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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Hydrogen and Sulfur Surfaces Effect on the Structural and Electronic Properties of Graphene Nano Ribbon Huda Bukheet Hassan
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Present work deals with the effect of hydrogen and sulfur surfaces on the structural and electronic properties of grapheme nano-ribbon using the B3LYP/DFT with 6-31G basis sets .Employed at the Gaussian 09 package of programs. The results showed suitable basis functions used to describe each GNR gave good relaxation and structural properties. The total energy was decreased when increasing the number of atoms in the structure. The LUMOs are greater than HOMOs in which these GNRs have the ability to donating or accepting electrons .The presence of the surfaces in the GNR increases the energy gap of the NR. For all structures, the IP is larger than the EA, means these GNRs need small energy to acceptance an electron and becomes anions. All GNRs have high electronic softness.Keywords: HOMO, LUMO, B3LYP, Softness and Hardness.
Biological Activity of Cefotaxime Sodium and their Complexes with Iron and Copper Metals Ayad M.J. Almamoori
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

This investigation was designed to compare between inhibitory effect of cefotaxime sodium and their complexes with heavy metals (iron and copper). In this study, five concentrations were used in range from 0.01 M to 0.005 M for cefotaxime sodium and 0.005 mL, 0.01mL from FeCl3 with 0.01mL cefotaxime sodium, and 0.005ml CuCl2 with 0.01mL cefotaxime. The statistical analysis results showed that cefotaxime sodium (0.01mL) have a highest inhibition effect on bacterial growth, and iron have a synergistic effect with cefotacime more than Copper. Also it was found that, E.coli species were recorded as most affected species by cefotaxime sodium, and their complexes relative to other species.Keywords: Biological activity, Cefotaxime sodium, Heavy metals, Cefotaxime sodium, biological activity, E.coli.
The Effect of Special Exercises According to the Phosphate Energy System in Developing the Rapid Ability to the Weapon Arm and the Accuracy of the Epee Attack for Girls Players Hussein Manati Sajit
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The current study is of great importance as the aim of the research is to prepare phosphate-strength exercises to develop the rapid ability of the weapon arm and the accuracy of the epee attack for girls' players. Learn about the impact of exercises with phosphate effort to develop the rapid ability of the weapon arm and the accuracy of the epee attack for girls' players. The researchers use the experimental method - the two equal groups a pretest and posttest to the nature of the suitability of the study. Select the research community for girls players in the Alfahtat club in Baghdad to the fencing, totaling (20) player, as it has been selected (16) player and (80%) of the total research community as it has been divided into two groups (Control and experimental) and each group (8) players. In order to achieve the same conditions in the training modules and thus control the search variable, the two groups were trained together as a single group, in all parts of the training unit and under the direct supervision of the researcher, with the exception of the main section of the unit, the players are distributed to their groups, so that the experimental group undergoes these exercises prepared by the researchers, while the control remains on the same exercises given by the coach them. The training program took (6) weeks by (3) training units in the week a total of (18) training units, ranging training unit time (90 minutes), the duration of the proposed exercises by researchers range (30-35) minutes from the main section of the training unit time, in the exercise design, the researchers adopted a repetitive training method (90-95%) of the maximum intensity of the player. The researchers used the maximum exercise time to determine the intensity of the phosphate exercise the researchers conducted some exercises and measured the time of some player's days before the start of the main experiment and verify this during the application of his experience and exercises in the experiment so the intensity of exercise is known to researchers. One of the most important conclusions reached by the researchers is that the phosphate exercise used in research can positively affect the rapid ability of the female players in the fencing, thus positively affect the skill of accuracy of the attack and hence the proposed training exercises have achieved its proposed goals.Keywords: Special exercises, phosphate energy system, rapid ability and epee. 
Estimation of Serum Levels of Testosterone and Estrogen in Vitiligo Patients Sherief Mahdy Hussein
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Vitiligo is an idiopathic systemic autoimmune disorder affecting skin, hair and oral mucosa. This genetic moreover acquired disease distinguished by melanin absence causes morbidity over all races. Although thyroid disorder has been known as a key trigger of this pathology, arange of other factors plays serious role in its presentation. Several hormones such as, testosterone and estrogen have been suspected as drivers of this disorder. The present study aimed to determine the levels oftestosterone, estrogen and the ratio of testosterone/ estrogen in serum of patients with vitiligo compared to matches control group .The study included50 patients from Egyptian population with lesions of generalized vitiligo (29 males and 21 females; median age 35.0 years; range 28–40 years and 50 healthy volunteers as control group (22 males and 28 females; median age 36.1 years; range 25–40years). All patients of vitiligo were recruited from Medical research center of excellence of National Research Centre, Egypt, during a period of 4 months (February 2019 to May 2019). The mean duration of the disease in the vitiligo group was 5.00years.Vitiligo diagnosis is based on if areas of patient's skin, hair or eyes lose coloring and confirmation is done using Wood’s lamp. Blood samples were obtained from both the patient and control groups, testosterone, estrogen and the ratio of testosterone/ estrogen. Results:  The present results declared significant elevation of testosterone (+144.5), estrogen (+116.048) as well as testosterone/ estrogen ratio compared to control subjects. Conclusion: Some endocrine markers play a principle role in pathogenesis and/or consequences of vitiligo. The abnormally disturbed levels of these markers lead to melanocyte damage and/or depigmentation.Keywords: Autoimmune disease, Melanin loss, Oxidative stress, Vitiligo, Estrogen, Testosterone, Testosterone /Estrogen ratio.
Synergistic Effect of 1-MCP Fumigated with Chitosan Coating on Shelf-life and Physico-Chemical Quality of Marian Plum (Bouea macrophylla) Fruit Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Marian plum fruit has high nutritional and functional components which are beneficial for human health. However it has a short shelf-life owing to its high respiration and ethylene production. 1-methylcyclopropene is an inhibitor of ethylene action even at low concentration to hinder ripening and improving storage stability on variety of fruits. Chitosan has strong antimicrobial and antifungal properties that could effectively adjust the permeability of gas exchange, slow down respiration rate, hinder fruit decay. Objective of this study focused on the evaluation of 1-MCP fumigation at different levels (20 ppm, 40 ppm, 60 ppm, 80ppm, 100 ppm) in combination with chitosan coating (0.1%, 0.15%, 0.2%, 0.25%, 0.3%) on shelf-life and quality of marian plum during 14 days of storage at ambient temperature. Our findings will provide better insights for manufacturers in postharvest management.Keywords: Marian plum, Chitosan, 1-MCP, Fumigation, Coating, Posthavest
Synthesis, Characterization and Antibacterial Studies of New Metal Complexes of α-Aminonitriles Derived from P- Chlorobenzaldehyde with 2-Aminopyrimidine Mohammed H. A. Al-Amery
Journal of Global Pharma Technology .
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Abstract

New metal ion complexes of some transition metal ions [Mn(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)] of previously prepared ligand 2-(4-Chlorophenyl)-2-(Pyrimidin-2-Ylamino)Acetonitrile was synthesized. The ligand was prepared by Strecker's procedure which included the reaction of P-Chlorobenzaldehyde with 2-Aminopyrimidine and the structures of the new metal ion complexes were characterized by Elemental Micro Analysis (C.H.N), Chloride Content, FT-IR, UV-Vis spectra, Thermal Gravimetric Analysis (TGA-DTG), flame atomic absorption, molar conductivity as well as magnetic susceptibility measurement. According to the obtained data the probable coordination geometries of these complexes were suggested as octahedral. All complexes were found to be non-electrolyte. The antibacterial activity of the ligands and their metal ion complexes have been studied by screening against various microorganisms, Staphylococcus aureus, Bacillus subtilis (Gram-positive), Escherichia and Pseudomonas aeruginosa (Gram-negativre). Agar (well-diffusion method) was used to determine the activity. The metal ion complexes gave the formulae: [ML2Cl2].nH2O.Keywords: 2-(4-Chlorophenyl)-2-(Pyrimidin-2-Ylamino)Acetonitrile, Transition metal ions.          
Comparing the Anxiety of Children When Entering and Leaving the Operating Room with and without the Presence of Parents navid kalani
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

Surgery is one of the most frightening therapeutic procedures that can in children so that it can prevent to achieve therapeutic purposes and its controlling is very important. This study was conducted to compare the children's anxiety when entering and leaving the operating room with and without the presence of their parents.Methods: In this clinical trial study, 38 children aged 3 to 9 years who underwent tonsillectomy surgery were randomly assigned to experimental and control groups. In the experimental group, parents were with children during induction of anesthesia. The anxiety of children was measured based on the m-ypas scale.  Finally, the data were analyzed using descriptive statistics, chi-square and Fisher test by Spss 21 software.Results: Mann-Whitney test showed that there is difference between experimental and control groups of children in terms of anxiety scales of children including emotional expressivity, vocalization, State Apparent Stimulated, and use of parents (p-value <0.05, Table 2), but there is no difference between two experimental and control groups in terms of scale of activity (p-value>0.05). Additionally, there is difference between them in terms of anxiety (p-value> 0.05). The mean of the anxiety in the experimental (43.68) reduced compared to control group (60.09). This means that the presence of parents has impact on level of anxiety during induction of anesthesia on 2 to 7 years old children undergoing surgery.Conclusion: The results showed that parental presence has impact on anxiety during induction of anesthesia on 3 to 7 years old children undergoing surgery. Keywords: Anxiety, Parents, Children.
Variable Parameters Affecting to Nile Tilapia (Oreochromis Niloticus) Fish-Paste Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Tilapia has emerged as one of the most cultivated and marketed species in Vietnam. There is not much research mentioned to processing of fish-paste of this valuable fish. In order to improving the added value of this fish, we investigated a production of fish-paste from Nile tilapia (Oreochromis niloticus). By investigation different parameters probably affecting to gelation, the results was noticed that the best physicochemical properties and sensory characteristics of fish-paste would be obtained by the addition of modified starch 1.5%: guar gum 1.5%. These results demonstrated that the addition of modified starch and guar gum in the formulation of Nile tilapia fish-paste increased the nutritional value of the product without reducing its sensory preference.Keywords: Nile tilapia (Oreochromis niloticus), fish-paste, Modified starch, Guar gum, Physicochemical properties.
Synthesis and Characterization of New Copolymers Containing Subs.-1,3,4-Oxadiazole Ring Raghad Hamed Ismail
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

New copolymers were prepared from monomer (5-vinyl-1H-tetrazole),which prepared from reacted acrylonitrile with sodium azide in presence zncl2 and another monomer was Methyl acrylate. comonomers were polymerization using[BPO]with heating to(80-90)c◦.The second step was prepared copoly acid hydrazide,Then reacted with different aromatic carboxylic acid in presence(pocl3)to optain subs.1,3,4-oxadiazole ring pendant on copoly(5-vinyl-1H-tetrazole-MA) .The prepared copolymers were characterized by FT-IR, and copolymers some of them 1H-NMR, and T.G.Keywords: acrylonitrile, Sodium azide, Copolymerization, Acid hydrazide, 1,3,4-Oxadiazole.
Prescription of Antihypertensive and Antianginal Medications within the Conditions of Outpatient Treatment of Patients with Ischemic Heart Disease Along with Hypertension Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Abstract Cardiovascular morbidity leads the world in the morbidity rate structure. An arterial hypertension and a stable angina are widely occurring among the population and, in terms of medical and social significance, stand at the head of the circulatory system diseases. The combination of these diseases is observed in 2/3 of patients. An important challenge for cardiology is to ensure a rational approach to the choice of medications for effective antianginal and antihypertensive therapy, its compliance with accepted treatment quality standards, the development of clear and scientific-based criteria for the use of medications, improvement of the patients’ quality of life while reducing the economic costs for medications supply. Purpose. To develop an approach to the optimization of medications supply for patients with ischemic heart disease in combination with arterial hypertension in inpatient and outpatient practice, based on the use of pharmacoeconomic and pharmacoepidemiological researches. Materials and methods. To assess the prescription structure of the various groups of antihypertensive and antianginal medications, an analysis of the past medical history in patients with ischemic heart disease in combination with arterial hypertension was carried out. Variation statistics methods have been applied in mathematical data processing. Results. Beta-blockers prevailed, followed by angiotensin-converting enzyme inhibitors, calcium channel blockers, and diuretics were found in the structure of medicinal benefits when prescribing pharmacotherapy to patients with stable angina pectoris with arterial hypertension. Conclusions. As a result of the research, it was revealed that the combination therapy in most cases was based on beta-blockers, angiotensin-converting enzyme inhibitors, diuretics in various combinations with each other.

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