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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,440 Documents
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Extracellular Biosynthesis of Silver Nanoparticles using Fusarium Graminearum and their Antimicrobial Activity Hamzia Ali Ajah
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Synthesis of silver nanoparticles (AgNPs) has become a needful field of used science. Biological production silver nanoparticles have been more benefit in the formulation of new pharmaceutical products. In this study we report extracellular of silver nanoparticles by Fusarium graminaerum. The fungal aqueous mycelial extract when added aqueous silver nitrate solution (1Mm) leads to the manufacture of silver nanoparticles extracellular. The silver nanoparticles were characterized by Atomic force microscopy. In visual analysis color change of silver nitrate solution into brown signifies the development of silver nanoparticles. and the antibacterial activity of Ag NPs produced was evaluated against some local pathogenic microorganism isolates, Staphylococcus aureus , Pseudomonas aeruginosa , Streptococcus spp ,  Klebsiella spp , E. Coli and Candida albicans, using the well diffusion method. Our results showed that the Ag NPs were produced by Fusarium graminaerum and their sizes 94 nm. Moreover Ag NPs proved excellent antimicrobial activity with zone of inhibition ranged between 15 to 35 mm.Keywords: Silver nanoparticles, Fusarium graminaerum, Antimicrobial activity, Atomic Force Microscopy.
Assessing the Performance of Nurses in the Standard Care of Airway and Oropharynx in Intensive Care Units of Ahwaz Golestan Hospital Nader Hasanvand
Journal of Global Pharma Technology Volume 08 Issue 02
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Abstract

Maintaining an open airway is one of the fundamental steps in the patients and due to complications associated with non-standard and high sensitivity in ICU, this study aimed to evaluate the performance of nurses in standard care of airway and oropharynx in the intensive care units of Golestan hospital in Ahwaz. in this cross-sectional study, by the checklist of care standards of airway and oropharynx and a questionnaire,  demographic information of 72 nurses working in the intensive care unit in Ahwaz Golestan hospital in 2015 were measured after written consent in different working shifts. The validity of questionnaire was verified by the viewpoints of professors of nursing and its reliability by agreement between the present observers. Eventually, the data collected was analyzed using descriptive statistics and Kruskal-Wallis test, Mann Whitney U and Pearson correlation coefficients using SPSS version 20. Among the care standards, cleaning the lumen of the catheter has been a measure which has been undertaken by the majority of nurses (98/6 percent), while reviewing a medical history of possible problems in patients was observed only in 23.6% of the nurses. Overall mean of use of care standards of airway and oropharynx was 9/92 ± 81/60 respectively. Also significant positive relationship was observed between job characteristics and their performance in the care of the airways (05/0> P). Although in most cases the implementation of care was optimal, the implementation of the measures examined in the patient's medical history is not done properly. Hence, the importance of standard care in patients required more accurate monitor of the performance of staff and the necessary steps also should be taken to rectify the affecting factors.
Investigation of Pineapple (Ananas Comosus) Wine Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Pineapple is a wonderful tropical fruit having exceptional juiciness, vibrant tropical flavor and immense health benefits. Pineapples are consumed as fresh, cooked, juiced, and fermented in a wide array of food stuffs. This fruit is highly perishable and seasonal.  Therefore we explored a wine fermentation from pineapple by focusing on the effect of different parameters such as Pectinex Ultra SP-L concentration and time of treatment for juice extraction, yeast inculate for wine fermentation, and secondary fermentation to wine quality. Our results proved that 0.4% Pectinex Ultra SP-L was used for juice extraction, 0.75% sacchromyces cerevisiae was used for the main fermentation at 11.5oC, and 3 weeks of sencondary fermentation in dark bottle at 9.5oC was applied to get a pleasant pineapple quality.Keywords: Pineapple, Wine, Fermentation, Sacchromyces cerevisiae, Pectinex Ultra SP-L.
Cyclodextrin-Based Nanosponges -A Promising Nano technological Drug Delivery System Hassanien Sagban Taghi
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Undoubtedly, Cyclodextrin-based nanosponges (CD-NSs) are patentable nanosized, efficient delivery system designated as a three-dimensional nanostructure network. It can form porous spherical nanoparticles with a crystalline or amorphous structure. The internal polarizability of NS can be easily adjusting by alternating the type of cross-linker (CL) molecules and degree of cross-linking. Cyclodextrin-based nanosponges are a safe and can form complexes with different types of lipophilic or hydrophilic molecules. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine.Keywords: Cyclodextrin, Nanosponges, Drug Delivery System.
Structural, Spectral and Thermal Studies of New Bidentate Schiff Base Ligand Type (NN) Derived from Mebendazol and 2-Aminobenzothaizol and its Metal Complexes and Evaluation of their Biological Activity Shaimaa A. Hassan
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

In this study, a new Schiff base [methyl (E)-(6-((benzo[d]thiazol-2-ylimino)(phenyl)methyl)-1H-benzo[d] imidazol-2-yl)carbamate] (L) was  prepared and it's complexes with metal ions MII=VO, Mn, Co, Ni, Cu ,Cd,Zn and Hg in ethanol and ace ton with mole ratio (M:L) (1:2). All complexes have general composition [M (L) 2 Cl 2].H2O, [(VO) (L) 2(SO4)].H2O. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV_Vis, 1HNMR, 13CNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against two type of bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry, the value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligand and starting material.Keywords: 2-Aminobenzothaizol, Mebendazol, Metal complexes, Biological activity.
PHYTOCHEMICAL SCREENING AND ANTICANCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF NAREGAMIA ALATA W&A abi raami
Journal of Global Pharma Technology .
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Abstract

Objective:The objective of the study was to evaluate the phytochemical and anti-cancer activity of hydroalcoholic extract of Naregamia alata.Naregamia alata (family Meliaceae) is used by various tribal communities and forest inhabitants for the treatment of a variety of diseases. The leaves and stems, combined with bitters and aromatics, are given in decoction for the treatment of biliousness.  Naregamia alata has been used in traditional medicines in India and in the treatment of rheumatism, itch, malarial and chronic fevers, wounds, anaemia, enlarged spleen, ulcers, vitiated conditions of pitta and vata, halitosis, splenomegaly, scabies, pruritis, dysentery, dyspepsia and catarrh. Methods The hydro alcoholic extracts of Naregamia alata was analysed for the presence of flavonoids, alkaloids, glycosides, steroids, phenols, saponins, terpenoid, cardiac glycosides and tannins according to standard method. Cell lines of  Dalton’s Lymphoma Ascites (DLA), Ehrlich Ascites Carcinoma (EAC)  methods have been used in experimental studies of anticancer activity. In the present study, cell lines induced cancer in mice was used to evaluate the anticancer activity. Results: The results of the present findings were the potential of the selected plant as a resource for the discovery of novel anticancer, agents. Conclusion: In this investigation the various parameters proven that the antitumor activity of hydroalcoholic extracts of Naregamia alata, in DLA and EAC tumor bearing mice.Key words: Naregamia alata, phytochemical screening, anti-cancer.
Pre-coordinated Deployment of Emergency Medical Team (Emt) Orthopaedic Spine Specialist-Cell: Experience in An Acute-Phase of the 2018 Lombok Earthquake by Yogyakarta Team Gean Juniwan Syahputra Batong
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Indonesia is located at the meeting point of three major continental plate-the Pacific, the Eurasian, and the Indo-Australian plates-and also on the “Ring of fire”, which makes Indonesia vulnerable to earthquakes and volcanic eruption. As population density continues to increase, challenges grow for emergency responders in the aftermath of such disaster [1].Sudden Onset Disaster (SOD) occur with little or no warning and often cause excessive injuries far surpassing the national response capacities. Following SODs a large number of Medical Teams or Emergency Medical Teams often arrive in-country to provide emergency care to patients with traumatic injuries and other life-threatening injuries. Emergency Medical Teams are groups of health professionals (doctors, nurses, paramedics etc.) that treat patients affected by an emergency or disaster. Emergency Medical Teams, according to their capability, classified into 5 types; such as EMT-1 Mobile, EMT-1 fixed EMT-2, EMT-3, and EMT Specialized cell. Providing trauma care or medical care in disaster setting is very challenging. After an earthquake, local medical infrastructure was often damaged or destroyed, thus healthcare responders may not be able to rely on the medical resources of the afflicted region. Therefore, healthcare responders must provide the necessary medical equipment and supplies which requires good planning, efficient resource allocation, and understanding of the injuries that are likely to be encountered. Earthquake-related trauma results in severe injuries and requires rapid response in the acute-phase. Spinal injuries are important issue because the delay in adequate management can cause the patient to fall into a worse state, which can result in death or permanent disability. Orthopaedic spine surgeon on a disaster team could be an important asset during the response. The aim of this report was to evaluate whether the challenges faced in an acute-phase of earthquake can be obstacles to perform adequate orthopaedic spine management.
Estimation Urinary Tract Infection in Obesity Patients Wathiq Essam Hameed
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Obesity is representing a global epidemic disease that causes by different factors like environmental, hereditary, medical disease antipsychotic drugs and steroids. Obese people are at high risk to develop many complications such as hypertension, diabetes, atherosclerosis, joints problems, cancers especially hormone dependent, respiratory problems and urinary tract infection and others. To show the association between urinary tract infection and obesity. Eighty-eight people were included in this study about 40 healthy peoples and 48 obese, Uren and data were collected from patients and control to detected urinary tract infection and this gropes classified according to degree of infection into mild, moderate and sever.  The results show the urinary tract infection increase in obese people than non-obese. The results of this study support the evidence that obesity associated with urinary tract infection and urinary tract dysfunction is frequently associated with changes in body weight and composition.Key words: Obesity, UTI.
Combined Effect of Nanoparticles and Leuconostoc mesentroides ssp. cremoris Bacteriocin against Listeria monocytogenes Isolated from Locally Soft Cheese Nibras Nazar Mahmood
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Listeria monocytogenes has been as important opportunistic bacteria for human since 1929 and as food borne pathogenic bacteria since 1981.  Out of Twenty samples of locally soft cheese, only two isolates of Listeria monocytogenes were isolated and identified using microscopically, cultural and biochemical methods. The isolates were multi drug resistant to ceftriaxone ,trimethoprime amoxicillin ,aztreoname, ciprofloxacin and penicillin. While, these isolates were sensitive to Ampicilin, imipenem, and azithromycin. The antilisterial activity of 400 µg/ml of both silver and zinc Nanoparticles and bacteriocin of L. mesentroides ssp. cremoris in soft cheese for 24 h. was evaluated. The results showed that bacteriocin, silver nanoparticles and zinc nanoparticles reduced the growth of L.monocytogenes in cheese with inhibition percent (49.48, 19 .38, 38.14) % respectively .The combination between bacteriocin with nanoparticles (1:1) showed increased in the reduction of L.monocytogenes growth with (58.76 and 67.01) % for bacteriocin with silver nanoparticles and bacteriocin with zinc nanoparticles respectively. These results indicate that the combination of bacteriocin with nanoparticles has a protective effect against   Listeria monocytogenes in locally soft cheese Keywords: Leuconostoc mesentroides; Cheese; Listeria monocytogenes; Nanoparticles.
Synthesis of Polymers Containing 5, 5-Dimethylhydantoin and Study of its Optical Properties Ali J. Al-Zuhairi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this research work, four aromatic polymers, known as 5,5-Dimethylhydantoin  derivatives. 5, 5-dimethylimidazolidine-2,4-dione have been condensed with different dihalolkanes (1,2-dichloroethan and dichloromethane respectively) to give  two different poly hetero aromatic polymers. Also 5,5-dimethylimidazolidine-2,4-dione have been treated with chloroacetic acid and polymerized with ethylene glycol and hydroquinone respectively to give two different polyester polymers. The prepared polymers have been identified using FTIR and 1HNMR instruments. All the prepared polymers have shown a high number average molecular weight (Mn) using Gel Permission Chromatography (GPC) technique. Where absorbance was measured by using a device (UV-Spectroscope).The optical properties of the prepared polymers have been studied. The transmittance, absorption coefficient, had been measured. Transmittance values of the four prepared polymers increases with increasing wavelength due to the decrease in absorption values because the transmittance is inversely proportional with absorbance. The absorbance values of the prepared polymers have been decreased with increasing the wavelength. The absorbance spectra of the polymer solution of the concentration (0.3 g/mL %) for polymer N2 and the concentration (0.2 g/ml %) for polymer N3 within the range (200-1100 nm).The highest absorbance value (310 nm) for polymer N2 and (330 nm) for polymer N3. the absorbance spectra of the polymer solution of the concentration (0.3 g/mL %) for polymer N4 and the concentration (0.2 g/ml %) for polymer N5 within the range (200-1100 nm).The highest absorbance value (310 nm) for polymer N4 and (330 nm) for polymer N5.Keywords: Absorption coefficient 5, 5-Dimethylhydantoin, Optical properties, Polymers.

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