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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Targeted Systems in Cancer Treatment Yuliya Tikhonova
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

The World Health Organization (WHO) estimates that in 2015 cancer was the first or second leading death cause before the age of 70 in 91 out of 172 countries, and ranked third or fourth in the other 22.  This study analyzes three main types of targeted cancer therapies: low molecular weight inhibitors; monoclonal antibodies; and immunotoxins. The low molecular weight inhibitors analyzed in the paper are Gleevec, Sprycel, VEGF targeting, Nexavar, Tykerb, Iressa, EGFR and HER2 Targeting, Torisel. The monoclonal antibodies include VEGF, EGFR and HER2, Herceptin, Avastin, CD20, Rituxan, Zevalin, Campath. The DAB389IL-2 (or Ontak - FDA Approved Medication for the Treatment of Acute T Cell Lymphoma) represents immunotoxins. It proves that depending on the location of the unregulated protein, different approaches are implemented. Monoclonal antibodies can block interactions and functions of unregulated proteins within the extracellular compartment, while low molecular weight inhibitors can reach proteins that are within the cell compartment. Currently, many of these drugs are used in combination with traditional cancer treatments to increase patient survival. As it was found, VEGF inhibitors, for example, Avastin, increased in low concentrations the survival time of patients with metastatic colorectal cancer from 13.8 to 21.5 months.Keywords:  Low molecular weight inhibitors, Gleevec, Pro-angiogenic molecules, Monoclonal antibodies.
Formulation and Evaluation of Oral Disintegrating Film Containing Lisinopril for the Effective Management of Hypertension and Cardiac Diseases Velayutham Pazhanivel
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

This study was aimed to develop oral disintegrating film (ODF) containing an anti-hypertensive drug Lisinopril. Five trial formulations (F1-F5) of Lisinopril ODF were prepared using Hydroxypropyl methylcellulose E15 (HPMCE15), Polyvinyl pyrrolidone (PVPK30), Polyethyleneglycol400, Polyplasdonexl, Mannitol, Peppermint oil, Propylparaben, Citric acid, and Allura red. The prepared formulations were evaluated for their Physico-chemical characters like weight, thickness, surface pH, folding endurance, and disintegration time. They were also evaluated for the content of Lisinopril. The above studies revealed that formulations trial F4 was better than other Formulations. Because, it has exhibited faster disintegration time (21.32 sec) when compared to the other formulation. So, F4 was selected for stability study (40ᵒC,75% RH) for six months and Scanning Electron Microscopy (SEM). The results of the above studies have shown that F4 was stable and has a uniform distribution of Lisinopril.
The Salient Features of Twin Language Development Peyman Rajabi
Journal of Global Pharma Technology .
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Abstract

Multifarious studies indicated that twin language has some prominent features, evinced from the onset of life, as compared closely with single-born children.The current paper intends to illustrate the characteristics of twin language by taking account the following key issues:The effect of genetic or environmental factors on language acquisition (naturevs. nurture).Mother and other older siblings’ interaction to promote the extent of twin language (nurture).The rate of understanding and misunderstanding of twins’ speech.The phonology quality of twins.The language problems which school-age twins more likely encounter in elementary school.This paper arrives at the conclusion that the growth of language acquisition, within twin children, in some suffers from lack of features of language aspects but in some other areas, the percentage of flaw is rare. This typically requires running some further research to expound the momentous issues of twin language due to generalizingwithout any problem.On genetic factors, linguistic discordant takes place but not in a way that leads to raze the construction of communication .In this respect, postnatal factors play crucial role to hamper to imping later language disorders. This lies on the roles of older siblings or parents, particularly mother, who are cognizant of their duties to pave the way for twins to procure language development with ease. Ascribing phonology deficit solely to twins but not on singletons is unfair and a sheer bias approach.Decoding of twin language sounds baffling in the rudimentary steps of interaction among children even the parents but this problem will be resolved by establishing situations to have more engagement with them. Determining commensurate plans by principles in schools, like social-action games and other cooperative activities pave the ground for the twins not to see merely one sibling on their side but variety of imitations, vocabularies of different social class, use of jargons and all aspects of expressive language.Keywords: Genetic, Environment, Maternal speech, Phonology, Misunderstanding, School-age.
The Effect of Adding Probiotics on Microbial and Organoleptic Characteristics of Beef Burger Product Asraa Yacoob Yousif
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The study examined the use of single and mixed probiotic isolates for the possibility of prolonging the preservation duration of meatballs in refrigeration. Chemical tests were conducted (free fatty acids, TBA and pH), sensory tests (color, flavor, juicy, tenderness and general acceptance), noting that the control sample was excluded from the experiment on the tenth day of conservation because the pH value exceeded the limit and according to the standard specifications. Samples of treatments with single and mixed probiotic isolates reached the allowable limits on the 11thday. A significant decrease in TBA and free fatty acid was observed in the single and mixed probiotic isolates compared with the control treatment during the preservation period. It was observed during the preservation period that the control sample was excluded from the experiment on the seventh day of preservation because the numbers of total bacteria and psychrophilic bacteria exceeded the permissible limits according to the standard specifications. The results of sensory evaluation showed a significant superiority of the probiotic isolates treated meat samples compared to the control sample, which improved all the sensory characteristics (color, flavor, juicy, tenderness and general acceptance). The highest of the sensory evaluation were in the mixed probiotic isolates treatments.Keywords: Probiotics, Organoleptic, Beef burger.
Comparative Study of Phytochemical and Phytomineral Analysis of Selected Peel Powders Gana Manjusha Kondepudi
Journal of Global Pharma Technology Volume 10 Issue 11 (2018) November 2018
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Abstract

 ABSTRACTObjectives: The present study was conducted to evaluate the presence of phytochemicals and mineral elements composition of selected peel powders of Annona sqaumosa, Actinidia deliciosa, Cucumis melo and Mallus pumila. Methods: The phytochemical screening was conducted for the presence of alkaloids, glycosides, phenolics, carbohydrates, aminoacids, saponins, tannins, terpenoids and phytosterols in the selected peel powders. Among all the phytochemicals, phenolics were common in all selected peel powders. The mineral analysis was conducted for both trace elements (Copper, Zinc, Iron, Manganese and Potassium) and toxic elements (Cadmium and Lead). Results: The results of the study indicated that all the selected peel powders showed notable trace elements and negligible amount of toxic elements. Conclusion: Based on the results it was concluded that the fruit peels are no more waste but excellent source of phytoconstituents  and minerals. Hence they can be used in the treatment of many diseases.
Effect of using Cordia myxa Crude Extract Creams in Wounds and Burns Treatments Aliaa S. Al-Faraji
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

It was found that the use of Bumper extract cream (Cordia myxa) has a high effect on the healing of wounds and burns in the experimental mice. All rat assemblies and experiments are designed according to the standard procedures. The creams were applied on laboratory mice (Swiss albino mice), which is located in the laboratories of the Center for the Preparation of Medicines / Ministry of Industry and graduated doses (1 and 2% w / w) and apply these creams to wounds and burns induced laboratory / for 10 days of treatment daily. A group of mice was designed also wounds and burns were stimulated, but treated with  Ficidin@ and Flamazin@ ointment were used as standard (2% w/w) for treatment of wound and burn respectively. The results of the study showed the effectiveness of the bumper extract with high concentration of 1% and 2% on the healing of wounds and burns compared to control and standard groups. The results of the textile cutting showed the effectiveness of the pampers on the formation of the granular tissue for burns and wounds, which in turn leads to the rapid recovery of these wounds and burns within 10 days. Results investigated the highest effectiveness of bumper extracts on the rapid recovery of wounds and burns in rats faster than using chemical medication, and thus support its traditional use.Keywords: Ficidin- Flamazin -Cordia myxa cream-Excision Wound & Burn-Healing.
Spectrum of Human Growth Hormone Receptor Gene Polymorphisms in Physiological Obese Subjects in Babylon Province, Iraq Hamzah H. Kzar
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: A peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals is called growth hormone. In human, growth hormone gene is encoded the protein growth hormone receptor that located on chromosome number 5. Obesity is a condition in which excess fat has accumulated in the body, such that it can have an adverse effect on health. Obesity is defined as a body mass index (BMI) of greater than 30 kg/m2. Aim: assessment of spectrum of human growth hormone receptor (HGHR) gene polymorphisms in obese subjects in Babylon province, Iraq. Subjects and Methods: this case-control study included two groups, the first 30 obese subjects (OS) and 30 non-obese subjects (NOS). We investigated GHR genetic polymorphism in both study groups by assessment of the genotyping, Fl/Fl, F1/D3, and D3/D3 of two alleles of GHR. We used allele specific PCR method to investigate the all genotypes and comparing the results with the levels of GH and leptin in serum of study groups. Results: the results of present study showed significant differences (p-value< 0.05) in levels of leptin (LEP) and human growth hormone (HGH) between OS and NOS groups. The genetic results suggested that F1/F1 genotypes have high prevalence in OS compare to NOS (odd ratio was 3.54, CI 95% 1.77-7.94). Conclusion: F1/F1 genotypes have higher levels of leptin and HGH and so it having more risk factor to induce obesity in Babylon population.   Keywords: Human growth hormone, growth hormone receptor, obesity, leptin.
The Effect of Capital Gain Tax on Capital Formation, Financial Development and Economic Growth, “Case Study of Selected Europe Union Countries” Majid Sameti
Journal of Global Pharma Technology .
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Abstract

The effect of tax on economic activities is an important issue in public finance. The fact that the existing system may decrease the investment motivation and consequently decrease the future life style is a great crisis. In addition to, the effects of tax system on capital formation, it can affect financial development and economic growth.  In this paper, by simultaneous equations system in GMM method, the impact of capital gain tax on the capital formation and financial development in selected Europe Union countries (Austria, Belgium, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Irelands, Italy, Netherlands, Spain and Sweden), will be studied in panel form. The results indicate that the capital gain tax growth rate, with one lag, increases the physical capital formation growth rate. Also, capital gain tax growth rate, with one lag, decreases the financial development growth and increases the economic growth rate. Keywords: Capital gain tax, Capital formation, Economic growth, Simultaneous equations system, GMM.
Extraction of Poly Phenols from Cladium Mariscus Seeds and studying its Antifungal Activity with Isolation and Identification of one Compound of Flavone Glycosides Husam M. Kredy
Journal of Global Pharma Technology .
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Abstract

Cladium mariscus is one of the plants belonging Cyperaceae family. It is a common plant in AL- Hammar marshes, eastern - south of Iraq. The aim of the present study was extraction poly phenols from C. mariscus seeds by using an ultrasonic-assisted extraction method. The yield of poly phenols extracted by this method was (0.43% w/w). One compound was isolated from the methanolic extract of the plant seeds. The structure of the new compound was identified via the basis of extensive spectroscopic analyses (UV-Vis, IR, 1H NMR, and Mass),  and some chemical test. Acacetin glycosides were expected compound, and the methods of spectroscopy showed that there are three molecules of hexagonal sugars linked with aglycone. The antifungi activity of methanolic extract was examined against fungus: A.flavus, A.fumigatus and C.albicans, by using the well disk diffusion method. The extract showed a clear inhibition effect against fungal at (50 %, 75 % and 100 % w/v) concentrations.  Key words: Ultrasound-assisted extraction, Cladium mariscus, Acacetin glycosides, Antifungal.
Nicotine and Amino Acids Binding, A Theoretical Studies Huda N. Al-Ani
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The binding of twenty Amino Acids to Nicotine, has been studied theoretically by using (DFT) Density Functional Theory of (HF) type, as well as the semi-empirical method (PM3) calculations are carried out by (MOPAC) computational packages, to calculate the molecular orbital's energies and some molecules properties. The studied system was: Cysteine (Cys), Methionine (Met.) and Valine (Val.) with Nicotine. The optimized geometry of the complexes showed interaction  between Nicotine  and  three Amino Acids molecules, Cysteine (Cys), Methionine (Met.) and  Valine (Val.), the binding energies for these interaction were calculated, the binding energies for these interaction varies from -5.188 to -7.223 Kcal.mol-1. Which attributed to the formation of hydrogen bonding   between the studied molecules as it agrees with IR- experimental data .Binding to proteins is an important determinant of the kinetics .Which restricts the unbound concentration and effects the distribution and diminution of it.Key words: Nicotine, Amino Acids, binding, Density Functional Theory (DFT).

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