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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Adsorption Characteristics of Heavy Metals on to Recycled Vehicular Tire Activated Carbon as Potential Adsorbent with Phosphoric Acid Tamatheir S. Musa
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Heavy metals considered poisonousness to plants and microorganisms in the earth and environmentally friendly contamination. The objective of the work is to transform vehicular tires, a greatly existing unwanted substance by treating with H3PO4  with  and without treatment at 900°C as a chemical agent into profitable adsorbent for the expulsion of Cu+2, Zn+2 and Pb+2ions. In this work, removal of Cu+2, Zn+2 and Pb+2ions by utilizing VTAC and the influence of different factors such as contact time, pH, adsorbent quantity, metal concentration and temperature on the adsorption have been calculated where the maximum adsorption of Cu+2 ,Zn+2 and Pb+2 was 99.994, 99.5667 and 96.3974, respectively for ACs which was treated with H3PO4 with treatment at 9000C and the equilibrium time was 72 hours and temperature of 30 0C, PH 3, adsorbent dosage 5 mg/L and initial concentration 30 mg/L. The isotherm models that studied Langmuir and Freundlich and present Freundlich more suitable due to have high value correlation coefficient (R2) and pseudo-first order and pseudo- second order kinetics also studied where pseudo-first order more suitable to describe the adsorption properties of VTAC as applied mechanism of Intraparticle diffusion model that appeared desirable results.Keywords: Activated carbon, Vehicular tire, Adsorption, Heavy metal ions.
Antirheumatoid Artritis Effect of Purslane Herb Extract (portulaca oleracea l.) to Rat (rattus norvegicus) Induced by Complete Freuds Adjuvant Rizqi Nur Azizah
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation of the joints of hands and feet. The research on antirheumatoid arthritis of ethanol extracts from Purslane (Portulaca oleracea L.) and effective doses of antirheumatoid arthritis. The research used 15 rats divided into 5 groups. Group 1 (1% Na-CMC); group 2 (prednisone) with the dose of 0.511 mg / kgBW; group III, IV and V were given ethanol extract of purslane doses of 100 mg / KgBW, 200 mg / KgBW and 400 mg / kgWW. The animal model of rheumatoid arthritis was made with intraplant injection of 0.1 mL Complete Freund's Adjuvant. The parameters observed were leg volume measurements and arthritis index. The leg volumes of data were analyzed by One Way Anova test followed by the L test while the arthritis index used the Kruskal-Wallis test followed by the Mann-Whitney test. In leg volume measurements, ethanol extract from the red root dose of 400 mg / kg reduced leg volume by 52.49% (p <0.05). Whereas in the arthritis index parameter, the ethanol extract from purslane dose of 400 mg / kg is significantly reduced the arthritis index (p <0.05) with arthritis index reduction by 50%. In conclusion, the ethanol extract from the purslane (Portulaca oleracea L.) with a dose of 400 mg/kg has better activity in treating rheumatoid arthritis in rats.Keywords: Antirheumatoid arthritis, Portulaca oleracea L., complete freund’s adjuvant.
Toxicopaphological Effects of Intravenous Injection of Layer Double Hydroxide (LDH) Nanoparticles in Male Rats Samia Kh. Mahmood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The rapid growth of using nanoparticles in different field of science, lead to the urgent necessity to study the toxicpathology of this submicron particle. Layer Double Hydroxide NPs have qualified features such as bio-compatibility, ion exchange and pH effect which make LDH NPs potential candidate for various biological applications such as drug delivery. Hence, in this study Mg-Al LDH NPs have been prepared by co precipitation method and injected intravenously. Twenty rats were divided into two groups as follows: Group I: Rats served as control and injected 1ml of distilled water intravenously for one month. Group II: Rats served as experimental and received by I/V injected in the tail vein 1ml of 0.00276 of Mg-Al LDH NPs g/ml. daily for one month. The sizes of LDH NPs have been measured by SEM which resulted size ranging between 50- 80nm in diameter. The liver, kidney, heart, lung, spleen and testes were examined histologically. The toxicopathological results were very severe in kidneys, lung, spleen and heart, while being moderate in liver and testes. In general, all organs showed necrotic changes with inflammatory cell infiltration, congestion and thrombosis in blood vessels.Keywords: LDH, Toxicopathological study, Nanoparticles, Rat.
The Effect of Continuous Feedback on High Service Learning According to Wrist Joint Modeling for Junior Squash Players Nouman Hadi Alkhazraji
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The research problem concentrated on lack of effectiveness learning for high serve skill of squash players. Plenty of technical mistakes in skill performing, lack of use of feedback and not specifying the appropriate time by the coach commensurate with stages of skill learning. Therefore, the researchers sought to emerged the ongoing feedback through the unites to learning the high serve skill of squash to increase the effectiveness of learning and accelerate it, and the continuous correction of mistakes in order to the learner can master the skill with the least numbers of mistakes. However, the aims of the research were to identify the effect of continuous feedback on learning the high serve skill of squash junior players and to identifying the superiority of the differences between the effects of continuous feedback in learning the two skills of high serve among squash junior players. However, the researchers used the experimental approach (Equal groups design) with pre and post-tests. The research population involved (22) squash junior players in the Babylon university. The researchers have been equalization a number of variables in the experimental and control groups which may impact on the results later. Nevertheless, the research results showed A positive effect of the using of continuous feedback units on learning and developing skillful performance for the high serve skill of squash junior players. In addition, the experimental group has improved as a result of the use effect of continuous feedback in learning the two skills of high serve among squash junior players comparing to the control group.Keywords: Continuous feedback, High serves wrist joint, Modeling and squash.
SPECTROGRAPHIC ANALYSIS OF TITANIUM ALLOYS IN PROSTHETIC DENTISTRY A.S. Utyuzh
Journal of Global Pharma Technology .
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Abstract

This paper considers changes in the chemical composition of titanium alloys according to the method of their treatment. It investigates the chemical composition of three original samples of titanium alloys, three samples after their casting and three samples after their milling. It is revealed that different methods of alloy handling lead to dissimilar changes in its chemical composition.Keywords: Spectrographic analysis, Titanium, Casting, Milling, Billet.
Adsorption Effect of the Modified Chitosan-Methionine Beads on Human Serum Lipids Profile and Total Protein Ahmed Saleh
Journal of Global Pharma Technology .
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Abstract

This research is concerned with one of the most important applications of surface chemistry which used in medical, physical and biochemistry.Place of conducting the research University, Faculty and Department. The research is based on the adsorption of lipid profile and total protein from human serum on the surface of  modified chitosan- methionine which are associated with two different types of cross linkers substances: glutaraldehyde with two different concentration (3.13,6.25%) to prepared beads type (A,B) respectively, and ethylene glycol diglycidylether (EGDE) to prepared beads type (C). The formed beads were characterized by using Infrared (IR) spectroscopy to confirm the cross linking reaction and using Scanning Electron Microscopy (SEM) to describe the surface of the beads that used in this research. UV-Vis spectrophotometer was used to determine the concentration of the adsorbents before and after the treatment. As for adsorption of lipid profile (total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and total protein (TP)), it was observed that the adsorption of adsorbents on prepared beads type(A,B and C) followed the order (type C > type A > type B), while in case of  (high density lipoprotein (HDL-C)) , it does not adsorbed or adsorbed very little in some cases on the surface of prepared beads. Keywords: Adsorption, Adsorbent, Chitosan, Methionine, Glutaraldehyde, Ethylene glycol diglycidyl ether, Lipid profile and total protein.
Effect of Botulinum Toxins Injection on Liver Enzyme and Histochange of Liver and Kidney of Female Rats Rana Talib Al-Muswie
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present work aimed to study the effect of Botulinum toxins on liver enzyme ,Urea ,Creatinine and histological change of liver and kidney .Two doses 0.1 and 0.2 ml of Botulinum toxins were used and the animals were injected Intramuscular administration of botulinum toxin for 1 day as two dose only. The alanine aminotransferase (ALT) level in the rats of the control group (A) is significantly lower (P<0.05) than both the rats group (B) treated with Botulinum toxins and group(C). The aspartate aminotransaminase (AST) level in the rats of the control group is significantly lower (P<0.05) than both the rats treated with Botulinum toxins. Also, The results showed a significant increase in the level of urea and Creatinine of the female rats treated with Botulinum toxins compared with control group, In the histologicaly, the results showed vaculation in hepatocytes, and infiltration of inflammatory cells in liver of group (B), while in group (C), there was inflammatory cells, detachment of some hepatocytes, and congestion in area of Portia,. Kidney of group B showed congestion of blood cells and increase number of nuclei. In kidney of group C there was an increase in the number of nuclei, edematous glomerulus, and glomerular lobulation.Keywords: Botulinum toxins; Liver Enzyme, Urea, Creatinine, Liver, Kidney.
In Vitro Determination of Antioxidant activity, total phenolics, total flavonoids, anti-cholesterol of extracts Saffron (Crocus sativus) Muhammad Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: In Indonesia, saffron (Crocus sativus) drinks are now the latest healthy lifestyle trend. Saffron is used as a natural antioxidant, where antioxidants are related to cholesterol inhibition. The antioxidant activity of saffron is closely related to the content of flavonoids and phenolic compounds. This study aimed to determine Saffron 50% ethanol extract's effect on antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC), and anti-cholesterol. Methods: Inhibition of antioxidant activity with 2-diphenyl-1-picrylhydrazyl DPPH, determining TPC using Folin-Ciocalteu and TFC reagent using AlCl3 reagent, and anti-cholesterol with Cholesterol Standard. Results: TFC 19.14 ± 0.9 mg QE / g, TPC 4.8 ± 0.9 mg GAE / g, antioxidant activity with extract IC 50 6939.02, Quercetin 9.57, Rutin 41.70, and decreased the greatest cholesterol occurred at a concentration of 400 ppm with a decrease of 13.22%. Conclusion: The 50% saffron ethanol extract can be an antioxidant and anti-cholesterol in vitro, but it needs further testing in vivo with the same extract.
Gender and Age Differences with Myocardial Infarction Symptom Presentation and In-Hospital Mortality Gulnara Bedelbayeva
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Myocardial infarction (MI) is the main cause of death and disability worldwide; it increases the risk of many chronical diseases. This study assessed the correlation between the sex and age of patients with chest pain symptoms and the in-hospital mortality rate. Observational study of 6513 registry patients (2741 women and 3772 men) from Cardio logical Centre of Myocardial Infarction of Almaty (Kazakhstan), 2010-2011. Differences between study groups were assessed by χ2 test for categorical variables, the t test for continuous variables, and the nonparametric Wilcoxon rank sum test for median comparisons.  The proportion of MI patients who presented without chest pain was significantly higher for women than men. There was a significant interaction between age and sex with chest pain at presentation, with a larger sex difference in younger than older patients, which became attenuated with advancing age. Multivariable adjusted age-specific odds ratios (ORs) for lack of chest pain for women (referent, men) were younger than 45 years, 1,30; 45 to 54 years, 1,26; 55 to 64 years, 1,24; 65 to 74 years, 1,13; and 75 years or older, 1,03. Two-way interaction (sex and age) on MI presentation without chest pain was significant (P<0,001). The in-hospital mortality rate was 14,6% for women and 10,3% for men. Younger women presenting without chest pain had greater hospital mortality than younger men without chest pain, and these sex differences decreased or even reversed with advancing age, with adjusted OR for age younger than 45 years, 1,18; 45 to 54 years, 1,13; 55 to 64 years, 1,02; 65 to 74 years, 0,91 and 75 years or older, 0,81. The 3-way interaction (sex, age, and chest pain) on mortality was significant (P <0,001). In this registry of patients hospitalized with MI, women were more likely than men to present without chest pain and had higher mortality than men within the same age group, but sex differences in clinical presentation without chest pain and in mortality were attenuated with increasing age.Keywords: Myocardial Infarction, Chest Pain, Mortality, Sex, Age.
The Effects of Using a Geometric Shaped Sponge on the Physiological Motion and Kinematics Variables to Perform the Front-Hand Somersault Skill Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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Abstract

The study included a number of axes that concentrated on using the sponges in the learning process as supportive means towards learning this particular skill which is considered rather difficult. A certain type of sponges where used to learn each stage of this skill. These types were different in shape and size, considering the height and potential of the individual sample, in order to help the learners master this skill in the best way possible. The learning group was given a 4-weeks course to learn the front-hand somersault using these supportive techniques, two credits a week. After 4 weeks, the result of each group was collected and compared (The original and the experimental group). The statistical results showed that the experimental surpassed the original one.Keywords: Sponge Pieces, Physiological Motion, Kinematics Variables, Performance Learning.

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