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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Correlation between Selective and Non-selective α-Blocker Drugs with Age, Prostate Volume and Different Benign Prostate Hyperplasia (BPH) Indicators Islam Abdul Rasool Hashim
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: This study aimed to evaluating  the correlation between(age, prostate size) and different BPH indicators such as ( PSA , IPSS , testosterone , estrogen ,Testosterone/Estrogen {T/E} ratio ) among two groups (one treated with selective and  another treated with non-selective α-blocker drugs) and untreated group. Methods: The study is a randomized control clinical trial carried out in Urology department during the period from September /2018 to May /2019.The study was based on 60 cases of symptomatic Benign Prostatic Hyperplasia, 30 patients treated with selective α-blocker drug (tamsulosin) and 30patients treated with non-selective α-blocker drug (alfuzosin) and 30 cases of newly diagnosed patients with BPH but did not take treatment for BPH disease, the range of their age was between (50-90). The variables age, prostate size, PSA, IPSS, testosterone, estrogen, T/E ratio were examined and appropriate statistical tests were employed for data analysis. Results: The results showed that there was a significant difference in correlation between age with IPSS and between age with  testosterone (p≤0.05)among treated and untreated groups and also showed a significant difference in linear  correlation between PSA ,Testosterone, Estrogen indicators levels and the  prostate size (p≤0.05) among treated and untreated groups  Conclusion: In men with biopsy-proven BPH , both International Prostate Symptom Score IPSS and testosterone increased and altering with ageing. Prostate size demonstrated significant positive correlations with Prostate Specific Antigen PSA, Testosterone, Estrogen among treated and untreated groups in this study.Keywords: BPH, Testosterone, Estrogen, PSA, IPSS, Tamsulosin, Alfuzosin.
Designing Boardgame Media for Child Growth Stimulation Through Children’s Games Nurlailis Saadah; Budi Joko Santosa; Budi Yulianto; Uswatun Khasanah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Educating children requires interesting and safe media. Childhood is a period of growth and development of various aspects which include fine motor, gross motoric, language, and social personal. Social interaction can use technology that is not limited to space and time through gadgets. If there is no control over the use of gadgets, children can become addicted to them, indifferent to those around them, and rarely communicate with people around them. To anticipate this, alternative media that are safer than gadgets is game board. Methods: This research method included 2 phases. Phase I was Research & Development model research, Phase II was the implementation of the model using Pre-Experimental Design research that applies non-randomized One-Shot Case Study. Data were collected by using interview, questionnaire and observation. The data was processed using the visual comparison matrix analysis method. An attractive game board must be supported by a good mechanism and visibility. Results: Children can grow and develop well if a healthy lifestyle is implanted like healthy food is. The solution to this problem can be achieved by designing educational board games as a medium for learning and playing. The reason is that board games have rules, goals, problems, players, procedures, etc. It can also train psychomotor, emotional, moral, cognitive, artistic, children’s language aspects with fun. The board game is expected to make children interact well so that all aspects of a child’s development run well. Keywords: Board games, Stimulation, Types of Children's Games
The Impact of Effective Teaching Strategies in a Variety of Physical Variables and Some Basic Skills for Students in Volleyball Thuraya Jwaid Mohin
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The common method of teaching the various skills in general and the ball in particular is the American method, which requires the teacher to be a decision maker to the student and not a slander of us on this method and reduce its advantages, but the present era is the era of knowledge and educational development should be accompanied by this Evolution Previous studies have confirmed that there are many teaching methods that are unique in each of the objectives and characteristics and have an effective role in correcting mistakes and investing time and velocity in the process of learning, but these methods meet neglect of most workers in the teaching of physical education, As well as that there are limited possibilities in the performance of sports and linking them to the basic skills of the game volleyball. So the researcher looked at this problem by introducing effective teaching with different strategies in some physical variables and the basic skills of students in the volleyball and output outputs and effective results of the educational process.Preparing educational units using effective teaching in a variety of strategies (technical, cooperative and differentiated learning) in some physical variables and basic skills of students in volleyball.Learn about the effect of using effective teaching in a variety of strategies in some physical variables and basic skills of students in volleyball.Identify which strategies are more influential in some physical variables and basic skills of students with volleyball.The researcher used the experimental method and identified the research community with the students of the second stage in the Faculty of Physical Education and Sports Sciences at the University of Babylon for the academic year 2016 - 2017, the total number of (95) students, consisting of four divisions where the random method was adopted in the selection of the sample (80) (A) The first experimental group, the second experimental group (B), the third experimental group (D), and the control group (C). The most important conclusions are:The results showed the effectiveness of effective teaching in the strategy of technical learning in the learning and development of physical variables (the strength characteristic of the velocity of the arms, the strength characteristic of the velocity of the legs, the velocity of transition).The results showed the effectiveness of effective teaching in the strategy of cooperative learning in learning and improving the physical ability of explosive power.The results showed the effectiveness of effective teaching with a different learning strategy in learning and developing physical variables in the third degree.Keywords: Teaching strategies, Physical variables and volleyball.
Investigating the Effect of Muscular Relaxation Technique on Sleep Quality in Children with Leukemia Treated with Chemotherapy in Educational Hospitals of Zahedan Zeinab Poodineh
Journal of Global Pharma Technology .
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Abstract

Introduction and objective: Sleep has long been considered as an important factor in human health. Sleepless clinically causes stress and the inability in performing social and job functions and it leaves considerable negative effect on quality of life and health status of people. Therefore, this study was conducted to determine the effect of muscular relaxation technique on sleep quality of parents of children with leukemia treated with chemotherapy.Methods this study is a randomized controlled intervention study in which 120 parents of children with leukemia were assigned in two groups of intervention and control. The intervention group received Benson's relaxation technique. Data collection tool included demographic information questionnaire and Pittsburgh Sleep Quality Index (PSQI). Data were analyzed by SPSS version 18 software, Paired Samples t-test, Wilcox on test, and t-test tests, Pearson correlation test, and One - Way ANOVA test.Results The mean score in the intervention group before and after intervention in the sleep quality was obtained 13.5 ± 60.5 and 5.7 ± 3.43, respectively, and significant difference was found between the quality of sleep in the two groups of intervention and control after intervention, and the relationship between quality of sleep of parents, education, gender, and their living place was not statistically significant.Conclusion The findings indicate that presence at hospital to care for the child could affect the sleep quality, because it disturbs the normal life conditions of the person. To improve their sleep status, is better that health care and management and personnel to take necessary steps to improve the quality of their sleep.Keywords: Muscular relaxation, Sleep quality, Leukemia, chemotherapy.
Assessment of Endocan with Progression and Severity of Diabetic Nephropathy in Babylon City Ahmed M. Mosleh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Diabetic nephropathy (DN) is one of risk complication in type2 diabetes mellitus (T2DM) that required for new biomarker for early detection and to decrease the progression in deterioration in kidney function. Excessive angiogenesis is a main factor in the development of diabetic nephropathy. Aim: Our aim was to examine the association between serum endocan levels and urine protein creatinine ratio (PCR) as biomarker for assessment DN This study focused on evalution of endocan as biomarker for establishing diagnosis of DN and evaluate its effect on progression and developing DN Methods: In this study we evaluated endocan and levels in DN and diabetes patients without nephropathy and compared them with healthy subjects. Poor glycemic control by assess HbA1c and duration of DM are proofed to be a risk factor for DN. Endocan estimation by ELISA technique. Blood urea and creatinine and protein in urine were estimated by spectrophotometric method. Results: Endocan levels in DN was 327.9‎±106.9 and in diabetic patient without nephropathy and healthy control were (206.3‎±91.5, 122.7‎±45.7), respectively which is statistically significant at p-value<0.05. Endocan is significantly correlated with protein to creatinine ratio (PCR) and estimated glomerulofilteration rate (eGFR) at p-value<0.05. Conclusion: Endocan could be used as reliable marker for assessment diabetic nephropathyKeywords: Diabetic nephropathy, Endocan, Type2 diabetes mellitus.
The Evaluation of Entrance Surface Dose and Quality of Radiograph in Thorax Radiological Examination Hermawan Dwi S
Journal of Global Pharma Technology Volume 10 Issue 10 (2018) October 2018
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Abstract

Introduction: Computed Radiography (CR) is a technology of digitally medical imaging which is applied in x-ray generator. It is relatively easy to operate. Hence, the operators often use high parameter because they assume that it can ease image post-processing without considering radiation dose resulted by the process which is further received by patient’s organ penetrated by x-ray. It is mostly used on radiological examination of thorax at X-ray Department. Objective: This article aims to evaluate the relationship between ESD and the quality of resulted thorax radiograph as a protecting effort from radiation using ALARA principle. Method: The data were collected by taking pictures of Longman Phantom with kVp variations from 45 kVp to 105 kVp at 2 mAs to 32 mAs. TLD was utilized for the ESD measurement. Then, the radiographs were submitted to a radiologist to read and to convert them into diagnostic value. Result: This article results in several satisfactory imaging qualities based on the statistics of third quartile, that is on the radiation parameter of 75 kVp/16 mAs with dose value of 1.05 mSv, and of 85 kVp/8 mAs with dose value of 1.11 mSv, while BAPETEN allows parameter with dosage under 0.4 mSv on 55 kVp/8mAs, 65 kVp/4 mAs, 75 kVp/4 mAs , 85 kVp/2 mAs, and 105 kVp/2 mAs. Conclusion: The result of the research shows that setting the same value of kVp and increasing the value of mAs will increase ESD value.Keywords: kVp, mAs, ESD, Radiography of Thorax, Computed Radiography.
Removal of Three Phenolic Compounds [Polychlorinated biphenyl (PCB 105, PCB 118 & PCB 150)] from Aqueous Solutions by Fiber Palm as a Biosorbent Athraa Hameed Mekky
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

 The aim of this work is to determine the potential of application of palm fiber as a biosorbent for removing of three phenolic compounds[polychlorinated biphenyl (PCB)] (2,3,3',4,4'-Pentachlorobiphenyl PCB 105, 2,3',4,4',5- Pentachlorobiphenyl; PCB 118, and 2,2',3,4',6,6'-Hexachlorobiphenyl; PCB-150 from aqueous solutions. The effect of pH, adsorbent dosage and contact time were investigated. Increase in the pH to neutrality resulted in the increase in the phenolic compounds adsorption capacity. The results showed that the increase in the fiber palm dosage to 0.5g/0.1L significantly increased the phenolic compounds adsorption rates. The adsorption process was fast, and it reached equilibrium in 30 min. contact time. The Freundlich and Langmuir adsorption models were used for mathematical description of the adsorption equilibrium and it was found that experimental data fitted very well to both Freundlich and Langmuir models. These results indicate clearly the efficiency of fiber as a low-cost solution for these compounds in aqueous solutions treatment and give some preliminary elements for the comprehension of the interactions between palm fiber as a bioadsorbent and the very polluting compounds from aqueous solutions.Keywords: Freundlich, Langmuir, Palm fiber and phenolic compounds.
Anti-diabetic Activity of Dry Extract of Gymnema Sylvestre Sanna Sboeva
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The purpose of the study was to study the mechanism of antidiabetic action and compare the hypoglycemic effect of taking extracts of different concentrations of gurmar in a laboratory rat population. Studies were conducted in 2018 in a population of 400 laboratory rats based on the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) (Moscow, Russian Federation). 300 animals made up the experimental group, 100 - the control. We used 25, 50, and 75% gurmar extract and diabeton, which were given orally to animals from the experimental group at a dosage of 70 mg to 1100 mg per 1 kg of body weight and 10 mg per 1 kg of body weight, respectively. Tests for glucose digestibility were performed by administering extracts of gurmar after fasting, dosage of 270 mg per 1 kg of body weight. The hypoglycemic effect of gurmar-based drugs activates enzymes associated with the inhibition of absorption of glucose from the intestine, as well as with its breakdown. Studies have established 25% as the most optimal dose of gurmar extract. The dosage in this case is 270 mcg per 1 kg of body weight. The maximum hypoglycemic effect is observed 2 hours after taking the drug. For high concentrations of the drug, a 25–30% lower hypoglycemic activity was recorded. Another drug, taken for comparison-diabeton, is superior in its effect to 25% gurmar extract by 20%. A 30% increase in beta-endocrinocyte nuclei may indicate an increased physiological activity of these cells.Keywords: Gurmar, type 2 diabetes mellitus, Extracts, Diabeton.
Comparison of The Role of VEGF-B, C and D in Angiogenesis and Peripheral Nerve Sprouting After Nerve Repair Post Neurotmesis Injury Ria Margiana
Journal of Global Pharma Technology Volume 9 Issue 11
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Introduction: Vascular endothelial growth factors B, C and D play various roles in angiogenesis and nerve cell sprouting.  The purpose of this study was to explore the individual roles of these growth factors in angiogenesis and peripheral nerve sprouting after nerve repair. Method: A systematic literature review of various databases was conducted for relevant data on the role of VEGF-B, C and D in angiogenesis and peripheral nerve sprouting after nerve repair (neurotmesis). The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines Results: Fifty-four studies that met the inclusion criteria were analysed systematically, and grouped into three categories of vascular endothelial growth factors (VEGF-B, VEGF-C, and VEGF-D). The findings highlight the diverse functions of VEGF-B, VEGF-C, and VEGF-D in angiogenesis as well as peripheral nerve sprouting through the VEGF-B/ VEGFR-1, VEGF-C/ VEGFR-3, and VEGF-D/ VEGFR-3 pathways. Conclusion: VEGF-B, VEGF-C, and VEGF-D each play a unique role in angiogenesis and peripheral nerve sprouting. VEGF-B plays a major role in controlling nerve sprouting and VEGF-C influences this process, while VEGF-D is not implicated in the regulation of primary sprouts Keywords - VEGF-B, VEGF-C, VEGF-D, angiogenesis, peripheral nerve sprouting
The Effect of Qualitative Exercises (Physical - Skill) in the Development of Rapid Strength and Lay up Scoring of Basketball Players Mazen Kadhim Nassif
Journal of Global Pharma Technology .
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Through the follow-up of the researchers of most educational and training units, they noticed that most players aged 13-15 suffer from weakness in the strength and speed of the strike of the arms and legs, which negatively affects the performance and difficulty of scoring points during the performance of lay-up scoring, since the way to achieve the ideal performance that aims to win requires the compatibility of many requirements, including a high level of performance interrelated and overlapping physical and skill capabilities among them, as physical capacity is the cornerstone on which to build the development of the skill, so researchers have considered this problem Through the preparation of exercises qualitative (physical - skill) and trying to overlap them to serve the skill performance attempt to develop the rapid force and lay-up scoring of basketball players. The objective of the research was to identify the effect of specific exercises (physical - skill) in the development of rapid strength and lay-up scoring of players in basketball. The imposition of research is a positive effect of the physical exercises (physical - skill) in the development of fast power and lay-up scoring of basketball players. The researchers used the experimental method in designing the one group to suit the nature of the problem to be solved, and represented the research in all members of the research community; the young players aged 13-15 years in the club sports fans - Kerbala, the 10 players. The most important conclusions were of specific exercises (physical - skill) and clearly affected the development of rapid power and the skill of lay-up pacification of basketball players. The recommendations are the need to pay attention to the specific exercises and the link between the physical and skill aspects during the exercise and the single training unit. And the need to pay attention to the training of the force of the fast because it described the physical task is needed basketball player effectively and continuouslyKeywords: qualitative exercises, Rapid strength and lay up scoring.

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