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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Evaluation of Red Beet Root Activity Physiologically and Histologically in Males Rats Ibrahem Hasan Al-Kraie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

This research design to study the effect of cadmium chloride (Cdcl2) and red beet root juice on heart and kidney by measured the physiological parameters in the experimental male’s rats for 30days.  Twenty males rats were assigned to 4 groups each group contain 5 rats. First group was the control group (G1), the second group was cadmium chloride group (G2), third group was cadmium chloride &red beet juice (G3), than last group was red beet juice (G4). The Cd-exposure group (G2) obtained drinking a water daily containing cadmium chloride (CdCl2) in concentration of 2.0 mg Cd/L, while the G3 group treatment with red beet juice 2ml with 2ml of Cdcl2, while the last group G4 treatment with 2ml of red beet juice only.  At the end of the experimental period, blood samples were collected to determine the changes of serum Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), Total protein (TP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST).  The results of the present study  indicated  that  a significantly increased  in serum  levels of TC, TG, LDL_C, VLDL_C, ALT, AST, & significant decreased  in the levels of HDL_C & TP in G2 group, while there are no significant changes of all parameters in G3&G4 group comparing with control group at Significant level (p≤0.05). Results registors also that are significantly decreased in some parameters contain T.C ,Triglycerides ,LDL_C,VLDL_C, ALT &AST concentration in G3 & G4 group ,while the results showed a significantly increased in parameters HDL_C & Total proteins comparing with G2 group that trated with cadmium chloride at Significant level (p≤0.05).  In the end of this study we find that exposure to low Cd concentration can effected on the lipid profile & lipoprotein &liver enzymes by increased this parameters, while red beet root juice treatmenting decreased that parameters.Keywords: Cadmium chloride (Cdcl2), Total cholesterol(TC), Triglycerides(TG), High density lipoprotein cholesterol (HDL_C), Low-density lipoprotein cholesterol (LDL-C), Very low density lipoprotein cholesterol (VLDL-C), Total protein(TP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST). 
Adsorption of Nitrate from Water by Zn-Al Layered Double Hydroxide Hamieda Eadan Salman
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Zinc-aluminum Layered double hydroxide was synthesized by copercipitation method in molar ratio Zn/Al 4:1.The prepared layered double hydroxide were characterized by Fourer-transform infrared spectra (FTIR),X-ray diffraction (XRD)and Atomic force microscope (AFM).The synthesized layered double hydroxides were used to study the adsorption of nitrate anion (NO3-) from water. The influence of some parameters on nitrate adsorption, including PH, temperature and adsorption of kinetics the results showed that the adsorption of nitrate anion (NO3-) on the surface of the layers (Zn/Al-LDH) increases by increasing the temperature but decreases by increasing the PH and the adsorption of isotherm is following the frindlch equation .The adsorption of kinetics were subjected to modified first grad false the lagergren equation. The thermodynamic parameters, such as (∆H, ∆G, ∆ S) clarified that the adsorption on the Zn/Al-LDH is endothermic and spontaneous.Keywords: Layered double hydroxide, Adsorption, Nitrate.
The Effectiveness of the Strategy (SCAMPER) to Generate Ideas in Learning the Skill of the Service is Facing from the Top and Down in the Volleyball for Students Saeed Gheni Noori
Journal of Global Pharma Technology .
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Abstract

The study objective to identify the effectiveness of the (SCAMPER) strategy to generate ideas in learning the skills of the service is facing from the top and down in the volleyball, the experimental society was used, while the research society was identified by students in the fifth grade preparatory class (scientific and biological) for the Secondary School of Civilizations for Boys in Misan Governorate / Iraq for the academic year 2017-2018, which reached (64) students, and distribution into two groups, the control group's branch of biological (28) students applied the experimental branch's group (28) students either the rest of the students excluded from the sample for their participation experience reconnaissance. The parity of the two groups has been carried out in the accuracy of the skill of service is facing from the top, it has been applied (12) and the educational unit for both groups in accordance with the program unified distributed according to two units per week of educational duration of the unit per (45) minutes, researchers have concluded that the effectiveness of the program prepared in accordance with the strategy (SCAMPER) to generate ideas in learning the skills of the service is facing from the top and down in volleyball the experimental group, as well as students interact with the strategic development of creative thinking.Keywords: Strategy (SCAMPER) for generating ideas, Service is facing top and down in the volleyball.
Efficiency of a High-dose Intravenous Immunoglobulin Therapy in Children with Autism Spectrum Disorders Associated with Genetic Deficiency of Folate Cycle Enzymes Dmitry V. Maltsev
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Previously, it has been repeatedly reported on the effectiveness of intravenous immunoglobulin therapy in some children with autism spectrum disorders without specifying selection criteria of potential responders to immunotherapy. Objective: to evaluate high-dose immunoglobulin therapy efficacy and safety in children with autism spectrum disorders and genetic deficiency of folate cycle. The studied group consisted of 78 children aged 2 to 10 years who have been on intravenous immunoglobulin at a dose of 2 g/kg per month for 6 months. The control group included children of similar age and gender distribution, which received only non-drug rehabilitation support. The dynamics of psychiatric symptoms were assessed using the Aberrant Behavior Checklist scale. Complete elimination of the phenotype of autism spectrum disorders has been obtained in 21 patients and an improvement was marked in 33 children of study group. In parallel, positive dynamic of other clinical manifestations of folate cycle deficiency phenotype was evaluated: PANDAS (19 out of 21), epilepsy (29 out of 36) and gastrointestinal (in 49 out of 68 children) syndromes.  Intravenous immunoglobulin has a complex positive impact on the manifestation of a genetic deficiency of folate cycle, including autism spectrum disorders, extrapyramidal disturbances, bowel syndrome, epileptiform brain activity, immune deficiency, and leukoencephalopathy.Keywords: Folate cycle, Intravenous immunoglobulin, Autism spectrum disorder.
Fabrication and Characterisation of Silymarin–Quercetin Loaded Polymeric Nanoparticles Using TPGS for Hepatic Drug Delivery Senthila Sivakami
Journal of Global Pharma Technology Volume 13 Issue 03 (2021) March 2021
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Abstract

Objective: The aim of the present investigation was to enhance the hepatoprotective activity of silymarin and Quercetin by incorporating it in TPGS-PLGA nanoparticles (NPs) for passive targeted delivery, thereby prolonging its retention time. Method: Poly lactide-co-glycolide (PLGA) nanoparticles were prepared by modified spontaneous emulsification solvent diffusion (SESD) method. TPGS as an emulsifier and further as a matrix material blended with PLGA was used to enhance the encapsulation efficiency and improve the drug release profile of nanoparticles. Silymarin and Quercetin were used as model drugs which are having poor water solubility. Result: The surface morphology and size of the nanoparticles were studied by scanning electron microscopy (SEM). Drug encapsulation efficiency and in vitro drug release pattern of nanoparticles were determined using High Performance Liquid Chromatography (HPLC).The nanoparticles prepared in this study were spherical, with size range of 150–250 nm. It was shown that TPGS was a good emulsifier for producing nanoparticles of hydrophobic drugs like Silymarin and Quercetin and improving the encapsulation efficiency, drug loading and drug release profile of nanoparticles. Conclusion: This research suggests that the combined therapy system of Silymarin and Quercetin could be a better approach for liver targeted drug delivery.
Production of Bio-Ethanol from Various Lignocellulosics Using High Yielding Isolate of Saccharomyces Cerevisiae Apn07: Mathematical Approach G. Narendra Kumar
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Bio ethanol is increasingly being used as fuel additive in automobiles and the maximization of its production from alternative renewable substrates like lignocellulosic materials are gaining significance. The present study attempts to optimize the media using 0.5% acid hydrolysates from rice husk, rice straw, and sugarcane bagasse and groundnut shell with sugarcane molasses for the production of bio ethanol using RSM analysis with CCD design. The strain of Saccharomyces cerevisiae APN 07 isolated from coconut toddy that yielded 9.6% ethanol when 1.5 ml of all five substrates were mixed in the combination of 15 ml each. Mathematical analysis of the results determined the correctness of the prediction. The coefficient of determination (R2) was 0.997034 signify that the response model could revealed 99.19 % of total difference. The value of (R2pred = 0.994989) indicates high accord between the experimental and predicted value. The high value of adjusted determination coefficient (R2adj¬= 0.993) indicated the significance of model. FTIR confirms the presence of alcohol (OH group). Batch kinetic studies agreed with the model for ethanol production.Keywords: Saccharomyces cerevisiae APN 07, RSM-CCD, Alcohol production.
Prospect of umbilical cord mesenchymal stem cell culture waste in regenerative medicine Jeanne Adiwinata Pawitan; Melisa Leviana; Dewi Sukmawati; Isabella Kurnia Liem; Ria Margiana; Twidy Tarcisia
Journal of Global Pharma Technology Volume 9 Issue 07
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Abstract

Abstract: Objective:to analyzevarious growth factor (GF) content in umbilical cord derived mesenchymal stem cell (UC-MSC) culture waste at harvest.Methods: We cultured UC- MSCs in complete medium, and collected the medium waste at harvests.  We noted the time of harvests, and measured the concentrations of EGF, VEGF, NGF and Pl GF in the various medium wastes using ELISA method. We grouped GF concentrations according to various culture lengthsat harvest, and calculated themean values and standard deviations of the various GF. We compareddescriptively the GF concentrations at various culture lengths at harvests to conclude which condition yielded the overall highest GF concentration.Results: EGF, VEGF and PlGF concentrations were highest at harvest day-3, whileNGF concentration was the highest at harvest-day-5, respectively. Therefore, overall highest concentration of most GF was at harvest day 3.Conclusion:UC-MSC culture waste at harvest day-3 containedEGF, VEGF, NGF and PlGF, which might be used in regenerative medicine.
Photocatalytic Degradation of Textile Dye Cristal Violet Wastewater using Zinc Oxide as a Model of Pharmaceutical Threat Reductions Ayad F. Alkaim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The photo catalytic degradation of Cristal Violet   dye (CV) has been investigated under UV irradiation in aqueous suspension of zinc dioxide under a variety of conditions. The degradation was studied by monitoring the change in dye concentration using UV spectroscopic technique. The effects of key operation parameters such as initial dye concentration, catalyst loading, as well as light intensity on the decolonization extents were studied. And found The initial increase in rate of dye degradation with increase in amount of catalyst is due to increase in number of active sites on the surface of photo catalyst  the rate of photo catalytic degradation and photo degradation efficiency increased with increasing is increasing with increasing UV light intensity.Keywords: Photcatalytic; Cristal Violet dye, zinc oxide
Influence of Osmotic Dehydration in Processing of Tamarindus indica Jam N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Tamarind (Tamarindus indica L.) has long been used as a spice, food component and traditional medicine. It has high content of total phenols, proanthocyanidin and tannins Tamarindus indica has a high commercial value affordable functional foods. Howeever it has short shelf-life during post-harvest handling owing to high moisture content. It’s necessary to preserve this valuable fruit for long-term use. Objective of this research focused on the effectiveness of various processing parameters such as pretreatment with KMS solution, sugar concentration, immersion time, and agitation speed during the osmotic dehydration of Tamarindus indica into jam. Our results showed that the optimal dehydration process should be pre-treated with 0.25% KMS solution, sugar 60oBrix, immersion in 75 min, agitation 500 rpm. From this approach, the added value of Tamarindus indica fruits would be enhanced. Osmotic dehydration showed minimum heat degradation to nutritional components owing to low temperature moisture removal. It contributed some advantages such as limiting the thermal damage to the aroma, color, preventing the browning of enzymes and decreasing the energy consumption.Keywords: Tamarindus indica, Osmotic dehydration, Pretreatment, Immersion, Agitation, Sugar.
Drill of the Absolute Torque and their Effect on Some Biochemical Variables for Some Stages of 60-Meter Hurdle-Runners Mazin Anhair Lami
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The need to apply special resistance exercises to athletics has become particularly strong and the indices are falling apart at every international tradition pattern of power workouts, according to the parts. Different which moves rotational movements especially running hurdles, so this search came to muscle totals operating for a 60-meter hurdles in accordance with the movements specify within the axis of the rotation of these parts, the angular kinetic work of these joints in order to achieve the condition of the runner’s power in such an efficiency to increase his muscle efficiency. The search applied to a group of runners who ran 60 roadblocks in Iraq and researchers prepared skill-based exercises with weight-added resistors to body parts according to the percentages of these parts, to develop kinetic variables. For some stages, 60 meters of hurdles were run and the exercises were applied for eight weeks, three training modules per week. The results have shown the evolution of these variables of force and speed and angles during the run, between the hurdles and the hurdle step for group research.Keywords: Absolute torque, Relative momentum and unbalanced Power.

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