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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Role of Biofilm in Reinfection in Catheter-associated Urinary Tract Infection in Iraqi Women Likaa Mahdi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Women hinge on knowledge of antimicrobial susceptibility patterns in the Iraq country of the practitioner. We conducted a survey of antimicrobial susceptibilities of 72 urine samples from catheterized women patient.  Isolates recovered from urine samples April 2014 to July 2014, samples collected from urinary catheterized women patient in Al-Yarmouk hospital in Baghdad/ Iraq. Resistance uropathogen (E. coli, Acinetobacter baumannii, Enterobacter Spp, Enterococcus faecalis, Klebsiella Pneumoniae, Proteus mirabilis) isolates to Amoxicillin and Gentamicin combined with high biofilm formation.  Escherichia coli are the majority common micro objects concerned in community-acquired -UTI in women. UTI which was cause by uropatho-genic; Isolates can eventually re-infection Acinetobacter baumannii (n=6), E. coli (n = 9), Enterococcus faecalis (n=3), Klebsiella Pneumoniae (n=2), Enterobacter Spp. (n=2) and Proteus mirabilis (n=5). The production of E. coli biofilms in-vitro was considerably common with strains the causes the biofilms. Biofilm assay could be supportive to select required patients for healing advance to eliminate unrelenting biofilm-formation.
Antioxidant Peel off Gel Mask with Stevia Rebaudiana Bert Extract Lia Kusmita
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Anti-oxidant activity is the activity to deter free radicals. Stevia rebaudiana Bert contains multiple compounds, such as flavonoid, that are capable of deterring free radicals.  The aim of this research was to produce peel off gel mask based on Stevia rebaudiana Bert extract with anti-oxidant abilities. Additionally, it was also used to determine the characteristics including pH, viscosity, dispersion, adhesion, and drying time of the preparation. This research was initiated by creation of the extract, continued by creation of peel off gel mask formula, and finalized by testing the anti-oxidant properties. The research showed a result with the value of Stevia rebaudiana Bert extract (IC50 = 60 µg/ ml). From the evaluation result of anti-oxidant activity from the peel of mask using Stevia rebaudiana Bert extract, it was proven that the higher the extract’s concentration, the smaller the IC50 value, which indicated higher anti-oxidant activity. The characteristic evaluation result of all formula showed that the characteristic evaluation value still fulfilled the set criteria to produced good peel off gel mask. Keywords: Stevia rebaudiana Bert; anti-oxidant; peel off gel mask
Effects of Aqueous and Alcoholic Extracts of Peganum harmala L. Seeds on Male Fertility of White Mice Treated with Olanzapin Drug Hind A. Hanon
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was designed to study the effects of aqueous and alcoholic extracts of Peganum harmala L. Seeds on male fertility of white mice treated with Olanzapin, males were 25 to 30 days old and had a mean weight of 35 g. The mice were divided into two groups, a total of 5 negative control males were injected with distilled water for 15 days, the positive control group (experimental group) injected with Olanzapin drug for 15 days, the was then divided into five subgroups, the first subgroup consists of 5 males were injected with the drug only, while the other four subgroups were dosed with aqueous and alcoholic extracts for 7 days. The first subgroup dosage was with low concentration of aqueous extract (12 mg / kg) and the second with a high concentration of the aqueous extract at a concentration of 24 mg / kg, the third subgroup was dosage with the low concentration of the alcoholic extract at 12 mg / kg and the fourth was dosage with a high concentration of the alcoholic extract at a concentration of 24 mg / kg. The results showed a significant increase (p <0.01) in the level of prolactin hormone in the positive control mice serum, compared to the control group as well as a significant decrease in the level of testosterone hormone as well as the characteristics of the epididymal sperms represented by sperm concentration and percentages of normal and moving sperm. The dosage with aqueous and alcoholic extracts of the Peganum harmala led to the occurrence of significantly higher concentration (p <0.01) of the testosterone hormone and significantly lower in the level of the prolactin hormone concentration when compared with the experimental group as well as a significant improvement of p <0.01) in the parameters of epididymal sperms, and the best concentration was for the aqueous plant extract which 12 mg / kg.Keywords: Olanzapin, Piganum harmala, Testosterone, Prolactin, Sperms.
Aflatoxins and Aflatoxigenic Fungi Contamination of Dried Fruits in Iraqi Market Mohammad J. Al-Jassani
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Objectives: Studying the incidence of Aspergillus sp. and Aflatoxins (AFs) contamination in dried fruits collected from local market of Hilla city and other origins. Methods: Intergenic fungi were isolated by direct plate method and were morphologically identified on specified media. AFs production by Aspergillus spp. were screened and determined by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). Results: Aspergillus spp. represented 93.33% of the total isolated mold species. A. niger was dominant (79.61%) and A. flavus was only 12.5%. Of the total Aspergillus spp., 54.4% found active aflatoxin B1 (AFB1) and aflatoxin B2 (AFB2) producers among 85.24% belong to A. niger and 14.75% belong to A. flavus. HPLC shows that 100% of dried fruit samples tested positive for AFs. Conclusion: Through our study the mold isolates showed different AFs production behavior that they are able to produce AFB1 and AFB2 at a pH range (3.1 to 4.5), optimum temperature at range (28-32ºC) and low aw for best AFs production and this needs much concern especially with dried fruit storage and treatment conditions.Keywords: Dried fruit, Aflatoxin, Aflatoxigenic fungi, TLC, HPLC.
The Impact of Quality Exercises in the Development of Compatibility and Motor Elasticity and Learning the Skill of Preparing for Students in Volleyball Firas Kahsop Rashid
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The importance of research lies in the set of quality exercises, their knowledge of compatibility, motor elasticity, and learning the skill of preparing volleyball for students.The problem of research: it was centered on the fact that most students are slow to learn motor skills, especially in the skill of set, because they are skills that require dynamic compatibility and high flexibility and lead in multiple forms while, and they need a great deal of time to learn and master this skill correctly in terms of ringing, cruise and proper timing, researchers believe that the reason for this is that teachers are less likely to use a variety of exercises and limit them to a specific type of exercise, which makes learning the skill of the set need a great deal of time.The Objective of ResearchPrepare quality exercises in the development of compatibility and motor elasticity and learn the skills of volleyball set for students.Identification of the impact of specific exercises in the development of compatibility and mobility flexibility for students.Identify the impact of specific exercises in learning the skills of volleyball set for students.Research HypothesisThere is an impact of quality exercise in the development of compatibility and mobility flexibility for students.There is an impact of specific exercise in learning the skills of volleyball set for students.As for research methodology and field procedures, researchers used the experimental approach to solve the research problem, and the research community was identified by the second-stage students of the Faculty of Physical Education and Sports Sciences/University of Kufa, and distributed to two groups (experimental and female officers) in the simple random manner ( The draw).The most important conclusions and recommendations are as follows:Specific exercises have helped to develop the kinetic compatibility of the men and the arms of the experimental group.Specific exercises have helped to develop mobility flexibility.Specific exercises have helped to learn the technical performance of the volleyball set skill of the pilot group.Keywords: Quality exercises, Motor elasticity and learning.
Extraction of Staphyloxanthin from Staphylococcus aureus and Studying Some Biological Effect of Staphyloxanthin Pigment Fatima Amer Abd Algabar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: This study aimed to extraction and purification of staphyloxanthine and to determine antibacterial effect of purified extract against pathogenic bacteria. Design and methods: To reach this goal from 306 samples of different clinical sources, Staphylococcus (22.8%) had been isolated and examined as S. aureus depending on cultural morphology, biochemical tests and Vitek2 system.  Staphyloxanthin pigment was extracted by using ethyl acetate with ethanol ,as wells the using qualitative and quantitative screening method to detect antibacterial effect of purified extract   then the results were statistically analyzed by SPSS to   perform the data analysis. Results: The results show significant difference in absorption of staphyloxanthin and the extracts; higher absorption of staphyloxanthin was recorded in tube 7 (0.998). Our study proved that purified extract of staphyloxanthin has an anti-bacterial effecting agent, It made inhibition zone against several kinds of gram negative bacteria at concentration (2, 20) mg/ml. This extract produces high inhibition zone (15mm) against Pseudomonas aeruginosa. In conclusion: our finding to confirm the ethyl acetate and ethanol method is very significant for extracting staphyloxanthin pigment. Our results indicate that column chromatography is one of the most important and widely used techniques for separation of pigment (staphylxanthin); also the purified extract of staphyloxanthin was established as anti-bacterial activity against several gram negative bacteria with highly inhibition zone against Pseudomonas aeruginosa. Keywords: Staphyloxanthin, Antibacterial, Purified extract, Well diffusion.       
Clinical Assessment of the use of Sublimated Mare's Milk in Complex Therapy of Mild and Moderate Psoriasis Bakytgul Yermekbayeva
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The article discusses the therapeutic effect of mare's milk in complex treatment in patients with psoriasis. Research objective: Clinical assessment of the use of sublimated mare's milk in complex therapy of mild and moderate psoriasis. Materials and methods: 20 patients in main group with mild and moderate psoriasis took part in the study - control, who during 12 weeks of standard therapy took sublimated mare’s milk and 20 comparison group patients on standard therapy. In the study participants in main group, the severity index of psoriasis course and spread (PASI) was calculated at 0 and 12 weeks.Results: A statistically significant decrease in the PASI index was found: after 6 weeks by 68%, with treatment within 12 weeks - by 88% (p = 0.0003) in the main group compared with the comparison group. Conclusions: in patients with psoriasis, it is necessary to include sublimated mare's milk in the complex treatment to increase the effectiveness of therapy and lengthen the period of remission. Keywords: Psoriasis, PASI index, Sublimated mare's milk.
Preparation, Identification, thermal and Spectroscopic Study of Schiff Bases Derived from Terephthalaldehyde and Their Binuclear Complexes with Some Transition Metals and Lanthanides Hassan. M. A. Al-Redha
Journal of Global Pharma Technology .
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AbstractThe study include preparation and Characterization and Thermal Analysis of four new compounds of the Schiff bases , This ligand was prepared in two steps, in the first step includes reacted terephthaldehyde with(1,2-ethylenediamine and 1,4-Diaminobutane) to give precursore compound which reacted in the second step with (O-Vanillin and 2-Hydroxy-1- naphthaldehyde ) to give the following ligands L1 = 6,6,-((1E,1,E)((((1,4Phenylenebis(methanylylidene))bis(azanylylidene))bis(ethane2,1diyl))bis(azanylylidenebis(methanylylidene) bis(2- methoxyphenol) L2 = 1,1,-((1E)-((((1,4-phenylenebis(methanylylidene)) bis(azanylylidene))bis(ethane 2,1- diyl))bis(azanylylidene))bis (methanylylidene)bis(naphthalene-2-ol)  L3 = 6,6,-((1E,1,E)-((((1,4-Phenylenebis(methanylylidene)) bis(azanylylidene))bis(butan 4,1- diyl))bis(azanylylidenebis (methanylylidene) bis (2-methoxyphenol) L4 = 1,1,-((1E)-((((1,4-phenylenebis(methanylylidene)) bis(azanylylidene))bis((butan 4,1- diyl))bis(azanylylidene))bis (methanylylidene)bis(naphthalene-2-ol) The Binuclear complexes were synthesized by direct reaction of the corresponding metal chloride(CuCL2.2H2O,NiCL2.6H2O,SmCL3.6H2OCeCL3.6H2O ) with the ligands. The ligands and their complexes were characterized by using Elemental Analysis (C.H.N), Infrared Spectroscopy (FT-IR), (UV-Vis), X-Ray, Nuclear Magnetic Resonance Spectroscopy (1H-NMR) Mass Spectra, Magnetic sensitivity and Molar conductivity techniques were applied. The stoichiometry for ion metal and ligands of complexes has been studied in Continuous Variation method (Job method). for all complexes and with ratio (2:1), thermal analysis. The data of these measurements be done suggest configuration geometry to this Complexes
Thermodynamic Parameters, NBO Analysis, HOMO-LUMO and MEP Analysis of (5R)-2-Methyl-5-[(2S)-6-Methyl-5-Hepten-2-yl]-1,3-Cyclohexadiene Using HF and DFT Calculations Mahin Ahmadianarog
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

Ginger plant is a well-known spice and flavoring agent which has also been used in traditional medicine in many countries. Ginger contains essential oils including Gingerol and Zingiberene. Zingiberene is a monocyclic sesquiterpene that gives a distinctive flavor to ginger. The quantum theoretical calculations for Zingiberene were performed by using HF/6-31G, HF/6-31G(d), B3LYP/6-31G, B3PW91/6-31G and BLYP/6-31G level. The EHOMO-1, ELUMO ELUMO+1, HOMO-LUMO energy gap (Eg), and dipole moment (µD) obtained for Zingiberene. According to the calculated HOMO and LUMO energies, molecular properties such as Ionisation Potential (I), Electron affinity (A), chemical hardness (η), electronic chemical potential (μ) and electrophilicity (ω) obtained and also show that charge transfer occurs in Zingiberene. The frontier molecular orbitals (FMOs) and molecular electrostatic potentials (MEPs), the chemical shielding tensors (CS), thermodynamic parameters, natural charge and NBO analysis were investigated for title structure by theoretical calculations. Keywords: Ginger, Zingiberene, Energy gap, Natural charge, NBO analysis.
Study the Level of Zinc, Copper and Magnesium on Iraqi Diabetic Patients Hiba Abid Al-Hussein Hassan
Journal of Global Pharma Technology .
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Abstract

This studyamidto measure and compare the levels of serum 0zinc, copper and magnesium0 ions in healthy individuals and diabetic0 patients. Its involved 80 patients, their age range from (20-80) years.  The study divided into three groups: T1DM (40) patients, T2DM (40) patients and (40) healthy subject as control groups .Analysis of zinc ,copper and magnesiumions was done in serum by using auto analyzer  spectroscopy,whileserum glucosewas determined by enzymatic methods using linear chemicals kit. This project done during period from (November 2015 to Jun. 2016) at teaching laboratories and medical city / Baghdad. The study showed0 a definite lowering of serum0 magnesium (p<0.01) and serum zinc0 levels (p<0.01) while increasing0 of serum copper (p<0.01) in diabetic group compared with the healthy control groups.Keywords: Diabetes Mellitus, copper, Zinc, Magnesium.

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