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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Caring Behavior Improvement Model on Nursing Students at Poltekkes Kemenkes Pangkalpinang Nurhayati Nurhayati
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

This study aims to establish models and measures of caring behavior in nursing students at the Poltekkes Kemenkes Pangkalpinang. The research method used is a quantitative method with survey techniques in phase I, and experiments by making a book as an experimental tool with the design of the One Group Pre-test Post-test for stage II. Furthermore, the data analyzed by qualitative methods in stage III. The sample consisted of 69 students; as a combination of first-year and second-year students. This study revealed that the Compassion variable influenced the formation of Competence, whereas the Conscience and Commitment variables did not affect the formation of Competency. Meanwhile, overall, the variable Compassion, Conscience, Commitment, and Competence influence the formation of Caring Behavior. Keywords: Behavior, Caring, Nursing, Students
Comparative Analysis of Types of Liability and Punishments for the Falcification of Mediсines in Countries of European Union Tulegenova Аigerim
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The article presents the results of an analysis of modern approaches in determining the types of responsibilities and penalties for falsification of medicines in the EU countries. It is determined that, process of recognition and implementation of norms and requirements of The Medicrime Convention in the states that are members to the Council of Europe continues and dynamically develops. The changes, which were adopted after the signature by the EU countries of The Medicrime Convention in 2011, are analyzed. Determined, that out of all liabilities which exist in jurisprudence in regards to the issue of falsification of medicines, the criminal, administrative and civil liabilities are applied. Current practice exists in all 28 EU states. It was found that in most of the EU countries (10 countries) relatively soft criminal sanctions (from 1 to 3 years of imprisonment) dominate for the falsification of medicines. In addition, there is no consolidated position as to what kinds of offenses for falsification in the pharmaceutical market criminal sanctions should be applied. It is found that the maximum values of penalties for falsification of medicines in the EU countries varies in a wide range of indicators (from 4,3 thousand euro to 1 million euros). Relatively soft criminal sanctions in most EU countries and a wide range of fines for drug fraud contribute to the migration of organized crime in the pharmaceutical business. However, it should be noted that the positive experience of struggling against counterfeiting in the EU has great practical significance for countries with low income and health systems, which are in the stage of reforming.Keywords: Falsification of medicines, Punishment for falsification of medicines, Types of liability for falsification of medicines, The Medicrime Convention.
Influence of roller compaction parameters on properties of granules and quality characteristics of finished product Olga Oleksandrivna Yuryeva; Yuriy Victorovich Naida; Oksana Volodimirivna Tryhubchak; Svitlana Nicolaivna Gureyeva; Yuliya Anatoliivna Kondratova; Andrew Mihaylovych Goy
Journal of Global Pharma Technology .
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Abstract

Roller compaction widely used in pharmaceutical industry as alternative to wet granulation. This technology acknowledged as more cost-effective and productive, improves granules properties, which in turn will enhance tableting process.Objective. Powder mixtures for products with immediate release: Glucose monohydrate 75 g granulated powder, Sodium picosulfate 7.5 mg tablets and Amlodipine/Valsartan 5/160 mg coated tablets.Methods. In this research the analysis of influence roller compaction parameters on flowability, bulk density and particle size distribution of granules was performed. Tablets, compressed from these granules tested for analytical properties (assay, dissolution, impurities) and technological properties (disintegration, friability, hardness).Results. For Glucose monohydrate 75 g optimum compaction parameters are primed: hydraulic pressure 50 bar and 1,25 mm screen size, with roller speed 11,5 rpm and roller gap 2,0 mm. The research of Sodium picosulfate 7.5 mg allowed determining the optimum compaction parameters: 50 bar hydraulic pressure, 0,8 mm screen size, 2.5 mm roller gap, roller speed 11 rpm, mill speed 80 rpm. For Amlodipine/Valsartan 5/160 mg optimal values of properties are indicated by regression analyses.Conclusion. As the result, influence of roller compaction parameters on quality characteristics of finished product and perspective of this technology for solid dosage forms manufacturing confirmed.
Determination of Clarithromycin and its Applications in Pharmaceutical Samples Using New Selective Electrodes Sarra A. Abrahem
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Two clarithromycin electrodes were constructed using clarithromycin-methyl orange as an ion pair complex in a Polyvinyl-chloride (PVC) matrix. These electrodes were plasticized using two plasticizers, Acetophenone (AP) and Di-butyl phosphate (DBP).Clarithromycin electrodes, a and b, gave slopes of 53.95 and 51.50mV/decade, and linear which ranged from (10-4-10-1, and 6×10-4-10-1 M) respectively. Electrode (a) relied on using a plasticizer (DBP) of a slope 53.95mV/decade, and a correlation coefficient 0.9996, with a detection limit of 5x10-5M in a lifetime of 26 days. The proposed electrode showed reproducibility and a good stability. It was therefore employed for determining clarithromycin within pharmaceutical samples. The measurements of interferences in the availability of (Na+, Cu+2, K+, Mn+2, Al+3, Fe+3, gelatin and sucrose) were also studied for selectivity coefficient determination using the separation method and the mixed method.Keywords: Clarithromycin, Methyl orange, Ion selective electrode.
Green Synthesis of Silver Nanoparticles by Mentha Spicata Aqueous Leaf Extract Najeh Hashim
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Silver nanoparticles which were synthesized by Mentha  spicata aqueous leaf extract were characterized by UV-Visible Spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Atomic Force Microscope. Antifungal activity tests were done against dermatophytes Microsporum canis, Trichophyton mentagrophytes, the result showed that silver nanoparticles was efficient in highest inhibition rate at 5 mg/ml. The antioxidant properties of the obtained biomaterial were assessed in vitro, using ABTS as free radical; the result suggests that silver nanoparticles present promising antioxidant activity; the effect of silver nanoparticles on human red blood cells hemolysis was investigated.  Keywords: AgNps, Nanoparticles, Antifungal, Antioxidant.
Development and Evaluation of Dipyridamole Multi Unit Floating Mini-Tablets Rama Koteswararao Kotharapu; Srinivas lankalapalli
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
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Abstract

The objective of the present work was to formulate and to characterize multi unit floating drug delivery system of Dipyridamole to increase the bioavailability and sustain the drug release properties up to 8 h with more predictable drug release kinetics that avoids all or nothing emptying effect. Dipyridamole floating mini-tablets were prepared  by effervescent approach with melt granulation and direct compression techniques alone and in combination using Hydroxypropyl methylcellulose (HPMC) K100M and Compritol 888 ATO at different concentrations (20%, 30% and 40% w/w) alone and in combination. Evaluations were carried out on physical parameters, floating behavior and influence of type of polymer on drug release rate of prepared mini tablet formulations. All the formulations were subjected to various quality control and in-vitro dissolution studies and corresponding dissolution data were fitted to popular release kinetic equations in order to evaluate release mechanisms and kinetics. All the dipyridamole floating mini tablet formulations followed zero order kinetics. As per Korsmeyer-Peppas equation, the release exponent “n” ranged 0.619-0.748 indicating that drug release from all the formulations was by non-Fickian diffusion mechanism. Based on the results, dipyridamole floating mini tablets prepared by employing combination of 15% w/w HPMC K100M and 15% w/w Compritol 888 ATO offered desired in-vitro floating time and drug dissolution profile.
Apoptotic Index of Amniotic Membrane Cells in Preterm Labor with Premature Rupture of Membrane (PPROM) was Higher than Preterm Labor without Premature Rupture of Membrane Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: Premature rupture of the membrane in preterm pregnancy is a condition that can cause increased maternal and perinatal morbidity and mortality. The study aims to compare the apoptotic index of amniotic membrane cells in preterm labor with premature rupture of membrane (PPROM) and without premature rupture of membrane. Method: This is a cross sectional study conducted at the Department of Obstetrics and Gynecology, Sanglah Hospital Bali. The Amniotic membranes were taken from the placenta after delivery then apoptotic index was measured by TUNEL examination. Result: The study included each 20 women from both groups. There was no significant difference of maternal age, gestational age, and BMI between groups (p>0,05). Chi-square analysis showed there was an association between the apoptotic index and preterm labor with PROM (p = 0.001). Subsequent analysis resulted in prevalence ratio of 19.0 (95% CI = 2.81 - 128.6). Conclusion: This study concluded that the apoptotic index of amniotic membrane cells in PPROM was higher than preterm labor without premature rupture of membrane. Keywords: Apoptotic index, Preterm Premature Rupture of Membrane, PPROM.
Oxidative Stress and Some Related Trace Elements in Women with Unexplained Infertility Khansaa A. Hussien
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

AbstractThis study aims to evaluate the oxidative stress and related trace elements (iron and copper) in women with unexplained infertility (UI). 60 women with unexplained infertility as well as (40) women with polycystic ovarian syndrome (PCOS) aged (20-35) year were included in this study. The women were divided according the type of infertility into primary and secondary groups (1ºUI, 2ºUI, 1ºPCO and2ºPCO) respectively. 50 healthy fertile women with the same age were included in this study as a control group. The results showed a significant increase in serum malondialdehyde (MDA) levels in all infertility groups compared to control group. Whereas serum levels of the antioxidants glutathione (GSH), superoxide dismutase (SOD) and ceruloplasmin (Cp) were significantly decreased in all infertility groups in comparison with control group. Serum levels of iron and copper significantly increase in unexplained infertility groups in comparison with explained infertility and control groups. No significant differences in iron levels between explained infertility groups and control. Whereas serum levels of the copper were significantly increased in explained infertility groups in comparison with control group. This study concluded that is a disturbance in serum oxidant- antioxidant balance in women with UI and PCOS infertility.Keywords: Unexplained infertility, Lipid per oxidation, Ceruloplasmin, Superoxide dismutase Iron, Copper.
The Correlation between the Performance of Some Basic Skills and the Level of Cognitive Achievement of handball Players Hossam Ghaleb Abdulhussein
Journal of Global Pharma Technology .
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Abstract

The importance of research in the analysis of the level of cognitive achievement and its relation to the skillful performance of handball game to improve the level of the game and thus benefit the acquisition of knowledge and theoretical information related to the game plans, which is generated through the explanation and theoretical discussions of the positions of the athlete during the application of skill or sports competition.The research aims atDesign a form for the collection of knowledge with indicators (law, Shoot, plans) for players who advance handball.Build a test for the scientific knowledge collection of players who advance handballTo identify the relationship between the achievement of knowledge of the players and the performance of some basic skills handball.The hypotheses of the research were:There are differences of statistical significance in scientific knowledge and the performance of some basic skills of handball.There is a significant relationship between the level of cognitive achievement and the performance of some basic skills of handball.The research areas were:Human Field: Al Qasim Club players in the Premier League handball.Time domain: from 12/1/2017 until 14/3/2017.Spatial space: the forum of youth of the denominator.The conclusions wereThere is a significant correlation between the cognitive achievement of the three axes and the following skills (handling, correction of jumping, defense moves, and wall of resistance).Keywords: Performance, Basic skills and cognitive achievement.
Several Parameters Influencing Wine Production from Mangrove Apple (Sonneratia ovata) Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The ripe mangrove apple is a potential source of natural antioxidants owing to its significant antioxidant activities. Phytochemical analysis of fruit extract revealed the presence of carbohydrate, protein, flavonoid and phenolic compounds. It can enhance the capability of antioxidant human body and therefore reduce the risk of chronic diseases. It is sweet in taste and usually consumed fresh or made into juice. There is limited study mentioning to processing of this functional fruit. Therefore we explored a wine fermentation from mangrove apple (Sonneratia ovata) fruit by focusing on the effect of different variables such as sugar supplementation, innoculum size, fermentation temperature in the primary fermentation, and fermentation time and temperature in the maturation to mangrove apple (Sonneratia ovata) wine quality (%v/v alcohol; g/l titratable acidity; oBrix residual sugar; sensory score). Our results proved that the primary fermentation should be conducted with 12% sugar ratio, 0.25% Sacchromyces cerevisiae inoculum at temperature 30.0oC in 15 days. The maturation was adequate in 10.0oC for 3 weeks to get a pleasant flavor and aroma. Mangrove apple (Sonneratia ovata) wine also evaluated the antioxidant capacity and total phenolic content. Mangrove apple (Sonneratia ovata) wine could be considered as a healthy source of antioxidants and phenolics ideal for daily consumption.Keywords: Mangrove apple (Sonneratia ovata), Wine, fermentation, Sacchromyces cerevisiae, Antioxidant, Phenolic.

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