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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Sustained release of drugs from prepared polymeric systems for Alzheimer disease protection Doaa E El-Nashar
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Slow release technique is a trial for long-acting protection from Alzheimer. Drug delivery systems, polymer based, can be designed to improve the pharmacological and therapeutic properties. Slow release technique gave the availability of drugs to deliver the right location in the body. The main principle of this technique is holding and keeping the drug on the polymer carrier for a sustained release of medicine in the body for a long period of time. The present work aimed to prepare polymeric materials from starch cellulose acetate coacrylate (SCACA), containing sodium bentonite nano clay and tween 80 as a surfactant for improving drug loading. The objective of this formulated natural polymeric product is to obtain practical effective sustained release drug systems by evaluating its potency in vivo for protection from Alzheimer disease. SCACA biodegradable polymeric system formulations containing anti Alzheimer drugs (such as Curcumin, Rosemary or Donepezil) were investigated through oral administration in experimental animals (rats). Methods: The characterization of the prepared polymeric system was carried out by FTIR and SEM. The drug release was measured spectrophotometrically. The invivo evaluation of the released drug against Alzheimer disease was an assessment of the effect in rats through biochemical and histopathological studies. Results: The slow release of the drug according to the study time illustrated that Rosemary, Curcumin and Donepezil estimated values through the tested time gave promising results, especially for releasing Rosemary, Curcumin and Donepezil. In the present investigation, the biochemical findings were also confirmed by histopathological observations which showed improvements in most biochemical parameters accompanied with amelioration in histological architectures in rats treated. Conclusions: Slow release technique is a good means for long-acting protection from Alzheimer's disease. Starch cellulose acetate coacrylate (SCACOA) is a good carrier for drugs such as Donepezil as a conventional drug while Rosemary, Curcumin as bioactive natural products. The invivo study for Alzheimer's protection gave promising results.
Investigating the Effect of Atorvastatin in Preventing Ventilator Associated Pneumonia among Patients with Cerebral Ischemia Hospitalized in ICU in Imam Khomeini Hospital in Urmia City Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Introduction:  ventilator associated pneumonia is one of the main reasons of death in patients under ventilator, especially those with impaired consciousness hospitalized in intensive care unit (ICU). Having anti-apoptotic, antioxidant, and immunomodulatory effects, atorvastatin can be effective in preventing pneumonia in patients with stroke who are under ventilator, while it is also prescribed to reduce cholesterol and accelerate recovery process in ischemia cases. The present study aims at investigating the preventive effects of atorvastatin on ventilator associated pneumonia among patients who suffer from stroke and are under the ventilator. Methodologies in the present study, 60 patients hospitalized in ICU unit under ventilator following an ischemic attack were divided to two groups of 30. The treatment group received a daily 40-mg dose of atorvastatin, while the control group didn’t. Then the occurrence of pneumonia was extracted for both groups during at least 14days of hospitalization, and the results were analyzed using SPSS20 software. Results the results of the study indicated that the amount of occurrence of pneumonia among patients treated by 40 mg atorvastatin was significantly lower than the patients in control group. Therefore prescribing daily 40 mg atorvastatin for the patients with ischemia in ICU unit who are incubated and are under mechanical ventilation would reduce ventilator associated pneumonia significantly. Conclusion atorvastatin has a significant reducing effect on occurrence of ventilator associated pneumonia in patients suffering from ischemic stroke in ICU unit, who are incubated and under mechanical ventilation, which will be proved clinically in the present study. Keywords: ventilator associated pneumonia, Cerebral ischemia, Atorvastatin. 
Preparation, Characterization and Antimicrobial Activity of Chitosan Schiff Base / Polyvinyl Alcohol Nanocomposite Eelaf N. Talib
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Schiff base of chitosan with Para-Dimethyl aminobenzaldehyde /PVA-Ag Nanocomposite have been prepared as antimicrobial polymer. The prepared chitosan Schiff base and chitosan Schiff base / PVA-Ag nanocomposite were characterized by FT-IR, SEM analysis and biological activity. The nanocomposite showed good activity against different types of bacteria.Keywords: Chitosan, Chitosan Schiff base, Ag-nanocomposite, antimicrobial polymer.
Application of Carrageenan, Xanthangum as Biodegradable Coating on Storage of Cherry Tomatoes (Lycopersicon Esculentum) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Cherry tomatoes (Lycopersicon esculentum) have been popularly consumed as functional food by their antioxidants as well as good apperance with bright red color and delicious flavor. But cherry tomatoes are prone to desiccation shrinkage and fruit softening during storage, resulting in the decrease of their commodity value. The major postharvest losses of tomatoes are due to fungal infection, physiological disorders, and physical injuries.  The prevalent method of preservation of postharvest cherry tomatoes is the use of moderately low temperatures and high humidity. However, low temperatures induce chilling injury. Application of edible coating on tomatoes is able to reduce quality changes and slow down moisture loss by controlling and modifying the internal atmosphere of the individual fruits. The great benefit conferred by edible coatings is that these are natural biodegradable products. An investigation on coating of cherry tomatoes by using carrageenan and xanthan gum was investigated. Cherry tomatoes which were coated with 0.75% carrageenan still maintained good quality until 30 days of preservation.Keywords: Cherry tomates, Carrageenan, Xanthangum, Biodegradable, Coating, Storage, Shelf-life.
The Effect of Gamma Rays in Some Optical and Physical Properties of the Material (PVA) Dissolved in Distilled Water Saad Khalid Rahi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This research includes a study of some optical properties of (PVA) which is dissolved in distilled water before and after irradiation by (γ-ray) the Radiation was done using Co60 source at the rate of 1.25 Mev and the irradiation process was carried out in the Institute and Hospital Radiation and Nuclear Medicine at dose of (8000 rad) with average radiation (500 rad / min) for (16 min). The study of optical properties had included measurement of absorbance, transmission, index of refraction has been measured for all concentration before and after irradiation, as well as the reflectivity, molar refractivity, and absorption coefficient has been measured. The  results shown that the value of absorbance, index of refraction, are increases as the solution concentration increased before and after irradiation, but the value of  transmission, absorption coefficient and reflectivity are decreased when the solution concentration increased before and after irradiation. All measurements are calculated at a constant temperature approximately to (25oC). The reason for the change at value of properties may be due to cross linking of polymer chains and then increased the average viscosity molecular weight for material (PVA) that used in this research. Keywords:  Health, gamma rays, Distilled water.
Oxidative Stress Status in Sera, Seminal Plasma and their Correlation with Lead (Pb) and Cadmium (Cd) in Iraqi Infertile Male Suha Hanoon Hasan
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Oxidative stress has been identified as a major mediator in various etiologies of male infertility. Lead and cadmium are two of the well-known reproductive toxicants to which human are exposed occupationally and environmentally. These heavy metals can lead to negative effects on the testicular functions. The aim of the current study is to look for the differences in the oxidative stress status in serum and seminal plasma of infertile male patients (oligo, azoospermia) groups compared to that of fertile healthy (control) group and to evaluate lead and cadmium levels in sera and seminal plasma of these groups in comparison to fertile healthy controls. The correlation between their level in seminal plasma and serum was also investigated. The current study included three groups of Iraqi male, 32 infertile patients with oligospermia, with 32 infertile patients with azoospermia, and 37 fertile healthy as a control group. The measured parameters included serum and seminal plasma total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), lead and cadmium concentration. The results in comparison with that of the control groups showed:-A highly significant increase differences in serum (TOS), (OSI), Pb, and Cd in serum of all infertile groups and between them.A significant decrease in serum TAC of azoospermia group, as well as a significant decrease in serum TAC of oligospermia group with significant differences between these two patients groups.No significant differences in seminal plasma TOS, TAC, and OSI in all of the infertile groups.In seminal plasma, a highly significant decrease in Cd and Pb of azoospermia group. Meanwhile a highly significant decrease in Pb of oligospermia group with highly significant differences between them. The results showed no correlation in the measured parameters between serum and seminal plasma of both studied patients.The Personal correlation analysis of TOS, TAC, OSI, Cd, and Pb revealed the presence of: - in oligospermia group, a strong negative correlation was found between serum, (TOS&TAC), and (TAC&OSI), meantime strong positive correlation between (TOS&OSI) also noticed. In serum azoospermia group a positive correlation between TOS&OSI and negative correlation between TAC &OSI were found. Meanwhile in seminal plasma a negative correlation was found between OSI&TAC. Furthermore, the result revealed, that the non-significant inverse relationship exists between lead and Cadmium concentration in serum and the number of sperm.Keywords: Male infertility, Serum & Semen, Total oxidant status, Total antioxidant capacity, Oxidative stress index, lead, Cadmium.
The Antimicrobial Activity of Silica Oxide Nanoparticles Against Some Bacteria and Fungi Isolates Ghaidaa J. Mohammed
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The capability of some bacteria and fungi to resist common antibiotics has been a guide to discover new planning to treat the infections connected to antibiotic resistance in the patients. In this study, the antifungal and antibacterial activity of silica oxide nanoparticles was detected in vitro against some bacterial species (Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Pseudomonas aeroginosa) and some fungi (Aspergillus terrus, Aspergillus parasiticus, Aspergillus flavus, and Candida albicans) and contrasted with antibacterial antibiotics (Amikacin, Amoxillin, Augmastin, Cefotaxine, Ceftazidime, Ciprofloxacin, Gentamycin, Meropenum, and Tetracycline) and antifungal antibiotics (Amphotericin B and Ketoconazole). Silica oxide suspension was prepared by acetic acid solution. Results showed that concentrations of (10-40) µg/ml of silica oxide have antifungal and antibacterial activity against the tested microorganisms in this work more than antibiotics. In conclusion, Silica oxide relates superior antimicrobial characteristics.                       Keywords: Antimicrobial activity, Silica Oxide, Bacteria, Fungi.                                 
Evaluate the Effectiveness of Oral Dosage with Probiotic Bacteria Lactobacillus rhamnosus GG, Lactobacillus Planetarium and Lactobacillus reuteri on Some Immune Indicators in Rabbits Rahem E. Alziadi
Journal of Global Pharma Technology .
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Abstract

This study was designed to evaluate some immune Indicators for rabbits oral dosage with three types of probiotics bacteria culture Lactobacillus rhamnosus GG, Lactobacillus planetarium and Lactobacillus reuteri. Rabbits were divided into four treatments, each subjected as the followings: treatment A, used as a negative control. treatment B,  sub divided into four groups: group1 used as a positive control  and other three groups were oral dosage with 1.0 µl\100gm weight\day with Lactobacillus rhamnosus GG, Lactobacillus planetarium  and Lactobacillus reuteri . Treatments C and D, the dose used was 200and 300µl\100gm weight\day from same. The results showed increasing in white blood cells (WBCs), red blood cells (RBCs) and hemoglobin (HB) and other parameters like immune origins weight (liver and spline) according to type of oral dosage bacteria and amount of dose, the dosage with Lb. rhamnosus GG bacteria was the beast compared with Lactobacillus planetarium  which were better than Lactobacillus reuteri dosage  and control. The study showed that dosage with 300µl\100gm weight\day was best comparing with other treatments and control respectively.Keywords: Oral dosage, Probiotics bacteria, Probiotics dose, Immune Indicators.
Biological Control of Fungal Brown Spot Disease in Rice Plants by Streptomyces spp. Farqad Fathi Hasan
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This study used thirty isolates of streptomycetes were isolated from different locations of soil. All these isolates were subjected for antagonistic test (as biological control agents) against Brown spot fungus Bipolaris oryzae. About 43% of  tested  streptomycetes  isolates  gave  antifungal  activity  against Brown spot fungus but 57% of  tested  organisms  did  not  reveal  any  antifungal  activity. The highest antifungal activity were obtained from two isolates (42 mm and 45 mm), both streptomycetes isolates were identified according to International Streptomyces Project (ISP) based on morphological (macroscopic and microscopic) and physiological characterization as Streptomyces orientalis and Streptomyces exfoliatus.Keywords: Biological control, Streptomyces orientalis, Streptomyces exfoliatus, Bipolaris oryzae, Brown spot disease.
Determination of Potential Compounds of Stevia Leaves (Stevia rebaudiana Bertoni) Against DPP4 as Candidates for Antidiabetic Drugs Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Diabetes mellitus is a metabolic disorder due to abnormalities in insulin secretion, insulin action, or both. Around 200 million people worldwide suffer from diabetes, most of which is type 2 diabetes. One of the targets of diabetes treatment is the DPP-4 enzyme which works to degrade incretin from the body. Sitagliptin, a DPP-4 inhibitor that has been approved for the treatment of type 2 diabetes. Besides using synthetic drugs, a biochemical compound can also be used for diabetes therapy, one of which is stevia leaf. This research was conducted to select compounds contained in stevia leaves based on their interaction with DPP4 in silico. The purpose of this study was to determine potential compounds from stevia leaves to be a candidate for antidiabetic drugs. Tests were carried out on DPP4 inhibitors, namely sitagliptin, and 10 compounds contained in stevia leaves. The results showed that there were three potential compounds namely isosteviol, steviol, and steviolmonoside. Testing the Lipinski's rule of five and pre-ADMET parameters implied that the three compounds had the potential to be used as candidates for antidiabetic drugs. Keywords: Stevia leaf, Stevia rebaudiana, Diabetes mellitus, DPP4, Molecular modeling.

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