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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Immunological Effects of Ceramic and Composite Subgingivally Extended Restoration Bilal Mohammed Obaid
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

In this study, 80 samples of gingival crevicular fluid (GCF) from patients have their teeth filled with different restoration materials , collected 20 sample of composite resin restoration material ,20 sample of crown ceramic restoration material , 20 sample of metal ceramic restoration material and 20 sample of control non-filled teeth. The purpose of this study was determine the effects composite rein , ceramic crown and metal ceramic crown restoration material on (GCF) levels of interleukin 1(IL-1 β) ,  interferon gamma (IFN- γ) , Matrix Metalloproteinase-8 (MMP8) and tumor necrosis factor (TNF- β ). Paper points (size 30) were inserted into the gingival crevice until mild resistance was felt, and kept in place for 30 seconds. Following collection of GCF the paper point placed in eppendroffs tubes contain (300 micro liter) phosphate buffer saline. GCF was eluted from paper point by centrifugation at 3000 rpm for 15 minutes after that the paper point was removed and GCF sample kept at -40 ˚C till analysis. Analysis of data for immunological parameter (IL-1β, IFN- γ, TNF- β and MMP8) that got from ELISA test. Finally, the results showed mean concentration of  IL-1β, IFN- γ, TNF- β and MMP8 in patients with restoration material ( composite resin , crown ceramic and metal ceramic) significant (P < 0.05) were higher than in control while MMP-8 in ceramic crown restoration material  high but no significant (P> 0.05 ).Keywords: Composite resin, Ceramic crown, Metal ceramic crown, Periodntitis IL-1β, IFN- γ, TNF- β, MMP8.  
Synthesis, Characterization and Biological Activity of New Derivatives of Hetrocyclic Compound Athraa B. Mohamad
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

This study included the preparation and characterization of a series of new derivatives of  pyrazoline, isoxazoline by two steps the first step involved the preparation of chalcones by reaction between aldehyde and acetophenone the second step involved the react of chalcones two stepe react chalcones with hydrazine to form pyrazoline also chalcones was reacted with hydroxylamine hydrochloride in present a basic medium for the preparation of the derivative isoxazoline The derivatives has shown moderate to good activity against gram-positive bacteria (Staphylococcus aureus), gram-negative bacteria (Escherichia coli)  when compared with standard antibiotic gentamycin .all prepared compounds were diagnosed by spectra of H1-NMR, mass.Keywords: Isoxazolin, Pyrazoline, Chalcones, Synthesis, Biological activities. ­­­­­­
The Diagnostic Value of Hba1c Turbidimetry Immunoassay in Sanglah General Hospital Denpasar, Bali, Indonesia Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Introduction: Diabetes mellitus (DM) is a common health problem in Indonesia. Currently, Hemoglobin A1c (HbA1c) is the gold standard to diagnose and monitor DM patient. HbA1c could be assessed using turbidimetry immunoassay and High-Performance Liquid Chromatography (HPLC). However, the comparison between the two devices is never conducted. Thus, this study aimed to determine the sensitivity, specificity, and correlation of HbA1c measurements using turbidimetry immunoassay method compared to HPLC as the gold standard. Methods: A cross sectional study was conducted from May to June 2017to measure the diagnostic values and correlation test between turbidimetry immunoassay method and HPLC. Diagnostic values were measured as sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Blood samples were collected in EDTA tubes and measured with turbidimetry immunoassay and HPLC, with a cut-off value of 6.5 mg/dL. Results: Fifty samples were collected during the study. HbA1c ≥6.5mg/dL were obtained from 27 samples, and normal results were obtained from 23 samples. Sensitivity, specificity, PPV, and NPV from turbidimetry immunoassay were 92.86%, 100%, 100%, and 91.67% respectively. Pearson correlation test of HbA1c result from turbidimetry immunoassay and HPLC revealed a strong positive correlation with r = 0,988. The ROC curve analysis yield AUC value of 0.926 with P=0.000 which indicate a strong diagnostic value.Conclusion: Turbidimetry immunoassay method had high sensitivity and specificity and had strong diagnostic value according to ROC analysis. There was also a strong positive correlation between turbidimetry immunoassay and HPLC HbA1c reading.Keywords: HbA1c, HPLC, Turbidimetry immunoassay.
The Relationship of Emotional Arousal with the Level of Acetyl Cholinesterase and Lactic Acid in Young Basketball Players Hayder Naji Habash Alshawi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The study of the relationship between emotional arousal and the enzyme acetyl cholinesterase in terms of (acid lactic acid) in young basketball players is of great importance which has played a large role in the direction of the researchers towards such a study. The problem of research was that the basketball game of games of relatively small space The researchers should study the effect of the enzyme acetylcholine in the emotional excitation and lactic acid to achieve the best results. The objectives of the research were to identify the level of emotional arousal, the enzyme acetyl cholinesterase and the level of lactic acid and the level of some of the effectors Physiological studies of young basketball players, and to identify the correlation between the level of emotional arousal and the enzyme acetylcholine acetate and lactic acid for young basketball players, the researchers used the descriptive method in a method of surveying and correlative studies to suit the nature of the problem, the players of the Middle and South Euphrates basketball players participating in The Premier League for the sports season 2016-2017, the nine clubs (Basrah, Maysan, Muthanna, Wasit, Dhiqar, Rafidain, Solidarity, Babylon and Karbala). The sample was selected in a simple random way, (20) players (10) for the Sports Solidarity Club and (10) for the Rafidain Sports Club. The researchers used the following tests: First: to measure the level of emotional arousal, second: biochemical variables, The concentration of lactic acid, measured the concentration of acetylcholine enzyme, and the researchers concluded the high level of emotional arousal of players as a result of the impact of psychological factor. Decreased action of the enzyme acetyl cholinesterase due to the concentration of lactic acid in the muscle, which leads to slow work and sending instructions Increase the proportion of lactic acid in the muscles as a result of the high level of emotional arousal and recommended the adoption of the results of research and use by basketball coaches to know the psychological effects of physiological basketball players. Attention to the psychological preparation of the players in the course of the training along with the physical numbers and skills and plans because of its importance in its reflection on the physical and physiological aspect and therefore on performance. To establish a department for sports medicine in faculties of physical education and sports sciences and provide all specialized devices in order to facilitate the task of conducting research and studies. Conduct research and similar studies by researchers to standardize and determine standard levels of emotional arousal scores on individual and group games.Keywords: Emotional arousal, Acetyl cholinesterase, Lactic acid and basketball.
Susceptibility of Porphyromonas Gingivalis Isolated from Patients Suffering from Periodontitis to Antibiotics Mohammed Oudah Hamad
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Twenty three of P. gingivalis isolated from ninety one patients complaining from periodontitis with different age from both gender in Babylon city. According to routine culture methods were done using differential media, anaerobic condition and morphological criteria such as microscopically and biochemically testsand percentage (25.3%). The activity of 27 antibiotics were tested towards the current  isolates,  and the results showed high degree of resistance for most antibiotics represented by: penicillin, ampicillin, amoxicillin ,carbenicillin, , tetracycline, doxycycline (100%), ticarcillin(92.6%) ,piperacillin (95.7%),erythromycin (85.2%) ,Co-trimoxazole and chloramphenicol (81.5%),cefepime (63.0%), cefixime ,ampiclox ,colistin(51.9%), ciprofloxacin and norfloxacin (56.5%), tobromycin  (52.1%), ceftrixzone,  aztreonam (47.8%), azithromycin, gentamicin and cefotaxime (44.4%) amoxiclave (37.1%),amikacin (33.3%),while The meropenem and impinem showed more effective against current isolates .The present results were consistent the what is known multidrugresistant P.gingivalis.The minimum inhibitory concentrations (MIC) of most present isolates were higher.Keywords: P.gingivalis, Periodontitis, Antibiotics resistance, Minimum inhibitory concentration.
Histological Description of Hedgehog (Hemiechinus auritus) Abdomen Skin Al-Zubaidi KA
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The present study was conducted on six healthy male’s hedgehog, to distinguish the normal histology of the abdomen skin. The hedgehogs were anesthetized by ketamine (15 mg/kg. body weight) injected intramuscular after scarfing of hedgehogs, the skinning of the ventral surface of the abdomen was carried out, then the skin specimens fixed in the formalin (10%). Routein histological processes were done. The histological structure of the hedgehog abdomen skin was revealed many invaginations of the skin folds projected from superficial surface; these folds had many bifurcation were divided by grooves, and the folds appeared as the ridges. The abdomen skins of hedgehog covered by keratinized squamous epithelium, the keratin layer consider as protective layer foe the superficial skin which represented the epidermis. Under lining the epithelium there was loose connective tissue that supported the superficial skin; and consisted of collagenous and elastic fibers as well as cellular elements such as fibroblasts, lymphocytes, myoid cells were distributed among collagen and elastic fibers which extended into the cores of the abdomen skin folds. Beneath the loose connective tissue, the dermal spines follicles were found and surrounded via a layer of smooth muscle fibers. Clusters of sweat glands were distributed deeply under the dermal spines follicles. Striated muscle fibers below the sweat glands. The striated muscle fibers were arranged; circular, longitudinal and oblique in the orientation, these muscle fibers which support the upper layer of the skin. The dermal papillae was absent in the hedgehog skin. Keywords: (hedgehog, Histology, Abdomen skin).  
Correlation Family Support on Independence of Patients Schizophrenic Activities Daily Living (ADL) Ronal Surya Aditya
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Family support for schizophrenics has proven to be very effective in supporting patients' healing and independence. And this program has been widely recommended by several minimum service standards published internationally. However, the reality is that the family is not yet fully supported, even though good family support can increase patient independence. Aims to find out the relationship between family support and ADL independence in schizophrenia patients. The research design used in this study was a correlation method that used a cross-sectional approach, with samples in this study were 70 family members with schizophrenia. The variables in this study are family supports (instrumental, informational, appreciation, assessment). Based on the results of statistical tests using the Spearman Rank shows ρ value for instrumental family support (0.020), informational family support (0.031), family support award (0.021), and family support assessment (0.021). Full family support is necessary and given to sufferers, especially schizophrenics. Comprehensive family support can be given if the caregiver is a member of the nuclear family who has a good psychological closeness with the sufferer. The results of this study can explain future approaches to dealing with the family support of schizophrenia patients Keywords: ADL Independence, Family Support, Schizophrenia.
Synthesis and Characterization of Novel Nematic Liquid Crystal Compound Mohammed Obaid Hasan
Journal of Global Pharma Technology .
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Abstract

A series of  N1-(4'-((4-(alkyloxy)benzylidene)amino)-[1,1'-biphenyl]-4-yl)-N4-(4'-((Z)-(4-(alkyloxy)benzylidene)amino)-[1,1'-biphenyl]-4-yl)terephthalamides were synthesized by thermal condensation reaction of N1,N4-bis(4'-amino-[1,1'-biphenyl]-4-yl) terephthalamide with 4-(alkoxy) benzaldehydes in absolute ethanol at reflux condition. The structure of the synthesized compounds were elucidated by FT-IR spectral data and determining the M.Ps, and element content (C.H.N %). Their liquid crystal properties were studied by measuring the values of the phase transition temperatures by differential scanning calorimetry (DSC) and the texture of mesophases by using optical polarizing microscopy (POM).The target compounds showed significant liquid crystal properties.Keywords: Nematic liquid Crystal, benzylidenaminoterephthalamides.
Wound Antiseptic Plants: An Overview of the Most Important Medicinal Plants in Iran Affecting Wound Infections Mahnaz Mardani
Journal of Global Pharma Technology Volume 08 Issue 08
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Abstract

Surgical site infection refers to infection in surgical site which is created within 30 days after surgery. Infection may occur by bacteria, viruses, protozoa, fungi and worms. In traditional Iranian medicine, many plants are used to control and treat infections. Therefore, the present paper aims to recognize and introduce antiseptic medicinal herbs by which we can produce effective natural remedies for infection control. Medicinal herbs such as chamomile, flax, veneris, oleander, savory, mallow, castor, sage, garlic, harmala etc. are the most important medicinal plants for disinfecting wounds in Iran. Keywords: wound, infection, herbs, Iran
Dental Caries and the Early Diagnosis using Low Level Laser Mahdi Ali Sukkar Al-Farawn
Journal of Global Pharma Technology .
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Abstract

The current comparative investigational work was performed to identify the reliability of the occlusal-caries-based (OC) detection using the laser fluorescence device (DD) and the traditional methods of visual-based inspection, probing-dependent detection, and periapical dental radiographs. Moreover, fissure sealant (FS) and fluoride-based topical application (FTA) was evaluated using the DD technique. Here, 60 patient molar teeth were selected for the current work from a school primary oral care center, Al-Najaf City during the years of 2016-2017. Those teeth were randomly divided based on the diagnostic tool used into VI, probing, dental x-ray, and DD (VPXD group, 40 teeth (females (n)= males (n) 6-7 years old) diagnosed as a positive sing or a negative sing for intact caries or an intact tooth respectively), FS application followed up with DD (FSD group, 10 teeth diagnosed before and after the application), and FTA followed up with DD (FTAD group, 10 teeth diagnosed before and after the application). The teeth were polished and then assigned to their diagnostic methods. The current work results identified that the DD was more reliable in detecting caries and evaluating FS and FTA than those in dental probe, VI, X-Ray. In conclusion, DD ensures a viable method for detecting protection of FS and fluoride application methods against caries.Keywords: DIAGNO dent, Fissure sealant, Fluoride, laser.

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