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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effectiveness of Schema Therapy on Severity of Depression and Rumination in Patients with Treatment Resistance Depression Simin Gholamrezae
Journal of Global Pharma Technology Volume 08 Issue 11
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Abstract

Background: schema therapy is an important method in treatment of mental disorders special in treatment of depression. This study aimed to determine the effectiveness of schema therapy on severity of depression and rumination in patients with treatment resistance depression. Method: This study was a quasi-experimental with a pre-test, post-test design that 48 patients with treatment resistance depression were selected through available sampling method and randomly assigned in tow groups. The experimental group educated 12 sessions of 90 minutes by schema therapy method. Groups completed the questionnaire of Beck depression (BDI-II) ruminative response scale (RRS). Data was analyzed with using the SPSS software and by multivariate analysis of covariance (MONCOVA) method. Results: The findings showed there was a significant difference between schema therapy and control group on severity of depression and rumination (P<0.05). Conclusion: Therefore, counselors and therapists can use schema therapy for decreasing symptoms of depression disorder and rumination.Keywords: Schema therapy, Severity of depression, Rumination, Treatment resistance depression.
Pervasiveness, Related Hazard Factors and Antimicrobial Defenselessness Example of Campylobacter Species among Dogs Hayder Hamzah Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Campylobacteris the most widely recognized bacterial cause for enteric sickness for the both humans and animals around the world. Over 90% of human Campylobacteriosisin industrialized nation’s results from utilization of debased chicken items, just as beef and milk. Drinking water and swimming water may likewise be a source of disease. To a lesser degree, contact with other nourishment animal species, wild birds, and pet dogs and cats has been related with human Campylobacteriosis. Ingestion of as few as 500 living beings can prompt contamination. At the point when center signs happens, early signs create after a brooding time of 1 to 7 days and incorporate fever, defame, spewing and migraine, which by and large last 1 to 3 days, trailed by as long as multi week of watery to ridiculous loose bowels and stomach torments. Zoonoses may be contracted from dogs and cats through introduction to their feces, parturient fluids, salivation, respiratory outflows, scratches, skin, conceal, pee, or outside parasites. Pollutions may be parasitic, bacterial, infectious or viral. Campybacteriosis has a higher rate in AIDs quiet than all in all populace causing extreme, frequently bleeding, looseness of the bowels and cramping, queasiness and fever. Most Campylobacter infections in canines and man are brought about by C. jejuni. Proof shows that contact with infected dogs, particularly diarrhoeic dogs can increase hazard of obtaining C jejuni..
Managing Consumer Loyalty in the Pharmaceutical Market of a Metropolis Olga Pashanova
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The article presents the results of a study of a complex of factors that determine consumer behavior in a pharmacy for visitors of an older age group (elderly people over 65). The main problems in providing pharmaceutical care to elderly consumers in the local pharmaceutical market of a large metropolis (for example, Moscow) are identified. Positive and negative factors of consumer loyalty of elderly customers of Moscow pharmacies are indicated. The purpose of the study was to formulate a comprehensive socio-psychological portrait of an elderly consumer receiving pharmaceutical assistance in pharmacies in Moscow. In order to achieve this goal, a study of the behavior of visitors to pharmacies over 65 years of age, their sociological surveys, as well as a survey of pharmacy managers and employees to identify positive and negative factors that affect the consumer behavior of the studied focus group of customers, were conducted. A sociological survey of visitors to Moscow pharmacies and a survey of managers and employees of pharmacies revealed the positive and negative factors of consumer behavior of elderly consumers and identified the main problems encountered in pharmacies in the provision of pharmaceutical care for this category of patients. A comparative analysis of Russian and world experience in serving elderly visitors in pharmacies was carried out. The necessity of studying the behavior of consumers of older adult focus groups is proved in order to improve the quality of pharmaceutical and psychological care. Elderly clients (over 65) account for 40-65% of visitors to Moscow pharmacies. The consumer behavior of the studied category of patients is characterized by pronounced polypharmacy, the need for advisory services and psychological assistance, the need for communication, a significant lack of information about the assortment, the interaction of drugs, their correct use, and storage. The psychological and medical problems in most elderly patients complicate the process of providing them with timely and high-quality medical care; require the use of a special psychotherapeutic approach in the work of pharmacy employees, and the introduction of a specific “client-oriented pharmaceutical advising”.Keywords: Elderly patients; Elderly consumers; Older adults; Polypharmacy; Pharmaceutical assistance; Pharmacy organizations; Socio-psychological portrait; Client-oriented pharmaceutical advising.
Preservation of Lingzhi (Ganoderma Lucidum) White Fresh Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Lingzhi (Ganoderma lucidum) has highly valued nutritional properties. Its potential beneficial effects on human health may be termed functional foods. The production of fresh Ganoderma lucidum is increasing. This trend is expected to continue in the coming years. Fruit boby of Ganoderma lucidum has a short shelf-life owing to its high rate of respiration and perishibility. In order to extend the fresh appearance or shelf-life of Ganoderma lucidum white fresh fruit bodies, we investigated on the preservation of Ganoderma lucidum fresh fruit body. Our results showed that washing Ganoderma lucidum white fresh fruit bodies with 0.15% peroxyacetic acid in 30 seconds and keeping them in PA bag without hole in 4 o C could maintain their weight and eliminate coliforms effectively.Keywords: Ganoderma lucidum, Lingzhi, shelf-life, Peroxyacetic acid, Coliforms, Preservation
Genotyping of Helicobacter Pylori Isolated From Iraqi Patient with Upper Gastrointestinal Disease Aseel H. Al-Sabary
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

H. pylori is one of the most frequent pathogen infected about half of the world population, despite that most infections are asymptomatic; some infections can develop chronic gastritis, peptic ulcer and gastric cancer. The aims of the study are the molecular detection of H. pylori and the main virulence factors association with clinical outcome of H. pylori infection. This study was start from February to September 2016, ninety two cases of H. pylori infections were detect in patients admitted to Medical Marjan City in Babylon -Iraq. The study display the high frequencies of H. pylori were observed for chronic gastritis, which h constituted 88% while low frequencies were 3.3% for gastric cancer whereas 8.7% for duodenal ulcer. Moreover, identification of H. pylori by PCR technique was performed on all gastric biopsy and ure C as well as ure genes were used as markers for confirmatory diagnosis of H. pylori through using specific primers of PCR technique. The result showed that, 84.8% and 73.9% of H. pylori were positive respectively for both genes. In additions, cag A gene was investigated in all H. pylori isolates. The result showed that65 (70.6%) was positive for PCR amplification of cag A gene whereas 56 (60.8%) was positive for PCR amplification of cag E gene. The frequency of the vac a gene found in the present study was 68.5% (63/92).It was concluded that the molecular detection of H. pylorigeno type is important tool to determine pathogen city of H. pylori.Keywords: Helicobacter pylori, Gastric biopsy, Gastric diseases, Ure A gene, Ure C gene, Virulence genes.
Assessment of the Effect of Local Application of Exogenous Melatonin on Bone Healing Process Muhanad Tareq Jehad
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Bone defects have become universal health care difficulty. Bone regeneration involves the differentiation of new cells and the formation of new bone tissues that results in an overall increase in volume of new skeletal tissues. Medical treatments for bone defects have been largely focused on replacing the lost bone with bone grafts materials. Aim of the study: is to evaluate the effect of local application of melatonin on healing of induced bone defect by histological and histomorphometric analysis.  Materials and methods: Twenty four adult male rats divided into control and melatonin  groups(8 animals) for  each  healing periods (1,2, and 4 weeks ).Two  holes induced in each rat femur ( one hole in right for melatonin application and one in left femur bones). Results: Histological findings indicated that bone defects in the melatonin group showed early bone formation, mineralization and maturation as compared to control ones. Mean values of studied (bone trabecular area and number) were higher in melatonin group and values of (bone marrow area) decreased in 2 and 4 weeks durations. Osteoblasts, osteocytes mean values were higher in melatonin group, osteoclasts highest values shown in 2weeks in control group. Conclusion: The application of melatonin was   effective in   bone healing process by   enhancement of earlier bone formation.Keywords: Bone defect, Melatonin, Histomorphometric analysis.
Expression of DAZL and BOULE in Spermatogenic Failure of Infertile Men: A Study Silvia Werdhy Lestari
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

DAZ-like (DAZL) on chromosome 3 and BOULE on chromosome 2 are genes included in the DAZ gene family. These genes have a role as regulator of specific cell cycle in germ cells. Mutations on DAZ gene family cause meiotic arrest and infertility. DAZL and BOULE are known to have interaction with CDC25 in regulating meiosis in the cell cycle. The examination of infertility on azoospermia cases, which are caused by spermatogenesis arrest, has so far been limited by histological examination from testicular biopsy. Therefore, molecular research is needed to determine the candidate genes that could be used as a marker in improving the quality of testicular biopsy examination. This research is a cross-sectional study which used 40 biopsy testes samples based on Johnsen scores 2 to 8. The mRNA expression analysis of DAZL and BOULE used qRT-PCR. The DAZL gene began to be expressed in scoring 5-8, where there was an increase from scoring 5-7 then a decrease in scoring 8. The BOULE gene began to be expressed in scoring 2 – 8, but there was an increase from scoring 4 – 7 and then a decrease in scoring 6 and 8. The correlation between the mRNA expressions of DAZL and BOULE showed a significant positive correlation (r = 0.415, p<0.05). These results indicated that both DAZL and Boule contribute in the failure of spermatogenesis.Keywords: Male infertility, Spermatogenic failure, Johnson score, DAZL, BOULE
Effectiveness of Drugs Therapy of Hypertensive Patients in Undata General Hospital Palu Ingrid Faustine
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Increased blood pressure above normal will result in increased morbidity and mortality by improving risk factor for other diseases. Data obtained from Undata General Hospital Palu, showed the number of hypertensive patients died in 2016 as many as 513 patients, this number increased in 2017 as many as 637 patients. This study aims to determine the accuracy of the selection of antihypertension therapy and dose as well as determine the effect of antihypertension drugs to decrease blood pressure in hypertensive patients in hozpitalized Undata Generala Hospital Palu in 2016-2017. This study uses a quantitative method with retrospective approach. The results showed that the most significant decrease in blood pressure based on length of stay occurred in patients with 4-7 days of stay ie 42.64/21.17 mmHg and the most significant reduction in blood pressure based on the treatment regimen occurred in three combination antihypertension 57.14/28.57 mmHg with a significance value of<0.05. So we concluded the accuracy of therapy and dose in hypertensive patients based on the guidelines JNCVII showed a patient diagnosed with mild, moderate, and severe hypertension overall proper drug selection and dose received by all patients with hypertension better use of antihypertension drugs singly or in combination in accordance with the standards of the JNCVII, and paired t-test for hypertensive patients with a single drug decreased blood pressure 37.80/16.19 mmHg (p=<0.05), hypertensive patients with two combinations of drugs decreased blood pressure 29.26/18.94 mmHg (p=<0.05) and hypertensive patients with three combinations of drugs decreased blood pressure 57.14/28.5 mmHg (p=<0.05).Keywords: Effectivenes, Drugs Therapy, Undata General Hospital, Hypertension.
Evaluation of some Virulence Factors, Hemagglutination and Agglutination of Antigens of Acinetobacter baumannii Isolated From Clinical Samples Fatima Rammadan Abdul
Journal of Global Pharma Technology .
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Abstract

A total of 50 clinical samples, isolated from various sources include blood septicemia, urine (UTI), wound and burn swabs and swabs of ear (otitis media). The isolates were identified according to the microscopical , morphological ,cultural, and biochemical tests, in addition to using VITEK-2 compact system. Results showed that (12) isolates were characterized as A. baumannii.  Frequency of positive A. baumannii clinical isolates was higher in blood (50%), followed urine (25%).  The sensitivity of isolates to eight antibiotics, the result showed highly level of resistance for most antibiotics and multi-resistance antibiotics. It was found that all (100%) of bacteria isolates were resistant to Ampicillin and Cefazolin, while Imipenem and Tobramycin were the most effective antibiotics. The isolates showed the ability of biofilm production by Congo red agar method (CRA), 7 (58.3%) isolates positive biofilm production, while 5(41.7%) isolates are non-biofilm production. Consequences of phenotype were demonstrated 4 (33.3% %) of the detaches were protease production, while (8) isolates (%66.7) were not producers of this enzyme, while Sera proteins of patients’ infected by A.  baumannii showed reactivity with A.  baumannii antigens (whole cells ) as :two A. baumannii antigens agglutinated in titer  1:64  of patients sera ( antibodies ) while  6, 3 , 2 ,5 of A. baumannii antigens agglutinated in the patients sera in titer (1: 8 ,1:16,1:128,1:256) respectively. Thee hemagglutinin of A. baumannii may be a virulence factor in the pathogenesis of infection; However, results founded a good correlation between ability of biofilm formed and the hemagglutination. Keywords: Acinetobacter baumannii, Virulence factors, Biofilm, Hemagglutination.                 
A New Method for Optimal Reconstruction of Radial Distribution Network; Case Study in KERMAN Mahdi Mozaffari Legha
Journal of Global Pharma Technology Volume 08 Issue 06
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Abstract

The availability of an adequate amount of electricity and its utilization is essential for the growth and development of the country. Development of distribution systems result in higher system losses and poor voltage regulation. Consequently, an efficient and effective distribution system has become more urgent and important. In medium voltage electrical distribution networks, reformed the loss reduction is very important and certainly in line with this, system engineering issue and use of proper equipment, a good work has been done. Hence proper selection of conductors in the distribution system is important as it determines the current density and the resistance of the line. In this paper examines the use of different evolutionary algorithm, imperialist competitive algorithm (ICA) to optimal branch optimization Reconstruction of aging of overhead conductors in t radial distribution systems with objective function to reduce the sum of capital cost and power loss cost and voltage deviation. This algorithm is easy to programming and needs no approximation of actual condition. The proposed method can be applied for optimal planning of radial electric distribution systems. Effectiveness of the proposed method is shown by case study in a radial network.Keyword: Optimization, Reconstruction, aging of overhead conductors, Imperialism Competitive Algorithm (ICA), Radial Distribution Networks, back/forward sweep, Voltage profile, Loss Reduction.

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