cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 175   176   177   178   179 
Analysis of Magnetic Resonance Image Segmentation Using Spatial Fuzzy Clustering Algorithm E. Udayakumar
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The paper presents the MRI brain diagnosis support system for structure segmentation and its analysis using spatial fuzzy clustering algorithm. The method is proposed to segment normal tissues such as White Matter, Gray Matter, Cerebrospinal Fluid and abnormal tissue like tumor part from MR images automatically. The most of MR image are corrupted by artifacts which lead to affect the image processing for analysis of brain images. Due to this type of artifacts and noises, sometimes one type of normal tissue in MRI may be misclassified as other type of normal tissue and it leads to error during diagnosis.The proposed method consists of pre-processing using wrapping based curvelet transform to remove noise and modified spatial fuzzy C Means segments normal tissues by considering spatial information because neighboring pixels are highly correlated and also construct initial membership matrix randomly. The system also uses to segment the tumor cells along with this morphological filtering will be used to remove background noises for smoothening of region. The paper results will be presented as segmented tissues with parameter evaluation to show algorithm efficiency.   Keywords: SFCM, NN, GLCM, DWT, MRI, CT.
Role of Chloride on Corrosion of Carbon Steel Reinforcing Bar in Simulate Concrete Electrolyte Abdulkareem M.A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

It is well known that chloride ion plays an important role in the destruction of various kinds of concrete structures such as bridges of buildings and reservoirs because of the corrosion of carbon steel reinforcement bar, causing huge human and material damages. In this study, the effect of saline conditions on carbon steel reinforcement was investigated artificial concrete solution in a range of sodium chloride concentrations from 0.5 to 4.5% and at temperatures of 20°C to 50°C. Three electrodes potentiostat was used to measure the corrosion rate and the probability of pitting corrosion through Tafel and cyclic polarization plots respectively. The measurements were supported using other techniques; atomic force microscopy and optical light microscopy. The results showed an increase in corrosion rates of the carbon steel reinforcing bar at all chloride ion concentrations, and increased with increasing the concentration and the temperature, all chloride concentrations showed susceptibility to pitting corrosion and highly depend on NaCl continents.Keyword: Reinforcing bar, Pitting, Artificial concrete solution.
Investacte the Role of Weissella Confuse on TNF-α in Serum and Liver Tissue of Mice Infected with Leishmania Donovani Dhilal Abdulelah Ibraheem
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Leishmaniasis is one,of the vector-borne diseases, caused by obligate protozoan parasites, they are.transmitted by sand, flies as extracellular. Flagellatedepromastigotes thatereplicate as an intracellulareparasite in.mononuclear cells of mammalian.hosts. Probiotics are microorganisms that provide health benefits when consumed and characterized by being of human origin, probiotics have benefits in health and diseases, there is some clinical applications using probiotic like: immunity function by increasing the number of IgA-producing plasma cells, improving phagocytosis as well as increasing the proportion of T lymphocytes and Natural Killer cells. The present study it is efficiency against Leishmania donovani compared with pentostam drug in vivo by measuring the levels of immune cytokines (TNF-α) in serum and liver tissue of infected mice and treatment with Weissella confuse bacteria and its supernatant for three weeks. The results of measuring the levels of TNF-α showed significant increase in mice serum and the concentration of TNF-α in liver tissue by immunohistochimsry showed increase in TNF-α secretion of treated mice with Weissella confuse bacteria and pentostam compared to non infected mice while mice treated with Weissella confuse supernatant showed less increase compared to the two previous groups. Probiotic bacteria and its supernatant have an affect on Leishmania donovani parasite through induce pro and anti-inflammatory cytokines in vivo. Keyword: Leishmania, Probiotic, TNF-α, Weissella confuse, Immunohistochimsry.
Antibacterial Effect of Diode Laser and Silver Nanoparticles against Biofilm Bacteria Thamer Mutlag Jasim
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The present study has been undertaken to illustrate the antibacterial effect of diode laser and nanoparticle on isolated resistant biofilm bacteria. From the patient with urinary tract infection (UTI).Atotal of 90(56%) urine samples from patients with urinary tract infection (UTI) from Al Yarmuk hospital in Baghdad showed growth on culture. Proteus mirabilis was the most common pathogen accounting for 21(37.5), Staph aureus 20 (35.7), Klebsiella pneumonia 15(26.78). The biofilm bacteria exposed to diode laser after   focal with alens of (15) cm after focal point for different time 0.5, 1, 1.5, 2, 2.5, 3 min. The synthesized nanoparticle was characterized by UV-spectroscopy. The antibacterial activity of synthesized silver nanoparticle was compared by agar well diffusion method. The effect of minimum inhibitory concentration (MIC) and sub (MIC) concentration of Ag NPs were determined by microtiter plate assay. The antibacterial effect of Ag NPs and diode laser has already been studied, Ag NPs, Laser group within our results, we found that that Ag NPs with lasers present low values in comparison With Ag NPs alone. The MIC value were higher these difference could due to divergence found in the cellular wall of each kind of bacteria. The synthesized silver nanoparticle and diode laser have shown good antibacterial efficacy as compared to laser alone and may prove to be better antibacterial agent against biofilm bacteria. The result showed the biofilm bacteria completely killed after exposure to diode laser for 3min with nanoparticles. In this study, synthesized Ag NPs have the efficient antibacterial activity against biofilm bacteria.  Ag NPs have an important function in the field of nanotechnology. The results of this work revealed the potential of the synthesized Ag NPs as safer bactericidal agent against biofilm bacteria. The laser light enhances the antibacterial activity of silver nanoparticles by at least one fold. It conclude that the Ag Nps combined with laser exposure be used as local effective antibacterial approach   inhibit the bacteria isolated from Urinary tract infection. The result stated that Ag NPs synthesized were nontoxic and good antibacterial agent against biofilm bacteria. These result that Ag NPS could be used as an adjuvant for the treatment of UTI infection disease.Keywords: Biofilm, Diode laser, Nanoparticle, antibacterial.
QUALITY OF LIFE IMPROVEMENT OF CHRONIC HEART FAILURE PATIENTS AFTER THE EFFECT ENHANCED EXTERNAL COUNTERPULSATION (EECP) THERAPY Starry Homenta Rampengan; Anita Dundu; Joedo Prihartono; Suzanna Immanuel; Minarma Siagian
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: This study aimed to evaluate the risk factor of depression level before and after EECP therapy in chronic heart failure (CHF) patients. Methods: We performed a double-blind random clinical trial between January 2014 and June 2015 in 99 patients with CHF who had received EECP therapy at Jade Cardiovascular Clinic, Manado, North Sulawesi, Indonesia. The CHF patients were categorized into 2 groups, i.e. 49 patients had sham EECP therapy and 50 patients had EECP therapy. The patients filled WHO-5 questionnaire before and after receiving EECP therapy. Statistical analysis was performed for all output, either for primary, secondary or safety output. Results: The baseline characteristics of both groups have no significant difference. We found no significant difference of WHO-5 questionnaire result in sham before and after EECP therapy, but in EECP group showed statistically significant difference (p<0.05). WHO-5 questionnaire attributes result were found significantly improvement of felt cheerful and good spirit (p=0.03) and woke up feeling fresh (p=0.030) in EECP group compared with sham group. Conclusion: EECP therapy was effective to reduce depression so that improve quality of life in CHF patients.Keywords - chronic heart failure, enhanced external counterpulsation therapy, quality of life, world health organization
Evaluation of Some Purine Metabolism Enzymes in Iraqi type 1 Diabetic Patients Wisam M. Mohammed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 1 diabetes mellitus (T1DM) is the result of the destruction of the insulin-secreting β-cells of the pancreas by a process in which T-cells play a central role. This study was conducted on 60 T1DM patients from both sexes that were randomly selected from those attending the National Diabetes Center for Treatment and Research at Al-Mustansiriya University/Baghdad between August 2016 to December 2016. For comparison, 24 apparently healthy controls were selected for the control group. Moreover, the study was conducted to evaluate serum adenosine deaminase (ADA) and 5-nucleutidase (5-NT); furthermore, xanthine oxidase (XO) enzymes were quantitatively determined manually in T1DM patients and the control group. Fasting serum glucose (FSG), serum uric acid, urea, and total protein were determined, as well as other anthropometric measurements, such as body mass index (BMI);waist to hip ratio (W/H) and thoracic to hip ratio (T/H).The diabetic patients had significantly higher levels of ADA and 5-NT enzymes (p<0.000) compared with those of control group. No significant difference (p<0.463) was observed in the serum XO enzyme between the patients and the healthy control group. Further, the level of UA was significantly lower (p<0.000) in the patients compared with that of the healthy control group. This study suggests a significant role for ADA and 5-NT enzymes and a non-significant role for XO enzyme, which, therefore, cannot be used for predicting the progression of T1DM in the early stages.Keywords: Diabetes mellitus, Type 1 diabetes mellitus, Adenosinedeaminase enzyme, 5-Nucleutidase enzyme, Xanthineoxidase enzyme.
Microscopic Hair Shaft Analysis in Iraqi Population Taghreed K.S Al-Ashoer
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hair is a biological evidence contributing important role at a crime scene. Microscopic hair analysis can help to identify of a suspect in forensic investigation. The principle of this study was to find diagnostic aspects of the hair shaft from the Arab Iraqi population through compound light and scanning electron microscopy examination and analysis of the shaft diameter, medullary index, ovoid body and medulla type for human scalp hair shaft in forensic analysis in the crime scene investigation. The investigation under compound light microscope included 76 out of 100 samples because of 24 hairs samples were deep black view and photos showed no data. The shaft diameter range of hair samples was 34.75 to 115µm.The medulla type classified into four groups as absent type (78%), continuous (13 %), fragment (8%) and interrupted type (1%). The medullary index of human hair was observed in ranging from 0.083- 0.189. The ovoid bodies in hair shaft samples were absent (80%) and present (20%) of all samples. In this study reported that no significant differences in shaft diameter, medullary index, medulla type and ovoid body among male and female groups. The scanning electron microscope results indicated that high amount of hair shaft damage and the difference between the individuals in outer cuticle scale pattern showed that all samples were imbricate type, while chipped, lifting, jagged and smooth reported 17%, 8%, 4%and 1%, respectively.Keywords: Hair shaft, Microscopic analysis, SEM, Iraq.
Association of ABO Blood Groups with Diabetes Mellitus Mohammed. L.A. Al-Baaj Al-Baaj
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this study is to highlight the potential relationship between blood groups and diabetes for the local population of the city of SuqAl-Shuyukh in Thi-Qar, Iraq. The study included the identification of blood groups to 276 diabetes patients for the period from December 2018 to March 2018. ABO blood groups of all subjects were determined by slide agglutination method. Chi- square statistical analysis among different blood groups between non-diabetic (n= 100) and diabetic population (n= 276) revealed no significant relationship of any blood group with diabetes mellitus (p ˃ 0.05). But relative risk (RR) were calculated in reference to blood group O, it has been observed that slight increase of risk of developing diabetes mellitus among AB (RR 1.111), a (1.045) and B (1.025).Keywords: Diabetes Mellitus (DM), ABO Blood Groups, A, B, AB, O.
The Degree of Agreement between Manual and Digital Histological Evaluation of Immunohistochemical Expression of Estrogen and Progesterone Receptors in Breast Carcinoma Hameda Abd-Al Mahdi Ghazi Ghazi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Malignant neoplasm involving the breast is by far one of the most frequent cancers that affect mankind. Globally, it is estimated that breast cancer accounts for about 25% of all cancers affecting women. Carcinoma of the breast is heterogeneous; however, they all share the common origin from the terminal duct lobular unit. They are generally classified into ducal and lobular. The three gold standard immunohistochemical makers, nowadays, are progesterone and estrogen receptors (PR and ER) and her2neu. Other markers like p53 and bcle2 expression are also important. The study of PR and ER receptors permits the decision of adding and adjunct mode of treatment, hormonal treatment. Aim of the study the objective of this study was to assess automated digital study of immunohistochemical markers as a substitute for the original manual method. Materials and methods: The present study included 35paraffin embedded, formalin fixed histological blocks of breast carcinoma. The duration of the study extended from January 2017 to June 2017 and was conducted in the teaching laboratories of College of Medicine, Al-Qadissiyah Univerist, Al-Diwaniayah province, Iraq. The paraffin blocks were retrieved from the teaching laboratories of Al-Diwaniyah teaching hospital, Al-Diwaniayah province, Iraq. Results: Following conversion into positive and negative cases, matching was assessed using kappa agreement statistic and the results were as following: number of positive ER cases were 14 and 16 according to manual and digital scoring, respectively; whereas the number of positive PR cases were 15 and 17 according to manual and digital scoring, respectively, as shown in table 3 and 4. The degree of agreement between manual and digital scoring was 0.87, considered good, in both ER and PR expression status. Conclusion Digital scoring appears to be faster than and as accurate as manual scoring; however it needs to be correlated with clinical prognosis of breast carcinoma.
Abdominal Fascia Suturing with Polypropylene Reduces intraabdominal Adhesion Incidence and Neutrophil, Macrophage, and Lymphocyte Infiltrations in Wistar Rats Ketut Sudartana
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Intraabdominal adhesion after surgery causes pain, infertility, and chronic abdominal pain. Intraabdominal adhesion also causes longer surgery time and increases intraoperative complications. This study aimed to prove that the use of polypropylene suture causes less intraabdominal adhesion and less inflammation compared to polyglycolic acid suture.  Methods: This was a randomized posttest-only control group study. Thirty-six mature male Wistar rats weighing 200-250 g were anesthetized with ketamine 50 mg/kg intramuscularly. It was incised on the inner abdominal wall layer by layer until peritoneum was seen. Wistar rats in Group A were sutured with polypropylene 4-0 with a half-centimeter apart. Rats in Group B were sutured with polyglycolic acid 4-0 suture. Peritoneum in both groups was not closed, and the abdomen was closed layer by layer, and then the lesion was enclosed with bandage. Relaparotomy was performed on day 14 and 30 to evaluate the presence of adhesion and inflammatory cells, MMP-1, TGF-ß, and TNF-α. Results: There was a significant difference between polypropylene-based sutures compared polyglycolic acid in terms of the presence of intraabdominal adhesion on 30 days after laparotomy (p=0.016). The infiltration of neutrophil, macrophage, and lymphocytes were significantly lower in polypropylene groups compared to polyglycolic acid (p<0.001). Conclusion: Polypropylene-based sutures resulted in less adhesion and inflammation compared to polyglycolic acid sutures in Wistar rats underwent laparatomy.Keywords: Laparotomy, Lymphocyte, Macrophage, Neutrophil, MMP-1.

Page 177 of 244 | Total Record : 2439

 175   176   177   178   179 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue