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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Influence of the Probiotics of Lactobifadol on the Exchange Processes, Literal Microbiocenosis, Productive Indicators of Goslings Ayrat Khabirov
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Inclusion of the probiotic supplement based on lactobacilli L.acidophilus and bifidobacterium B. Adolescentis to the diet of young poultry (goslings) at a rate of 0.2 g per 1 kg of body weight weekly, with subsequent weekly intervals, throughout the growing period provided: an increase in live goslings weights at 62 days of age by 3.7% compared with the intact group. The introduction of probiotic Lactobifadol to the body of goslings had a stimulating effect on protein and carbohydrate metabolism. The average total protein content from 20 days to 62 days in the control group increased by 12.6%, compared to the control group. In the blood serum of goslings, the average glucose content from 20-day to 62-day in the experimental group increased by 4% compared with intact birds. The average content of calcium and phosphorus in the blood serum of goslings of the experimental group from 20 days to 62 days of age was 14.8% less than in the control group of goslings. In the intestinal microbiocenosis, changes have occurred in the direction of an increase in the number of lactobacilli and bifidobacteria, with a significant decrease in the representation of E. coli. The use of Lactobifadol allowed to obtain a higher yield of gutted carcasses from goslings, to increase the mass of gutted carcasses by 6.64%. The use of Lactobifadol in growing of goslings allowed to receive an additional income of 23 rubles per 1 head.Keywords: Probiotic Lactobifadol, Goslings, Live weight, Daily average growth, Morphological blood parameters, Serum biochemical parameters, Microflora, Lactobacilli, Bifidobacteria, E. coli, Meat quality, Eviscerated carcass yield, Economic efficiency.
The Effectiveness of the Differentiated Education Strategy According to the two (Sensory-intuitive) Patterns in the Development of the Skills of Defensive Performance in the Volleyball for Students Ali Hussein Said Al-Moussawi
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The progress that covered all areas including the sports field, and in many countries of the world was not coincidental, but adopted those countries many of the elements of progress, and that sport is one of the most important aspects of life and the progress of countries to build human education, physical and mental and so that sport can achieve these goals Less time using modern teaching strategies, and it is known that the skillful defense performance of the student in volleyball is related to learning within the educational institution and is a measure to evaluate the level of skill and defense performance of the learner and scientific achievement, and this investigation largely thanks to the use of the process-based Educational methods and ways and means and activities that help students so, so it could be among the reasons attributed to them this weakness in the technically gifted defensive performance is the continuation of teachers in the use of traditional teaching strategy, despite its effectiveness in certain conditions and situations. The research community determines the students of the fourth stage in the Faculty of Physical Education and Sports Sciences University of Kerbala for the academic year (2017 - 2018) and through the results reached the following conclusions:The use of a distinct learning strategy according to the two modes (sensory-sensory) has an effective effect on the development of the aerodynamic skill of the students.The results showed that there is a preference for the use of a differentiated learning strategy based on the sensory-sensory pattern.Keywords: Education strategy, (Sensory-intuitive) patterns and defensive performance.
Expression relative of RANK, RANKL and OPG gene on Rat Femoral Fracture Healing Process in Delayed Union Model after Pulsed Electromagnetic Field exposure Luluk yunaini
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Pulsed electromagnetic field (PEMF) is application medical devices in healing bone fracture. Osteoblast and osteoclast cells have regulation in femoral fracture healing process. PEMF exposure has effect in cell nucleus activity. Genes that have critical role in bone remodelling are Receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG).This research aimed to analysis effect PEMF exposure in improve bone fracture healing process with delay union model, which its expression level in RANK, RANKL and OPG gene. Our research used experimental design. Sample for this research was callus from rat femoral fracture with delay union. qRT-PCR technique with Livak’s measurement were used to detection expression relative. Statistic analysis used two way ANOVA with a significant differences value p <0.05. The result showed that relative expression on RANK, RANKL and OPG have significance different in PEMF group and times (days) group. We found that the PEMF group can expedite the higher expression relative of RANK, RANKL and OPG than non PEMF group. The result has concluded using PEMF can improve the healing to normal union process on rat with delay union model.
Opportunities for the Prevention of Hypertension by Nutrition Correction Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

AbstractIntroduction. There is much evidence of a relationship between salt intake and blood pressure levels. Limiting sodium chloride consumption significantly lowers blood pressure. The purpose of this study was to study the effectiveness of lowering blood pressure while limiting salt intake in men and women with high and normal blood pressure.Materials and methods. An annual study was conducted, a prerequisite of which was the selection of 2 groups: survey and comparison. They were comparable in terms of gender, age, professional composition and number of participants. To carry out a dietary examination required limiting the salt in the cooking to 0,5 g per serving.Results and discussion. After one year of dietary intervention, a significant decrease in systolic (SBP) and diastolic blood pressure (DBP) was found in men and women in the intervention group (p < 0,05) compared to the control group, which showed a natural decrease in blood pressure, a significant decrease in blood pressure was observed during the study period (p < 0,05). In addition, there was a significant decrease in body weight in the intervention group compared with the control group.Conclusions. Reduced salt intake significantly reduced SBP and DBP in men and women with high blood pressure over a longer follow-up compared with the control group.
Effect of Growth Regulators and Irradiation and Methyl Jasmonte in the Induction and Production of Flavonoids in Callus of Vitis Vinifera In-Vitro Sarab, A. Almukhtar
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Plant tissue culture technology was used in the induction of callus from the node of the Vitis vinifera and thus stimulated to increase the production of flavonoids. The study was carried out in three stages after the sterilization of the explant: The first consisted of the establishment of callus cultivars by culturing the node on the MS medium, which is equipped with different concentrations and types of growth regulators. The second stage was performed by exposing the induced callus tissue to different doses of gamma radiation, while the third stage was performed by Cultivation the irradiated and unirradiated callus on the MS medium which was provided with different concentrations of methyl Jasmonate. The results of the study showed that auxien 2, 4-D had the highest wet and dry weight of (1817.20 and 94.38) mg respectively, while NAA achieved a wet and dry weight of (677.02 and 71.16) mg respectively, The concentration of 2.5 mg / L of auxien resulted in the highest rate of wet and dry weight of callus of (1991.75 and 124.75) mg, respectively. The irradiation treatment was significantly higher in the concentrations of Gintestnic, Rutin, Quercetin, Proanthocyanin, Nargnine, and Hesperdine of (133.08, 149.44, 157.82, 48.03, 89.42, and 72.75) and μg / g respectively were significantly higher than those obtained from the comparison treatment which achieved the lowest concentration rates. Keywords: Callus, flavonoids, grapes, methyl Jasmonte, irradiation.
Sperm Detection in Congenital Ejaculatory Duct Cyst Repair: A Case Report Ahmad Ricardo Silalahi
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Ejaculatory duct cyst is a very rare case. We report a 26-year-old man with primary infertility complaining of aspermia since before marriage, precisely since the first wet dream. General physical examination and hormonal levels were in normal values. The cyst was visualized through abdominal TRUS, MRI and abdominal ultrasound (USG). The sperm detection test was performed before and after repaired by TURED. Before repair, the sperm was absent at Cowper’s gland secretion, post orgasmic urine and post massage prostate. After repair, sperm was detected in cyst aspiration fluid and useful to distinguish ED cyst between the Mullerian duct and utriculus cyst. In addition, after one month post repaired, the sperm concentration, motility and morphology increased. The improvement of sperm quality is useful to determine the infertility program whether IVF, IUI or natural pregnancy.Keywords: Ejaculatory duct cyst, Male infertility, Sperm detection.
Alleviation of Oxidative Stress and Suppression of Inflammatory Cytokines in STZ -induced Diabetes by Banana (Musa paradisiacal), Kiwi (Actinidiadeliciosa planch) and Olive (OleaeuropaeaL.), by-products, Extract: Comparative Study Hanan F. Aly
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The effect of peels (kiwi, banana and leaves (olive and banana)acetone extract 80%on streptozotocin (STZ) induced diabetic rats was investigated. Oral administration of 500 mg crude extract /kg body weight for 30 days post induction of diabetes, showed remarkable improvement in all biomarkers under investigation compared to standard drug. Olive leaves showed the highest percentage of improvement in glutathione (GSH), nitric oxide, (NO), glutathione peroxidase (GPX) glutathione –S-transferase (GST) ,catalase, lipid peroxide (MDA) , urea  ,creatinine, tumor necrosis factor- α(TNF-α) interleukin 1β(IL1-β)  (41.74,138.68, 48.77, 26.15, 27.84, 73.54, 97.92, 81.37, 52.96 and 40.24% , respectively).While, banana leaves and kiwi peels extracts showed the highest percentage of improvement in antioxidant enzyme paraoxonase (PON1) and transforming growth factor β(TGF β)reached  16.90 and 41.81%, respectively. From a histopathological point of view, treatment of diabetic rats with different extracts revealed regeneration and amelioration effects of extracts on the pancreas and renal tissues in diabetic rats and apparently normal. It could be concluded that the anti-hyperglycemic properties of plant extracts may offer a potential therapeutic source for the treatment of diabetes. Further work on isolation and characterization of active constituents in these wastes is needed.Keywords: Diabetes, Inflammatory cytokines, Antioxidant, Oxidative stress.
Diagnosis and Management of Interventional Endovascular Carotid-cavernous Fistula: a Retrospective Study Luh Putu Lina Kamelia
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Carotid-cavernous fistula (CCF) is a consequence of incremental intracavernous pressure. The direction of drainage is usually multidirectional. Initial DSA (digital subtraction angiography) solves in obtaining its information along with advanced technology nowadays. Aim: The study aims to analyze clinical characteristics, cerebral angiographic features, and management of endovascular embolization of CCF. Methods: The study is a retrospective analysis of each patient diagnosed with CCF. They were treated with endovascular embolization from January 2019 to April 2010 at the Brain Center Dr. Wahidin Sudirohusodo (DWS) General Hospital Makassar. We performed DSA on all patients before the endovascular procedure with catheterized access through the right femoral artery. Result: Angiograms of all patients showed typical CCF lesions, 8 patients then received endovascular management by coiling method, 2 were treated with a detachable balloon, while 1 received an Onyx injection. All patients experienced gradual improvement for orbital symptoms. Conclusion: Endovascular embolization-followed cerebral DSA is a useful diagnostic and therapeutic management to improve patients' clinical symptoms with CCF. Keywords: Carotid-cavernous fistula, Digital subtraction angiography, Embolization, Balloon, Onyx.
Hospital-Acquired Urinary Tract Infection, Microbial Causative Agents and Antibiotic Resistance Pattern in Southern Iran: A Prospective Study Farzaneh Dehghan
Journal of Global Pharma Technology .
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Abstract

Background Objective: Antimicrobial resistance is a problem in hospital-acquired urinary tract infection (UTI), and is the most frequent nosocomial infection. This study was carried out to determine the prevalence of Hospital-acquired Urinary Tract Infection (HAUTI)  a etiological microorganisms and their antimicrobial resistance to commonly used antibiotics. Methods: This cross-sectional study was performed in a referral state general hospital in Bandar abbes, Southern Iran between January, 2014 and December, 2015. All cases   admitted to the different wards   of Shahid Mohammadi Hospital and recognized as symptomatic and asymptomatic   HAUTIs, after 48 h of admission, and those who were readmitted to the hospital because of a UTI up to 48 h after discharge from the hospital were included as the targeted population. According to the checklist, the risk factor and demographic information of these patients were recorded. The identification of isolated microorganisms was done by standard microbiological test, then antimicrobial susceptibility testing of all bacterial isolates was performed by disk diffusion method and statistical analysis was done using SPSS software version 20.0.Results In this study, 1.57% of the 19,768 hospitalized patients   acquired   HAUTI. The most commonly isolated gram negative bacteria  are Escherichia coli 26.7%(82), followed by Acinetobacter baumannii  15.3%(47) and among gram positive organisms, it was Candida spp 23.5%(72). Gram negative bacteria were most resistant to Ceftriaxone, non-fermented bacteria were most resistant to Cefazol in, Cotrimoxazole and Nalidixic acid, Staphylococcus spp were resistant to Ampicillin, Enterococcus fecalis was resistant to Gentamicin and Nalidixic acid while Streptococcus agal actie did not show any resistance pattern .Conclusions The results of this study are indicative of a big challenge about the prevalence of multi-drug resistant bacteria in the studied hospital that limits therapeutic options, if infection con­trol policy and continuous monitoring of ESBL bacteria are not used.Keywords: Antibiotic resistance, Hospital-acquired Urinary Tract Infection.
Synergistic Effect of Pectinolytic and Proteolytic Enzymatic Clarification on Cantalopue Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Cantaloupe is consumed worldwide thanks to its sweetness, juicy taste, pleasing flavor, and nutritional value. It’s highly perishable under ambient condition if fresh consumption cannot move quickly. It’s urgent to process this therapeutic fruit in industrial scale. In fact, it can be processed into different products including functional juice. Clarity in fruit juices is desirable to make it useful in international standard. Objective of this study focused on the effectiveness of various processing variables affecting to cantaloupe juice turbidity and clarity. In our research, a mixture of pectinase and protease in different concentration (0.03%:0.07%, 0.04%: 0.06%, 0.05%:0.05%, 0.06%:0.04%, 0.07%:0.03%), holding temperature (26, 28, 30, 32, 34oC), holding time (45, 60, 75, 90, 105 min), pH (4.3, 4.5, 4.7, 4.9, 5.1), agitation (250, 500, 750, 1000, 1250 rpm) were examined. Carotenoid (µg/g), flavonoid (g/L), turbidity (NTU) and viscosity (cP) were key indicators to determine the optimal treatment. Our results showed cantaloupe fruit juice would have the best carotenoid, flavonoid, clarity as well as viscosity  by treatment of pectinase: protease ratio concentration 0.06%: 0.04%, temperature 20oC in 75 min at pH 4.7 with agitation 1000 rpm. Synergistic effect of the combined usage of pectinase and protease enzymes was clearly demonstrated. From this finding, the added value of cantaloupe juice would be improved in storage as well as commercial distribution without any worry about haze cloud.Keywords: Cantaloupe, Juice, Pectinase, Protease, Carotenoid, Flavonoid, Turbidity, Viscosity.

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