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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Molecular Characterization of AmpC Beta-Lactamase Gene Producing Carbapenem-Resistant Klebsiella Pneumoniae from Hilla River Waters-Iraq Fatima Moeen Abbas
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

This study was carried out to identify the prevalence of blaAmpC  producing Klebsiella pneumoniae isolated from surface waters of Hilla River. During the period from January to April 2015,one hundred and one water samples were collected from 10 various locations of Hilla river. Thirty five (34.6%) isolates were specified as K. pneumoniae. All K. pneumoniae isolates were subjected to antibiotic susceptibility testing using Kirby-Bauer disk diffusion method. The higher level of resistance was observed for penicillin antibiotics (ampicillin and piperacillin) with (57.14%) and (54.28%) resistance rate, respectively. Cefoxitin resistant isolates were checked for AmpC β- lactamase production phenotypically using modified three dimensional tests. Four (25%) isolates were screen-positive. Carbapenem resistance was identified in 2 isolates of K. pneumoniae, these were analyzed further by Polymerase Chain Reaction (PCR) assay for detection blaAmpC gene, 2 (100%) isolates gave positive result.Keywords: Klebsiella pneumoniae, AmpC β-lactamase, Carbapenem resistance, PCR, River water.
MODELING OF HUMAN CASPASE-5 PROTEIN AND DOCKING STUDIES OF CASPASE-5 INHIBITORS AGAINST MODELED CASPASE-5 Haripriya Munipalli
Journal of Global Pharma Technology Volume 02 Issue 07: (2010) July 2010
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Abstract

The present study is aimed at building human caspase-5 protein structure by homology modeling. Human interleukin-1 beta convertase P20 (1RWN) and human caspase-1 (3E4C) crystal structures from blast results were taken as caspase-5 structural relatives (from protein data bank). The former showed 58% and the latter, 57% sequence identity with the target caspase-5 protein. The 3D-model was generated by using modeler in Accelrys discovery studio 2.5. The energy refinement was also been carried out in the modeler protocol. The Ramachandran plot showed 89.1% of residues in the favorable region. Further, binding site analysis was done to decipher the interacting residues at the active site region of the modeled protein. Then, docking of Pyrazinone mono amide analogues, peptide aldehydes, substituted P4 aryl sulfonamides on a pyridine scaffold analogues, P1 aspartyl ketone derivatives on a pyridine scaffold analogues and a P3 sulfonamide-modified thiophene derivatives against modeled human caspase-5 protein were performed using ligandFit. The results showed that Cys161, Arg55, Val214 and His113 were found to be among the interacting residues of caspase-5 with all the types of inhibitors. These 4 residues of caspase-5 active site were found to be interacting with the crystal ligand (copied from 1RWN) also. The dock scores of P4 aryl sulfonamides on pyridine scaffold analogues and P1 Aspartyl Ketone derivatives on Pyridine Scaffold analogues were higher indicating their high activity against caspase-5 compared to that of pyrazinone monoamide analogues and tetra peptides.Keywords: 1RWN; 3E4C; Ligand Fit; Human Caspase-5; Homology Modeling; Ramachandran Plot
Frap Assay and Nitric Oxide Free Radical Scavenging Activity of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: Oxidative stress resulting from accumulation of reactive oxygen species has been associated with disease. Research study was undertaken to investigate and evaluate the in vitro antioxidant activities such as FRAP and Nitric oxide of ethanolic extract of cordia obliqua.Methods: The ethanolic extract of cordia obliqua was examined by Nitric oxide radical scavenging activity and Ferric Reducing Antioxidant Power Assay with reference standard ascorbate respectively through in vitro models.Results: Ethanolic extract of cordia obliqua showed significant free radical scavenging activity than that of standard.Conclusion: In vitro study indicates that these plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.
Long Term Use of Ovarian Stimulation Drugs May Affect Thyroid Function Ajile Elttayef
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: The use of ovarian stimulation drugs has increased worldwide; this is associated with physiological and biochemical alteration in different body systems. This study aims to evaluate the impact of different types of ovarian stimulation programs on thyroid hormone levels through different time exposure. Methods: Eighty women were involved in this study. Twenty women were considered as a control group (volunteers with no history of any health problems). The rest show no sign or symptom for thyroid impairment, they were divided into three groups, Group (A) contain twenty women treated with Clomid only, group (B) another twenty women treated with pergonal only, and the last twenty women group (C) were treated with both Clomid and pergonal (Mix). Measurement of TSH, T3, and T4 concentration before and after administration of different ovarian stimulation drugs and for a different time exposure. Results: This study proved a variation in thyroid hormone level during different time exposure and with different drugs used, some of them show no significant difference in the levels of thyroid hormones for two month after administration (group A) as compared to the control group, while in group (C) the increased of TSH hormone was significant (P
Effect of ZnO Nanoparticles on AST Activity in Gingival Cervicular Fluid of smokers and Nonsmokers Chronic Periodontitis Patients: in Vitro Study Zainab A. Salman
Journal of Global Pharma Technology .
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Abstract

Objectives: current studies to estimate the effects of cigarette smoking on oral periodontal health, and due to the lack of studies that simultaneously compared the periodontal condition smokers with periodontal disorders, and nonsmokers with periodontal disorders, we assessed the periodontal condition in these two groups.  The effect of ZnO NPs on aspartate aminotransferase (AST) activity in Gingival Cervicular Fluid (GCF) of smokers and nonsmokers patients with chronic periodontitis was studied as a part of assessment of tissue damage that has been occur due periodontal disease and smoking. Nanoparticles (NPs) have been studied in different areas to evaluate the effect of nanoparticles on the activity of enzyme as a part of more accurate diagnosis. Materials and Methods: GCF samples for 26 persons (aged 35-50 years) with chronic periodontitis were collected as patients group. Powder of ZnO NPs (< 80 nm) was used in this study. The activities of AST enzyme   in GCF were estimated in (smoker and nonsmoker) patients group with and without ZnO NPs as a pertinent biomarker of chronic periodontitis. The impact of ZnO NPs on AST activity in GCF of patients with chronic periodontitis was evaluated in terms of group with AST activity was assessed by colorimetric method. Results: results were showed that AST activity in smoker patients group with and without ZnO NPs was higher than its activity in nonsmoker patients.  Conclusion:  The impact of ZnO NPs on AST efficiency in GCF may be due to the vital role of ZnO NPs in durability against pathogens, in another hand, this impact may be reflects the changes on protein structure after interaction with ZnO NPs.Keywords: Gingival crevicular Fluid, aspartate aminotransferase , ZnO NPs , smoker and nonsmoker Chronic periodontitis .
The Investigation of Pharmacological Activity of Antihistaminic Gels with Dimebon Mayorova Alena Valentinovna
Journal of Global Pharma Technology .
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Abstract

The article covers the review of results of investigation for application safety of traditional gel with dimebon and gel with microcapsules dimebon of prolonged anti-allergic action. We have estimated the irritant action is situ and in vivo, studied acute toxicity by the survivability of mice considering calculated LD50. We have determined a signified antihistaminic (anti-oedemic) effect of gels with external application by the reduction of time and intensity of modelled limb swelling of rats. We have established regenerative action of gels by the reduction of burned skin area, augmentation of tissues epithelization and eschar rejection.Keywords: Dimebon, Gel, Anti-allergic action, Antihistaminic, Anti-inflammatory action. 
Serum Adiponectin Level as an Indicator for Incidence of Type -2 Diabetes Mellitus and Myocardial Infarction in Iraqi Population Shahlaa Kh. Chabuk
Journal of Global Pharma Technology .
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Abstract

Objective lower level of "adiponectin" were observed to be related with obesity, type 2" diabetes" and "CAD" because of the significance of it in this field this consideration was assigned to the role of  "adiponectin" on rate ofT2DM crosswise over classes of BMI, , baseline  glucose and insulin. We likewise proposed to contemplate the relationship of "adiponectin" with rate of incidence of myocardial infarction (MI) regardless the BMI and other traditional risk factors. Subjects and methods: This case-control think about was completed in patients took care of Marjan teaching hospital in Babylon province in Iraq from September 2016 until January 2017. The contemporary investigation was incorporated 54 patients, among of them. 27patients experiencing T2DM and 27 patients experiencing MI contrasted with 25 healthy volunteers of a similar age and sex. Blood sample was taken for evaluation of "adiponectin", and insulin resistance by Elisa technique. Totally the patients experienced a therapeutic checkup and estimated their BMI.Results: the primary consequences of contemporary examination were revealed a critical reduction in the sera level of "adiponectin" in patients with T2DM paralleled with those of control group(P<0.05) . What’s more, a very noteworthy increment in the sera level of HOMA-IR in patients with T2DM contrasted and those of control group (P<0.01). Additionally present outcomes demonstrated reduction "adiponectin" level significantly (P<0•04) contrast with control group• notwithstanding that present result did not demonstrate any significant correlation between "adiponectin" and BMI in MI patients. Conclusions Present examinations suggested that, "adiponectin" consider as predictor for occurrence of T2DM based on the increase BMI that lead to development of insulin resistance, also contemporary study showed that "adiponectin" was linked with MI incidence with no association presented with BMI, sex, age and other CAD risk factors.
Effective of Lemongrass (Cymbopogon citratus L.) Essential Oil Incorporated in Chitosan-Based Edible Coating to Extend Hen Egg Shelf-Life during Storage N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Hen egg is one of the finest foods, offering human a complete balance of essential nutrients with proteins, vitamins, minerals and fatty acids with huge biological value. Eggshells have been regarded as natural protective barriers of eggs. However, eggs encounter different problems, such as weight loss, interior quality deterioration, and microbial contamination. Chitosan has attracted much attention owing to its extraordinary performance such as well-forming, low gas permeability, biocompatibility, strong antimicrobial attributes. Our present research focused on the application of lemongrass (Cymbopogon citratus L.) essential oil incorporated in chitosan-based edible coating to extend egg shelf-life during storage. This research was conducted from 2018 to 2019 in the scientific laboratory of Soc Trang Nanotech Ltd. Results revealed that 0.4% lemongrass oil incorporated with chitosan 1.5% was appropriated to extend hen egg shelf-life for 8 weeks. Chitosan incorporated with lemongrass essential oil coating is considered an efficient and practical way to preserve eggs at room temperature.Keywords: Hen egg, Lemongrass essential oil, Chitosan, coating, Shelf-life, storage.
Peripheral Neutrophil-to-Lymphocyte Ratio (NLR) and Breast Cancer Distant Metastasis: Analysis of a Simple Diagnostic Biomarker Ni Putu Yenny Kendarini
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Introduction: Neutrophils and lymphocytes serve as easily accessible indicators representing the immune landscape in breast cancer. Combination of such variables in the form of neutrophil-to-lymphocyte ratio (NLR) allowed for extensive analysis and better interpretation. The heterogeneity in predictive role of NLR to prognosticate breast cancer sruvivalcould be attributed to metastatic spread. Methods: Data from breast cancer patients attending Oncology clinic in Sanglah Hospital, Bali was collected retrospectively. Samples were selected by simple random sampling technique from a sampling frame of patients with available preoperative complete blood count in the registry. Bivariate and multivariate analysis was performed with NLR value stratification using optimal NLR cut-off value derived from receiver operating characteristic (ROC) curve analysis. Results: A total of 51 patients diagnosed within the period of January 2016 through November 2017 were investigated. The cut-off point of NLR value in this study was 3.1 (Area under ROC curve [AUC]: 0.826). A significant association between NLR value and distant metastasis was found consistentlyin bivariate (PR 5.4, 95%CI 2.5-11.8, p=0.001) and multivariate analysis (Adjusted PR 4.9, 95%CI1.53-16.1, p 0.01). The association was not affected bybreast cancer subtype, histological grading, lymphovascular invasion, and tumor-infiltrating lymphocytes level. Conclusions: The NLRvalue was found to be an independent factor for distant metastasis in breast cancer. Its added value on diverse NLR clinical prognostication utility warrants further prospective investigation. Keywords: Neutrophil to lymphocyte ratio, Neoplasm metastasis, Breast neoplasms, Biomarkers.
External Morphological Study of Aporiacrataegi (Linnaeus, 1758), (Lepidoptera: Pieridae). Northern Iraq Mouhannad M. Aljaf
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

This work was included external morphological study of male Black veined white butterfly Aporiacrataegi L. 1758. The study involved morphological characters of many body regions, in addition the male genitalia. This morphological characters study supported by illustrations, it should be noted the work specimens were collected from northern Iraq.Keywords: Butter fly, Lepidoptera, Pieridae, Aporia, Description.

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