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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Impacts of Graded Doses of Zincsulfate on Caspase-3 Enzyme Level and Myocardial Apoptosis in Mitoxantrone-induced Cardiotoxicity in Rats Taif M. Maryoosh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Zinc is regarded as a necessary mineral for cell division and the production of DNA and protein; furthermore, such mineral has a main role in alleviating cardiovascular diseases and may have protective effect in coronary artery disease. Mitoxantrone is an anthracenedione antineoplastic agent used in the treatment of leukemia, lymphoma, breast and prostate cancer; moreover, such drug can induce cardio toxicity in up to 18% of treated patients which is mainly characterized by the development of left ventricular dysfunction, which is manifested as decreased left ventricular ejection fraction and congestive heart failure. Objective: This study is designed to investigate the impacts of graded doses of zinc sulphate on mitoxantrone-induced cardio toxicity in rats via exploring the role of apoptosis in this toxic effect. Methods: Forty-eight adult rats of both sexes were utilized in this study; the animals were randomly divided into six groups of 8 animals each. Group I: distilled water (negative control). Group II: orally-administered zinc sulfate (15mg/kg/day) Group III: orally-administered zinc sulfate (30mg/kg/day).Group IV: Intraperitoneally injected with a mitoxantrone at a dose (2.5 mg/kg) to reach a total cumulative dose of 7.5 mg/kg on day 20. Group V: Orally-administered zinc sulfate at a dose (15mg/kg/day) with an intraperitoneal injection of mitoxantrone at a dose (2.5 mg/kg) was administered to reach the total cumulative dose of 7.5 mg/kg on day 20.Group VI: Orally-administered zinc sulfate at a dose (30 mg/kg/day) with an intraperitoneal injection of mitoxantrone at a dose (2.5 mg/kg) to reach total the cumulative dose of 7.5 mg/kg on day 20. Forty-eight hrs after the end of treatment duration (i.e. at day 22nd), each animal was euthanized by diethyl ether and ketamine, and then after cervical dislocation, the heart of each animal was excised for homogenate preparation to estimate the activity level of caspase-3 enzyme and to detect DNA fragmentation by the utilization of terminaldeoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay. Results: Oral administration of zinc sulfate [(15mg/kg/day with total cumulative dose (7.5 mg/kg) of mitoxantrone] (Group V) resulted in non-significant (P>0.05) difference in caspase-3 level in the cardiac tissue homogenate compared to the corresponding  levels in group of rats intraperitoneally injected with total cumulative dose of 7.5 mg/kg of mitoxantrone (Group IV). In contrast, there were significant reduction (P<0.05) incaspase-3 level in the cardiac tissue homogenate of rats orally-administered zinc sulfate [(30 mg/kg/day) with total cumulative dose (7.5mg/kg) of mitoxantrone] (Group VI) compared to the corresponding levels in group of rats intraperitoneally-injected with total cumulative dose of 7.5mg/kg of mitoxantrone (Group IV). In addition, there was an improvement in the immunohistochemistry of rats’ heart in Group VI; where, numbers of the apoptotic cells were reduced compared to Group IV. Conclusion: Zinc sulfate at a dose (30 mg/kg/day) inhibits mitoxantrone-triggered cardiomyocyte apoptosis.Keywords: Mitoxantrone, Cardiotoxicity, Zinc sulfate, TUNEL-assay, Caspase-3.
Application of Carrageenan, Guar Gum as Biodegradable Coating on Storage of Persimmons (Diospyros Kaki) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Persimmon (Diospyros kaki) is fleshy fibrous tropical, deciduous fruit belonging to Ebenaceae family. Persimmon is classifed as a low-acid fruit, presenting titratable acidity. Persimmon is popular and widespread fruit that is enriched with many bioactive compounds, including polyphenols, terpenoids, steroids, flavonoids, carotenoids, minerals and dietary fiber. Although consumed fresh, losses that occur during persimmon storage are, to a large extent due to excessive ripening, loss of firmness, rot and the incidence of fruit peel browning. The fresh fruits are highly perishable and there are several problems related to their conservation, originating at harvest time when a series of processes begin that influence the quality of the product and its consequent loss. One way to increase the availability to the consumer, and even provide more value to the end product, is edible coating. An investigation on coating of Persimmon by using carrageenan and guar gum was investigated. Persimmon fruits which were coated with 0.75% carrageenan still maintained shelf-life until 30 days of preservation.Keywords: Persimmon, Coating, Carrageenan, Guar gum, Preservation, shelf-life.
Flow Injection Determination of Mebeverine Hydrochloride Using Fluorescence Resonance Energy Transfer (Fret) Via Isnag-Fluorimeter Hayder Q. Munshid
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

A new approach was used for the determination of Mebeverine hydrochloride (MIP-HCl) via the fluorescence resonance energy transfer (FRET) from erythrosine B (Erth-B) which used as a carrier stream. The method was applied using flow injection system of a new homemade ISNAG fluorimeter with fluorescence measurements at ± 90◦ via 2×4 solar cell. The linear range for the new developed methodology was 0.01 – 0.6 mmol/L with correlation coefficient r = 0.9577. While the L.O.D was 0.699 µg/sample (sample volume 250 µL) from the stepwise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph. The method was successfully applied to the determination of Mebeverine hydrochloride (MIP-HCl) in three different pharmaceutical drugs. A comparison was made between the newly developed method analysis and the classical method using t-test. It was noticed that there was no significant difference between the two methods at 95 % confidence level.Keywords: Mebeverine hydrochloride, Erythrosine B, Flow injection analysis, Fluorescence Resonance Energy Transfer (FRET).
Synthesis New Polymeric Composite Materials Derivatives from thiosemicarbazide Maha T. Sultan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this work tow monomers were prepared by using Thiosemicarbazide free-radical polymerization was used to polymerize monomers one with itself to produce tow polymers (P1, P2) and the second with Nano silica grafted meth acrylic acid to produce tow Nano composite (C1,C2) All the prepared compounds were characterized by FT-IR Spectroscopy. The structures of standard Nano silica and Nano composite were studied by Atomic Forces Microscopy (AFM).The X-ray diffraction offer information on molecular structure configuration of the Nano composite after modification which showed different in intensity between Nano silica and their Nano composite.Keywords: Triazole polymer, Nano composite, Modification.
Effect of Solution Viscosity on the Linear Optical Properties of Orcein Dye Talib M. Abbas
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

In this study, the effect of solution viscosity on the linear optical properties of the orcein was studied. For this purpose, different concentrations of the orcein solution were prepared in the ethanol solvent (1x10-3, 1x10-4, 1x10-5) Ml. After measuring the absorption and florescence spectra of three concentrations, the linear optical properties were identified. The results showing increasing absorption coefficient and refractive index with concentration increase. From florescence spectra, the life time of florescence energy level is increasing with concentration increase, and quantum yield decreasing with concentration increase. By varying the viscosity of the orcein solution -(1x10-3, 1x10-4, 1x10-5)Ml- by adding (2)ml of the glycerin, the absorption and florescence spectra of three concentrations with glycerin were measured and the linear optical properties were identified. The results showing increasing absorption coefficient and refractive index of each concentration after adding glycerin, except the absorption coefficient of (1x10-3Ml) concentration. While there was a decrease in life time quantum yield of florescence energy level of each concentration after adding glycerin, except the absorption coefficient of (1x10-3Ml) concentration.Keywords: Orcein, Absorption and Fluorescence spectra, Linear optical properties, Viscosity effect.
Effect of Method and Type Additive Fertilization with Date Palm Wastes on Growth of Cucumber Plants under Open Field Conditions M. M. Muslat
Journal of Global Pharma Technology .
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Abstract

This experiment was carried out in spring of 2017 in a field of the Horticulture department and Garden Engineering / College of Agriculture / Baghdad University (Abu-Ghraib) , alternative site for Anbar University, to study the effect of  method and type of organic fertilization with Date palm waste (decomposed Date palm leaves and decomposed grinder Date palm seeds ) Add To the soil by weight : weight ratio and spraying the extract of decomposed grindery Date palm seeds on cucumber growth under field conditions, according to RCBD. Treatments included T0 was the control using recommended  chemical fertilizer (260 kg urea / h + 340 kg super phosphate / h and 100 kg K / h using potassium sulphate) , T1 , T2 and T3 was organic fertilizer consisting of 2.5%, 5% and 7.5% decomposed Date palm leaves wastes  respectively, T4, T5 and T6 fertilizing with 4%, 6% and 8% decomposed grindery Date palm seeds  respectively, and T7, T8 and T9 addition of 2.5%, 5% and 7.5% decomposed Date palm leaves wastes respectively with foliar spray by extract of decomposed grindery Date palm seeds , T10 add organic fertilizer consisting of decomposed Date palm leaves 5% and 4% decomposed Date palm seeds . Half of the fertilizer recommendation was added to all organic fertilization treatments. The data were analyzed by Gen Stat program and the results were tested according to LSD test at a 0.05 probability level. The results showed that organic fertilization with decomposed Date palm leaves increased the vegetative growth.  T9 exceeded most of the studied traits, It given 100% germination ratio, rate of leaf area was 4305 cm2, phosphorus ratio in leaves was 0.3833, potassium in leaves was 1.2000%. T5, T4 and T6 were exceeded significantly about the other treatments in speed of germination were 7.24, 6.75 and 6.60 plant per day respectively.  T8 given highest rate of plant height was 175.1 cm. T7 given highest chlorophyll content in plant leaves was 62.10 Spad. T3 given highest dry mater of vegetative part was 11.17%.Keywords: Organic fertilization, Foliar application, Date palm wastes, Plant extract Cucumber.
A Novel Instrumental Method for the Determination of Cobalt (II) ion using NAG-ADF-300-2 Analyser, via the Formation of a Precipitating Reaction Product Through On-Line Long Distance (300 mm) and Short Path Length (2 mm) Chasing of Sample Segment Nagam Shakir Turkie Al-Awadi
Journal of Global Pharma Technology Volume 11 Issue 05.
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A new instrument is presented for determination of Co (II) ion using precipitation reaction NAG-ADF-300 – 2 analyser is used for attenuation of incident light (white snow light emitting diode) at two stages, first one is 110 mm while the second one is 60 mm with a separation distance of 100 mm reaction of Co (II) ion with rubeanic acid in alkaline medium forms a black precipitate. The attenuation of this precipitate to the incident light is measured in a very repeatable, reproducible manner of RSD% less than 1% at variable concentrations. Line or calibration graph extend from 0.02 – 0.1 mmol / L Cobalt (II) ion. 30 sample / hr. can be handled. This instrument is easy to use and have extended ranged of working parameters. 50-500 µL samples can be manipulated using 2- line system. Limit of detection (L.O.D) is 0.5µmol L-1 at 50 µL for cell A and 7 µmol L-1 at 200 µL sample volume for cell B. The method was applied successfully for the determination of Co (II) ion in two different alloys.Key word: Turbidometry, Flow injection analysis, Cobalt (ll) Ion. and snow white light emitting diode.
Effect of Topical Laportea Decumana Leaves Extract on Labor Pain and Cortisol Level in the First Active Phase of Inpartu Condition Sisma HL
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

This research aims to obtain the effect of L. Decumana extract toward labor pain and cortisol level in the first active phase of inpartu condition. This research used True Experimental with pre post test control group on the first active phase in inpartu condition. This research was combining pharmacology and non-pharmacology method. In choosing the research’s subject, consecutive sampling and randomization were applied to divide the subject into four groups. To measure the pain level, Visual Analog Scale (VAS), and saliva liquid was applied to measure the level of cortisol. The smallest average of pain level before the treatment was KS+V group (6,40) and the highest was LD+KS group (7,70). After the treatment, the smallest level was in LD+KS (5,60) group and the highest is in the SP+V group (7,00). It meant that there was reduction in the pain level before and after treatment. L. Decumana as the medical medicine can be used as reducing the first active phase of labor pain in inpartu condition. However, the further research is needed to prove the effect of biomarker L. Decumana to initiate labor.
Effect of Radiation on Employers in Radiology (X- rays, CT Scan and Magnetic Resonance Imaging )In Al-muthanna Province-Iraq Hanaa Ali Aziz
Journal of Global Pharma Technology .
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Abstract

The aim of  this study was evaluated  the effect of radiation  on the hematological  parameter  of employers  in X- rays, CT scan  and  MRI units, during the period from October-2016 up to  March–2017. Fifty sample were examined  in the present study as well as twenty apparently  healthy  people   selected  as the control, their  ages  ranged  between  25-36 years  old. The samples were examined by using hematological tests. The study showed a significant   increase at (P<0.05) in Male, age groups (31-36) and blood group B. The  study  indicated  a  significant  decrease  at (P<0.05) in  red blood cells(RBC)  and  hemoglobin (HB)  compared  with  control   groups. Also, indicated a significant increase at (P<0.05) in white blood cells (WBC), Neutrophil, Monocyte and Lymphocyte compared with control   groups.                                                                                               Keywords: Hematological, Radiation, MRI, CT scan, Iraq.
Studying on the Effects of Family-centered Care Program on the Incidence of Early Complications of Cataract Surgery Introduction and Purpose Rahim Baghaei
Journal of Global Pharma Technology Volume 08 Issue 02
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Abstract

Introduction Family members are one of the basic components of patient care system undergoing Cataract surgery .planned care to patient and their families increase awareness and knowledge and reduce their problems significantly. Candidate patient and their family should be educated to side effects of Cataract surgery ,advantages and disadvantages of surgical and postoperative care ,surgical procedures ,types of anesthesia ,medication and symptoms of post-operative ,duration of antibiotic use, and they have be trained clearance and follow up. Method:In this quasi-experimental study with gradual sampling,80 patients referred to the clinic of Urmia Imam Khomeini Hospital,40 patients were educated intervention and control groups. After obtaining informed consent and research goals for intervention group with family participation and according to the developed protocol, the family-centered teaching booklet was presented and the control group received routine care. Finally, the incidence of early complications in both groups were examined. the obtained information by using SPSS software and descriptive and inferential statistical tests were analyzed .Results: The results of the present study shows that amount of incident of early complications in the intervention group in comparison with control group has declined in the most sides of research, so this reduction is eye discharging in first and third week and it`s tearing in the third week. Conclusions:The result of this study will be concluded that family –centered cares includes training package to patient and their families has reduced the complications and problems of surgery. therefore, it is recommended that written educations all ophthalmology clinics and hospital wards be made available to patient and their relatives.Keywords: Nursing care plan, Home care, Cataract surgery, Complications.

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