurrence adamantinoma of tibia and was confirmed by histopathologic result. Discussion we performed a limb salvage procedure via wide excision and reconstruction using osteocutaneous fibular ­graft. We were able to preserve the anterior tibial and posterior tibial neurovascular bundle. The recipient anterior tibial artery and vein was chosen to anastomose to donor vessels. The flap is vital and the patient discharged on 5th day. Conclusion: The limb salvage surgery with reconstruction procedure using osteocutaneous vascular zed fibula graft is a feasible surgical treatment in case of recurrence adamantinoma of tibia. Osteocutaneous fibula graft has been proven to be an ideal choice due to very high bony union rates, provide well-perfused bone, the capability of osteogenesis, and improved regional circulation. Keywords: Adamantinoma, Recurrence, Intercalary reconstruction, Osteocutaneous fibula graft, Limb salvage surgery.
Preparation and Characterization of Nanohybrid Antioxidant from Propyl Gallate and Evaluation of its Antioxidant Activity Abeer Muhammedali Alnasrawi
Journal of Global Pharma Technology .
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Abstract

In this study a nanohybrid antioxidant Mg/Al-PG-LDH was prepared by intercalating propyl gallate (PG) between magnesium/ aluminum layered double hydroxides. Identification of the prepared compound by the FT-IR revealed that some functional groups had been shifted either to higher or lower frequencies indicating the preparation of new compound. X-ray diffraction analysis confirmed the crystalline   nature of the prepared compound. The antioxidant activity of the nanohybrid compound was evaluated using three methods. In the ABTS cation radical scavenging assay the IC50 of PG and Mg/Al-PG-LDH were (50 and 100) µg/ml, respectively. By using ferric reducing antioxidant power (FRAP), analysis of the results allowed to rank the antioxidants used in this study as follows: Mg/Al-PG-LDH < Trolox< PG. The standard antioxidant butylated hydroxyl anisole exhibited the highest chelating effect in compare with the nanohybrid antioxidant and PG.Keywords: Propyl gallate, Nanohybrid antioxidant, FT-IR, XRD, ABTS, FRAP, and Chelating effect
The Role of Levan Produced from Pseudomonas fluorescens as Antipathogenic Substances and Phagocytic Enhancer against Some of Bacterial Isolates Alaa Raheem Kazim
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Levan is a natural substance that produced from many organisms, levan recognized as a homopolysaccharide with multi-functional features and a wide range of potential industrial applications. Pseudomonas fluorescens had the capacity to produce levan in the total absence of air which exhibited broad antibacterial spectra against foodborne pathogenic bacteria.  The results showed that three isolates of bacterial isolates were classified as a member of Pseudomonas fluorescens with antibacterial activity when tested against various pathogenic bacteria; levan has antibacterial activity against Staphylococcus. aureus, E.coli and Listeria but it had no activity against Salmonella  typhi, the results showed that levan increased phagocytic activity, The phagocytic index against S.aureus increased in the presence of levan in compared with control (without levan). The phagocytic index was (65%) when used levan in concentration (200µg ∕ ml|) while the phagocytic index was (40%) in control (without levan).Keywords: Levan, Antimicrobial activity, FT-IR, Pathogenic bacteria, Phagocytic index.
An Update of In Vitro Fertilization-Intra Cytoplasmic Sperm Injection: A Review of Sperm Selection Methods Marianne Ingrid Aror
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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In Vitro Fertilization (IVF)-Intra Cytoplasmic Sperm Injection (ICSI) is a well-known infertility management, but the success rate remains low. One of etiologies is the sperm factor. The objective of this review is to explore the update of sperm selection methods for selecting the best sperm quality for IVF-ICSI. Initially, semen analysis should be conducted hence sperm motile and morphology data are obtained. If there is standard sperm morphology in semen analysis, then in the motile sperm organelle morphology (MSOME), important sperm organelles are also obtained, such as nuclues, which are supplemented with vacuole data. Then, due to limitation of semen analysis, the analysis of sperm DNA fragmentation exists to analyze the quality of sperm DNA integrity. Sperm DNA fragmentation is caused by apoptosis. Magnetic Activated Cell-Sorting (MACS) is a sperm selection method that selects non-apoptotic sperms for IVF-ICSI. Finally, Physiological ICSI (PICSI) method is performed to select qualified sperms based on its binding with hyaluronan, immitating the physiological process in natural fertilization. It is important to select the best sperm quality through the most appropriate selection method to increase the success rate of IVF-ICSI. Keywords: IVF-ICSI, Sperm selection, DFI, MSOME, MACS, PICSI.
Production of Slime Layer by Staphylococcus Epidermidis Isolated from Hip and Knee Joint Infections during Revision Arthroplasty of Patients in Abn- Sina Hospital in Baghdad Hadi Abdulah Abd Ali Al-Zuhairi
Journal of Global Pharma Technology .
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Abstract

This study was carried out to determine the ability of Staphylococcus epidermidis strains to produce slimelayer and biofilm formation during a period of study which extended from1 October, 2016 till 1 October, 2017.Analytic Profile Index (API) system for Staph (Bio-Merieux, France) was used to identify of bacteria to specieslevel. According to Kirby-Bauer (disk diffusion) technique, the antimicrobial susceptibility test was done.Frequency of Staphylococcus epidermidis strains isolated from hip and knee joint infections was higher inmale than female patients, 12(85.7%) vs. 2 (14.3%) (P-value ≤ 0.05).From antimicrobial susceptibility test, themost effective antibiotic was Vancomycin which showed 100% susceptibility rate and the highest resistancerate was to Benzylpenicillin (85.7 %.) followed by Erythromycin and Ampicillin (78.6%). Staphylococcusepidermidis strains were revealed different degrees of resistance towards remaining antibiotics. Out of 14Staphylococcus epidermidis strains under study, 11(78.6%) of Staphylococcus epidermidis strains were slimelayer production, while only 3(21.4%) of Staphylococcus epidermidis strains were non slime layer production(P-value ≤ 0.05) this indicate that Staphylococcus epidermidis strains from Hip and knee infections have theability to format biofilm.Key words: Staphylococcus epidermidis, Hip and knee infections, Osteomyelitis, Slime layer production andBiofilm formation.

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