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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Assessment of Learning Efficiency in Iraqi Nursing Education Ahmed Sh. Alzuheri
Journal of Global Pharma Technology .
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Abstract

Many nurses make up the health system. Therefore, their education has a significant impact on the health of society. One way to ensure their abilities is to provide effective education. Nursing is professional discipline. A professional is an individual who possesses the knowledge and skill of experts in a particular field acquired through formal education in higher education institutions and through experience, which uses that knowledge and skill on behalf of the community through specific customer service 11. Objective: To assess the nursing education colleges regarding nursing education process. Design: Descriptive design (cross-sectional) survey study design has conducted throughout the period of 1 September 2016, to July 20th 2017 in order to Assessment of learning efficiency in Iraqi nursing education. After getting the approval of the University of Babylon / College of Nursing Council for the study, the researcher has submitted a detailed description including the problem statement, questionnaire and objectives of the study to the Ministry of Planning (Central Statistical Organization), which was accepted the study instrument. Later, the permission is presented at all nursing colleges in Iraq. Results: The finding of the study indicate that there is a clear shortage in the number of faculty members of all academic rank, in relation to the number of existing colleges, and also this shortage exists in the number of faculty members for students, in most colleges.Keyword:  Learning efficiency, Nursing education, Iraqi.
Metformin Attenuates Cognitive Deficits in Experimentally Induced Alzheimer’s Disease Laxmianarayana Bairy Kurady
Journal of Global Pharma Technology .
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Abstract

A study was undertaken to evaluate the effect of metformin on learning memory inexperimentally induced Alzheimer’s disease in Wistar rats. A total of 30 Wistar rats were divided in tofive groups of six rats each. Group 1 served as control. In Group 2,3 and 4 Alzheimer’s disease wasinduced by administering aluminum chloride (17 mg/kg) orally to the animals for a period of 4 weeksonce daily. Group 1and 2 received distilled water, group 3 received rivastigmine (0.3mg/kg) and group 4and five received metformin 100mg/kg. All the rats were subjected to passive avoidance test. At the endof the experiment the rats were sacrificed and brain acetylcholinesterase level was estimated.Administration of aluminium chloride resulted in poor learning and memory and this was significantlyreversed by rivastigmine and metformin. In conclusion, the memory impairment induced by aluminumchloride was revered significantly by both rivastigmine and metformin.Keywords: Alzheimer’s disease, Metformin, Rivastigmine, Passive avoidance test, Acetylcholinesterase.
Immunological Study and Molecular Detection of Listeriosis of Aborted Women in Al Muthanna Province Sarah Zegheer Hussein
Journal of Global Pharma Technology .
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Abstract

Abortion is considered as one of the important clinical problems that may affect pregnant women causing dangers to the mother and her fetus This study designated for immunological and molecular detection of Listeriosis in Al Muthanna province during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in human. This study was carried out in Children and delivery's Hospital at Al Muthanna Province during 26/11/ 2017  to 25/ 4/ 2018, 100 women who had single or repeated abortion were selected for this study, and they were referred with a physician report for TORCH tests to determine the final diagnosis of pregnancy loss. The 50 controls were healthy pregnant women with a history of a normal pregnancy. Blood, serum, swab, and placenta were collected for tests NBT, MTT, ELISA and RT-PCR). The test is done to estimate the phagocytic activity in abortive women, the results of (NBT) test showed a significant difference (P<0.001) in phagocytic activity (39.6%) in the blood abortive women compared with healthy individuals as controls. The MTT assay used for evaluating the lymphocyte transformation index of peripheral blood leukocytes in abortive women The results of MTT assay showed a significant difference (p<0.0001) in the lymphocyte transformation index (34%) in the lymphocytes of abortive women compared with controls. Indirect ELISA assay was IgG done to diagnosis human listeriosis as the causative agent of abortion. The results of an Indirect ELISA IgG was 10(10%) for L. monocytogenes. Real-Time Polymerase chain reaction results showed 7(7%) was positive L.monocytogenes that is done by using SYBR Green I dye and the diagnostic gene was hlyA L. monocytogenes.Keywords: Abortion, Listeriosis, ELISA, RT-PCR, and Al Muthanna province.
Synthesis, Characterization and Spectrophotometric Studies of New Hydrazone Derived from Ethyl benzoate Sajid H. Guzar
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present work includes synthesis and characteriation of new hydrazone derived from ethyl benzoate. Firstly, benzoate hydrazide [A] has been synthesized from the condensation of ethyl benzoate with hydrazine.Then the benzoate hydrazide was reacted with phenylisothiocynate to prepare [B]. Cyclization reaction of product [B] with sodium hydroxide produced terazole derivative [C].On the other hand, alcylation reaction of compound [C] with chloroethylacetate in the presence of Sodiumacetatetrihydrate  as a catalyst resulted [D]. The acid hydrazide derivative [E] has been synthesized by the reaction of compound [D] with hydrazine hydrate . Finaly,  hydrazone derived [M] was synthesized by the condensation reaction of the acid hydrazide [E] with 5-bromo-2-hydroxy benzaldehyde . The synthesized compounds were characterized by UV-Visible, FT-IR, 1H-NMR ,13C-NMR and Mass spectra. Analytical spectrophotometric study of the complexes  of Lead (II),Cobalt(II) and Cadmium (II) with the hydrazone[M]  was achieved. At a pH value of 7.0. lead, cadmium and cobalt salts reacted with [M] to form a 1:1 yellow, 1:1green, and 1:1 viole complexes  with absorption peaks at 397, 389 ,and 396 nm, respectively. Under the optimal conditions, Beer’s law was obeyed over the ranges  of 0.01- 0.000001 The apparent molar absorptivity and Sandell’s sensitivities were 8.5 ×102,8.0 ×103, and 9.8 ×102 L·mol−1·cm−1 respectively, and 0.00964, 0.00600, and 0.00275 µg·cm-2 respectively. The detection limits were found to be 32.75, 41.85, and 40.66 µg/mL-2 respectively.Keywords: Hydrazones Schiff base, Ethyl benzoate, Analytical studies. Introduction
Design and Development of Losartan Potassium Press Coated Tablets for Pulsatile Drug Delivery S Ramkanth; Ashok Kumar Janakiraman; Saminathan Kayarohanam; Vetriselvan Subramaniyan; Sinouvassane Djearamane
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
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The objective of the present study was to design and evaluate time-dependent pulsatile delivery systems (PDDS) of losartan potassium pulsatile press coated tablets. Losartan potassium (LP) is angiotensin II (AG II) receptor antagonists to treat hypertension. LP pulsatile systems are time-controlled drug delivery systems which are designed to mimic the circadian rhythm of the body and deliver the drug at a specific time. LP core tablets were prepared by direct compression method using a single punch machine. The prepared tablets were shielded with a combination of different grades of Hydrosy propyl methyl cellulose (HPMC) and Ethyl cellulose (EC) as coated materials. Prepared core and pulsatile tablets were optimized and evaluated for various properties like diameter and thickness, uniformity of weight, hardness, friability, disintegration time, drug content and in vitro dissolution studies. The drug release profile LP pulsatile tablet batch of LH-3 designated as the optimized batch that shows the lag time 8 hrs with complete drug release of 99%. LP pulsatile tablets will be taken at bedtime, releasing the drug in the morning hrs when the symptoms are more prevalent can prove to be a revolution in the treatment of hypertension.
Synthesis of Novel Methoxy Substituted Benzothiazole Derivatives and Antifungal Activity against Aspergillus Niger Akhilesh Gupta
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background Aspergillus species mainly cause a spectrum of disease ranging from airway colonization. In case of respiratory tract, aspergilloma is the most common form of pulmonary involvement, which is usually accompanied by preexisting lung disease finally architectural abnormalities most commonly stem from tuberculosis, although other associated conditions, such as sarcoidosis, bronchiectasis, and neoplasm, have been documented. Synthesis and screening of benzothiazole derivatives have great importance in heterocyclic chemistry because of its potent and significant biological activities. Methoxy substitution at benzothiazole has already proven its bioactivities in diversified areas. Methods Methoxy substituted benzothiazole derivatives were synthesized by reaction of 3- chloro-4-methoxy-aniline with potassium thiocyanate under temperature control and presence of bromine in glacial acetic acid and ammonia. Substituted nitrobenzamides then synthesized by condensation of, 2-amino-4-chloro-5-methoxy-benzothiazole with 2(3or4)-nitrobenzoylchloride acid in presence of dry pyridine and acetone. Finally, newly synthesized derivatives (K-01 to K-09) were synthesized through replacing of chlorine of nitrobenzamide by reaction with 2-nitroaniline, 3-nitroaniline, and 4-nitroaniline in presence of DMF. Analtytical characterization was performed by TLC, melting point, IR and NMR spectroscopy. Antifungal activity was performed against Aspergillus niger by cup plate method (diffusion technique) using griseoflavin as standard. Compound K-05 and K-06 showed potent antifungal activity against Aspergillus niger while compound K-01 and K-03 showed moderate inhibitory activity at both concentrations 50µg/ml and 100µg/ml as compared to standard. Conclusion In the present work efforts have been made to synthesized methoxy substituted benzothiazole derivatives and screened for antifungal activity. Compound K-05 and K-06 found as most active against Aspergillus niger.Keywords: Methoxy-benzothiazole, Benzothiazole, Antifungal activity, 2-substituted benzothiazole, Cyclization of benzothiazole, Aspergillus niger.
The Effectiveness of Cognitive-Behavioral Therapy (CBT) Based on Kesh's Eight-Step Model on Body Image and Self-Esteem among Married Women in Birjand Zahra Khayati
Journal of Global Pharma Technology .
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Background and objective: In recent decades, body image problems have been considered by clinical practitioners and some therapeutic methods have been designed for them. At present, a widespread attention is paid to cognitive-behavioral therapy, because this type of treatment provides clear and complete methods for intervention and measurements. The present study was done to investigate the effectiveness of cognitive-behavioral therapy based on Kesh's eight-step model on the body image and sexual self-esteem among married women in Birjand. Method: This was a semi-experimental study which was carried out on 30 married women referred to Omid Counseling Clinic in Birjand. The subjects were selected through convenience and voluntary sampling method and randomly assigned to experimental group (n=15) and control group (n=15). The experimental group received eight 90-minute sessions of training techniques of cognitive-behavioral therapy based on Kesh's eight-step model. The instruments to collect data were Multidimensional Body Self-Relations Questionnaire (MBSRQ) and Zeanah and Schwarz   Sexual Self-Esteem Inventory for Women (SSEI-W). To analyze data, multivariate analysis of covariance in the environment of SPSS software (ver. 21) was used. Findings: The results of covariance analysis showed that there was a significant difference between the mean scores of body image in experimental and control groups based on group membership in the post-test with 99% confidence (P<0.01), and the intervention effect was 0.49. Also, there was a significant difference between the mean scores of sexual self-esteem in experimental and control groups based on group membership in the post-test with 99% confidence (P<0.01), and the intervention effect was 0.38.ConclusionOverall, it can be said that the cognitive-behavioral therapy based on Kesh's model can be used as an appropriate intervention method to treat problems related to body image and sexual self-esteem.Keywords: Cognitive therapy based on Kesh's eight-step model, Body image, Sexual self-esteem.
Metal Complexes of Mixed Ligands (Quinolone Antibiotics and α-Aminonitrile Derivatives) Their Applications: An Update with Fe (III), Co (II) and Ni (II) Ions and Study the Biological Activity Aseel H. Abd Al-Ameer
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Quinolones (ciprofloxacin) have abroad- antibiotics spectrum with best oral absorbing. Consequent to the biological action located on nucleus of CH3COOH which works in the 3-location and in best state a piperazinyl base circle (or any type of N-heterocycle) at 7- positron and an oxygen carbonyl atom at 4-position). Quinolones (L1) and 2-phenyl-2-(1-Naphthylamitie) acetonitrile (L2) can bind to the ions for metal return making complexes which acting as binary ligand. The complexes and ligands which diagnosed by Micro element analysis chloride container, FTIR, UV-Vis spectra, conductivity in addition to measurement of magnetic susceptibility. Under this act founding the likely geometries shapes were proposed as octahedral complexes, several of them were classified as non-electrolyte the rest consider as weak electrolyte. The L1and L2 with [Fe(III),Co(II) and Ni(II)] respectively provided the formulae:   [ML1L2 Cl]Cl.2H2O and [FeL1L2Cl]2H2O       Were M:{ Co2+ and  Ni2+}Keywords: Quinolones (ciprofloxacin), 2-phenyl-2- (1-Naphthylamine) acetonitrile. 
Low Serum 25- Hydroxyvitamin D among Beta-Thalassemia Patients in Iraq Riham Hussein Noor Almosawi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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This study aimed to investigate characteristics of patients like type of Beta-Thalassemia,  age, gender, and estimation of vitamin D level in the serum of patients with β – thalassemia. Samples of blood were collected from 98 β-thalassemia patients and 32 healthy controls. The quantitative assays of 25-hydroxy vitamin D were detected by using the quantitative sandwich ELISA technique. Serological experimental analysis found that the mean 25-hydroxy vitamin D was significant decrease in patients group in comparison to control subjects (P<0.001).Keywords: β-thalassemia, Patients, Serum, 25-Hydroxyvitamin, Iraq.
Estimation of Dioxins in Workers Collecting and Burning of Waste Hamid J. Mohammad
Journal of Global Pharma Technology Volume 11 Issue 03
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The study included measuring the concentration 17 congeners from PCDD/Fs (7 PCDDs and 10 PCDFs) in the blood lipids of workers collecting and burning of waste for 56 candidates, the range of age was 23–42 years, classified into two categories depending on the period of exposure. The first category (category 2) includes 27 persons, the exposure period was <10 years, the mean age was 30.3±3.5 years, the mean PCDDs, PCDFs and PCDD/Fs were 8.61, 5.34 and 13.95 (pg WHO–TEQ/g lipid), respectively. The second category (category3) includes 29 persons, the exposure period was >10 years. The mean age was 35.6±2.8 years, the mean PCDDs, PCDFs and PCDD/Fs were 9.89, 5.65 and 15.54 (pg WHO–TEQ/g lipid), respectively. The data were compared with a control group (category1) (general (non-exposed) populations) including 50 candidates; the mean age was 32.2± 2.6 years, the mean PCDDs, PCDFs and PCDD/Fs were 6.87, 3.38 and 10.25 (pg WHO–TEQ/g lipid), respectively. A probability of 0.05.Keywords: PCDD/Fs, Burning of waste, Polychlorinated dibenzodioxins, Polychlorinated dibenzofurans.

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