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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Confirmatory Detection of Escherichia Coli O157:H7 in Diarrheic and Non-Diarrheic Calves by using Real Time PCR with Studying the Antimicrobial Susceptibility of these Bacteria Mustafa Salah Hasan
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Shiga toxigenic E. coliO157:H7 is one of the Shiga-toxin producing types of E. coli, which can produce disease in man and animals. The aims of this study were to detect O gene (rfbO157) and H gene (fliCH7) and determine the pattern of antimicrobial susceptibility of 32 E. coli O157:H7 isolates. The isolates isolated by conventional culture methods and latex test from faecal samples of 4 calves suffering from diarrhoea and 28 calves’ apparent normal. DNA was extracted from these isolates and the real time PCR was applied on the extract of DNA for confirming the diagnosis ofrfbO157 and flic H7 genes. Seven antimicrobial discs were used in this study. The result presented that all the (32) isolates were possessed the rfbO157 and flics H7 genes. The susceptibility test of the isolates revealed that all isolates were highly resistant to Erythromycin (100%) and Cephalothin (96.87 %). Less resistance to Tetracycline, Trimethoprim-Sulfamethoxazole and Chloramphenicol at different percentage (31.25%), (12.5%) and (9.37%) respectively and all isolates showed high sensitivity to Gentamicin (100 %), Enrofloxacin (100 %). In conclusion, the real time PCR can be used as a sensitive and reliable tool for diagnosis of E. coli O157:H7 and these bacteria showed high resistance to antibiotic.Keywords: E. coli O157:H7, real time PCR, rfbO157, flic H7, antibiotic susceptibility.
Spectrophotometric Determination of Ceftotaxime Following Azo Dye Formation with Resorcinol Muthana S. Mashkoor
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A sensitive, selective, rapid, simple and accurate of the spectrοphotometric determination of ceftotaxime in bulk and in dosage forms. This method depend on diazotization of primary amine group of cefotaxime with sodium nitrate and hydrochloric acid followed by coupling with ceftotaxime in aqueous mildly acidic medium to form azo dye a stable orange. Showed obeyed beers law between 0.5- 15 ppm, with molar absorptive 4.4*104L.mole-1.cm-1 at 456nm.Sandells sensitivity 0.008µg.cm-2, limit of detection (LΟD) 0.185ppm and limit of quantification (LΟQ) 0.619 ppm. This method has been successfully applied to determination of ceftotaxime in bulk and in pharmaceutical preparation, tablet with a good recoveries 99.43-100.32 %.Keyword: Cefotaxime, Resorcinol, Diazotization-coupling, Spectrophotometry.
Synthesis Characterization and a Physical Study of New Polyborate Compounds with Some Transitions Metal Mohsin. E. Aldokheily
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

This Study include preparation of polyborate compounds containing some transition metals cations  complexes which are:  [Ag (NH3)2][B5O6(OH)4].7H2O(1), [Hg(NH3)(H2O)][B5O6(OH)4]. 10H2O(2),[Hg(NH3)(H2O)][B5O6(OH)4][B3O3(OH4)].9H2O(3),[Zn(NH3)3(H2O)3][B5O6(OH)4].3H2O(4),[Zn(NH3)2(B6O7(OH)6)](5),[Zn(NH3)(H2O)5][B5O6(OH)4][B3O6(OH)4].4H2O(6),[Cd(en][B6O7(OH)6](7),[Cu(en)3][B5O6(OH)4]2.4H2O(8),[Zn2en3(B6O7(OH)6)2].3H2O(9),[Cu(1,2dmp)3] [B5O6(OH)4]2. 6H2O(10). The prepared polyborate compounds were characterized by elemental analysis (C.H.N), Infrared (FT-IR), Nuclear Magnetic Resonance Spectroscopy (1H-NMR), (13C-NMR), (11B-NMR). Some of the prepared compounds was a physically studied by measuring the molar conductivity which were used to determine thermodynamic parameters i.e the ion association constant Ka, Enthalpy ΔH 15°"> , Entropy ΔS 15°">  and Gibbs free energy ΔG 15°">  implenting Shedlovsky technique with matlab program. The values of Ka, ΔG 15°">   for pentaborate compounds were always greater than other compounds, due to the fact the pentaborate compounds more favored in ion-pair formation than other followed by hexaborate compound then the compound that containing double composition of penta and Triborates. All reactions are endothermic which were supported by the positive values of the enthalpy ΔH 15°.">Keywords: Pentaborate(2-), hexaborate(2-), polyborate, Shedlovsky technique.
Synthesis Conditions of Ag Core@ Aushell System by Laser Ablation with (1064, 532, 355) nm Wavelengths as a Suitable Model for care Skin Enhancement Ghaleb Al-Dahash
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Laser ablation in liquid technique (PLA) has become a more important for the preparation of NPs. Metal targets were laser ablated in liquid for preparation of spherical Ag @ Au core @ shell NPS colloidal solution for refractive index sensing. In our research was prepared Core-shell Nano colloid system of Ag @ Au by using pulses of Nd-YAG laser with (1064, 532, 355) nm wavelength and (80 @ 60) mJ energy in ethanol liquid. The Surface texture, topography and morphology studied by Transmission Electron Microscopy (TEM) and Scanning Electron Microscope (SEM).Our structural analysis indicated the grains show spherical shape, where TEM images showed formation of Core-Shell clearly, UV-Visible spectroscopy has been employed for the optical properties measurements, Absorption peaks shifted to lower wavelength (blue shift) (UV). The effect of (Ag -core) was more effective than the (Ag - shell), and so by the sliver core effect (Ag -Core), and this confirms clear evidence that the effect of the (Core) influential, which dominates the effect of (shell).
Green Chemistry, Characterization and Study of Medical Application Silver/ Polymer Nanocomposite Khalidah Khalaf Jabbar
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Over the last few years, the green consistency over nanoparticles (NPs) the usage of drive into extracts has emerged as a hopeful methodology because of the fabrication of metal NPs (especially silver, copper, and riches NPs), so kind of it entails an easy, fast, low-cost, then environmentally pleasant bioprocess. The consistency atop nanoparticles through the use of the biochemical rejoinder regarding propulsion dust reply since page banish as regards but facile, quick & eco-friendly microwave assisted adjustment of doublet polymers polymethyl methacrylate & poly butyl methacrylate and joining nanocomposites Ag/Polymethyl methacrylate (Ag/PMMA) then Ag/ Poly butyl methacrylate (Ag/PBMA). The synthesized nanoparticles had been characterized through FT-IR, UV-visible, X-Ray Diffraction (XRD) afterward Transmission Electron Microscopic (TEM) studies. Nanocomposites, Scanning Electron Microscopy (SEM) and TG/DTA.XRD studies but TEM pictures evolved average particle quantity concerning synthesized nanoparticles 20 nm. Thermal lookup rose that standard hot regarding Ag/PMMA then Ag/PBMA nanocomposites reduced as it should be among pursuance with city related to Ag nanoparticles of the polymer matrix.Keywords: Green synthesis, Metal nanoparticles, Metal/ Polymer Nanocomposite, Medical Application
Detection of Fima and Fimh Genes in Klebsiella pneumoniae Isolated from Necrotizing Enterocolitis Patients in Infants Luma Abdalhady Zwain
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Sixty-four clinical isolates were collected from the children's protection hospital by Medical city in Baghdad for children infected with Necrotizing Enterocolitis where included (41) samples belong to stool and (14) samples belong to blood and (9) samples belong to urine for the period of 29/1/2018 to 4/4/2018. All the samples were cultured on MacConkey agar and Blood agar for the purpose of diagnosis.  All isolates were identification depending on macroscopic, microscopic, biochemical tests and definite with Vitek-2 compact system, forty three isolates were obtained from all samples, (26) isolates as K. pneumoniae (60.46%) and 8 isolates as E. coli (18.60%) and 4 isolates as P.aeruginosa (9.30%) and 2 isolates were K.oxytoca (4.65%) and 2 isolates were E. cloacae (4.65%) and 1 isolates was P. hauseri (2.32%). The results showed that K. pneumoniae was the predominant in the samples which taken from infants infected to Necrotizing Enterocolitis. In these study, oame of virulence genes have been investigated for K.pneumoniae included both fimA and fimH gens which encodes for the fimbriae adhesion protein that belonging to type 1 fimbriae named Fim protein, and the results showed presence of fimA and fimH genes (100 %).Keywords: Klebsiella pneumoniae, Isolation, Identification, Necrotizing, Enterocoliti, fimA, fimH.
Evaluation the Efficiency of Magnesium Oxide Nanoparticles in the Reduction of Ochratoxin A and in the Inhibition of Asperillusniger Shahbaa H Majeed
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This study was conducted in Mycotoxins Laboratory /Department of Plant Protection/College of Agriculture at" University of Baghdad". This study aimed to determine the efficiency of magnesium oxide nanoparticles (MgO) (NP) in the inhibition of Aspergillusniger growth and in the degradation ocra a toxin. The results found that MgOnanoparticles significantly inhibited the growth of A. niger. There were significant differences between all the concentrations of MgOnanoparticles in comparison to control groups, while no significant difference was fund between the concentration of 2% and 3%;a significant differences also was detected between the concentrations (2 and 3)% for the first concentration (1%) and the 95% for concentration of(3%). Moreover, the results observed that MgO nanoparticles was potential in the reduction of ocra Atoxin A that produced from A. nigerusing Performance liquid chromatography (HPLC) technique; the percentage of reduction of toxin were 90.1%, 92.2%, 93.7% for concentrations of NaO2 1%, 2% and 3% respectively, however the best reduction percentage was 92.2% with concentration of 0.06 μg/kg after the treatment with MgOnanoparticles at 2%. Keywords: Ochratoxin A, MgO (NP), inhibition of Aspergillusniger, Reduction.
Genotype Distribution Pattern, Subgenotipe and Subtipe of Hepatitis Virus B in Generalpopulation from Six Munipios in Timor-Leste Da Silva H
Journal of Global Pharma Technology .
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Abstract

Hepatitis B virus infection (HBV) remains a serious health problem in Timor Leste, but data on its prevalence is still very limited. According to some reports, the prevalence of HBsAg in the general population in Timor-Leste ranges from 6.9% - 8.1%. Previous research on blood donors in the city of Dili also indicated the biodiversity of the HBV genotype and HBsAg subtype. This study aims to determine the distribution patterns of genotypes, subgenotypes and subtypes of HBV in the general population in six municipios present in Timor-Leste. This study was conducted using a Cut Lintang design to find out, genotype distribution pattern, subgenotype and HBV subtype. HBsAg examination is done by immunochromatography method. Determination of genotype, subgenotype and HBV subtype was done by analysis of nucleotide sequence of S. gene. The results of 683 subjects from six Munisipio in Timor Leste obtained 69 positive HBsAg. From 69 samples of HBsAg tested positive, genotype C predominant (72,8%), followed by genotype B (25,7%) and genotype A (1,5%). From the subgenotype A1, B3, B7, C1, C2, C7 and C10 there were 3 dominant subgenotypes, subgenotipe C2 (25,8%), followed by subgenotipe C10 (19,7%) and B3 subgenotype (16 , 6). All the major subtypes of HBsAg were found in Timor-Leste, subtype adr (71.2%), followed by ayw subtype (24.2%), adw subtype (3.1%) and ayr subtype (1.5%). Conclusions from this study were three genotypes of HBsAg in the general population of 6 municipios present in Timor-Leste ie genotypes A, B, and C, Subgenotypes A1, B3, B7, C1, C2, C7 and C10, subtype adr, adw, ayw ayr. Genotype C, subgenotype C2, C10 and B3 and subtype adr are the most common genotypes, subgenies and subtypes found in the general population at 6 Municipio in Timor-Leste.Keywords: Genotype, Subgenotype, Hepatitis B Virus Subtype, Timor-Leste.
Characterization of Biofilm production in antibiotic resistant Klebsiella pneumonia isolated from different clinical samples in Iraqi hospitals Rawa Abdul Redha Aziz; Sawsan Sajid Al-Jubori
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

Objective(s): Klebsiella pneumonia is a causative agent of chronic infections leading to increase morbidity and mortality; especially when performing biofilm(1). Therefore, biofilm formation has been linked to the survival of pathogenic bacteria in the hospital environment, leading to susceptible bacterial colonization which creates an important public health problem. Therefore, to characterize biofilm production in local Iraqi K. pneumonia isolated from different clinical samples in Iraqi hospitals using phenotypic biofilm assays including scanning electron microscopy. Material and Methods local isolates were collected from different Iraqi hospitals and re-diagnosed by compact Vitek 2 and genetically by using housekeeping gene (16s rRNA and 23s rRNA 639 bp). Phenotypic detection of biofilm formation among isolates was screened by using microtiter dish assay, twitching motility assay, and scanning electron microscopy (SEM).Results: It was found that 22/24 (91.67%) of isolates could form biofilm (OD≥0.68). Twitching motility test revealed that 20/24 (80.3%) of isolates could move on the M63 medium. Scanning electron microscopy showed 83.3% of K. pneumoniae isolates made biofilm in different stages started with adhesion step and ending with a mushroom like architecture as highly magnification images showed on glass cover slips embedded statically in LB broth. It was interesting that K. pneumoniae S2 demonstrated a dense mat of cells aggregates on cover slips generating different biofilm formation step. Conclusion K. pneumonia could produce biofilm, describing the ability to resist many kinds of antibiotics and rising a concern of disseminating chronic infection among hospitalized patients in many hospitals in Baghdad.  
Evaluation the Fractions from Extract Ethanol Psidium Guajava Leaves on Total Phenolic Content, Antioxidant Activity and Its Antibacterial Activity of Staphylococcus Aureus. Mustofa Ahda
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: The aims of this research to find the potential extract and fraction from ethanol extract of Psidium Guajava L for natural antioxidant and antibacterial. The extract and fraction of Psidium Guajava L was analyzed the phenol total content, antioxidant activity and its antibacterial. Methods: The ethanol extract of Psidium Guajava L was extraxted using n hexane, ethyl acetate and water. The all fraction and ethanol extract of Psidium Guajava L was determined the scavenging activity, penolic compound. The scavenging activity was determined by DPPH method. The phenolic compound was determined with Folin-Ciocalteu method. Results: The result of this research showed that the fraction of ethyl acetate has highest antioxidant activity with the value is 9.07 µg/mL. It is also supported by the result of screening phytochemical that ethyl acetate fraction contains mostly complete of chemical substances. However, The highest total phenol content was found in water fraction with phenolic content of 26%. The anbacterial activity of ethanol 96% extract of Psidium guajava leaves and ethyl acetate fraction have a highly activity to inhibit the Staphylococcus Aureus. Conclusion: The fraction of ethyl acetate has a highest of antioxidant activity, although it doesn’t have highest of total phenolic content. The highest of total fenolic content from water fraction is 26%. The scheme of antibacterial activities potential of Guajava extracts are ethanol 96% extract = ethyl acetate fraction > n-hexane fraction = water fraction

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