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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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A Review of Probiotics Role in Enhancing Sperm Quality Andrian Fahmi Bahar
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Probiotics have been used widely in medical world, but its use in infertility, especially in male infertility, is yet still unbeknown. The aim of this paper is to review the usefulness of probiotics in enhancing sperm quality in order to treat male infertility. Methods: Narrative review on literature surfing in the Pub med database, as well as  key words, that is probiotic, Lactobacillus, sperm quality, male infertility, sperm motility, sperm concentration, sperm morphology, sperm DNA fragmentation. Results: The results on literature surfing are mainly yielding to the positive effect of probiotics in enhancing sperm quality in animals, and in human, although there are some literature that shows conversely. The production of Gamma-Amino Butyric Acid and antioxidants by the probiotics are thought to be the main mechanism for the improvement of the sperm quality, especially in the enhancement of the sperm concentration, motility and the decrease of the DNA fragmentation. Contrarily, negative results left another mystery for researchers to solve. Conclusions: Although the probable mechanisms of probiotics role in enhancing sperm quality have been unveiled, still more researches should be performed to find more evidence in this issue.Keywords: Probiotic, Sperm quality, Sperm motility, Sperm concentration.
Adsorption Ability and Kinetic of (Congo Red, Methyl Green) Dyes on Iraqi Siliceous Rocks Israa Mohammed Tawfeeq
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this study used Iraqi Siliceous Rock powder (SRP) as a suitable surface to study removing of dyes, which are they [Cong red dye (CR) and Methyl green dye (MG)]. Adsorption isotherms and the factors which influence the adsorption process such as temperature and salt effect were studies. Adsorption isotherms of (CR) were found to be comparable to Temkin equation according to Giles classification. Adsorption isotherms of (MG) were found to be comparable to Freundlich equation according to Giles classification. The adsorption process on surface was studies at various temperatures. The results indicate that the adsorption of (CR) on surface decreased with increasing temperature (Exothermic process), while the adsorption of (MG) on surface increased with increasing temperature (Endothermic process). According to above results of thermodynamic functions (ΔG, ΔS, ΔH) were calculated.  The salt effect of adsorption of (CR, MG) dyes at (293 K) were studied .The adsorption quantity for (MG) increasing with increasing the salt solution, while the adsorption quantity for (CR) dye decreasing with increasing the salt solution.  The Kinetics of adsorption process of (CR, MG) dyes on surface were studied. The results were treated according to (Lagergren equation). The Kinetics experimental data properly correlated with First-order kinetic model.Keywords: Siliceous Rock, Adsorption, Congo red Dye, Methyl Green Dye.
Synthesis, Characterization and Biological Activities of New Azo Dyes -Azomethine Compound and Their Metal Complexes Rehab Al-Hassani
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The new ligand (2-thioxo-5-((4-(1-(p-tolylimino) ethyl) phenyl) diazenyl) dihydropyrimidine-4, 6(1H, 5H)-Dione (R1) have been synthesized and characterized by micro elemental analysis, Mass, (1H-13C) NMR, FT-IR, and UV-Vis spectroscopic techniques. (R1) acts as a ligand coordinating with some metal ions Co(II), Ni(II), Cu(II), Au(III) and Pt(IV) generated fife mononuclear metal complexes, represented as [CoR1Cl2(H2O)2] (a) , [NiR1Cl2] (b) , [CuR1Cl2] (c), [Pt(R1)2Cl2]Cl2(d) , [Au(R1)2]Cl3(e) .The Structures of the new compounds were characterized by elemental , FT-IR  and UV-Vis Spectra. The magnetic properties and electrical conductivities of metal complexes were also determined. The antibacterial activity for the (R1) and its metal complexes were studied against two types of pathogenic bacteria (Escherichia coli, and Staphylococcus aureus) Furthermore, the antifungal activity against two fungi) Candida albicans, and Aspergillusflavus (was studied for (R1) and its metal complexes. The anticancer activities of the ligand and their metal complexes have been extensively studied on The La cancer cell line.
Molecular Detection of Par influenza Virus 1, 2, 3 and 4 Serotypes and Immunological Response in Otitis Media Patients in Babylon-Iraq Ayam M. Salih
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

(AOM) occur as a case of viral upper respiratory tract infections in young children. Respiratory viruses and AOM both exhibited seasonal discrepancy. Respiratory paramyxo viruses consist of human par influenza viruses are highly distribution, cause the common of childhood croup, bronchiolitis, and pneumonia.  The study was start from6March 2016 to 20May   2016 fifty  cases of otitis media infection were detect  inpatient’s admitted  to AL- Hilla teaching hospital in Babylon - Iraq. Ear swabs and nasopharynx secretion specimens were collected for studies the viral infection detection. The results display the percentage of parainfluenza virus in AMO 22(44%) was positive from fifty cases. The results also show percentage of parainfluenza virus one; two, three, and four types   were   27.2%, 22.7%, 31.8% and 18.1% respectively the study include measurement of IL-6 cytokine by using ELISA assay. Results show elevation level of IL-6 in sera of otitis media patients comparative with control group. The highest level of IL-6 in male occur in (>5-6 year) age group it was 218.39 Pg/ml .The result also shows elevation of IL-6 level in female The highest level of IL-6 in female occur in (>6-7 year) age group it was 209 Pg/ml. Result shows significant differences comparative with control group (P ≤ 0.05).Keywords: Otitis media, Ear swabs, Nasopharyngeal secretion, Parainfluenza virus, Cytokines. 
Synthesis and Spectroscopic Studies of Some Heterocyclic Compounds (Oxazepane -4, 7-Dione, Azetidin-2-one) Derived from 2-Chloro -1, 8-Naphthyridine-3-Carbaldyhyd and Studying their Bacterial Activity Khamaael M. Fayyadh
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Some new 2-chloro -1,8-Naphthyridine-3-carbaldyhyd  (K1) has been synthesized using N-acetyl-2-amino pyridine with through Vilsmeier-Haack cyclization to  preparation the compounds of Synthesis of  3-chloro-4-(2-chloro1,8-Naphthyridine-3-yl)-1-phenylenazetidin-2-one by ring closer reaction through the reaction of the compound (K5-7) with chloro acetyl chloride in presence of drops of tri ethyl amine in 1,4-dioxane ,andas has been prepared (R) 2-(2-chloro1,8-Naphthyridine-3-yl)-1-phenyl-1,3-oxazepane-4,7-dione from reaction the compound (K8-10) with  of Malic anhydride ,The newly synthesized compounds were characterized by spectroscopic evidences such as IR and 1H NMR. The synthesized compounds were screened for their in vitro antibacterial activity, compounds were shown good activity.Keywords: 1, 8-naphthyridine, Vilsmeier-Haack, Azetidine, Oxazepane-4, 7-Dione.
Analytical and Theoretical Studies of Some Diazo Dyes Hanan M. Ali
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Analytical studies were carried on diazo dyes that characterized 4,6-bis((E)-(3-nitrophenyl)diazenyl) benzene-1,3-diol (1), 4-((E)-(3-nitrophenyl)diazenyl)-6-((E)-(4-nitro phenyl)diazenyl)benzene -1,3-diol (2), 4-((E)-(2-nitrophenyl) diazenyl)-6-((E)-(3-nitro phenyl)diazenyl)benzene-1,3-diol (3) and 4,6-bis((E)-(2-nitrophenyl) diazenyl)benzene-1,3-diol (4). The results of the solvents effects and the pH effects were showed high solubility of these dyes in ethanol and the suitable pH values were found to be in the pH 12. Three isopiestic points were gained in the results of the azo dyes (2), (3) and (4). Add to which, the ionization (pKa) and the protonation (pKb) constants were calculated by using the half height method. The results were showed that the pKa1 values were absence intheresults ofdiazo dyes (3) and (4). Theoretical studies also approved the structures of diazo dyes (1), (2), (3) and (4). These studies were focused in the relation between the structure and the properties of these molecules. Due to the internal coordinate mechanics (ICM), the conformational analysis, the molecular mechanics (MM2) and the optimal minimization were attended for each azo dye.Keywords: Azo dyes, Internal coordinates, Conformational analysis, Molecular mechanics, Ionization constant and Protonation constant.
Think Pair Share (TPS) Method Improves Knowledge and Attitude of School-Age Children in Vegetable Consumption Praba Diyan Rachmawati
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

School-age children need vegetable consumption to meet optimal growth and development needs. However, it remains a challenge to ensure the need of adequate quantities of vegetable consumption. The Think Pair Share (TPS) method may offer the solution of this problem. The aim of this study was to analyze the effect of applying health education with a think pair share on the knowledge and attitudes of school-age children in vegetable consumption. This study used a pre-experimental research design. The population in this study was  40 students at a fourth-grade elementary school and employed total sampling technique. The independent variable was health education with a think pair share learning method, while the dependent variables in this study were knowledge and attitudes. Instruments in this study were questionnaires of knowledge and attitudes. The data were analyzed using Wilcoxon Sign Rank Test statistical test  with significance α≤0.05. The results of the statistical tests showed significant effect on knowledge (p=0.000) and attitude (p=0.000) of children in consuming vegetables. Think Pair Share method can increase the knowledge and attitude of children in vegetable consumption. Future studies may consider using this method as a medium of health education to increase vegetable consumption in school-age children.Keywords: Attitude, Knowledge, Think pair share, Vegetable consumption.
The Role of Meta-Cognitive, Dysfunctional Cognition and Early Maladaptive Schemas on Obsessive Compulsive Disorder Fatemeh Rezaei
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

This study aimed to examine the mediating role of meta-cognitive and dysfunctional cognition in the relationship between early maladaptive schemas and obsessive-compulsive disorder (OCD). The study participants consisted of 600 staff of Khuzestan Steel Company (KSC). They filled out the following questionnaires: Obsessive-Compulsive Inventory-Revised (OCI-R, Obsessive Beliefs Questionnaire-44 (OBQ-44), Dysfunctional Attitude Scale (DAS), Young's 90-item Early Maladaptive Schemas Questionnaire, Meta-Cognitive Belief Inventory and Negative Automatic Thoughts Questionnaire (NATQ). The results indicated that the proposed model has an acceptable fit (RMSEA=0.078). According to this model, early maladaptive schemas directly and indirectly predicted the OCD (β=0.93, P<0.0001) through metacognitive beliefs (CI= 0.18-0.09) and dysfunctional cognition (CI= 0.31-0.14). It was also revealed that dysfunctional cognition is mediating between early maladaptive schemas and the OCD (CI= 1.14-0.13). This study illustrated that the early maladaptive schemas restrain the surface cognitive processing. Therefore, it is recommended that the early maladaptive schemas, metacognition, and dysfunctional cognition are attended to treat the OCD.Keywords: Early Maladaptive Schemas, Meta-cognitive, Dysfunctional Cognition, Obsessive-Compulsive Disorder.
A Review on the Most Important Medicinal Herbs Native to Iran with Anti-Acetaminophen Toxicity Mahmoud Mirhosseini
Journal of Global Pharma Technology Volume 08 Issue 11
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Abstract

Acetaminophen is an analgesic and anti- fever drug, which can be toxic in high doses and leads to hepatic and renal injury. Acetaminophen poisoning can cause many complications and injuries in the body including vomiting, diarrhea, malaise, shock, jaundice, and liver failure and in some cases will lead to myocardial and kidney damage. Against all toxic and destructive effects of drugs like acetaminophen, some compounds are found that can partially restrain poisoning of abuse such compounds. In this review article, medicinal plants native to Iran have been reported, which are used to protect acetaminophen toxicity. In this review study, searching the articles with key words such as acetaminophen, hepatotoxicity, herbs, extracts, and essential oils were used. Searching the articles was conducted through databases of income in Iran like Google Scholar, ISI January, MegaIran, and a number of other databases. Medicinal plants including green tea, turmeric, cress, dandelion, and capers are the most important medicinal plants against the toxicity of acetaminophen. It seems that pharmacological bioactive and antioxidants substances obtaining from plant and biological materials are anti- acetaminophen poisoning.Keywords: liver, Toxicity, Acetaminophen, Herbs, Iran.
Chemical Modification of Chitosan for Metal Ion Removal Zakia S. Mohsin
Journal of Global Pharma Technology .
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Abstract

This study is interested with a significant application of surface chemistry in the fields of treatment of pollution. It deals with adsorption systems of chemical pollutants(some heavy metal ions) on surface (modified chitosan).Atomic absorption spectrophotometry technique have been used to results adsorption data at different conditions of (contact time, pH).Chitosan were modified from benzoyl chloride reaction with ammonium thiocyanate and then its resulting composite reactor with carboxylic acids at room temperature, the  chemical structures  of modified polymer was to elucidated using FTIR and 1HNMR. Chitosan modified compounds have been evaluated as a good material for adsorption of heavy elements in water solutions.

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