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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Formulation, Characterization and In-Vitro Evaluation of Dasatinib Loaded Solid Lipid Nanoparticles for Oral Delivery Mohamed Yasir Arafath
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
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Abstract

Objective: Dasatinib (DST) is a BCS Class II drug having very low solubility and high permeability. The absolute bioavailability of DST is about 14 to 34% due to an extensive first-pass effect. For improving the bioavailability of DST, solid lipid nanoparticles (SLNs) were developed using triglycerides (trimyristin, tripalmitin, and tristearin). Methods: Hot homogenization followed by ultrasonication method was used to prepare DST-SLNs. The prepared SLNs were characterized for particle size, Poly dispersity index (PDI), Zeta potential (ZP), Entrapment efficiency (EE) and Drug Content. Invitro release studies using dialysis bag method in 0.1N Hcl and pH 6.8 Phosphate buffer were conducted. Results: DST-SLNs prepared with Dynasan-118(E4) having the size of 150.73nm, PDI of 0.20, ZP of -29.1 mV with 93.56% of EE were optimized. In addition, long-term physical stability of the optimized SLNs was investigated at refrigerated and room temperature for 180days and it was stable for long period. FTIR and DSC studies revealed that no interaction between the drug and lipids. Scanning electron microscopic studies showed nearly spherical shape particles with increased polydispersity index. Formulation containing Dynasan-118(E4) showed highest percentage drug release among all the prepared SLNs. Release of drug from DST-SLNs (F4, S4, and E4) followed Higuchi, the best fit with the highest correlation coefficients were shown in Higuchi plot. The mechanism of release is by diffusion controlled as indicated by R2 value of Higuchi and n value of Korsemeyer-Peppas equation. Conclusion: Dasatinib loaded solid lipid nanoparticles is a good drug delivery system with desirable release characteristics.
Association of TCF7L2 Gene with Familial Combined Hyperlipidemia in Diabetes Mellitus Type 2 Females Iraqi Patients Najwa Sh Ahmed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Genomic polymorphisms of transcription factor7 like 2 {TCF7L2} gene are scanned to be powerfully related to diabetes mellitus type 2 (DM2) in female Iraqi population. The point of this examination was to break down the relationship of TCF7L2 gene polymorphisms with DM2 in a very female populace of Iraq. Familial combined hyperlipidaemia (FCHL) is described by hypercholesterolaemia, hypertriacylglycerolaemia, or both. Also, instabilities in glucose metabolism are normally realized in FCHL. Thus, we guessed that TCF7L2 may add to the genetic  defenselessness for this basic dyslipidaemia.. Techniques: 70 DM2  female patients and 60 healthy samples were chosen for the current study. Has been conducted designedly of one primer for amplification to scan the gene and using PCR technique with sequencing. We examined the impact of the TCF7L2 variations on FCHL and its segment characteristics triacylglycerol (TG), apolipoprotein B (ApoB) and  total cholesterol (TC). The Results: For total participants, the (T/C vs. TG + GT) were significantly greater in samples with DM2 than in healthy controls, and FCHL, TC, ApoB or glucose for DM2 were associated with T>C and G>T .This result revealed that the risk of DM2 was raised by the existence of the T>C and G>T genotype of TCF7L2 gene in Iraqi female. The frequency  of the T allele in TCF7L2 gene was greater in DM2 patients than in healthy samples. Conclusions: Our analysis proposed that the genetic polymorphisms of TCF7L2 were significantly related with high T>C and G>T in FCHL families with DM2 in the female populace of Iraq.Keyword: DM2 ;TCF7L2; FCHL; Hypertriacylglycerolaemia.
Effect of Oct3 Genetic Polymorphism on the Response of Metformin in Type 2 Diabetes Mellitus: Narrative Review Swathi Swaroopa Borra; Bhavya Chebrolu; Poojitha T; Sujin Bright F J; Sadagoban GK; Arun Kanniyappan Parthasarathy
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
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Abstract

Context: Metformin, the first line therapy of Type 2 Diabetes Mellitus is known to be transported by OCT3 (Organic Cation Transporter 3). Polymorphisms in this gene may lead to interindividual differences in the response to metformin. Objective: This study aims to compile and summarise the effect of OCT3 polymorphism on effect of metformin. Methods: PubMed/MEDLINE, ResearchGate, Google Scholar, Cochrane Library and Scopus were used for literature review. Cmax (Maximum concentration), Tmax (Time to reach maximum concentration), AUC (Area under the curve) and Kel (Elimination rate constant) were used to assess pharmacokinetics and HbA1c (Hemoglobin A1c), blood glucose levels for pharmacodynamics. Results: Data extraction showed that 19 OCT3 polymorphisms were analyzed in various ethnic communities with the plurality of Asians. The results of these genotype alleles were found to be favorable (9), negative (3) and have no impact (7) on the response of metformin. A positive effect on metformin response was expressed as higher Cmax (Maximum concentration), AUC (Area under the curve), lower Kel (Elimination rate constant) or reduced HbA1c (Hemoglobin A1c), FBG (Fasting blood glucose). Conclusion: Influence of OCT3 polymorphisms on metformin responses were unique to the population. This recommends new research requirement on association between OCT3 polymorphism and Metformin.
Genetic Detection for Staphylococcus aureus bacterialin Urinary Tract Infection cases in Hilla City Ali Kadhim Aljarah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Fourteen urine Specimens were collected of patient with Different Ages & gender that had been infected with the UTI that previously Diagnosed in Hilla Educational Hospital in period from Feb. 2016 to Mar. 2016 for detection of Bacterial causative agent that cause the UTI , samples were transferred directly to laboratory then centrifuged in ( 3000 rpm ) for 15 min., taking pellet for bacterial culturing on mannitol salt agar in 37C° for 24 hr. in aerobic conditions changing the media to yellow color as an indicator for growth of S.aureusthen followed by DNA isolation from bacteria for further genetic detection by PCR, selecting ( mec A1 gene ) as an indicator gene that related to the virulence factors in the S.aureus, agarose gel electrophoresis for  mec A1 primer amplification showed 32 positive result indicated to the presence of this bacteria as one of most causative bacterial pathogenic agent in UTI, these rapid definitive diagnosis is useful for further treatment by selection the determined antibiotic drug latterly.Keywords: Mec A gene, Staphylococcus aureus, UTI, PCR
Characterization and Evaluation of Antioxidant activity of Crataeva magna Lour (DC) RADHA krishnan meera
Journal of Global Pharma Technology Volume 09 Issue 09
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Abstract

Objective: The present study was designed to investigate the anti-oxidant activity of the ethanolic extract of Crataeva magna Lour DC. The root bark of Crataeva magna Lour DC belonging to family Capparaceae is used in anti spasmodic, hypotensive, anti-inflammatory, hypoglycemic, anti protozoal, analgesic purposes.Methods: The ethanolic extract was evaluated by TLC and the antioxidative potential of ethanolic extract of Crataeva magna Lour DC was evaluated using 1,1-Diphenyl-2-Picrylhydrazyl (DPPH), hydrogen peroxide and xanthine oxidase inhibition assay.Results: The ethanolic extract of Crataeva magna Lour DC exhibited highest level of antioxidant activities. The ethanolic extract of Crataeva magna Lour DC showed up to 76% inhibition of DPPH free radical at 517 nm at high concentration of 1 mg/ml. The in-vitro xanthine oxidase inhibition of root ethanolic extract revealed significant (69%) inhibitory activity at 30 µg/ml and it compared with the standard drug quercetin which showed 70% inhibition at 30 µg/ml. In hydrogen peroxide scavenging activity the test extract shows 26% of inhibition when compared to the standard ascorbic acid.Conclusion: The presence of strong antioxidant activity of ethanolic extract of Crataeva magna Lour DC can be a great scope for further studies on this plant regarding its antioxidant potentials.Keywords: Root bark of Crataeva magna Lour DC, TLC, Antioxidant activities. 
Effect of Salvia officinalis on Thyroid Gland Function in Male Rats Ihsan Raisan Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The objective of the current study is to evaluate the protective role of Saliva officinalis extract against carbimazole that induce hypothyroidism. Experimental albino rats were divided into four groups, first group considered as a control group. While other three groups administrated Saliva officinalis extract, carbimazole and Salvia officinalis extract and carbimazole respectively. Rats were scarified at the end of experimental and blood samples collected. T4, T3 and TSH levels were assayed and data underwent statistical analysis. Results showed that T4 and T3 levels   significantly increased in rat’s administrated Saliva officinalis extract compared to the control group. While carbimazole significantly reduced these hormones in comparison with other groups.  On the other hand, treatment rats with Salvia officinalis and carbimazole increase T3 and T4 significantly. TSH significantly elevated in rats treated with carbimazole compared to groups treated with Saliva officinalis, carbimazole and Saliva officinalis respectively. It’s concluded that Salvia officinalis reduced effects induced by carbimazole in thyroid function.Keywords: Salvia officinalis, Thyroid hormones, Carbimazole.
The Possible Role of JC Polyomavirus after Kidney Transplantation Haidar A Shamran
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Background John Cunningham virus (JCV) is one of the highly sero-prevalent viruses worldwide, and after primary infection it remains latent and then reactivates in immunocompromised patients, high JCV viruria seen in renal transplant recipients (RTR), some of them progress to polyomavirus associated nephropathy (PVAN). The objectives of this study are to determine JCV viruria and viremia in RTR and correlate them with urine cytology results and patients' renal function. Methods a prospective study conducted from October 2015 to to March 2016. Seventy-one (71) RTR, and 71 apparently healthy age and sex-matched normal donors as controls were enrolled in this study. Urine samples taken from all RTR cases and control, while plasma was taken from only 50 RTRs and 50 controls. Urine cytology smears were prepared and Pap-stained for decoy cells (DC) screening. Viral DNA was extracted from 1 ml urine, and from 200µl for plasma samples, and then the viral DNA was detected and measured by a real time-PCR instrument, using q RT-PCR kits for JC virus. Results Thirty one (43.70 %) of RTR and 10% of the controls were JC viruria positive, the mean of JCV viruria was 6.8 x104, and 1.04x103 copies/ml for RTRs and controls respectively (p<0.001), and 19/33 (57.58) of RTRs who had abnormal creatinine clearance were JC viruria positive (p=0.025). All 50 RTRs and the 20 controls had negative JC viremia. The rate of occurrence of DC in urine cytology was 28.17% for RTRs while none of the control subjects had DC in urine, but no correlation between JC viruria and the rate of decoy cell shedding in RTRs. Conclusion High prevalence of JCV viruria in RTRs, and associated with impairment of their renal function, which might suggest a pathological role of this virus have impact on renal function.Keywords:  JC Polyomavirus, Kidney transplantation, Real-time PCR.
Feasibility of Bitterness Reduction in Bitter Gourd (Momordica Charantia) Dried Powder By Blanching, Enzyme, and Wall Material N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Momordica charantia, commonly known as bitter gourd has been traditionally used to treat diabetes and its complications. Several medicinal properties of the bitter gourd have been studied such as anti-diabetic, anti-ulcerogenic, antimutagenic, antioxidant, anti-tumour, anti lipolytic, analgesic, abortifacient, anti-viral, hypoglycemic and immunomodulatory. Medicinal value of bitter melon has been attributed to its high antioxidant properties due in part to phenols, flavonoids, isoflavones, terpenes, anthroquinones, and glucosinolates, all of which confer a bitter taste.  However, oral consumption of bitter gourd products could be a problem due to the bitter taste. Bitter taste should be eliminated. β-cyclodextrin is one of the most common materials used in microencapsulation process. β-cyclodextrin comprises seven units of glucopyranose. An attempt studied the feasibility of bitterness reduction in bitter gourd dried powder by treatment of blanching (100oC in 10s; 95oC in 15s, 90oC in 20s, 85oC in 25s), enzyme (florosil 2g/100ml and naringinase 8 mg/100ml), and wall material (β-cyclodextrin, sodium alginate, carrageenan, pectin). Reduction of bitterness and enhancing palatability are obviously observed by treatment of Momordica charantia dried powder by blanching 100oC in 10s, enzymatic treatment with florosil (2g/100ml) + naringinase (8 mg/100ml) and spray drying at inlet temperature 155oC, out let temperature 85oC, feed rate 15 ml/min with β-cyclodextrin 0.5% as wall material. Keywords: Momordica charantia, Dried powder, Bitterness, β‐cyclodextrin.
Quality efficiency indicators of pharmacy management: characteristics, current features, opportunities and threats of the development Iryna Volodimirivna Pestun
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The purpose of this work is a comprehensive research, analytical study and systematization of the pharmacies` management (networks) feature and trends in Ukraine in accordance with qualitative criteria. The objective is to determine the features and possibilities of improving the quality of pharmacies' management (networks), existing threats (risks) of their achievement, which allowed to highlight the topical issues and directions of the decision in the management of pharmacies and their networks. On the bases of scientific literature, regulatory documents, statistical data, information sites of the Internet and structural-logical, analytical methods, generalization, comparison, grouping, and formalization of reasoning were identified problems and trends in this area. The main groups of qualitative criteria for the pharmacies’ (networks) management effectiveness are: provision of pharmacy (network) management process; managerial decisions making; customer service; social management efficiency; the personality of the head; work with personnel. According to the results of the research, individual differences in ensuring the effective management of pharmacies and their associations (networks) are highlighted. It is shown that qualitative indicators of effective management of pharmacies (networks) are characterized by their dependence on the social and economic processes in society, changes in legislation, state and change of health protection, implementation of government social programmes, market and pharmacies informatization, consumer attitudes to treatment and their solvency, etc.Keywords: Pharmacies, Qualitative criteria of management efficiency, Possibilities of strengthening the management efficiency qualitative criteria, Threats.
Oculohypotensive Effect of Nitric Oxide Donor in Glaucomatous Male Rabbits Mustafa Ghazi Al-Abbassi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective: The aim of present study was to evaluate the effect of topical nitric oxide donor in lowering intraocular pressure of glaucomatous male rabbits. Method: Thirty two albino rabbits weighing (2.5-3.5 kg) were used in the study and allocated into four groups include: normal group, glaucoma induced group, sodium nitroprusside (SNP) group and timolol group. Glaucoma induction was done by single intravitreal injection of 50 units of freshly prepared alpha-chymotrypsin in 0.1 ml of sterile saline. The treatment was applied twice daily: at 9:00 a.m. and at 1:00 p.m. during 12 day. The intraocular pressure was recorded two times a day: at 9:00 a.m. and at 12:00 p.m. The parameters that measured include; the intraocular pressure, pupil diameter, corneal sensation, light reflex, conjunctival redness and cyclic guanosine monophosphate (cGMP) level in aqueous humor. Results: The results revealed a high significant decrease in intraocular pressure and a high significant increase in cyclic guanosine monophosphate level, also no variation in pupil diameter, positive pupillary response to light, no corneal sensation, and no conjunctival redness were observed. Conclusion: The findings suggest that sodium nitroprusside has oculohypotensive action and it may prove to be an additional effective for the management of glaucoma.Keywords: Glaucoma, Nitric oxide donor, intraocular pressure.

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