cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 170   171   172   173   174 
Molecular Detection of Per-1 Type Extended Spectrum Β-Lactamase among Clinical Isolates of Klebsiella Pneumoniae in Baghdad Hospitals Buthainah Mohammed Taha
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study was aimed to determine the presence of PER-1 type Extended-Spectrum β-Lactamases (ESBLs) in clinical isolates of Klebsiella pneumonia in Baghdad. During a period extended for three months ((July- September, 2014), 26 clinical K. pneumoniae isolates were collected from two hospitals in Baghdad (Fattima-AL-Zahra hospital for pediatric and obstetric and Baghdad Teaching Hospital). Out of these 26 isolates, 11 isolates from blood, 7 from urine, 6 from sputum and 2 from wound. All isolates had 100% resistance to ampicillin and cefazolin while the most effective antibiotics were imipenem and meropenem with high sensitivity rate (92.31%). Out of 26 K. pneumoniae isolates, 17(65.38%) isolates were positive ESBL producing isolates phenotypes and 9(34.62%) isolates were negative ESBL producing isolates (non ESBLs) .Genotypic Detection of blaPER-1 gene by polymerase chain reaction showed that out of all seventeen ESBL-producing K.  Pneumoniae isolates by phenotypic detection, 6 isolates (13.8%) were contained blaPER-1 gene (925bp).Keywords: Klebsiella pneumonia, Blaper-1 gene, Extended-spectrum β -lactamases (ESBLs).
Netherton Syndrome in Combination with Iron-deficiency Anemia Ekaterina Orlova
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Netherton syndrome (NS) is a rare severe autosomal recessive disorder of cornification characterized by a triad of symptoms: congenital ichthyosiform erythroderma, trichorrhexis invaginata and an atopic diathesis with elevated immunoglobulin E (IgE). Skin surface recovered in the background of IDA correction with iron preparations and vitamin and mineral complexes. Family history: patient has a 55-year-old uncle with ichthyosis vulgaris and her 4-year-old daughter suffers atopic dermatitis. The patient was treated with systemic steroids (prednisolone solution 90mg per day IV days 1-5; 60 mg per day, days 6-11; 30 mg per day, days 12-15) with marked improvement of the skin lesions in 1, 5 weeks. At the time of discharge from the hospital almost complete regression of eruptions and desquamation was observed, there were some residual effects in the form of post-inflammatory erythema. We present a case of a 29-year-old woman with Netherton syndrome, primarily diagnosed with atopic dermatitis. The iron-deficiency anemia concurrent with gastro-intestinal tract disorder was also observed. Topical corticosteroid therapy showed no clinical improvement. Combined in-depth clinical assessment and genetic testing resulted in NS diagnosis with subsequent successful systemic therapy-intestinal tract. Trichoscopy examination of the scalp hair demonstrated trichorrhexis nodosa, one of the typical NS signs. Initial parameters. HGB: 95.0g/l (normal range 120-140g/l), RBC: 3.451012/l; (normal range 3.7-4.71012/l), Hypochromia: ++ Color indicator: 0.64 (normal range 0.85-1.15), Eosinophils 13%; (normal range 0-5) and serum IgE level of 156 IU/ml (normal range 20-100 IU/ml). Quality blood indicators after treatment are within normal limits or close: HGB level has increased, eosinophils number has decreased, which indicates an almost complete inflammatory process cessation in the body. The main change vital for the body, which the physiological blood indicators depend on, is an increase in iron content (almost 1.5 times). Indicators of toxic substances, such as uric acid, decreased. Each of the patients with Netherton's syndrome requires a strictly individual approach. Emphasis on the advisability of prescribing systemic glucocorticosteroids is also essential, as well as the dosage of aromatic retinoids. In this case, the dosage and prescription of drugs of this type depends on the disease severity, in particular on the pathology’s manifestations on the skin surface.  Genetically caused disease (Netherton syndrome) proceeded against the background of acquired disease (anemia). Our strategy has shown effectiveness, caused by systemic steroids.Key words: Netherton syndrome, Trichorrhexis invaginata, Ichthyosiform erythroderma, SPINK 5, Iron-deficiency anemia.
Production of Curcumin- Dry- Salted Spot-Fin Spiny Eel (Macrognathus Siamenis) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Macrognathus siamensis is a tropical fish founding in the rivers of Southeast Asia. Coming from the natural resource, it flesh has valuable nutrients. Objective of this research focused on the processing of spot fin spiny eel into the curcumin-dry-salted product by salting and drying method. Different technical experiments were investigated such as the effect of salt, curcumin ratio during soaking, temperature of drying, and packaging storage to chemical, microbial and sensory characteristics of the finished product. Results revealed that dry salting was better than wet salting. With addition of 0.75% of curcumin, drying at 50oC in 4 hours, the curcumin-dry-salted spotfin spiny eel products had the good physicochemical, microbiological and sensory characteristics. By preserving under vacuum at 4oC, the curcumin-dry-salted spotfin spiny eel could be maintained shelf-life for 12 months without any deterioration.Keywords: Spot-fin spiny eel, Macrognathus siamenis, Curcumin, Salting, Drying, Vacuum, Shelf-life.
Pregnane-X-Receptor Genotype and Hepatotoxic Incidence on Tuberculosis Patients Receiving Antituberculosis in Bali i gusti ayu artini
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Drug-induced liver injury might lead to serious illness. One of the drugs that potentially toxic to the liver is antituberculosis. Many factors could influence antituberculosis-induced liver injury, including genetic variation. One of such genetic variation is polymorphism of pregnane-x-receptor (PXR) gene. PXR plays a crucial role in the regulation of many drug metabolizing enzymes and drug transporters. The association between PXR polymorphism and hepatotoxic incidence in several studies showed the inconsistent result. Therefore, it’s very important to study the PXR genotype pattern and its relation with hepatotoxic incidence among tuberculosis patients who received antituberculosis treatment. This study aimed to investigate the incidence of hepatotoxic according to PXR genotype pattern among tuberculosis patients who received antituberculosis treatment in Bali. Methods: This study was a cross-sectional study. About 65 subjects were enrolled in this study, selected from tuberculosis patients who attended the pulmonary outpatient clinic of Sanglah Hospital, Bali Indonesia and received the antituberculosis drug. Identification of PXR genotype was performed using PCR/RFLP technique with MboI restriction enzyme. Results: The proportion of wild type and mutant genotype of PXR were 72.3% and 27.7%, respectively. There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR. Conclusion: There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR on tuberculosis patients who received antituberculosis in Bali.
Antiseptic White Honey Liquid Soap Formulation and its Effectiveness against Nosocomial Infections Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa Multiresisten (PaMR) are the main bacteria that cause nosocomial infections. Prevention of MRSA and PaMR transmission can be done by maintaining a clean body through the use of antiseptic bath soap that is sensitive to this bacterium. This study aimed to carry out a white honey antiseptic liquid soap formula that could be useful for killing MRSA and PaMR bacteria. This research was based on laboratory research on white honey as an antiseptic derived from natural ingredients. Organoleptic examination, pH, viscosity, consistency, antibacterial effectiveness for 56 days of storage, then from the evaluation results of the formula was best done a hedonic test. Statistical calculations with fixed random block complete design models were applied for a conclusion of evaluation tests. The results of the test activity of the liquid shower soap showed that all three formulations had activity against the MRSA and PaMR bacteria. Growth Inhibitory Concentration Minimum preparation of antiseptic liquid bath soap was 12.5% w/v. Antiseptic liquid soap with a concentration of 12.5% had a phenol coefficient of 0.4167 for MRSA bacteria and 0.9 for PaMR bacteria. The comparative test results showed that the best formula (F2) activity was 0.859: 1 against MRSA and 0.7167: 1 against PaMR compared to liquid bath soap in the market. The test results showed that the best liquid bath soap formula based on stability and the lowest GICM value was white honey antiseptic liquid soap with a concentration of 12.5% w/v.Keywords: Antiseptic bath soap, Nosocomial infections, White Honey, Methicillin-Resistant Staphylococcus aureus (MRSA), Multiresistent Pseudomonas aeruginosa (PaMR).
The Study Influence of Cigarette Smoke by Using Laboratory Animals in Behavioral Test «Open Field» Mustafa S Rauan
Journal of Global Pharma Technology Volume 9 Issue 11
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: All organs and systems of organs suffer from smoking without exception. On average, a smoker lives 10 years less than a non-smoker. In addition, given the harmfulness of second-hand smoke, there is no clear boundary between the smoker and the non-smoker. In this article we have examined the harm of polycyclic aromatic hydrocarbons as one of the harmful constituents of cigarette smoke. Methods: Depending on the drug and their concentration laboratory animals were divided into three groups. Number of laboratory animals in each group was 10.  For first group was given only water. In second group during 4 weeks we used the passive smoking method. In third group during 4 weeks we used the passive smoking method. During the experiment for the testing animal behavior was used "Open field" method. Results: In conclusion, on the behavioral indicators compared with the second and third group in the control group acts sniffing, stand with support, stand there is a significant prevalence of these indicators. Conclusion: Especially there is a sharp change in performance compared to the third group. This is due to a high state of anxiety in laboratory animals the second and third groups compared with the control group. On this we can talk about the positive impact on the overall recovery of the organisms by the action of the drug Ecdyphyt. Keywords: Polycyclic aromatic hydrocarbons (PAHs), "Open field" method, Behavior of laboratory animals, The drug Ecdyphyt.                                                        
Extraction Flavonoid Compound from Foeniculum Vulgare and Study its Anti-Bacterial Activity Mohanad Jawad Kadhim
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This investigation incorporated the extraction of the flavonoid compound in the fennel plant and the investigation of the natural viability of this compound by secluding it and playing out a few synthetic breaks down, to be specific the utilization of IR spectra, Uv spectroscopy, TLC, Using the shading information of the concentrate. Two distinct kinds of Staphylococcus aureus were watched. We watched the impact of flavonoids on the bacterial separates of positive and negative cumin individually (Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922). The adequacy of flavonoid extricate was observed to have the capacity to repress positive or negative bacteria. The zone of microbes’ hindrance19mm, 20mm.Keywords: Flavonoid, Antibacterial movement, Fennel plant, Foeniculum vulgare, phenolic compound, antimicrobial.
Differentiated Approach to Surgical Treatment of Cholelithiasis Complicated by Choleducholithiasis and Obstructive Jaundice Aliya M. Aitbayeva
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study contributes to solving problems of steady increase in cholelithiasis incidence with high percentage of associated complications, high mortality rate and unsatisfactory outcomes. This study rises from universally recorded increase in the incidence of gallstones, from the prevalence of complicated disease forms, from high mortality rate and unsatisfactory treatment outcomes. This study aims to improve the outcomes of surgical treatment in patients with complicated cholelithiasis who underwent a differentiated surgical intervention. This study analyses treatment outcomes in 140 patients who undergone surgery for cholelithiasis complicated by choledocholithiasis and obstructive jaundice. Patients underwent surgical interventions in a clinical unit under the West Kazakhstan Marat Ospanov State Medical University in 2014/2018. The findings show that a surgical approach towards the treatment of patients via minimally invasive surgery should depend on the severity of obstructive jaundice. Postoperative complications were found in 7.8% of patients in the main group, and the death rate was 1.1%. By contrast, in the control group, 32% had postoperative complications and the death rate was 4%. If differentiated, minimally invasive surgical treatment of cholelithiasis complicated by choledocholithiasis and obstructive jaundice allows avoiding serious complications when correcting abnormalities in the biliary system via traditional laparotomy with a wide incision. These findings suggest that a differentiated approach can significantly improve treatment outcomes in patients with cholelithiasis complicated by choleducholithiasis and obstructive jaundice.Keywords: Cholelithiasis, Choledocholithiasis, Obstructive jaundice, Endoscopic interventions.
Effect of Retention of Results on Patient Satisfaction with Orthodontic Treatment Anton Timoshin
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Currently, the number of requests for orthodontic care has increased significantly. This is facilitated by a number of factors -the technical capabilities of orthodontists, which have grown many times due to technological progress and the ability to provide the necessary assistance at almost any age; the need for an aesthetic result, which is formed under the influence of the media. As a result, there are high requirements for both yourself and your appearance, as well as for the orthodontist. Thanks to new technologies, such as cortical support, it became possible to solve the treatment of dental anomalies, which previously could only be cured by surgery. But at the same time, such an important issue as the retention of the results achieved remains open. We studied the objective parameters that changed as a result of orthodontic treatment (teleradiography orthopantomography, analysis of control and diagnostic models), and compared them with the subjective assessment of patients. We have found that the patient's motivation, desire to cooperate with the doctor, a clear understanding of the treatment goals allows you to get a high-quality result and keep it for a long enough period of time. Keywords: dental anomalies, orthodontic treatment, bracket system, period of retention, treatment planning.
Analyze the Educational Needs of Nurses in Kermanshah Ayatollah Taleghani Hospital in the Case of Preventing Occupational Risks Related to Biological Agents Seyedeh Sara Hosseini
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The most significant occupational injuries among nurses are associated with biological agents which include multiple underlying cases. Therefore, the design and implementation of educational programs with operational objectives and based on needs assessment on prevention of occupational risks can be increasingly effective on maintain and improvement of nursing staff health. Methods: Statistical population of this cross-sectional study includes Kermanshah Ayatollah Taleghani Hospital nurses and a sample of 70 nurses participated in study. Data collection tools included demographic information questionnaires and 10 items related to prevent nursing occupational hazards biological agents. When responses were evaluated, the collected data were analyzed using SPSS18 software, independent t, Spearman and Pearson tests and results were presented in terms of statistical indicators. Results: 30% of participants in study were nurse's aide and 70% were nurses. Two items are introduced as the first priority of educational needs including familiarity with transmissible diseases in wards or hospital and care oneself during disease, injury or skin lesions of hands until complete recovery. In most cases, there was statistically significant relationship between variables and items. Conclusion: Nurses' knowledge on safety rules is more important in prevention of occupational hazards and as a result, application of these principles. In this regard, considering biological agents has been focused and needs assessment of educational planning will be effective on increased participation of nurses in teaching and learning process and will promote their knowledge and skills.Keywords: Nurses, Nurse's aide, Occupational hazards, Biological agents.

Page 172 of 244 | Total Record : 2439

 170   171   172   173   174 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue