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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis and Biological Evaluation of Oxazolone Derivatives G Mariappan; Dipankar Sarkar; Rashmi Karki; Lipika Pandey; Deepak Kumar
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
Publisher : Journal of Global Pharma Technology

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Abstract

A new series of oxazolone derivatives (OXZ1 to OXZ5) were synthesized. The structures of the synthesized compounds were assigned on the basis of UV, IR, 1 H NMR and Mass spectral data. The synthesized compounds were screened for analgesic and anti-inflammatory activities. Among the entire test compounds OXZ1, OXZ2 and OXZ4 showed promising analgesic activity as compared to std. pentazocine. In case of anti-inflammatory activity, all the compounds are active. But OXZ2 was found to be more active as compared to std. aspirin. From both activities, the compound OXZ2 shows significantly more analgesic and anti-inflammatory activity. All the experimental results were statistically significant at p<0.01 level.
Photo Catalytic Degradation of Reactive Blue 4 Dye using Hydrothermal Synthesized ZnO Nanoparticles Hassan A. Alshamsi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The research reports the preparation of zinc oxide nanoparticles (ZnO NPs) using hydrothermal process. Several techniques  were used to characteristic ZnO NPs which included x-ray diffraction (XRD), scanning electron microscopy (SEM) ,transmission electron microscopy (TEM),atomic force microscope (AFM),and Fourier-transform I Infrared Spectroscopy (FTIR).Also, the research included photo catalytic activity of ZnO NPs for Reactive Blue 4 dye  removal from aqueous solution under light irradiation  from 100 W . It was shown that the use of ZnO as photo catalyst have acceptable photo catalytic activity for degradation of dye. It has been found that maximum percentage removal of dye was achieved at 0.8g/L ZnO mass, pH 6, temperature 303K and dye concentration 20 ppm. The photo catalytic degradation was monitored by measuring the absorbance of the dye at its λ max using UV-Vis spectroscopy.Keywords: Hydrothermal, ZnO, nanoparticles, Photo catalyst, dye, SEM.
The Effect of Special Exercises to Develop Some of the Variables and Basic Skills of the Young Basketball Hasan Saleh Mahdi Al-Okbi
Journal of Global Pharma Technology .
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Abstract

The importance of research is reflected in the fact that it helps to detect the effect of aerobics and to know its efficacy with antioxidants that work to get rid of the free radicals causing fatigue to young basketball players. Researchers used the experimental approach to fit the nature of the problem on the players of the Sports Solidarity Club youth basketball season (2017-2018) (13), the comprehensive survey method was adopted in the selection of the sample and three players were identified for the purpose of conducting the exploratory experiment, reaching The final number of members of the main sample is (10) players. Through a gathering of data, most importantly, the exercises used, which were specialized exercises in the type of skill and complex exercises and skilled exercises for the speed of performance contributed to the development of some of the basic skills of basketball, for both the jump and high pituitary and chest handling and defensive movement, there was a direct impact of the effort in the proportions of salts in the body due to exposure to effort bodily led to fluid loss.Keywords: Physiological variables, Basic skills and basketball.
Preparation and Extensive Characterization of Fullerenol C60 Abdulkareem M. A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Recently, functionalization processes onto the outer surface of fullerenes such as C60 and C70 with various groups attracted large interesting from scientists, which including convert sp2 hybridization carbon atoms to sp3 hybridization that aim for enhancing its solubility in an organic polar solvent. This work converts the fullerene C60 successfully to hydroxyl functionalized fullerene which called fullerenol C60.The hydroxyl functionalized fullerene C60 nano-product was characterized using FTIR, 1H-NMR, 13C-NMR, AFM, SEM, TEM, EDX, TGA, and XRD examinations, they proved the fullerenol C60 structure and demonstrated the remarkable change in fullerene C60 topography from un-uniform particles to shape like spherical with high aggregation.Keywords: Fullerene C60, fullerenol, functionalization.
The Impact of Age and Parity in the Incident of Premature Rupture Membranes (PRM) Tinuk Esti Handayani
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction: One of the most prominent problems due to pregnancy complications is the incidence of PRM. Premature rupture of membranes(PRM) is a complication in pregnancy and childbirth that plays a role in increasing meternal-perinatal morbidity and mortality which can be caused by infection. The purpose of this study was to determine the effect of age and parity on the incidence of PRM PRM at Widodo Ngawi Hospital. Methods: Case control analytical observation research design. The sample of cases of maternal PRM with a sample size of 30 respondents. The sample of maternal control was 30 respondents. Samples were taken using simple random sampling technique. The independent variables are age and parity, and the dependent variable is PRM. Data collection used a secondary data type checklist. Data analysis used Logistic Regression Test with a significant level of 0.05. Results: The results showed that most of the mothers aged 35 years (79.3%) and p value = 0.004. The OR value of the age variable is 7,020, the conclusion is that age has a 7 times greater risk of causing PRM. Multigravida parity (72.2%) and p value = 0.010. The OR value of the parity variable is 6.481, it can be concluded that parity has a 6 times greater risk of causing PRM. p-value
Effects of Silica Nanoparticles on Some Indicators of Fertility and Histological Changes in Male Rats Alaa Mohammad Hasson Al-Husseini
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The current study has been designed to evaluate the effect of silica Oxide nanoparticles (SiO2NPs) exposure on the reproductive performance of male rats. Forty adult Wistar male rats ( aged 60-70 days with body weight130-140 g), were randomly divided into four equal groups , 10 rats per group : control  group were received physiological saline, and three treated groups were administered by gavage at dose (1 mg , 10 mg and 100 mg/kg Body weight) of SiO2NPs suspension  daily for 22 days,  Body weight , some characters of sperms (sperm count, percentage of motility , abnormality , sperms viability ) and histological changes in testis and epididymis were investigated. The results showed insignificant decrease (p ≥ 0.05) in body weight of three treated groups in comparison with control group. Experimental results obtained from SiO2NPs treated  male rats  showed significant decrease (p<0.05) in sperm count , percentage of motility and viability sperms , while a significant  increase (p<0.05) in  percentage of dead and abnormality sperms  compared to control group, histopathological results revealed changes in tissues of testes such as atrophy in some seminiferous tubules with expanded lining . Also noted tubules in both testis and epididymis are empty from sperms with hyperplasia and damage in stereocilia of tubules lining cells of epididymis.Keywords: SiO2NPs, Rats, Reproductive, Sperm, Testis, Epididymis.
Influence of a New Preparation on the Microstructure of Separate Internals of Animals Secondary to Immunization RA Asrutdinova
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

The current paper evaluates the influence of a test sample of polysaccharide-based new preparation on the microstructure of separate internals of rabbits after vaccination under the conditions of industrial rabbit breeding. Post vaccinal immunomorphological changes, particularly in liens of the test group, included formation of multiple lymph nodes, saturation in periarterial zone of T-lymphocytes in the formed nodes after the action of the vaccine and “Gemiv” polysaccharidic preparation. Lien lymphatic tissue was represented by middle and large lymphocytes. The structure of the liver was preserved even by the end of the experiment. A significant amount of binuclear hepatocytes was observed, which is indicative of reparative capability. The studied organs testified that the use of polysaccharidic preparation “Gemiv” during vaccination of rabbits against salmonellosis had no negative influence on the function and structure of the internals.Keywords: Immunostimulant, Vaccination, Young stock, Organ minute structure.
Determination of Trifluoperazine Hydrochloride in Pure form and Dosage form via Reaction with Sulphanilic Acid Diazonium Salt Sahar Rihan Fadhel
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A simple and sensitive spectrophotometric method for determination trace amount of Trifluoperazine Hydrochloride in tablet pharmaceutical preparations were described. The method was based on the coupling reaction of drug with (0.25 mole.L-1) diazonium salt prepared from reaction of sulphanilic acid with (12.07 mole.l-1) hydrochloric acid at (0-5Cº) present sodium nitrite in basic medium of sodium hydroxide (0.1 mole.l-1) to produce orange color azo dye compound can be absorbed at 500nm, the optimum reaction conditions and other analytical parameters were evaluated. The high accurate and precise results obtained with RSD%, Recovery%, ere% and D.L were 0.8142, 100.019, 0.0574, and1.1205 µg.ml-1 respectively, the linearity of rang (5.0-140 µg.ml-1). The proposed methods were successfully applied to the determination of Trifluoperazine Hydrochloride in tablet pharmaceuticals without any effect of interference of chemical materials in tablet formulation.Keywords: Trifluoperazine Hydrochloride, sulphanilic acid, spectrophotometry, azo dye coupling.
Isolation and Antimicrobial Characterization of Aerobic Pathogenic Bacteria from Egg Shell and Egg Contents in Table Eggs in Erbil Ahmed I. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Contaminated eggs are the major reservoirs for many foodborne pathogens and their ability to produce toxins causing diseases or even death in human. One of the essential quality characteristics of eggs is hygienic quality, lack of good hygienic practices, which may lead to loss the quality and deterioration of eggs. This study was focused on fresh chicken eggs to determine the prevalence and level of contamination in process as well as risk of antibacterial resistance of isolated bacteria. The level of contamination of table eggs with pathogenic bacteria and the antimicrobial resistance (AMR) were examined. Total numbers of 72 fresh chicken eggs were collected from eight flocks including conveyer belt and storage eggs from two large scale poultry layer farms in Erbil. The total bacteria on its eggshell was counted, bacterial loads were ranged between 5.174-5.854 log cfu/ eggshell. Bacteria isolated colonies subculture on Macconkey agar and gram negative baccilli were inoculated on VITEK® 2 ID-GNB (identification-Gram-negative bacilli) and antimicrobial susceptibility testing (AST)-GN69 cards. The bacterial pathogenic contamination ratio was 22.2% Staphylococcus and 22.2% enterobacteriaceae mostly (E-coli 11%). Whereas no bacteria were found in polls egg contents. The highest resistance rate was detected against Cefazolin, Amoicillin, Trimethoprim/ Sulfamethoxzol, Nitrofurantoin, Ciprofloxacin, Levofloxacin. The high sensitivity rate was recorded against Piperacillin/Tazobactam, Imipenem, Ertapenem, Gentamycin, Tobramycin, Cefipime, Cefitraxone. The results of this study conclude that the bacterial load on egg shells and contents were at the accepted level while the isolation of pathogenic bacteria due to lack of hygiene practice should be considered, also we suggest that the farmer must fumigate the fresh eggs with a good hygienic practice before marketing.
Study the Optical and Spectral Properties of Organic Dye as an Effective Medium in Dye Lasers Afrah M. Al-Hussainey
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

In this study, the absorption and fluorine spectra of the Acriflavine solution dissolved in ethanol and different concentrations were studied. The optical properties (absorption coefficient, linear refraction) and spectral properties (Fluorescence lifetime and Quantum Yield fluorescence) were calculated. It is observed that increasing the concentration increases the absorbance values and decreases the permeability values, thus increasing the values of the absorption coefficient and the refractive index. Also, the values of the fluorine intensity increase. The top of the emission spectrum is transferred to the longer wavelengths.Keywords: Acriflavine dye, Absorbance, Fluorescence, Dye Laser.                     

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