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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Evaluate the Effectiveness of Training with Michael Frey Approach along with Drug Control in Reducing Anxiety, Increasing Adaptability and Resiliency Female High School students Mohsen Saeidmanesh Saeidmanesh
Journal of Global Pharma Technology Volume 08 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

The aim of this study was to evaluate the effectiveness of training with Michael Frey approach along with drug control in reducing anxiety, increasing adaptability and resiliency is female high school students. The research method was experimental with pretest-posttest control group. The study population included all high school female students in Isfahan city were in the third quarter of 1395. Using 40 high school girls were selected by convenience sampling. Connor-Davidson Resilience and questionnaires, social adjustment Bell and Beck Anxiety Inventory was ¬Ml them and then randomly divided into two experimental and control groups. The experimental group in 12 sessions 90 sessions of cognitive behavioral group under Michael Frey was placed. Again, both Connor and Davidson Resiliency Questionnaire, social adjustment Bell and Beck Anxiety Inventory was taken. The results of analysis of covariance showed that cognitive-behavioral intervention anxiety level students Michael Frey significantly (P <0.05) decreased and the adaptability and resilience was seen significant changes. The results of this research can be concluded that cognitive-behavioral intervention to reduce anxiety Michael Frey students has a positive effect but had no significant effect on the resiliency and adaptability.Keywords: Training, Michael Frey, Anxiety, Resilience, Adaptability.
Preparation and Evaluation of Hydrogels Containing Methanolic Extract of Brassica Oleracea ver. Italic Tahir Ansari
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: Herbal medicine usage is increasing nowadays because their usage is acceptable by most people to be safe and produce fewer side effects than synthetic drugs. This present study has been undertaken with the aim to formulate and evaluate herbal gel containing Brassica oleracea ver. italica methanolic extract.  Method: The gel formulation was designed by using methanolic extract of Brassica oleracea var. italica, Carbopol 940, propylene glycol, methyl paraben, propyl paraben and required amount of distilled water. PH of skin was maintained by adding tri-ethanolamine drop wise. The prepared herbal gel formulation was subjected to preliminary evaluation such as pH, total phenolic content and total flavonoid content, viscosity, drug diffusion study and anti-inflammatory study.  Result: The result of anti-inflammatory study showed that the gels with extract concentration of 1000 µg/ml have comparable anti-inflammatory activity with the Diclofenac sodium (100 µg/ml).Conclusion: Formulation of gel containing B. oleracea var. italica extract is a good attempt as herbal formulation has high demand in the market.Keywords: Brassica oleracea var. italica, Carbopol 940, Hydrogel.
Bioactive Phenolic Compounds from Natural Zygophyllum fabago Plant: Isolation, Purification and Characterization Omar T. Ali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This study is to investigate the chemical constituents of the aerial parts of Zygophyllum fabago in Iraq. The compounds were isolated by silica gel and column chromatography from deferent extracts. Their structures were characterized by various spectroscopic data (HPLC, 1H and 13C-NMR) and compared with the literature. As a result, three phenolic compounds were isolated, and their structures were identified as Catechol, Coumarin and Resorcinol. Biological testing of the extracts against six different Gram-positive and Gram-negative bacteria showed significant results.   Keywords: Zygophyllum fabago, Bioactive, Purification.
Immunohistochemistry Detection Method of Rejection Reaction of Human Umbilical Cord Derived Mesenchymal Stem Cell on Rat Sciatic Nerve Tissue Ria Margiana; Ahmad Aulia Jusuf; Silvia Werdhy Lestari
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Abstract:Human umbilical cord derived mesenchymal stromal cells (UC-MSCs) that are accessible from cell banks can be actuated to separate into different cell sorts, accordingly making them handy potential hotspots for cell-based treatments. In injured peripheral nerves, Schwann cells (SCs) add to useful recuperation by supporting axonal recovery and myelin remaking. Here, we first exhibit a framework to induce UC-MSCs to separate into cells with SC properties (UC-SCs) by treatment with β-mercaptoethanol took after by retinoic corrosive and an arrangement of particular cytokines. The UC-SCs are morphologically like SCs and express SC markers, including P0, as evaluated by immunocytochemistry and converse interpretation polymerase chain response. Transplantation of UC-SCs into transected sciatic nerves in grown-up rats improved nerve recovery. The viability of UC-SCs for axonal recovery was tantamount to that of legitimate human SCs taking into account histological criteria and useful recuperation. Immunohistochemistry and immunoelectron microscopy additionally showed myelination of recovered axons by UC-SCs. These discoveries demonstrate that cells with SC properties and with the capacity to bolster axonal recovery and reproduce myelin can be effectively actuated from UC-MSCs to advance practical recuperation after peripheral nerve injury. This framework might be pertinent for the advancement of cell-based treatments.
Teeth Samples in Forensic Evidence: A Literature Review Taif Mothhar Al-Khalidi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Dental identification seem to be more powerful source in forensic evidence to identification disaster victim, mass graves and  fires victims .DNA evidence can eliminate suspect so it consider as tool  for innocence or condemnation. Use dental record as x-ray and dental cast can allow dental remains to be connected to victim. In brief, pulp and cement um are most appreciated sources of nuclear DNA in the tooth and both these tissues and dentine are   good   sources   of   mt DNA. Dentine   and   pulp are protected via enamel. Teeth are   not in save from contamination their lower porosity make them most resistant to contaminants than skeleton (bone).This research present a literature review refer to importance of forensic dentistry  and the main methods of extraction  DNA  from teeth samples and the role of DNA in  teeth  in forensic investigations.Keywords: DNA, PCR Inhibitors, Forensic Destiny, Human identification.
Pharmacoepidemiology of Antiretroviral Drugs in a Tertiary Care Teaching Hospital Pragna Malavika Malavika B; Saravana Kumar RT; Lakshmi BVS
Journal of Global Pharma Technology Volume 12 Issue 07 (2020) July 2020
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Abstract

Background: India has a large population using antiretroviral drugs (ARV) which has potential therapeutic efficacy and high toxic properties resulting in diverse adverse drug reactions (ADRs). Adherence to the ART is a crucial challenge to be addressed as it plays a major role in the success of HIV management. Aim: To determine the prescribing pattern of antiretroviral drugs uses at an ART center and the levels of adherence to the drugs and the associated adverse effects. Materials and methods: It is a retrospective analysis of the clinical records related to HIV-infected adults who were receiving treatment at an ART Center in Andhra Pradesh state. The main outcomes of the study are demographic details of the patients, the pattern of ART combinations prescribed, adherence to the given ART, and analysis of reported ADRs. Simple descriptive statistics and chi-square tests are the statistics used to measure the outcomes. Results: A total of 430 HIV patients’ records were selected and assessed. Tenofovir (TAF)+ Lamivudine (3TC) +Efavirenz (EFV) (66.5%) was the most prescribed ARV combination. The majority of 348 patients (80.9%) were good adherence and showed a significant association with therapeutic outcomes. The most common clinical ADRs found in this study were gastrointestinal disturbances (30.9%) followed by dermatological problems (20.4 %). Conclusion: Despite drug toxicity, ART treatment bears potential therapeutic efficacy and is considered as the only means to increase life expectancy in HIV infected patients. Detailed patient counseling and monitoring improve therapeutic outcomes and patients adherence.
The Extent to Which Some of the Infant Formulas Available in Iraqi Markets Conform to the Standards and Meet the Requirements of Ideal Infant Growth Mohanad Abbood Alhamid
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

This study was conducted in the laboratories of the College of Agriculture \ University of Kufa and the laboratories of the College of Food Sciences \ University of Al-Qasim Green. To determine the extent to which the specifications of different samples of infant milk formulas available in the local markets of Najaf province meet the standard specifications, meet the requirements of the ideal growth of Infant, and compare them with the overall composition of breast milk. Four replicates of different production batches were used for each model of infant formula. Nactalia1, Dielac1, Evolac1, Celia2, Dielac2 and Sunnybaby2.The results showed a decrease in the amount of energy processed by the milk formulas Dielac1, Celia2 and Sunny baby2, which were 65.48, 63.27 and 65.78 kcal / 100 ml, respectively, compared to the amount of energy provided by the mother to her infant. The amount of protein in all Infant milk formulas with genetic fructose intolerance especially during the first four months of life. It was also observed that the percentage of whey protein in the milk formulas Dielac1, Evolac1 and Dielac2 was similar to that in cow's milk at 17%, 20% and 16%, respectively. But increased to 25% in Celia2 milk and were close to the proportion of breast milk in the milk formula of Sunnybaby2 and Nactalia1 48% and 52%, respectively. It was also found that both mothers and experts accepted all infant milk formulas under study.Keywords: Infant formula, Nitrogen distribution, Sensory evaluation.
Isolation and Molecular Characterization of Lactobacillus Genus from Patients Wear in Fixed Orthodontic Appliance Anphal Ihsan Jasim
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: The fixed appliances might prevent effective oral hygiene and cause high cariogenic challenge. Objective: This study was examining the presence of lactobacillus Spp by traditional culture and PCR methods. Material and Method: A total 74 patients with age range from 15 to 35with mean age (19.67) that enrolled in this study. The samples were collected from patients admitted to orthodontic department in collage of dentistry during the period from November 2017 to March 2018. The result:  The result were shown 59 of 74 was positive result, Thirty eight of 59was positive in PCR technique while 21of 59 positive in culture ,The methods of PCR and growth detected this bacteria was only 35.6%positive in culture ,while PCR methods were 64.4%%. Conclusion: the higher level of bacteria detected by PCR than routine culture method  confirm that  the PCR method is very sensitive, specific and time consume technique for detecting of oral bacteria.Keywords: Orthodontic Appliances, Lactobacillus, Polymerase Chain Reaction, Biofilm formation, Culture.
Spectral and Linear Optical Characterization of Organic Laser Dyes Mixture Solution Noor K. Abdulmutalib
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Spectral and linear optical properties for mixture of compounds Aurintricarboxylic Acid after polymerization (H1) and  Aurintricarboxylic Acid after closer ring (H2), were determined at different concentrations (3* 10-4, 6*10-4 and 9*10-4 ) M in Dimethyl sulfoxide (DMSO) solvent at room temperature. The intensity of absorption range is towards longer wavelengths (red shift); organic laser dyes have a spectrum within range (240-600) nm. Results demonstrate that mixture of laser dyes are effective optical materials when contrasted with single laser dyes. It can be utilized as resonator in cavity lasers.Keywords: Linear and nonlinear properties, Mixture dyes, Optical limiting, And organic laser dyes.
Determination Levels of Anxiety for Patients Undergoing Endoscopy at Marjan Teaching Hospital in Al- Hillah City Ali Ahmed Zghair Al-Khafaji
Journal of Global Pharma Technology .
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Abstract

Background: Upper and lower endoscopy are commonly used to identify and treat numerous gastrointestinal illnesses. These procedures may reason some difficulty for patients such as ache, tachycardia, and in some cases, even a provisional desideration; these difficulties might have unaffected psychological impaction up on the patient health state and may reason a rise in anxiety levels (Previti et al., 2016 Aim of the study: To determine the levels of anxiety for patients undergoing endoscopy. Methodology: Quantitative – Cross sectional design was selected to determine the anxiety levels for patient undergoing endoscopy from the period between 11-October 2016 to 31 August 2017.The digestive system center at Marjan teaching hospital was selected as a risk area to collect the data, purposive sample from (150) patient who scheduled for upper and lower endoscopy were selected. After their agreement to participate in the study. Special anxiety scale adopted after modification. Results: The majority of the study sample 79 (52.7%) were male, 44 (29.3%) between age group (18-27) years old and 50 (33.3%) were with primary education. Most of the study sample 77 (51.3%) recorded moderate anxiety level. Conclusion: Most of the participants recorded moderate anxiety level.  Recommendation: Training program may be helpful of the health personnel who work in the clinical area which content all the necessary information related to this procedure, which may prepare them to play their role as education providing the patient with all information, answer all questions and using different educational strategies such as audiovisual taps.Keywords: Determination, Endoscopy, and Anxiety Levels.

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