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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Probiotic Extracted from Lactobacillus Sp. Antagonist Helicobacter pylori of Human Stomach Ulcer Ghydaa H. Aljeboury
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Total of (130) samples of stomach ulcer were collected from patients suffering from peptic ulcer who visited three different hospitals in Baghdad. After testing the sensitivity test against Helicobacter pylori against 10 antibiotics, the sensitivity test for 10   antibiotics demonstrated the efficacy of the antibiotic cephotaxim and rifampicin in the elimination of the bacteria. According to the results of the sensitivity test, one of the isolates of the Helicobacter pylori 4 (HpG 4) was chosen for being resistant to all antibiotics (except amoxicillin). Two isolates of Lactobacillus acidophilus, Lactobacillus plantarum were selected based on their high inhibitory activity against Helicobacter pylori growth bacteria for subsequent experiments .The minimum inhibitory concentration of Lactic Acid Bacteria concentrated filtrate was performed for three times .The concentrated filtrate showed the efficacy in minimizing and inhibiting the growth of pathogenic bacteria Helicobacter pylori. So the aim of the study was to discover the role of probiotics in   the treatment of Helicobacter pylori infection and study of effect of probiotic on reducing Helicobacter pylori stomach ulcer as supporting and safer.  Keywords: Human Stomach Ulcer; Probiotic Extracted; Lactic Acid Bacteria
Protective Effect of Goat Kefir on Arsenic-Induced Ovarian Oxidative Stress in Female Rats Nur Aisyah Laily
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

Objective: To determine the role of goat kefir in ovarian protection from arsenic-induced ovarian oxidative stress. Methods: twenty female wistar rats were randomly divided into five groups; one group was treated as control, one group was treated with arsenic 2 mg/kg/day only, while three groups were treated with different doses (1.25, 2.5, 5 mL/kg/day) of goat kefir and arsenic for 35 days. After 35 days, the rats were terminated, then the ovaries were taken for analysis of MDA levels and SOD activity using spectrophotometry. Results: arsenic exposure significantly increased MDA levels but did not significantly decrease ovarian SOD activity compared to the control group. Kefir administration at doses of 1.25 and 2.5 mL/kg/day could reduce ovarian MDA levels although it was not statistically significant. However, MDA levels were greater in the 5 mL/kg/day group than the arsenic-only group. Kefir increased ovarian SOD activity at all three doses although it was not statistically significant. Conclusion: goat kefir was able to reduce MDA levels and increase ovarian SOD activity in rats that were exposed to arsenic although it was not statistically significant.
The Effectiveness of Life Skills Training in Male Students’ Anger Control Eshrat Takrousta
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

This study aims to determine the effect of life skills training to primary sixth-grade students of 18 region of Tehran education. This is a semi-experimental research with pretest-posttest design and control group. The statistical population includes the primary sixth-grade students of region 18 of Tehran education who were sampled using multi steps random sampling method.  Aggression questionnaire of Nelson et al (2000) is used to collect data. The research hypotheses regarding the effect of life skills training (emotional management) to students on their anger control is examined by univariate analysis of covariance (ANCOVA). Results of the test show that anger life skills training to students is effective in controlling primary sixth-grade male students’ anger and 57.5% of subjects’ anger control variance is explained by the independent variable, i.e., life skills training. Moreover, multivariate unilateral intergroup covariance analysis (MANCOVA) is used to measure the effect of life skills training on anger control components of the participants. The results reveal that the average score of students in failure, physical aggression, relationships with peers and relations with authorities is simultaneously different between the members of the control and life skills training groups.Keywords: Life skills, Anger, Students.
Effect Aqueous Extract of (Cyperus rotundus) tuber on Histological Structure of Testes in Alloxan-Induced Diabetic Male Albino Rats Zahraa Kareem Al-Mayali
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Histological structure of testes in alloxan-induced diabetic rats was investigated after daily oral administration of (Cyperus rotundus) tuber aqueous extract for one month. Therty were divided into 5experimental groups, each group contain 6 adultmale albino rats weighing 150-200 g. Testes samples were obtained and processed for microscopic evaluation after staining the prepared sections with both Heamatoxylin and Eosin. There was a found severe histopatholoigical changes belong to rats injected with alloxan showing seminiferous tubules completely destroyed and nucleus going out from the testis, also presence many bleeding area, absence the connective tissue and leydig cell while showed No histological changes were found in the examined organs belong to rats treated with Extract of Cyperus rotundus.Keyword: Diabetes mellitus, Testis, male reproductive system, MSD, Cyperus rotundus, Glimepiride.
Investigation of Heat Pump Drying for Herbal Passion Flower (Passiflora Foetida) Tea Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

Passion flower (Passiflora foetida) is indigenous to many parts of Vietnam. Passion flower is a highly valued calmative nerve, used for nervous relentlessness, as a gentle sedative for sleep difficulties, and to reduce anxiety, neurasthenia, and nervous disorders. Passion flower is generally considered to be a safe herb, well tolerated and side effects are rare. Biologically active constituents include flavonoids, maltol, and indole alkaloids alkaloids, among numerous other constituents.  In order to utilize this good source as a healthy herb, we attempted to produce dried passion flower herbal tea. Heat pump technology has been used for heating, ventilation, and air-conditioning in fruit and vegetable industry. The main objective of heat pump drying is to produce a dried passion flower tea of desired quality at minimum cost and maximum throughput and to optimise these factors consistently. We focused on investigation of blanching, drying and storage of dried passion flower tea. Results showed that blanching at 95 oC in 10 seconds, drying by heat pump at 20 oC, vacuuming and packing in PET/AL/PE bag could maintain the flavonoid content in the dried passion flower tea.Keywords: Passion flower, Passiflora foetida, Heat pump drying, Herbal tea, Vacuuming, Blanching.
Effects of Solvent Composition on Profile of Total Extracts, Phenolic Compounds, and Antifungal Activity of Sterculia quadrifida R.Br Bark Rollando Rollando
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Faloak bark extract has antibacterial, antioxidant and anticancer potential but no optimal solvent has found to extract the active compounds of faloak bark. Therefore, it is necessary to optimize the solvent against the faloak bark. This study aims to determine the optimum solvent of methanol, ethyl acetate, petroleum ether, and water in order to produce an optimal response value in the extract, total phenolic, and inhibitory results in antifungal tests. Extracts obtained through reflux extraction for 2 hours and extract yield calculated. The extract results tested to determine the total phenolic content and inhibition of antifungal test. The determination of the optimum solvent composition carried out using Rstudio v.3.2.2 software with ANOVA parametric test or Kruskal-Wallis non-parametric test and using Design Expert v.11 software with Simplex Lattice Design (SLD) method. The results showed that the solvent composition of faloak bark extract (Sterculia quadrifida R.Br) in giving the yield of extract, total phenolic, and optimal antifungal inhibition was methanol:water 0,438:0,562.
Isolation of Silica from Some Species of Diatoms in Iraqi Water Shaimaa Setae M. Ali
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

We obtained these diatoms species growth from diatoms (Nitechia acuta, cocconeis pediculus, Nit dissipata, stephanodiscus astrea, syndra ulna, Diploneis).According to scanning electron microscope, the SiO 2 morphologies of having microspores and fibers in the surface of 59.81 m 2 /g. All results refer that the basilica specimens get found in this study. The prepared basilica material having Porous structures which its ability, it can be used in other industrial applications.
Antioxidant Activitvity and Immunomodulator of Indonesia Black Rice(Oryza sativa L. indica) Extract Fadjar Kurnia Hartati
Journal of Global Pharma Technology .
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Abstract

The aim of this study to explore the foodstuffs potentially as an immunomodulator for use of synthetic immunomodulatory in the long term, in addition to considering also has negatively affect to the organs. The materials normally used as an immunomodulator is a substance containing phenol and flavonoid that has antioxidant activity. One of them is Indonesia black rice. This study was performed by in vitro test so that the samples that tested were in the extract form. Extracts were tested were ethanol and water extract of black rice. The use of water as a solvent extract because the sample is food, While ethanol is also used because ethanol is not toxic and the compounds present in black rice are also polar so polar that they can be used in dissolving polar and semi-polar compounds. Each extract was measured levels of phenol, antioxidant activity and its effects on lymphocyte proliferation (as an organ where immune cells produced). The treatment was health control, pain control, 50,100 and 200µg/ml. The results showed that ethanol extract of black rice and water containing phenol compound and has activity as an antioxidant, it also very potential as immunomodulators because the extract can increase lymphocyte proliferation.Keywords: immunomodulator, ethanol, water, Indonesia black rice.
Effect of H2O2 and Ascorbic Acid in β- Hemolysin Production from Clinical Isolates of Staphylococcus Aureus Atyaf Ali Sahib
Journal of Global Pharma Technology .
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Abstract

Oxidizing agents and antioxidants are recently used in wound treatment and health care. The effect of such chemicals as H2O2 and ascorbic acid on beta hemolysin production by clinical isolates of Staphylococcus aureus (which were obtained from wound swabs) was investigated. Hemolytic activity was assayed semi- quantitatively (by measuring the diameter of the hemolytic zone around the wells in blood agar that contain the bacterial crude toxin) and quantitatively (hemolysis %) using the standard curve of osmotic hemolysis by Na Cl. The experiment  was optimized by selecting the optimum culture medium, type of blood, pH of the medium, incubation temperature, number of rpm in shaker incubator and incubation time. The higher production of the hemolysin was obtained when Staphylococcus aureus grown in the medium containing (0.05 mM) of H2O2 and (5  MM) of ascorbic acid, whereas the toxin production decreased in the media containing these substances in lesser concentrations.  Keywords: S. aureus, Hemolysin, H2O2, Ascorbic acid.Introduction
Evaluation of Implant Stability and Marginal Bone Level for Immediately Placed Dental Implants in Fresh Extraction Sockets Augmented with Phase-pure Beta-tricalcium Phosphate Ali Ghaith Ahmed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Objectives: The aims of this study were to evaluate dental implant stability and marginal bone level after immediate implant placement with simultaneous grafting of the gap with alloplastic material. Materials and methods: This prospective study included patients who required an extraction of hopeless teeth and subsequent immediate implant placement at a non-molar site, Full thickness mucoperiosteal flap was elevated and the buccal plates were intact in all cases. Following dental implant placement the primary stability was measured with Periotest. The gap was filled with alloplastic grafting material (Easy graft) and wound closure, then a cone beam computed tomography (CBCT) was taken. 6 months later, a second CBCT was performed and a comparison between them was made for the evaluation of marginal bone level change. Results: Twenty patients with 31 dental implants were enrolled in this study. The difference between base line and 6 months for buccal cortical plate level , palatal/lingual cortical plate level were 0.93 ± 1.15 mm , 0.57 ± 0.94 mm respectively  with a highly significant difference (P=0.007) between buccal and palatal cortical plate. For primary implant stability the mean was 4.98 ± 4.26 PTV, while secondary stability was 1.36 ± 2.96 PTV with a highly significant difference (P=0.001) between primary and secondary stability. Conclusion: Good primary implant stability was achieved even in the presence of gap and the stability was adequate to attain good secondary stability after 6 months. Gaps more than 2 mm were successfully managed with rapid setting Easy graft with promising influence on stability and marginal bone level. Implant length inversely affected PTV. Bone resorptions of the cortical plate occurred more labailly/ buccally than palatally/ lingually and maximum resorption happened in the canine region.

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