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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Characterization, Antimicrobial of Studies New 2,2'-{(1Z,2Z)-ethane-1,2-Diylidenebis[(2Z) Hydrazin-1-yl-2-ylidene-1,3,4-oxadiazole-5,2-diyl]}Diphenol and their Transition Metal Complexes Azhar Hameed Gatea
Journal of Global Pharma Technology .
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Abstract

A new ligand 2,2'-{(1Z,2Z)-ethane-1,2-diylidenebis[(2Z)hydrazin-1-yl-2-ylidene-1,3,4-oxadiazole-5,2-diyl]}diphenol and its Cr(III) , Co(lll) and Ni(ll) complexes were synthesized . The ligand and its complexes were characterized by elemental analysis, conductance measurements, as well as spectroscopy (H1NMR, IR, mass), magnetic susceptibility. A new ligand and its complexes were screened for their antibacterial activity against two kinds of strains Escherichia coli (gram negative bacterial strains) and staphylococcus aureus (gram positive bacteria strains) using the agar disk diffusion method.
LACTOFERRIN AND FERRITIN IN A LABORATORY CONTROL OF A TOXICITY LEVEL OF ANTI-TUBERCULOSIS DRUGS Igor Kuznetsov
Journal of Global Pharma Technology Volume 08 Issue 08
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Abstract

Introduction: The impact of anti-TB drugs has a huge load on the immune system, which often leads to the state of maladaptation. In this regard, it is necessary to develop new approaches to immunomodulation, which can be monitored in a laboratory by changes in concentration of ferroproteins of blood, lactoferrin and ferritin. In destructive forms of pulmonary tuberculosis, the level of lactoferrin and ferritin in blood decreases, and with the increase in their concentration, the condition of patients improves. Materials and Methods: The effect of immunomodulator trekrezan on the development of a toxicity level of anti-TB drugs was studied. The indicators of a toxicity level include: the increase in the total protein content, urea in blood serum, hemoglobin concentration, decrease in the number of red blood cells, increase in the number of leukocytes, lymphocytes, increasing activity of alanine aminotransferase and aspartate aminotransferase. We simultaneously examined the changes in the concentration of lactoferrin and ferritin. We studied 6 groups of patients with a diagnosis of Cavernous lung tuberculosis. Results: In the group which took only basic medication + trekrezan + pyridoxine (2 courses), the best positive changes were registered at the end of the course of chemotherapy. All the above-mentioned laboratory indicators were in the normal range. After one month of the treatment, lactoferrin increased by more than 10 times, and the concentration of ferritin increased significantly, with its subsequent normalization. Discussion: It is claimed that the higher the concentration of lactoferrin and ferritin, the stronger the body’s defenses, and the double course of trekrezan and pyridoxine extremely minimizes the toxicity of chemotherapy. Keywords: lactoferrin, ferritin, trekrezan, toxicity, immunity.
Purification and Characterization of Karadi Sheep Milk Proteins Jasim M. S. Al-Saadi
Journal of Global Pharma Technology .
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Abstract

The distribution of nitrogen in Karadi sheep milk showed protein nitrogen to be 94.6% of the total nitrogen, non-protein nitrogen 5.4%, casein nitrogen 72.9% and whey nitrogen protein 21.7%. β-Lacto globulin (β-Lg), α-lactalbumin (α-La), κ-casein (CN), αs-CN and β-CN were purified from sheep milk using gel filtration and ion-exchange chromatography. The molecular weights of the purified α-La, β-La, κ-CN, β-CN and αs-CN were 14.01, 18.05, 21.3, 24.8 and 24.95 kDa, respectively. Phosphorus levels in κ-CN, β-CN and αs-CN were 3.14, 7.84 and 11.75 mg/g protein respectively. Κ-CN contained 49.1 mg carbohydrates/g protein.Keywords: Sheep milk, Protein purification, Chromatography, Caseins, Whey proteins.
Influence of Surfactants Solutions on Staphylococci Biofilm Omar Abdulkareem Ali
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Staphylococci known to form biofilm on various clinical and biomaterials, so increase resistance to antimicrobial agents through biofilm formation strategy. The intracellular adhesion had been required for biofilm formation by Staphylococci. In this research, the main goal was detecting the biofilm formation capability regarding Staphylococcus sp. isolates on 96-well microtiter plates, also studying the impact of surfactants solutions extracted from Lactobacillus acidophilus in biofilm formed through Staphylococcus sp. Seventy-four Staphylococci isolates had be utilized in this research, the solid biofilm forming capacity had be confirmed through incubating these isolates in microtiter plates for 48 hours and at a temperature of 37Celsius. Afterward, during the next 24-48 hours, observations have made over removing the established biofilms of Staphylococci isolates with surfactants solution. The results hinted at the elimination of these biofilms in surfactants concentration-dependent way, with an observation that after 48 hours of incubation, the biofilm biomass reduction had been considerably greater.Keywords: Lactobacillus; Surfactants; Biofilm; Adhesion; Staphylococci.
A review of mobile applications for diabetes: could it replace the role of professional health care? Lusy Noviani; Ajeng Diantini; Anas Subarnas
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background: The prevalence of diabetes is increasing year to year, despite various attempts to reduce prevalence have been made. The role of professional health teams (PHTs) is critical to manage diabetes progression. Advances in technology such as Mobile Applications (MA) have provided new opportunities to support the success of diabetes treatment. This article aims to provide a critical analysis of the challenges that are not fully fulfilled and highlights directives for future research that can enhance the implementation of MA in diabetes management. Methods: A systematic review has been conducted. A number of articles related to mobile applications and diabetes mellitus published between 2011-2020 have been taken from Google Scholar, PubMed, and Medical ProQuest, and 15 articles were selected based on criteria set. Results: Each study appears to have different features in design MA, affecting the results varied in the 15 studies reviewed. Mobile technology-based applications demonstrated their role in improving communication, being accessible, facilitating self-management processes, improving compliance with treatment, and ultimately improving blood sugar control. Conclusion: The role of PHTs is important for the successful implementation of the fast-developing sensor and transfer app in the medical sector. It is the role of a PHTs to select adequate devices, apply them, and earnestly analyse their effectiveness and economic feasibility.
Immunohistochemical Evaluation of Growth Factors in the Peripheral Blood Vessels of Patients with Severe COPD and Osteoporosis Igor V. Manzulo
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The expression of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGFβ) in the blood vessels of striated muscle specimens of 20 severe chronic obstructive pulmonary diseases (COPD) with osteoporosis and healthy subjects were assessed by immunohistochemistry method with using immunoperoxidase reaction with monoclonal and polyclonal specific antibodies. The serum levels of VEGF and TGFβ were studied in 74 severe COPD patients and 36 healthy individuals using immynoenzyme (ELISA) methods. Elevated level in TGF-β and reduced serum VEGF were associated with low bone mineral content and muscle mass in the COPD patients. Increased expressions of TGF-β2 and VEGF were observed in the vascular wall in the severe COPD group with osteoporosis. Intensities of staining in the arterial structures were higher in the COPD group, which were primarily presented in the endothelial and muscular layers. Thus, our study strengthens the hypothesis that change tissue and serum markers of the vascular remodeling are involved in pathophysiology of bone damage in severe COPD.Keywords: Chronic Obstructive Pulmonary Disease, Osteoporosis, Vascular Endothelial Growth Factor, Transforming Growth Factor Beta, Vascular Dysfunction.
Investigating the Prevalence of Hepatitis B and C among Thalassemia Patients in Jahrom: A Cross-Sectional Descriptive Study Vahid Mogharab
Journal of Global Pharma Technology .
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Abstract

Introduction: Thalassemia is a hereditary anemia which is inherited by the child from the parents. The prevalence of this disease is not equal in Iran. Blood products are used in order to treat thalassemia, especially thalassemia major, exposing the patients to the risk of infections including hepatitis B and C. Due to the vaccination against hepatitis B in thalassemia patients, its prevalence has been significantly decreased. However, hepatitis C is considered a prevalent disease, such that the hepatitis C virus can be claimed to be the most prevalent cause of chronic hepatitis in specific thalassemia groups. Therefore, the present study was conducted to investigate the prevalence of Hepatitis B and C among Thalassemia Patients in Jahrom. Method: This research was a cross-sectional descriptive study. In the present study, 167 patients with thalassemia in the Cooley's Ward of Shahid Motahhari Hospital were examined. Collected data included age, sex, duration of receiving the product, type of received product, type of thalassemia (major, intermedia), type of hepatitis (B, C), number of individuals with hepatitis, examination of the liver enzymes of individuals infected with hepatitis, and number of individuals who had undergone splenectomy. Data were analyzed in SPSS 11 using the chi-squared statistical test. Results: From among 167 thalassemia patients in the present study, 164 patients (98.2%) had thalassemia major and 3 patients (1.8%) had thalassemia intermedia.  Most cases of thalassemia (50 men and women, 60.24%) were found in the age group of 14-26 years. The prevalence of hepatitis B was 0% among thalassemia patients. The prevalence of hepatitis C was 7.93% (13 men and women) only among thalassemia major patients. The level of liver enzymes (AST, ALT) was higher among patients with hepatitis C compared with others. No significant relationship was observed between the number of cases with hepatitis C and age, sex, and times of blood transfusion (p>0.05).Conclusion: According to this study, the prevalence of hepatitis B and C was low among thalassemia patients in Jahrom.Keywords: Hepatitis B, Hepatitis C, Thalassemi.
Synthesis, Characterization and Electrical Study of Ligand 5, 5'-(4H-1, 2, 4- triazole - 3, 5- diyl) bis (azaneylylidene)) bis (methaneylylidene)) bis (4,1-phenylene)) bis (methaneylylidene)) bis (azaneylylidene)) bis (4H-1, 2, 4- triazol- 3- amine with Some its Transition Metal ion Complexes Amal H. Anatheil
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

A new series of  some transition metal  ion (Cr  (III), Co (III), Fe (III) and Ni (II) complexes of new ligand {5, 5'- (4H-1, 2, 4-triazole- 3,5-diyl)bis(azaneylylidene))bis(methaneylylidene)) bis(4,1- phenylene)bis(methaneylylidene)) bis (azaneylylidene)) bis(4H-1,2,4-triazol-3-amine}(L) were  synthesized .A ligand was synthesized by reaction 2,5-di amino-1,2,4-triazole  and  two mole for Terephthalaldehyde in presence of ethanol and drops for acetic acid  to give 4,4'-((1Z,1Z')-((4H-1,2,4-Triazole-3,5,-diyl)bis(azaneylylidene))bis(methanelidene))dibenzaldehyde. Followed by reaction with two mole for 2, 5-diamino-1, 2, 4-triazole to give (L). The newly synthesized compounds were characterized by Fourier transform infrared (FTIR) Spectroscopy, Nuclear Magnetic Resonance Spectroscopy(1H NMR), elemental analyses (C, H, N), Mass Spectra data, magnetic susceptibility data, Molar electrical conductivity and atomic absorption. The Hyperchem 0.75 program have been used to draw the ligand geometry optimization and then study the electrostatic potential that given right data about the active site. It has been shown through all the above diagnostic measures that ligand is formed with the (Fe, Co and Cr) ions tetrahedral complexes and with the nickel formed square planer complex, Electrical insulation properties were studied for L and their complexes with (Fe, Co and Cr) , The measured electrical conductivity results are measured at room temperature with the applicable field frequency, Note when frequency increase the applied field of (50 Hz -1MHz) Connectivity increases due to the direct relationship between frequency and electrical conductivity. During the study, both ligands and their complexes were I2-doping showed that iodine increased the conductivity of Ligand, reduced the conductivity of complexes.Keyword: 1, 2, 4-Triazole, Terephthalaldehyde. Electrical conductivity, Doping, Magnetic susceptibility.
Alkaloids from Alphonsea Elliptica Barks and Their Biological Activities Saripah Salbiah Syed Abdul Azziz
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

This study was carried out to investigate the phytochemicals from the barks of Alphonsea elliptica. The barks  were harvested from Hutan Simpan Sembarong, Kluang, Johor; and extracted using dichloromethane (DCM), hexane and methanol successively. Isolation of dichloromethane crude extract was then performed using silica gel column chromatography and preparative thin layer chromatography (PTLC)techniques. Structural identification were carried out via 1D and 2D NMR, UV, IR, MS and comparison with reported data. Phytochemical study of the barks led tothe isolation of five alkaloid in which two were oxoaporphines; atherospermidine (1) and liriodenine (2),two were dioxoaporphines;cepharadione A (3) and N- methylouregidione (4), and an azafluorenone alkaloid;kinabaline (5). The hexane, DCM, and methanol crude extracts, together with five isolated alkaloids, were tested for theirradical scavenging activity,inhibition of xanthine oxidase activities and cytotoxicity. Atherospermidine and liriodenine possessed antioxidative activities with IC50 value of 20.17 and 10.73, respectively. Atherospermidine, liriodenine, N-methylouregidione and kinabaline showed xanthine oxidase inhibitiory activityof 46.29, 7.66, 42.10 and 50.72 μM,respectively. Meanwhile, atherospermidine, liriodenine, cepharadione A and kinabaline showed cytotoxicity  against breast cancer cell line with IC50 89, 86, 79.85 and 62 µg/mL respectively.  All the alkaloids tested in this study were isolated for the first time from this species while Cepharadione A is reported for the first time in a species belongs to Alphonsea genus.Keywords: Alphonsea ellipticaHk. f. et Th., Alkaloids, Radical scavenging activity, Xanthine oxidase, Cytotoxicity.
The Adsorptive Removal of Rhodamine 6G Dye from Aqueous Solution by Using Poly (Fumaric Acid-Co-Acrylic Acid) Hydrogels Wissam L. Benyan
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The removal of rhodamine 6G from aqueous solutions was achieved by adsorption using poly (fumaric acid-co-acrylic acid) as adsorbent surface. Several variables that affect the adsorption were studied including adsorbent dosage, contact time, pH, temperature and ionic strength. The results indicate that hydrogel has a strong capability of removing rhodamine 6G dye directly from aqueous solutions. The equilibrium adsorption data is analyzed using three common adsorption models: Langmuir, Freundlich and Temkin. The Thermodynamic parameters ΔH, ΔG and ΔS are calculated for the adsorption rhodamine 6G onto hydrogel.Keywords: Hydrogels, Rhodamine6G, Adsorption, Isotherms, Thermodynamic.

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