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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Effect of Thymus Vulgaris Extract on Smooth Muscle Relaxation of Guinea Pig Aortic Ring: Study In Vitro Muhammad Basheer Abdullah Alsubbi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Objective: Hypertension appears to have a complex association with endothelial dysfunction. One of herbs that potential to develop as anti hypertension is Thymus vulgaris which contains high concentrations of phenols, including thymol and carvacrol that offer protection from hypertension. This study aimed to prove the correlation between different concentration of Thymus vulgaris extract and response of aortic ring relaxation. Methods: Using a laboratory experiment (in vitro study), treatment with provision doses of Thymus vulgaris extract was conducted to guinea pig (aorta ring) after pre-contracted by phenylephrine (PE). Thymus vulgaris extract (TM) at the doses of 0.0625, 0.125, 0.25, 0.5 and 1% were administered to experimental groups including 5 doses of extract with intact aorta rings and 5 doses of extract with denuded aorta rings. Pearson correlation test and T-test were used to analyzed the data. Results: The results indicate that administration of Thymus vulgaris extract can decrease the contraction of aorta guinea pig. Different doses of Thymus vulgaris extract have different relaxation responses of smooth muscle cell in aortic rings of guinea pig. The lower concentrations doses of Thymus vulgaris extract (0.0625% and 0.125%) can cause an effective and better relaxation effect on contraction of smooth muscle in denuded aorta than in intact aorta. Conclusion: The higher concentrations doses of Thymus vulgaris extract (0.025%, 0.5% and 1%) can increase the contraction of smooth muscle for both intact and denuded aorta of guinea pig.Keywords: Thymus vulgaris, intact aorta rings, denuded aorta rings, phenylephrine 
Effect of Thyroxine Tablets Treatment on the Oxidative Stress in Hypothyroid Women Al-Shimaysawee Sadeq
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Objective: Although some researches informed increased oxidative stress (OS) in hypothyroidism, the influence of treatment with levothyroxine is did not considered widely. Hence, we directed this article to examine the influence of levothyroxine therapy on oxidative stress in hypothyroid women. Methods: The current study included 42 women hypothyroid patients treated with thyroxine& 25 untreated in addition to 40, age matched healthy females used as a control group. The thyroid function test, serum reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferases (GST) levels were measured. Results: The results showed that serum GSH level revealed significant increases in hypothyroid untreated patients. In contrast, GSH treated level showed nonsignificant increases when compared with those of the control group, but the results of CAT levels failed to indicate significant variation in the two groups while the serum GST level revealed significant decreases in hypothyroid untreated patients in contrast, GST treated level showed nonsignificant increases when compared with those of the control group. Highly significant (p<0.01) positive correlation was obtained for GSH levels with thyroxine in treated hypothyroid women whereas CAT levels failed to exhibit significant correlation with throxine tablets treatment also Significant (p<0.05) positive correlation was obtained for GST levels with thyroxine in treated hypothyroid women. Conclusions: Hypothyroidism is associated with elevated oxidative stress and thyroxine tablets are modulate the oxidative stress in treated hypothyroid women patients. Keywords: Thyroxine Tablets, Oxidative Stress, Hypothyroid Women.
In-vitro Antioxidant and Cytotoxic Activities of Silver Nanoparticles of Mangiferin Isolated from Mangifera indica Mahendran Sekar
Journal of Global Pharma Technology Volume 11 Issue 06 (2019) June 2019
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The present study aimed to synthesize mangiferin AgNPs and evaluate its in vitro antioxidant and cytotoxic properties. Mangiferin AgNPs was prepared using silver nitrate solution and characterized by SEM and Zeta potential measurement. In-vitro antioxidant and cytotoxic studies of mangiferin and its AgNPs were conducted by using DPPH and MTT assay method, respectively. The synthesized mangiferin AgNPs with particle size ranges from 25.30 - 40.79 nm. The charge of mangiferin AgNPs were confirmed by Zeta potential and found to be −33.7 mV. Mangiferin AgNPs showed 90.43 ± 1.90 % of inhibition at 500 µg/ml and the activity was well comparable with mangiferin in DPPH method. Mangiferin AgNPs exhibited significant reduction in cancerous cell growth when compared to Mangiferin in all the tested concentrations ranges from 10-100 µg/ml. This results representing that the mangiferin AgNPs was a capable nanocarrrier for distributing mangiferin to cancer cells. In future, mangifrin AgNPs will be further tested with other cancer cell lines to confirm its safety and effectiveness.
A Seventeen-year-old Boy Patient with Lupus Nephritis as a Complication of Systemic Lupus Erythematosus (SLE) at Sanglah General Hospital, Bali, Indonesia: a Case Report Anak Agung Ngurah Subawa
Journal of Global Pharma Technology Volume 12 Issue 01
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Background: The systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations. SLE indicated by the presence of autoantibodies to the nucleus components and immune complex deposits. Prevalence ratio of SLE is higher in women than in men, but male patients seem to have a higher frequency of symptoms and more aggressive disease. So, this case study aims to evaluate A seventeen-year-old boy patient with lupus nephritis as a complication of Systemic Lupus Erythematosus (SLE) based on laboratory evaluation. Case Description: A seventeen-year-old male patients referred to the emergency department in Sanglah General Hospital with swelling on both eyelids and legs for two weeks before admission. The patient has high blood pressure, discolouration of urine and significant weight gain about 14 kilograms in two weeks due to swelling. Several examinations performed and the results were indicating anaemia, proteinuria, hematuria, hypoalbuminemia, high BUN and creatinine level, hyperkalemia, hyperphosphatemia and high titer of ANA-IF and anti-ds-DNA level. The patient diagnosed with lupus nephritis and treated with antihypertension and diuretic. Conclusion. The most common complication of SLE is lupus nephritis, and its prevalence varies significantly by region, race and tribe. Although overall improvements in the treatment of SLE patients have increased in kidney survival rates, the prognosis remains unsatisfactory. Early detection and diagnosis should be done so that the patient’s condition worsens not occur because the late diagnosis of LN can increase the risk of End-Stage Renal Disease.Keywords: Autoimmune Disease, Lupus Nephritis, Systemic Lupus Erythematosus. 
The Gap Analysis and Measurement of Customer Satisfaction in the Delivery of Services in Isfahan Province Gas Company Based on Parasuraman Model Abdol Ali Keshtegar
Journal of Global Pharma Technology .
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One of the indicators of efficiency of administrative system in developed countries is improving the quality of services offered to the citizens. One of the appreciable indices of public satisfaction is customer’s satisfaction with the delivery of services by the same organizations.This research’s design is to fulfil the intentions of the companies, which is to obtain the relative satisfaction and to receive valuable feedbacks of subscribers. The methodology of this study is surveyand is conducted as an applied research. The population of this study consisted of all households covered by the gas company in Isfahan province, which is equal to 191152 households. Sampling in this study is random cluster sampling and questionnaire and library resources are two major methods which are used to gather information and data. Statistical methods and data analysis methods to measure customer satisfaction are CSM,descriptive and inferential statistics using SPSS, and performing adaptive comparisons of the results obtained fromthe homes and offices and results of honoring client. Some of the main questions raised in this research are: optimum level of service received from Isfahan Province Gas Company and the average satisfaction with the service received? Time span of receiving service of Isfahan Province Gas Company (in minutes or days) and consistence with the standard time to service delivery? After the necessary calculations results were as follows: The results showed that in the majority of cases, the provision of services by the gas company is proportional to the standard time. Due to the lack of familiarity with the standards of work time, in most cases it is possible that the services provided in standard time be realized, but the customer satisfaction with the service received is still not so high.Keywords: Satisfaction, service recipients, Isfahan Province Gas Company, CSM.
Hepatoprotective Potentials of Menaquinone - 7 against Doxorubicin Associated Hepatotoxicity Ruaa F. A. Al-Zubaidi
Journal of Global Pharma Technology .
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Abstract

Dox, is still widely used in modern cancer treatments for different type of malignancy despite the advent of targeted therapy. However, its beneficial effect was limited by its toxicity on various organs. The objective of this study was to investigate the hepatoprotective effect of menaquinone-7 against hepatotoxicity induced by doxorubicin in rats. Sixty adult rats of both sexes were used in this study; the animals were randomly enrolled into six groups of 10 animals each. Group I: negative control; Group II: Menaquinones-7 at a dose of 16µg/kg; Group III: Menaquinones-7 at a dose of 48µg/kg; Group IV: positive control (Doxorubicin 15mg/kg); Group V: Menaquinones-7 at a dose of 16µg/kg administered prior to a single dose of Doxorubicin 15 mg/kg; Group VI: Menaquinones-7 at a dose of 48 µg/kg administered prior to a single dose of  Doxorubicin 15 mg/kg. On day twelve of the study, the liver of each animal was excised for homogenate preparation and estimation of malondialdehyde, total antioxidant capacity and caspase-3 by ELISA technique as the markers of oxidative stress and apoptosis respectively. High dose of Menaquinones-7 significantly (P<0.05) decreased malondialdehyde content, and increase total antioxidant capacity content in group VI compared to group IV. However, neither group V nor group VI exhibited significant (P>0.05) differences in caspase-3 activity in liver tissue homogenate compared to positive control group. Menaquinones-7 may have hepatoprotective effect against doxorubicin-associated hepatotoxicity in rats.Keywords: Menaquinone-7, Doxorubicin, Hepatotoxicity, Rats, Tissue homogenate.
Biological Activity Study of Schiff Base ligands and their Complexes: A Review Lekaa K. Abdul Karem
Journal of Global Pharma Technology Volume 11 Issue 05.
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Schiff  Bases (SB)  stand for  multipurpose  ligands  created  from  prime  amines  condensing  with carbonyl groups. These represent imperative compounds in pharmaceutical and medical domains as a consequence of their widespread spectra of organic performances. The majority of them exhibit antibacterial, antifungal and antitumor activities. Transition metal compounds based on biological SB ligands were extensively investigated. This study reviews the synthesizing and organic activities of SB and its complexes. Keywords: Metal complexes, Schiff Bases, Antitumor activity, Antimicrobial activity, Nonlinear optical properties.
Optimization and Validation of the Simultaneous Determination of Vildagliptin and Metformin, in Bulk and Formulation by A Reverse Phase HPLC Method Using D-Optimal Experimental Design K Balamurugan; Kirtimaya Mishra
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
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This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti-diabetic drugs Vildagliptin (VLD) and Metformin (MET).The optimization of the HPLC methodology included several variables, of which the impacts of each was studied. After a sequence of preliminary-screening experiments, the composition of the mobile phase and the pH of the added buffer solution were set as the examined variables, while the capacity factor (K1) of first peak i.e Metformin (MET), resolution (Rs) between Vildagliptin (VLD) and Metformin (MET), Separation (S) for both the drugs and the retention time (Rt2) of the second peak i.e Vildagliptin (VLD) were chosen as the dependent variables. Using the D-optimal design, the ideal chromatographic conditions for the separation were identified. The technique proved to show good harmony between the experimental data and predictive values throughout the studied parameter range. The optimum assay conditions were carried out with a Onyx C18 Monolithic column (100mm× i.d., 5µm) connected with an Onyx C18 guard cartridge (4mm×3mm i.d., 5µm) and a mixture of methanol (MeOH)/acetonitrile (ACN)/potassium dihydrogen orthophosphate (KH2PO4) (pH 4, 0.003 mol L−1) (31.362:10:58.638, v/v/v/v) as the mobile phase at a flow rate of 0.4 mL min−1 and detection wavelength of 220nm. The run time was under 8 min, which is a lot shorter than the prior optimized methods. The improved analytical method was validated as per FDA guidelines.
The Role of Quilting Technique of Mastectomy Flap in Prevention and Reduction of Seroma Complication in Breast Cancer Patients Mohend Abbass
Journal of Global Pharma Technology .
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Background: Seroma remains an unresolved problem Post mastectomy surgery and several techniques have been reported to prevent or decrease this complication. The aim of this study is to evaluate effectiveness of Quilting or tacking mastectomy flap in preventing or reducing seroma formation.  Patients and Method: This hospital-based prospective cohort study included patients with diagnosed breast cancer between December 2010 and December 2016. Mastectomy with axillary clearance surgery was done for them. Socio-demographic Characteristics which include age, BMI, smoking history and family history of breast cancer were taken for all patients. Data were collected on the day of surgery and followed for two weeks postoperatively. Patients were divided in two groups according to the technique of closure of mastectomy flap . Non quilting technique was done to the first group of patients between December 2010 till January 2014 and the quilting techniques were done for second group of patients between February 2014 till December  2016. Primary outcome were the presence of Seroma complication and the amount of fluid collection that require aspiration. Secondary outcome were the mean differences of fluid drained by the drainage system, time to remove drain, stage of disease, level of axillary clearance, distribution of patients according to type of malignancy, Oestrogen receptor, progesterone receptor and Her2 /Neu receptor status. Result: During the study period between December 2010 and December 2016, 82 Patients with diagnosed breast cancer were included in this study. Majority (84.1%) of patients presented with Invasive ductal carcinoma. There was significant association between type of operation and  presence of seroma, more seroma occur among patients treated with Non quilting technique (46.8%) in comparison to quilting technique (20%)  (P- value 0.012) and more time needed to remove drain among patients treated with Non quilting technique (with mean 5.74 days) in comparison to quilting technique (with mean 4.74 days). There were significant differences between means of amount of aspiration among patients with seroma (n=29) by study groups, more amount of aspiration among patients treated with Non quilting technique (with mean 144.54 ml) in comparison to quilting technique (with mean 60.71 ml). There was significant association between presence of seroma and BMI (P- value <0.001) and level of clearance (P-value 0.021) and no association between presence of seroma and Smoking, family history and stage of disease. Conclusion: Quilting or tacking mastectomy flap to the underlying muscles and fascia to obliterate the surgical dead space is effectiveness in prevention and reduction of seroma formation.Keywords: Breast cancer, Mastectomy flap, Quilting technique.
Administration of Binahong (Anredera Cordifolia (Ten) Steenis) Leaves Extract Fixes Pancreatic β-cell Damage through Lowering Blood Glucose and Advanced Glycation End Products (AGEs) Level in Hyperglycemic Wistar Rat Sri Wahyuni; I Wayan Putu Sutirta Yasa
Journal of Global Pharma Technology .
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Background: Increasing production of free radicals is one of the factors that cause hyperglycemia. Chronic hyperglycemia can increase the production of reactive oxygen species (ROS), resulting in oxidative stress. The aim of this study is to determine the effectiveness of binahong (Anredera cordifolia (ten) steenis) leaf extract in fixing the pancreas β-cell damage rate in alloxan induced hyperglycemic Wistar rat. Methods: This study used randomized pre and post-test control group design. Fifty Wistar rats were divided into two control groups and three experimental groups administered with difference doses of binahong leaves extract; 0.5 mg/kg BW (P1), 2.0 mg/kg BW (P2), and 5.0 mg/kg BW (P3). Hyperglycemic state obtained by inducing the rats with alloxan. Results: The result showed that mean blood glucose levels were decreased in the positive control group (glibenclamide) (185.98 mg/dL) and the experimental groups; P1, P2, and P3 (181.36 mg/dL, 184.61 mg/dL, and 163.36 mg/dL, respectively). The mean differences between P1 and P2 and between P1 and P3 were statistically significant (p < 0.05). The AGEs level for the positive control group (glibenclamide) is 0.224 mol/L and for the experimental groups are 0.219 mol/L, 0.212 mol/L, and 0.188 mol/L for P1, P2, and P3, respectively. The differences were statistically significant. Conclusions: Administration of binahong leaves extract can improve the damage rate of pancreas β-cell through lowering the blood glucose and AGEs level in hyperglycemic Wistar rat and that the effect is significant at the dose of 5.00 mg/kg bw per day.Keywords: Anredera cordiofolia (ten) steenin, blood glucose and AGEs, hyperglycemia.

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