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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis of New 2, 4, 5-triphenyl imidazole Derivatives Derived from benzoin and Studying their Biological Activity Rana S. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this work a series of new 2, 4, 5-triphenyl imidazole derivatives were synthesized. In the beginning, compound [1] was formed from the reaction of benzoin and benzaldehyde in the presence of ammonia, which was reacted with sodium hydride in DMF to obtain imidazole salt. This salt was reacted with adipoyl chloride to give compound [2]. Acid hydrazide derivative [3] was obtained from the reaction of compound [2] with hydrazine hydrate.  After that Shiff bases [4-9] have been synthesized from the reaction of compound [3] with different aromatic aldehydes. These new formed compounds were diagnosed by 13C-NMR, 1H-NMR for some of them (in Ahl-Albate University in Jordan) and FT-IR spectroscopy (In Baghdad University). All of the prepared products have been studied their biological activities toward two kinds of bacteria. These products showed good efficacy to moderate toward bacteria.Keywords: Imidazole, Shiffs bases, Biological activity.
Antibiotics Treatment for Acute Respiratory Tract Infections (ARTIs): Evaluation of Doxycycline Resistance Cases at a Community Health Center in Urban Area of Indonesia. Danni - Ramdhani
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Abstract. Acute respiratory tract infections (ARTIs) are a major health problem in developing countries. This infection can occur in the upper or lower respiratory tract which is accompanied by inflammation. Doxycycline is highly recommended for the treatment of ARTIs patients allergic to penicillin. This study aimed to evaluate the effectiveness of doxycycline in the treatment of ARTIs through its antibiotic resistance rates, and identify bacteria that have been resistant to doxycycline antibiotics. This study consists of the stages of rejuvenation of clinical isolates from ARTIs patients at a community health center in the Urban Tasikmalaya area, identification of bacteria, and testing for antibiotic resistance using the paper-disk method. The results of resistance tests from 116 single clinical isolates showed that there had been resistance to doxycycline antibiotics in the treatment of ARTIs in the urban area of Tasikmalaya with a category of 64.29% being resistant; 14.29% intermediates and 21.42% are still sensitive. The results of bacterial identification showed that doxycycline was resistant to the Corynebacterium, Streptococcus, Staphylococcus, Haemophillus and Bordetella bacteria groups. Doxycycline treatment for ARTIs infection is considered not very effective. Another class of drugs as a substitute for doxycycline for patients allergic to penicillin is needed.
Prolactin Supplementation in Sperm Preparation A Study of Sperm DNA Fragmentation Silvia W. Lestari
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

One of the infertility management is performing intra uterine insemination (IUI), yet several reports indicated that the success rate is remained low. Sperm preparation, as one of contributing factor to IUI succeeds, has a possibility in generating on sperm DNA fragmentation. Recently, prolactin (PRL) is proved in enhance the sperm motility and protect the DNA integrity of the sperm. This study aimed to evaluate the efficiency of sperm preparation, in selecting sperm prior being utilized for IUI by PRL supplementation, based on the sperm DNA fragmentation. Semen samples were gained from 10 normozoospermic male who underwent sperm preparation for IUI. Semen analysis was performed to measure the sperm motility and velocity, before and after sperm preparation based on the WHO guideline. Samples were incubated at 500 ng (PRL 1), 750 ng (PRL 2), and 1000 ng (PRL 3). The Sperm Chromatin Dispersion (SCD) test was performed to evaluate the sperm DNA Fragmentation index (DFI). The percentage of motile sperm was higher in prepared sperm than in whole semen. PRL supplementation could not increase the percentage of motile sperm in sperm preparation by DGC method, while in SU method PRL worked uniquely in different concentration, since the lowest concentration performed the best result. The level of DFI after the supplementation of PRL was decrease in prepared sperm compared to the whole semen. PRL was proved to select the better sperm quality with decreased sperm DNA fragmentation in sperm preparation, particularly in moderate and severe DFI category.Keywords: Density gradient centrifugation, Prolactin, Sperm DNA fragmentation, Sperm motility, swim up.
Implementation and Performance Assessment of Compressed Sensing for Images and Video Signals Charu Bhardwaj
Journal of Global Pharma Technology .
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Abstract

Compressed sensing is an optimization based formalized framework based upon sub-Nyquist sampling principle of exploiting only the sparse signal of interest. It exploits the sparsity of the signal to reconstruct it from less number of measurements than required by the Nyquist sampling criteria. A nascent field of compressive sensing is explored in this paper for accurate acquisition and reconstruction of signals, images and video sequences.  The algorithm is proposed for compression and efficient recovery of image and video based on the concept of compressive sensing. Three basic reconstruction techniques (Basic Pursuit (l1) Minimization, Least Square (l2) Minimization and Orthogonal Matching Pursuit) are applied on image samples and they are compared based on quality performance criteria. The performance parameters like compression ratio, peak signal to noise ratio and structural similarity index are evaluated for different image and video samples for critical analysis of these performance parameters is done for different reconstruction schemes. Finally it is concluded that compressive sensing based approach is better than the traditional compression schemes and Basic Pursuit (l1) methods gives the better image quality with a tradeoff among other parameters enabling faster acquisition, compression and reconstruction.Keywords: Compressed sensing, Sparsity, Structural similarity index, Basic Pursuit Minimization, Least Square Minimization and Orthogonal Matching Pursuit.
Effect of Citric Acid Application on Anatomical and Physiological Properties of the Vegetative Parts of a Species of Tamarindus Indica Cultivated in Iraq Suha Dhia Twaij
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The present study included details of the anatomical properties of the vegetable parts of the stem, the cultured leaf in Iraq for some species of Tamarindus indica. The study examined the stomata index and the rate of both the length and width of the complex stomata and the thickness of the cuticle, the parenchymal and sclerenchymal tissue, phloem and xylem. It was taken the parts mentioned and measured after the treatment of the plant with citric acid and measured for the treated species with citric acid and untreated. The study showed that there is a clear variation in the properties above.
Effect of Blanching and Probiotic to Eggplant (Solanum Melongena) Fermentation Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The eggplant (Solanum melongena, L.) is a good source of minerals and vitamins. Being rich in fiber and having low lipid content, it contains a variety of phytochemicals, such as polyphenols, which provide important health benefits. However, the short shelf life of eggplant can be a major cause of postharvest losses especially during peak harvesting season. Fermentation is one of the most convenient technologies for the production of shelf stable food product. The objective of this study was to evaluate different aspects affecting to the fermentation of eggplants such as concentration of CaCl2, temperature and time for blanching; effect of ratio Lactobacilus acidophillus to the antioxidant of fermented eggplant. Results showed that eggplants should be blanched in hot water 95oC in 10 seconds with the present of 2.0% CaCl2. Moreover, the fermentation process for pickle eggplants had the best antioxidant by Lactobacilus acidophillus at ratio 1.5 x 108 cells/ml. Blanching and fermentation had significantly affected to antioxidant capacity and firmness of pickle eggplants.Keywords: Eggplant, Pickle, Fermentation, Blanching, Lactobacilus acidophillus, Antioxidant.
Aphasia after Spinal Deformity Correction Surgery in Adolescent Idiopathic Scoliosis A Case Report Aji Antoro
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

AbstractIntroduction. Advancement in operative techniques, better understanding of biomechanics and breakthrough in technology making spinal deformity correction surgery become more feasible and conducted more often. Majority of the neurological complications were related to spinal cord disruption due to technical issues. However, neurological complications that were attributed to a brain pathology, were more likely to be of ischemic origin.Case Illustration. We performed spinal deformity correction surgery on a 20-year old man with adult idiopathic scoliosis classification Lenke 2AN, with Cobb angle of 68°. On the second day, the serum sodium level showed a reduction. MRI examination revealed hyper acute infarct lesion on the posterior lobe of left temporo-parietal aspect. However, DSA examination was unremarkable. On the third postoperative day, his motoric and sensory functions, and sodium level returned to normal state. His cognitive function and communication abilities were able to return to normal gradually.Discussion. Stroke that occurs during spinal deformity correction surgery is reported in 5.8% of operative cases. Prone positioning accompanied by extension of the neck can compress vertebral arteries, causing reduction in vascular flow. Therefore, inappropriate prone positioning on the operating table for a prolonged period may cause cerebral ischemia.Conclusion. This case may serve as a reminder to surgeons and anesthesiologists towards the existence of such complications. Full awareness of the risk, good preoperative assessment, good surgical training, good communication, good teamwork, and good intraoperative and postoperative monitoring will minimize the risk for neurological complications.
Effect of Intraperitoneal versus Oral Drench of Beta-Amino Butyric Acid on Platelets in Sprague Dawley Rats Mustafa Salah Hasan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

To study the effect of oral and injected BABA on platelet production this study was done, The first group (intra peritoneal injection group): This group consisted of 20 animals given (BABA) after dilution with 2 ml distilled water by intra peritoneal injection for four weeks, this group was divided according to BABA concentration into three secondary groups (5 animals per group): first concentration (1g/ kg), second concentration (0.5 g / kg), third concentration (0.25 g / kg) and control group was injected with distilled water 2 ml once a week for four weeks, The second group (orally drenching group): This group included 20 animals also given the substance (BABA) at the same concentrations and doses of the first group at the same time using oral route. Keywords: BABA, Rat, Platelets.
Three and Four Membered Heterocyclic Rings Substituted Derivatives of Phenobarbital and Using CPE for Determination of PB (II) Ali Jassim Al-Zuhairi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

A series of three and four member rings N-substituted Phenobarbital have been synthesized. The nitrogen atoms have been alkylated first to form N-carboxymethyl followed by cyclization reaction to form three and four heterocyclic rings. All the synthesized compounds have been identified using I.R, 1H NMR, and then using its heterocyclic rings by determination of lead (II) by cloud point extraction (CPE) techniques.  Keywords: 5, 5-substituted Phenobarbital, 1, 2-Diazetidine, 1,2-diaziridin, Cloud point extraction, Triton X-114.
The Effect of using the Multimedia Method in Teaching Some of the Basic Skills of Football in the Students of the Second Stage in the Faculty of Physical Education and Sports Sciences Hussein Habib Mosleh
Journal of Global Pharma Technology .
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Abstract

The objective of the research is to prepare an educational program using multimedia. Learn about the effect of using the multimedia method in learning some basic skills of football for students of the Faculty of Physical Education and Sports Science. The researcher stressed that there is a clear impact of the educational program using the method of multimedia in learning the basic skills of football students of the Faculty of Physical Education and Sports Science Anbar University. The researcher used the experimental method in the design of the experimental and control groups. The study sample was 60 students divided into two groups of 30 students per group. The duration of the curriculum was from 25/2/2018 to 27/4/2018 at two units per week and six weeks. That there is an impact of this approach in the learning of students in the skills of football. Hence the researcher stressed through the most important recommendations that the program prepared can be applied by the colleges concerned and for different skills and other games.Keywords: Multimedia, Scoring, Handling, Rolling and putting down and football.

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