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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Preparation of Poly (Hydroxamic Acid) from Poly (Styrene-co-Methyl Metha Acrylate) and the Study of the use of Water Purification of Heavy Metal Elements Noor Fakhrie Mohammed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In this study, the poly (styrene-co-Methyl metha acrylo hydroxamic acid) was prepared from the poly(styrene-co-methyl metha acrylate) which  prepared  by free radical polymerization using the benzoyl peroxide initiator to  co- polymerization between (methyl metha acrylate) and (styrene) at atemperrature 70 ⁰C a mixing ratio (1:1) a conversion rate 20% and then conversion the polymer output to poly (hydroxamic acid) by reacting with hydroxyl amine hydrochloride in a strong base medium using potassium hydroxide with thermal escalation for 48 hours. The resulting poly (hydroxamic acid) and poly (styrene-co-Methyl metha acrylate) were identified by the FT-IR spectra. An adsorption study of heavy metal ions such as Fe3+, Cu2+, Co2+and pb2+ by poly (hydroxamic acid) was done. The effects of time, temperature and an acid function on adsorption ions were also studied. Calculation of desorption temperature of the metallic ions at two thermal degrees 10, 20 ⁰C shows that adsorption is chemical type.Keywords: Hydroxamic acid, Poly Hydroxamic acid, heavy metals, Adsorption.
Preparation, Characterization and Study Antibacterial Activity of Schiff Base and O-(Carboxyl) Chitosan Derivatives Biopolymer Mahmood M. Ahmed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Thiadiazole, Schiff bases are very important compounds used in the biological and industrial field and for this reason, chitosan has been modified with these compounds. Vehicles are prepared in the following ways. Initially, 2-amino-5-mercapto-4,3,1 tahiadiazole [1] were introduced according to the lectures through the thiosemcarbazide interaction with carbon disulphide in the presence of anhydrous sodium carbonate in absolute ethanol.2-amino-5-mercapto-4,3,1-tahiadiazole was activated with Salicylaldehyde in the presence of ethanol and a compound was obtained [2]. The compound [2] was then reacted with chloroacetic acid in the presence of anhydrous sodium carbonate in the distilled water Obtain the compound [3] .Schiff bases compounds [4-5] Attended with an Anthranilic acid reaction, 4-amino benzoic acid with benzaldehyde derivatives with absolute ethanol .The compounds [3-4], [6] were treated with chitosan (CS) for modulation and compounds [7-9].  The synthesized compounds were characterized by FTIR, 1HNMR, melting point.Keywords: Schiff base, Biopolymer, O-(carboxyl) chitosan derivatives, Antibacterial activity.
Synthesis, Characterization and Study the Biological Activities of new Schiff Base [5, 5,- (Ethane-1, 2- Diyl) Bis (4- ( 4-Bromobenzylideneamino)-4H- 1, 2, 4- Triazole- 3- Thiol)] and its Complexes with Cu (II), Cd (II), Hg (II) and Ag (I) ions Nada A. Rasheed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A series of coordination compounds of Cu(II), Cd(II) , Hg(II)  and Ag(I) ions with 5,5, -(ethane-1,2-diyl)bis(4-(4-bromobenzylideneamino)-4H-1,2,4-triazole-3-thio), as a ligand has been successfully prepared in alcoholic medium. The synthesized complexes were characterized quantitatively and qualitatively by using: elemental analysis CHNS, FT-IR spectroscopy, UV-visible spectroscopy, 1H and 13CNMR, atomic absorption measurements, magnetic susceptibility, thermal analysis) TG and DTG) and conductivity measurements. This ligand coordinates as a bidentate that to the metal ions through sulphur and nitrogen of (azomethine group) atoms. According to the spectral data, Cu(II)- complex has coordination of 6 with octahedral geometry while the Cd(II)-complex and Hg(II) have coordination of 4 with exhibited tetrahedral ,and the Ag(I)-complex has coordination of 3 with exhibited trigonal planer ,  The Schiff base and its metal complexes have been screened for antimicrobial activity against four  bacteria, namely :(Staphylococcus aureus, , Streptococcus sp. , Klebsilla Pneumonia  Escherichia coli )and the  fungi, namely ( Aspergillus flavus ) .Keywords:  Triazole complexes; Schiff base-triazole; Biological activity.
Association between Hypothyroidism and Herpes Simplex Virus with Interleukin-23 Sahar H. Al-Hindawi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Hashimoto’s thyroiditis and Hypothyroidism play a distinct role in the suppression and reactivation of herpes viruses. Herpes simplex virus infections have been assumed as one of the factors that may trigger autoimmune thyroid diseases; however, IL-23 has an important role in the pathogenesis of several inflammatory and autoimmune conditions. Objective: This study aimed to investigate the association between thyroid hormones in hypothyroid state and the Herpes simplex virus status in such patients; besides detecting the role of IL-23 in these cases. Materials and Methods: The present study included 65 Iraqi female hypothyroid patients with age ranged between 26-54 years and 25 healthy controls with age ranged between 25-50 years. Serum samples were collected from the study groups. Levels of thyroid hormones (TSH, T4, and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. The detection of herpes simplex virus IgG and IL-23 levels in the serum samples were determined by an enzyme linked immunosorbent assay (ELISA) kits. Results: The current study results revealed that serum IL-23 and HSV levels are increased significantly (P<0.001) in the hypothyroid patients group as compared with control. There was a significant positive correlation between TSH and (IL-23, HSV); also between IL-23 and HSV (P<0.01). Moreover, there was a significant negative correlations (P<0.01) between IL-23 with (T4, T3) and between HSV with (T4, T3).  Conclusion: The present study pointed to the association between thyroid hormones deficiency in Hashimoto thyroiditis cases and IL-23 levels through disruption of the patient’s immune system; and with Herpes simplex viruse-1by their role in the replication.Keywords: Hashimoto Thyroiditis, Hypothyroidism, Herpes Simplex Virus, IL-23.
Tissue culture technician and in vitro screening of rice (Oryza sativa L) callus for salt tolerance Arshad Alhasnawi
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

World wide, the most important cereal crop is rice (Oryza sativa L.) However, its production goes through from salty environments in several areas since it is one of the salt perceptive crops. NaCl mainly contributes salinity that is one of the significant abiotic stress aspects and, the leading cause of crop failure in the world. Tissue and cell culture methods have been applied to gain salt tolerant plants through using in vitro culture methods. In the present paper, the vitro screening of plant germplasm for salt tolerance, as a successful employment of this technique in rice is raised. The current review, focus on plant tissue culture as a method applied for in vitro to protocol for callus induction and screening of salt tolerance and revival of rice in the laboratory.
Herbal Drugs, Diet and Lifestyle Changes for Liver Diseases- A Review S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

The liver is an important part of human digestive system. The organ’s function include food metabolism, energy storage, waste removal, detoxicification, immune system support and production of chemicals. There are several things damage the liver such as toxic substances, viruses, medications, genetic diseases and alcohol. Some of the herbal drugs and its extracts showed a good potentials for use in liver diseases.  Therefore, the present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity. In addition diet and lifestyle changes can help to improve the conditions of hepatotoxicity. 
Mesoporous Silica and Zno@Sio2 as Adsorbents for Crystal Violet Dye Removal from Aqueous Solutions Sameer H. Kareem
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Sol-gel method was used to prepare two samples of mesoporous Silica (mSiO2) and zinc oxide- mesoporous silica (ZnO@mSiO2) in the presence of HydroxycetylHydroxy ethyl Diamonium Chloride (dehyquart) surfactant as template. The two adsorbents prepared were characterized by nitrogen adsorption-desorption, XRD and AFM techniques. The results show that the mSiO2 sample has a mesopores in the range 2- 8 nm with a high degree of ordering of the porous structure, while Zn@SiO2 sample has pore distribution in the range 2-50 nm. The adsorption ability of the two adsorbents to removal of Crystal Violet (CV) dye from aqueous systems has been studied using a batch experiments method to measure the adsorption as a function of contact time and adsorbent dose at the temperature 293 K. Adsorption isotherms were fitted with the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich models and the results show a best fitted for the two adsorbents, and the adsorption processes were physical adsorption type. The kinetic data were analyzed and found to match well with pseudo-second order kinetic model.Keywords: Mesoporous silica, Crystal Violet, Zn@SiO2, Adsorption isotherm.
Determination of Diethyl Amine by Stop Flow Technique Dakhil Nassir Taha
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The aim of this research is determination of diethyl amine by stop flow injection analysis technique. The method is based on the reaction between diethyl amine with NQS reagent. This method involves a homemade new valve, which is manufactured from a cheap available material. Optimization of the conditions of the reaction includes, flow rate, sample volume, reagent volume, reagent concentration and reaction coil length were done. Linearity was in the range of (1-10 v/v %), correlation coefficient (R2) was 0.9967. The method was applied successfully to the determination of diethyl amine in aqueous solution. Keywords: Diethyl amine, FIA, Stop flow technique, Dispersion.
Laboratory Evaluation of Supernemic Insecticide (Neem Oil) and its Effect on Larvae of Big Headed myiasis Blow Fly Chrysomya Megacephala (Fibricius, 1794) (Diptera: Calliphoridae) Nawal Sadiq Mehdi
Journal of Global Pharma Technology .
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Abstract

This study was carried out to evaluate the efficiency of Supernemic in the control of larvae of big headed myiasis fly Chrysomya megacephala by direct spraying and food treatment, the results of direct spraying of the second instar larvae with concentrations 0.3, 0.6 and 1ml.l-1 led to cumulative mortality reached 25, 37 and 59% respectively, with a decrease in the emergence number of adults insects to 75, 36 and 41%, respectively, as well as 76% of the adults which produced from larvae were treated with 1 ml.l-l of supernemic died after 24 hours, some of malformation in the dead larvae was noted such as blackening the whole body of the larva or appearance of black spots on it. The treatment of larval food with same concentrations showed a cumulative mortality reached 27, 64 and 65%, respectively, and the adults emergence percentage were 67, 36 and 35 respectively, we conclude that the larvae of this fly were sensitive to the insecticide, as well as food treatment was more efficient in controlling of this fly compared to the direct spraying treatment.Keywords: Neem oil, Myiasis, Chrysomya megacephala.
Incidence and associated risk factors of LV clot among patients with myocardial infarction of Urmia Seyyed-O- Shohada heart center Alireza Rostamzadeh
Journal of Global Pharma Technology Volume 08 Issue 09: (2016) September 2016
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Abstract

BackgroundBased on previous experiments with a limited number of samples, it seems that the use of anticoagulants(heparin or subcutaneous high dose heparin) reduces by 50%of the progression of left ventricular embolism.In this study, we determined to investigate the incidence and factors associated with left ventricular thrombusin patients with acute myocardial infarction admitted to Seyyed-al- shohada University Hospital.MethodsIn this analytic cohort study, patients with myocardial infarction were included and risk factors of LV clotfollowing of myocardial infarction as, diabetes mellitus, smoking, hypertension, dyslipidemia, higher age,gender, extent of cardiac involvement, LV diastolic dysfunction and reperfusion were evaluated. Also, otherechocardiographic parameters as LV size, LV systolic and diastolic dysfunction, assessed and recorded in acheck list. Finally effect of each factor on incidence of LV clot was evaluated separately.ResultsIn our study, we found no significant association between underlying disease, diabetes, history of prior MI,history of hyperlipidemia, smoking and SK infusion, but there was a significant association between the typeof MI and clots in the left ventricle. In this study, we found no significant association between the incidence ofthrombus within the left ventricle and Primary PCI. Also receiving Heparin and/or Enoxaparin and Metoral arenot significantly associated with LV clots. However, there is no significant association between LV size andcount of involved leads in the incidence of left ventricular thrombus.Conclusion: Finally, according to the results of the study it can be said that the time from onset of the pain untilrevascularization in the hospital, had an important role in preventing LV clots and the outcomes of the patient.Key words: Incidence, risk factors, LV clot, myocardial infarction.

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