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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Kinetic Games and Their Impact on the Development of Some Adaptive Abilities and Behavioral Psychological Compatibility of Students with Slow Learning Ammar Khaleel Ebrahim Al-Ezzi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The interest in childhood and caring for the important trends in the present time because of the great impact in building their physical, dynamic and emotional as it is the basis on which to build the rest of his future life, the more well prepared by satisfying his needs in a suitable way to achieve psychological balance and social helped to build a personality from Where the strengths and weaknesses, and the researchers' observation of this class of students slow learning separated from their peers in one row and integrated only in the study of physical education and sports sciences and hence the importance of research by helping this group to become people The aim of the study was to identify the effect of motor games on the development of some adaptive abilities and the behavioral psychological compatibility of students of slow learning. The researchers hypothesized that kinetic games had an effect on the development of some compatibility abilities and behavioral psychological compatibility of learning slow learners. (10) Learning slow learners. After performing Pretests of some compatibility abilities and behavioral psychological compatibility, exercise exercises were performed for 9 weeks with two teaching units per week. The researchers found that there are significant differences for some compatibility abilities and behavioral psychological compatibility of the Pre and post-test and for the benefit of the post-test. The researchers attributed the reason for this to the effectiveness of motor games within the educational units as they were the age and abilities of the students, which helped satisfy their desires as a result of emptying their negative emotions and towards good performance The researchers recommend the need to use motor games, competitions and ball games that develop muscular compatibility as well as the establishment of courses for teachers of special education to develop the mental abilities of students slow.Keywords: Motor games, Harmonic abilities, Behavioral psychological compatibility and learning disabilities.
Contribution of Equilibrium Variables with the High Spike Accuracy of the Position Diagonal Center (4) in the National Volleyball Team Players Ban Faisal Al-Azzawi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

What is important about this study is whether there is a relationship between the ability to balance and beating overwhelming for the Iraqi national team volleyball? The study aims to identify the percentage of the equilibrium contribution and its variables with the accuracy of the skill of beating the high spike Diagonal center (4) in the players. In the national volleyball team season (2016-2017), the researchers used the descriptive approach in the style of associative relationships to suit the problem of research. The research community included all the players specialized in the high beating of the Iraqi national team applicants in the ball The researchers concluded that the equilibrium variables contributed accurately and quickly to the high landslide of the region (4), and the researchers recommended the emphasis on the stability exercises, which showed a significant contribution and impact in the accuracy And the speed of beating the Diagonal high ground, and the adoption of tests of accuracy and speed in the assessment of the level of the ballots in the national team because it gives greater realism to the level of training.Keywords: High spike, Accuracy and diagonal center.
CRUSADE Bleeding Score as a Predictor for the Risk of Bleeding Events in Patients with Acute Coronary Syndrome: A Prospective Study from Tamil Nadu Aneena Suresh
Journal of Global Pharma Technology Volume 12 Issue 10 (2020) Oct. 2020
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Abstract

Background: The CRUSADE bleeding risk score is an accurate and robust risk-stratification tool for predicting hemorrhagic complications in patients with Acute Coronary Syndrome (ACS). However, studies assessing and validating this score especially within Indian population are scarce to almost non-existent. Objective: To evaluate the Crusade Bleeding Score in predicting the risk of bleeding events in patients with acute coronary syndrome. Methods: This cross-sectional study was conducted at a secondary care hospital in Tamil Nadu, India. A total of 72 patients with ACS on treatment with anti-thrombotics that fulfilled the inclusion criteria of the study were prospectively recruited. The patient’s demographic data along with their past medical history pertinent to the study was collected and the scores for each patient was calculated. Results: Significant major bleeding was found among considerably older, female patients, diabetic and hypertensive patients, as also among patients having lower GFR values. Five patients classified under the Very High-Risk Category of the CRUSADE bleeding score further went on to develop hemorrhagic complications thereby validating the score among the study population. Conclusion: The CRUSADE bleeding score was found to be an accurate predictor of bleeding events within our study population with good validity. We further recommend the suitable use of the CRUSADE bleeding risk score in clinical practice as there is a need for stronger evidence to support the use of risk stratification systems to optimize therapy and improve patient outcomes in India.
Work’s Environment Effect on Metal and Male Reproductive Hormones Levels: Circulating Testosterone, LH, and FSH are Positively Associated with Cadmium, Lead, and Molybdenum Farha A.Ali Shafi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Objectives: The present study was carried out to investigate the concentration cadmium (Cd.), lead (Pb.), and molybdenum (Mol.) in blood samples of petrol stations workers and its relationships with the male reproductive hormones levels such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and Testosterone. Methods: This study included 31 workers in 4 petrol station in different sites of Thi-Qar city/Iraq, who were working since more than 5 year in the petrol station and spend more than 12h work time, and ten healthy in different sites of a same city. Both groups age were ranged from 23 to 45 years old. Heavy material (Pb, Mo, and Cd) were determined by atomic absorption method using Shimadzu AA-7000 Dual Atomizer system. Hormones level (FSH, LH, and testosterone) were determined by enzyme linked fluorescent assay (ELFA) using the Bio Mérieux VIDAS Automated Immunoassay System. Results: Our results found significantly higher Cd, Mo, and Pb levels in Petrol workers compared to control (p<0.05). While no significantly differences were detected between FSH levels in control and Petrol workers groups, significantly higher testosterone level was found in Petrol workers compared to control (p<0.05). Conversely, significantly lower LH level in Petrol workers group than it in control group (p<0.05). Conclusion: the petrol station workers exposure to Cd, Pb, and Mol which lead to increase its levels in their blood due to neglect the occupational safety instructions. Thus associated positively with the testosterone level and negatively with the LH level in their blood.
Anti-microbial Susceptibility of Staphylococcus aureus Isolated from Different Clinical Infection Enas Jalil Baqer Almayali
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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This study investigated staphylococcus aureus in many of the infected clinical samples and their resistance to antibiotics .The study included two mainaxes, the first axis is diagnosis of bacterial isolates according to approved diagnostic systems, the second axis is determine the resistance and sensitivity of the antibiotic.  A total of 250 clinical samples were collected from several places of the body from Al-Hakim General Hospital and Al-Sadr city medical in Al-Najaf city during the period from November 2018-Febray 2019. Samples were under study (ear, eye, wound, urine, tonsils, diabetic foot and aspiration fluid) for both sexes and different age group. The results of the bacterial diagnosis showed that sample was infected with staphylococcus aureus (20 isolated from diabetic foot, 10 isolated from ear ,10 isolated from urine , 15 isolated from wound, 15 isolated from aspiration fluid),depending on characters of culture media, Gram stain, biochemical test and Vitek-2 for identification . The study also examined the sensitive test by testing disk diffusion depending on the locations of the disease. Isolated from ear, wound, diabetic foot, aspiration fluid were resistance to penicillin family. While isolated from urine were variable to it family. All isolated were sensitive to vancomycin, teicoplanin, impenem, meropenam. All isolated were sensitive to amikacin, refampine, except isolates from diabetic foot were resistant to it. Cefidinr more kind of cephalosporin gives sensitivity to study isolated. Quinolones, macrolides, aminoglycoside were variable depending on location of the disease.Keywords: S. aureus, Sensitivity
Removal of Alizarin Red Dye from Aqueous Solution with Bio Sorption Technique Using Snail Shell as Low Cost Adsorbent Muneer A Al-Da&#039;amy
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Study evaluated the feasibility of removing Alizarin Red dye from aqueous solutions, using snail shell. The effect of contact time, adsorbent does, pH, ionic strengthinitial dye concentration and temperature on adsorption was studied. The pH 2.0 was observed to show optimum removal for Alizarin Red. The equilibrium time was fixed at10min. Maximum adsorption of Alizarin Red was a achieved at the suggested optimum conditions initial dye concentration 30mg.l-1 weight of adsorbent 0.01g .The adsorption isotherms could be well-defined with the Temkin isotherm model instead of the Freundlich isotherm model. Change in entropy (ΔS°), Gibb’s free energy change (ΔG°), and enthalpy (ΔH°) were calculated for the adsorption of Alizarin Red dye.Keywords:  Adsorption, Alizarin Red, Snail shell, Langmuir, Freundlich, Temkin.
Synthesis, Characterization and Study Thermal Stability of New Polythiadizole Derivatives / Silica Nanocomposites Maha T. Sultan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

New nanocomposites containing polythiadizole were synthesized by free radical polymerization and examined their thermal properties. All monomers, polymers and nanocomposites were characterized by FT-IR spectroscopy. The thermal stability were investigated by thermo gravimetric (TG), differential scanning calorimetry (DSC) and differential thermal analysis (DTA). Synthesis of polymer and their nanocomposite had characterization by FT-IR, thermogravimetry (TG), Diffraction scanning callomatry DSC, Differential Thermal analysis DTA,the state of the nanocomposite were evaluated via X-ray diffraction (XRD).The results of thermal analysis showed that nanocomposite more stable than their polymers.  Keywords: Thermal stability, Polymers, Thiadiazole, Nano composite.
Anti-Amnestic Effect of Iridoids Fraction from Pentas Lanceolata Leaves against D-Galactose Induced Brain Aging in Rats Azza F. Arafa
Journal of Global Pharma Technology Volume 12 Issue 01
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In this work the anti-amenstic effect of the iridoids-rich fraction isolated from Pentas lanceolata (IFPL) leaves was investigated using D-galactose (D-gal) to artificially create aging in rats. Thirty-two rats were divided as follows: 1st group served as control; 2nd, 3rd and 4th rat groups were injected intraperitoneally with 100 mg/kg D-gal five days/ week for two months. The 2nd group was left untreated. While, 3rd and 4th groups were treated daily orally with IFPL (50 mg/kg b. wt.) and the reference drug donepezil (10 mg/kg b. wt.), respectively for one month. Behavioral tests, T-Maze and beam balance, showed deterioration in cognitive ability of aging rats. D-gal caused a remarkable decrease in oxidative biomarkers except lipid peroxides which revealed a significant increase. In addition, D-gal-treated rats showed a significant decrease in the levels of neurotransmitters, while, a significant increase in acetylcholineasterase (AChE) was recorded. Furthermore; caspase-3 levels were elevated in aged brains which were confirmed by immunohistochemical analysis. Histopathological alterations were observed in these rats. Treatment of these rats with IFPL exhibited improvement in behaviour, neurobehavioral changes, modulated oxidative stress as well as apoptotic markers which is confirmed by histopathological investigations.These findings provide scientific evidence that IFPL extract has antioxidant, anti-inflammatory, immunomodulatory, anti-apoptotic and anti-amnesic properties against D-gal induced brain aging.Keywords: D-galactose, Brain aging, Pentas lanceolata, Iridoid-rich fraction
DNA-In Situ Hybridization for Molecular Localization of Human Cytomegalovirus in Cervical Tissues from Iraqi Patients with Cervical Adenocarcinoma Saad Hasan M.Ali
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Cervical cancer pathogenesis is a multi-factorial process where cervical epithelium is exposed to several important carcinogenic influences. On epidemiological bases, cervical cancer has the characteristics of a venereal disease and among many genital infective agents; human cytomegalovirus (HCMV) might have a role in the etiology of this neoplasm. This study aimed to investigate rate of HCMV infections in cervical aden carcinoma using DNA -in situ hybridization (DISH) and to evaluate their impact on the expressed histopathological features of those cancers.  This study was designed as retrospective research. A total number of forty-nine (49) patients who had undergone hysterectomies or punch biopsies from their cervices were included. Among these, twenty-one (21) formalin-fixed paraffin-embedded tissue blocks were from cervical aden carcinoma while twenty-eight (28) cervical tissue blocks (either without any significant pathological changes or have chronic cervicitis) were included as a control groups for this study. Molecular detection of HCMV in those tissue blocks were performed by using ultra-sensitive versions of DISH technique. Human CMV DNA was found in 12 out of 21 (57.1 %) cervical adenocarcinoma tissues while no HCMV DNA was detected in any tissues from chronic cervicitis group or those in the histopathologically- healthy control group. Among those twelve positive results of Human CMV DNA –ISH reactions, eleven cases (91.7 %) of cervical adenocarcinoma have well or moderate differentiation while only one case (8.3%) was of poor grade.Keywords: Cervical adenocarcinoma, HCMV, DNA-ISH.
Association of Tumor Necrosis Factor-α-308 gene Polymorphism with Psoriasis in Babylon Province Mona N. Aterehi
Journal of Global Pharma Technology .
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Psoriasis is an immune mediated skin disease with wide-world prevalence involves both genders and different age, it a multifactorial disease influenced by genetic and environmental factors. The current study objectives to evaluate the association of Tumor Necrosis Factor-αgenes polymorphism (SNPs) with psoriasis by PCR-RFLP while there serum levels determined by ELISA. Methods case-control study (64) patients with psoriasis and (38) apparently healthy people as control matched with disease group. All samples collected in Marian Medical City in Babylon Province. Polymorphism (SNPs) determined by Polymerase Chain Reaction (PCR), restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing techniques, while there serum levels determined by ELISA .Results this study revealed a significant increasing of TNF-α in patients compare with controls (P<0.01). Also, there a significantly regression between severity of disease and TNF-α serum level (-r=0.49, p=0.0001). Genetically, analysis of the Single Nucleotide Polymorphisms PCR-RFLP genotyping for TNF-α -308 SNP, Genotype distribution in patient were AA 5 (7.81%) ,AG 24 (37.50%) and GG 35 (54.69%) while in control 10 (26.31%), 16 (42.11%) and 12 (31.58%) respectively. Conclusion: The massive majority of single nucleotide polymorphism in the TNF-α gene have a clinical importance concerning psoriasis. There is an interaction among the single nucleotide polymorphism of TNF-α gene and it is serum level.Keyword: Psoriasis, Tumor Necrosis Factor-α polymorphism, PCR-RFLP Polymorphism.

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