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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Analysis of the study sample of patients and their use of antihypertensive drugs in monotherapy Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction: Cardiovascular diseases are the primary socio-medical problem of the industrialized countries of the world. One of the most important in terms of increasing life expectancy and the preservation of the viability and quality of life is the solution to the question of the proper therapy of cardiovascular diseases and their timely prevention. The purpose of this study was to determining the structure of patients' use of antihypertensive drugs, as well as to study the subjective factual and prognostic assessment of patients' effectiveness of treatment. Materials and methods: Methods such as: questionnaires of patients (content analysis of case histories) were used. Data processing was performed using statistical and mathematical methods and graphical analysis. Results and discussion: There were some patterns of lowering blood pressure in patients on the background of monotherapy of hypertension and patients following the doctor's instructions for treatment. Conclusions: As a result of the study, it was found that most patients follow the recommendations of doctors on the appointment of antihypertensive drugs.
Anti-Dermatophytes Activity of Macroalgal Extracts (Chara vulgaris) Isolated from Baghdad City-Iraq Ahmed S. Dwaish
Journal of Global Pharma Technology .
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Abstract

In the present study, the metabolic andethanolic extracts of specie (Division: Chlorophyta)  Chara vulgaris was tested  for antifungal (Dermatophytes) activity for in vitro at concentration (100,50 and 25 mg/ml) against two clinical isolates of Dermatophytes fungi (Trichophyton rubrum and Trichophyton mentagrophytes) by measuring  percentage of inhibition growth. The results indicated that the hot ethanol extract of Chara vulgaris was more efficient(89.8 %) inhibition growth at concentration 100 mg/ml and the lowest effect was (20.4%) at concentration 25 mg/ml  against the tested pathogenic fungi.  Chemical analyses showed that the active chemical compounds for hot ethanolic and methanolic alga (Chara vulgaris )extracts  were contains alkaloids, phenols ,Terpenes , Steroids, Flavones, Resins ,Saponines and tannins. Finally the result of GC mass analysis for Chara vulgaris extracts proved the presence of many antimicrobial activity compounds.Keyword: Fresh water algae, Anti-Dermatophytes activity, Hot ethanolic and methanolic extracts, Baghdad City-Iraq.
Assessment of Common Practical Skills in Clinical Medical Students in Shiraz, Fasa and Jahrom Universities of Medical Sciences: A Cross-sectional Study Esmail Rayat Dost
Journal of Global Pharma Technology Volume 08 Issue 03
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Abstract

Introduction: This study has been conducted to assess common practical skills in clinical medical students in  Shiraz, Fasa & Jahrom Universities of Medical Sciences. The ability for practical skills is an important goal for medical education and these skills are essential for the diagnosis and treatment of diseases. As a result, the present study has been carried out with aim of evaluating common practical skills in clinical medical students in   Shiraz, Fasa & Jahrom Universities of Medical Sciences. Method: The present study is a cross-sectional study. In this study, 100 internship students were selected and data were collected by questions about 25 clinical skills. Data analysis was performed by SPSS software version 11 and statistical tests. Results: The results showed that the capabilities of medical students in practical skills are far from the ideal situation. 78% of students believed that they did not have the necessary ability to do practical skills. Most of them have not gained these skills under the supervision of qualified persons. 82 percent of students evaluate the quality of education in these procedures unfavorable. And a high percentage of them believed that they needed to retrain these skills. Conclusion: This study demonstrated that no attention has been paid to practical skills training and therefore teaching students about the clinical skills before entering the clinical departments is very important.Keywords: Medical education, Practical skills, Evaluation of medical students.
Review on Cyclic Adenosine Monophosphate signaling pathway (cAMP), DLK Signaling Pathway, RAS/RAF Signaling, Retinoic Acid Signaling, Phosphatidylinositol 3-kinase (PI3K) as the Signaling Pathways Involved in Peripheral Neuronal Generation Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Neuronal regeneration is the physiological process wear, after neuronal injury, the body stimulates mechanisms of self-healing. Thus, through coordinated different processes and signaling that involves diverse molecules in the body, the nerves are able to regain, to some extent, their initial capability to transduce and convey signals. After, neuronal injury, there is a defect in the normal signal transduction. This presents with different symptoms depending on the system in which the nerve belongs. This may be mortar or sensory. Injury to mortar neurons means the supply of the muscle innervated is cut off. This, therefore, implies that the muscle will not have enough power or will become spastic. It is in response to this injury, that the nerve, through some intricate intrinsic signaling pathways, is able to regenerate in order to return the normal physiologic functioning of the body. Methode of this paper is summed up with systemic reviews of articles in the same topic under study. The articles were searched using the Pubmed search engine and were all in English. None of the articles was translated. The inclusion and exclusion criteria was guided by PRISMA guide, as a predetermined outline. The result of this article is out of forty-three, eight articles were selected as eligible, this is because they met the PRISMA criteria and had adequate relevant and supporting experiments to back the signaling pathway under study.  These articles had a clear and elaborate outline of the whole signaling pathway, the associated molecules, the interconnections between the pathways, supporting experiments and even recommended research in the same field or topic. The comparison of the strengths of facts backing the individual pathways was used to determine the pathway that is most involved, or that can be presumes the “mother” signaling pathway in the process of neuronal regeneration.Keywords: Neuronal regeneration, Neuronal injury, Signaling pathway.
DFT Method, Molecular Orbital’s, and Electronic Spectra Study for Characterization the Biological Activity of New Ebselen [2-phenyl-1, 2- Benzisoselenazol-3(2H)-one] Derivatives Ahmed Abdul Sattar Ali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Glutathione peroxidase (GPx) is one of the most potent antioxidant enzymes that is based on the selenium metal ion in the active site and plays an important role in reducing hydrogen peroxide and lipids. As low levels of GPx lead to an increase in hydrogen peroxide levels and thus cause direct damage to living tissue and many diseases infection. The number of selenium-containing compounds has been developed for their ability to treat or minimize peroxides. Ebselen “2-phenyl-1, 2- benzisoselenazol-3(2H)-one” is one of the most promising compounds as an antioxidant and have been shown to mimic the glutathione peroxidase activity in vitro. In this paper, seven different chemical derivatives of ebselen (a compound scientifically proven as an antioxidant) were designed by replacing or adding chemical groups and studying the effect of these changes on the behavior and effectiveness of the compound by studying the electron density of the central atom (selenium), HOMO, and LUMO. The stable geometrical shape of the compounds was also determined by calculating frequencies, bond energies and ion extraction for derivative compounds. On the other hand, the polarity of these derivatives and their solubility were calculated as well as the calculation of the Mulliken charge and electronic spectra measurements “infra Red (IR), UV-visible”. Some of the compounds were characterized by having a better biologic effect than Ebselen while some of the derivatives were reversed.Keywords: Glutathione peroxidase (GPx), Ebselen, HOMO, LUMO, Density Functional Theory (DFT), Becke3-Lee-Yang-Parr (B3LYP).
Phenotypic and Genotypic Study of Sodium Azide Effect on Proteus Mirabilis Swimming and Swarming Phenomenon Luma Abd Alhadee
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The present study intended to detect the effect of sodium azide on P. mirabilis swimming and swarming phenomenon. Twenty one isolates of Proteus bacteria were collected from different clinical and animals samples for the period from October 2017 to November 2017. All isolates were identification depending on microscopic characterization , biochemical tests and Vitek 2E  compact system, it appears that eighteen  isolates were belong to P. mirabilis . All P. mirabilis isolates were able to swim and swarm over semi-solid media. The addition of sodium azide with (0.001, 0.01, 0.1) % concentrations was able to inhibit swimming and swarming phenomenon. Using PCR technique, WosA a gene responsible of swarming regulation was detected in all isolates and its expression was measured using RT-PCR in normal and sodium azide conditions. The result of molecular detection of WosA gene showed that all of the P. mirabilis isolates were possessed this gene and the levels of fold change of wosA gene were 0.19 and 0.12 for swimmer and swarmer cell respectively. The levels of fold change of wosA gene were 0.4 for the concentration (0.001%) of sodium azide when compared with control 1 fold change.Keywords: Proteus mirabilis, Swimming, Swarming, Sodium azide.
Estimation of TSH, T3, T4 and Testosterone Concentrations in Patients Suffering From Myocardial Infarction (MI) in Baghdad City-Iraq Noori Mohammed Luaibi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The most common cause of morbidity and mortality is cardiac disease, even minor alterations in thyroid hormone levels adversely effects on the cardiovascular system. In acute cardiac problems hypothyroidism occurs and it is associated with the increase of cardiac mortality. The purpose for this study is to investigate the alterations in hormone concentrations TSH , T3 , T4 , and testosterone  in patients suffering from myocardial infarction  in Baghdad city According to statistical analysis  revealed that the level of T3 , T4 and testosterone  were decreased in comparison with healthy control group and the decreasing value of these hormones were continuing to occur especially in 7 and 14 days after myocardial infarction occurs .While the levels of TSH illustrated increment in various periods of time used in this study after admission of myocardial infarction.Keywords: Myocardial infarction, TSH, T3, T4, Testosterone. 
Assessment of Natural Radioactivity and Radiological Hazard in Soil Samples of the Most Popular Tourist Place in Babylon, Iraq Inaam H. Kadim
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

In the present investigation, the activity concentrations of 238U, 232Th and 40K in soil samples collected from the most popular tourist place in Babylon, Iraq are determined using gamma ray spectroscopy. The measured activity concentration ranges from 5.8 to 30.4 Bq kg-1 with an average value of 14.92  Bq kg-1 and 2.9 to 45.39 Bq kg-1 with an average value of 24.7  Bq kg-1 and 110.6 to 369.9  Bq kg-1 with an average value of 285.13 Bq kg-1, for 238U, 232Th and 40K, respectively. The radium equivalent activity ranges from 19.06 to 85.64, which is lower than the safe limit 370 Bq kg-1 as set by the Organization for Economic Cooperation and Development. The absorbed dose of all the investigated samples varies from 10.32 to 40.03 nGyh-1.The annual effective dose equivalent ranges from 0.04 to 0.047 mSv. The values of internal and external hazard index of all the samples ranges from 0.3 to 0.1, and 0.08 to 0.26 45 respectively. It is observed that the soil of tourist place in Babylon is suitable for construction purpose without posing any health hazard.Keywords: NaI Tl) detector, Natural radioactivity, Annual Effective Dose, Soil samples.
Mechanical Behaviors of Epoxy Resins with Phenolic Formaldehyde Resin Reinforced by Nanoparticles Ziad T. Khodair
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The importance of Nano molecular polymers has grown in the industry, depending on its mechanical and physical properties. With the development and growth of technology, engineering applications of polymers have increased, combining light weight and high density, enabling them to be used in high performance applications. The present research aims to study the mechanical behavior of epoxy resin with phenol formaldehyde resin and the reinforcement of Graphite nanoparticles (10 nm) and weight loss (0-40%). These characteristics include compressive force, flexural force, and elastic coefficient. The results showed an improvement in the properties of composite materials after reinforcement by graphite (Nano and micro), which will increase the properties by increasing the proportion of nanoparticles compared to micro particles.
Synthesis, Characterization and Antifungal Activity of Some Indolo [2-3-b] Quinoxaline Derivatives Khitam Abdul Kareem Ismail
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this research the focus was to synthesis new series of indolo [2-3-b] quinoxaline through the reaction of Isatin with 4-methyl-o-phenylenediamine in the presence of water to obtain 2-methyl-6H-indolo [2-3-b] quinoxaline (A1). Compound (A2) was prepared by refluxing  of compound (A1)  with chloroacetyl chloride in the presence of triethylamine, compound (A2)  was treated with hydrazine hydrate to give 2-hydrazino-1-(2-methyl-indolo[2,3-b]quinoxalin-6-yl)-ethanone (A3), While the Schiffe bases (A4- A8) were synthesized by the condensation of compounds (A3)  with aromatic aldehydes. The prepared compounds identified by spectral methods [FTIR, 1H-NMR] and measurement some of its physical properties. Furthermore we were studied the effects of the preparing compounds on some strains of Antifungal activity.Keywords: Isatin, Indolo [2-3-b] quinoxaline, Antifungal Activity, Schiffe base. 

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