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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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New Schiff Base Fluorescent Chemosensors for Metals: Synthesis Characterization and Applications May Jaleel Abed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The focus of preparing and applying distinctive fluorescent chemosensors and samples can be split into two remarkable meetings. The first arrangement with the Schiff base-determined fluorescent chemosensors, using metal cation detection and the subsequent collection, concerns the improvement of the new Ru (II) ppy luminescent D.N.A atomic tests. Particles that have their structure and capacity as chemosensors at the top of the priority list (based on the previous one). Only compounds fitted with adequate receptors, specifically intended for their target visitors and coupled with appropriate fluorochromes so far as synthetic sensing can be efficiently performed by conceivable photophysical processes.
Cloning and Expression of GST-HMPREF0351_11084 Gene in JM105 Cells: A New Potential Protein Vaccine for Pneumococcal Sddiq Ghani Al-Muhanna
Journal of Global Pharma Technology .
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Abstract

The HMPREF0351_11084 gene encoding pneumococcal vaccine antigen A family protein (GeneID: 12999770) was optimized and synthesized, then sub-cloned into pGH cloning vector. The amplified HMPREF0351_11084 gene was incorporated into Bam HI and Eco RI sites of pGEX-2T GST expression vector under the control of tac promoter. The recombinant pGEX-2T was transformed and expressed into JM105 cells. The protein of expressing bacteria was analyzed by SDS-PAGE and the target protein was detected by Western blot - enhanced chemiluminescence (WB-ECL) assay. The result shows predicted target fusion protein with molecular weight 51.2 kDa. The current study describes for the first time the expression of HMPREF0351_11084 gene, and so attempts to produce a new potential protein vaccine for pneumococcal. Further extensive study is required to generate more data about HMPREF0351_11084 protein and evaluate its immunization in elicits antibodies that are capable of passively protecting against pneumococcal infections.Keywords: Fusion protein, PGEX-2T, HMPREF0351_11084, ECL, Pneumococcal vaccine.
Bioinformatics Analysis of HSP90 in Amniotic Fluid and Amniotic Membrane Cells as A Potential Anticancer Drug Target Hakimeh Zali
Journal of Global Pharma Technology Volume 08 Issue 05
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Abstract

HSP90AA is a crucial protective chaperon protein in normal and cancer cell. It has been previously determined HSP90AA down regulate in tumor cell treated with extract of amniotic membrane (AM) stem cells. Aim of this study find out the pathways and molecules associated with reduction of HSP90AA by bioinformatics methods. Network analysis defined the principal functions of HSP90AA in cancer survival and proliferation through interaction with important proteins with different functions such as AR, AKT, HIF1A and P53 to promote tumor cell proliferation and angiogenesis. Gene ontology analysis released the regulation of nitric oxide synthesis activity. In sum up results distinguished the misexperssion of HSP90AA may due to down-regulation of its transcription factors or systemic changes in gene expression of cancer cell after treated with extract of AM cells and induce apoptosis in oxidation state.Keywords: Hsp90AA, Cancer, Amniotic membrane, Epithelialstem cells, Mesenchymalstem cells, Apoptosis
Molecular Study of Mastitis Susceptibility in Human Rawaa K. Judi
Journal of Global Pharma Technology .
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Abstract

Total of (260) clinical samples of blood and milk were collected from women, (160) sample from patients suffering from mastitis (80 samples from blood and 80 samples from milk), and (100) samples as control. Clinical samples were collected from mastitis women who visit the breast cancer consultant clinic in AL-Hilla Teaching Hospital at Babylon Provinces and Private Clinics. The period of samples collection were extended from October (2017) to January (2018). The mean of complement component 5a (C5a) levels in milk of women infected with mastitis was higher (250.9±15.8pg/ml) than the healthy ones (121.55±11.02pg/ml). The level of IL-6 and TLR2 concentrations in serum were measured in women mastitis cases as well as in the control groups by using ELISA technique. The mean of the serum levels of IL-6 in women infected with mastitis was higher (404.73±52.92 pg/ml) than the healthy ones (198.37±28.66 pg/ml). The mean of the serum levels of TLR2 in women infected with mastitis was higher (147.74±27.11pg/ml) than the control groups (83.36±8.58pg/ml). Genotyping of TLR2 polymorphisms was carried out by using Restriction fragment length polymorphism-Polymerase Chain Reaction (RFLP-PCR) technique. The polymorphisms in the single nucleotide for human TLR2 (Arg753Gln) gene polymorphism was detected in mastitis cases and the control groups, and the association between these polymorphisms with host susceptibility to mastitis was also determined. The results showed there was no differences between mastitis patients and control groups for alleles frequencies regarding Human TLR2 (Arg753Gln) polymorphism. However, that there were statistically significant difference in the frequency of TLR2 (Arg753Gln) genotype between patients with mastitis and control groups (P<0.05). Women with GA heterozygous genotype was overrepresented among the mastitis patients 22(50%) than in the controls 12(27.3%), suggesting an association with mastitis susceptibility; whereas the GG 20(45.5%) and AA 12(27.3%) genotype was more common in healthy subjects, than in mastitis patients 15 (34.1%) for GG and 7 (15.9%) for AA, suggesting a protective association with mastitis. The G and A alleles frequencies did not statistical difference as it was reported in Human TLR2 (Arg753Gln) between mastitis cases and control groups, the G allele frequency was 52(59 %) in the mastitis patients and same frequency in the control individuals, whereas A allele frequency was 36(41%) in the mastitis patients and in the control individuals.  Keywords: Mastitis, Gene polymorphism, Complement component, RFLP-PCR.
Screening for Heme Oxygenase Enzyme among Clinical Isolates of Escherichia Coli Isolated from Urine Sample Murtadha K. Alkreami
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A total of (150) urine sample were obtained from different patient which is (male, female and pediatric) who are suffering from urinary tract infection and are using catheter indwelling, who are admitted to the merjan teaching hospital in Hilla city for a period rang from (July to September 2018), only 36 isolates (24%) were diagnosis as E. coli. Three genes related to heme oxygenase production and transported are studied. These genes are (chuA, chuS and chuT) and the result showed that 26 isolates (90%) from total sample carry chuA in genetic marker and 25 isolates (85%) from total sample carry chuS in genetic marker and only 18 isolates (58%) from total sample carry chuT in genetic marker, and the total positive results of isolates which carry all these three genetic marker in genomic material is only 15 isolates. These (15) isolates were undergone for induction and production of HO-1 enzyme, through detection of beliverdin in chochlate agar and also through estimation free iron spectrophotometrically. The results showed that all isolates gave positive results for enzyme production through production of biliverdin and high levels of free iron when compared to control groups.  Moreover, two different antibiotics are used to show their effect on enzyme activity, and the results revealed that neomycin and ciprofloxacin have an effect on enzyme activity in the presence of imidazole buffer.
The Effectiveness of Reduction of Weight Metal Contents of Pb, and Hg in Water Electro-coagulation Method Ferry Kriswandana
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background and Aim: Heavy metals in certain levels can reduce the quality of air, water, and soil. Furthermore, causing health problems for plants, animals and humans, when there is accumulation as a result of industrial activity. Until now, the reduction of heavy metal content in liquid waste has been carried out physically, chemically and biologically. Therefore it is deemed necessary to reduce levels of heavy metals in liquid waste by electrocoagulation. The purpose of this study is to study the performance of electrocoaglation as a reducing agent in reducing Pb and Hg levels in water, so that it can provide references and input for the electroplating industry, batik industry, and others. Method and Materials: This research is a true experimental research with a post test only control group design, which is a research design consisting of a control group and an experimental group. The research sample will be examined in the laboratory. The sample used in this study is a preparation that has been made by dissolving Pb and Hg so that it is like waste from the batik industry or electroplating waste or battery factory waste. The variations in this study were the current / voltage (16, 20, and 24) volts and the detention time (30, 40, 50, and 60) minutes. The independent variable is electrocoagulation which is equipped with cathode and anode. This variable will affect changes in the dependent variable. The dependent variable in this study is the quality of the waste after electrocoagulation by observing the parameters of Pb and Hg. Statistical Analysis: Data analysis using the One-way Anova test or One-way Anova. Results: The results of this study indicate that electrocoagulation as a reducing agent at 16 Volts, 20 Volts, and 24 Volts with a contact time of 30 minutes, 40 minutes, 50 minutes and 60 minutes has a significant effect on Pb and Hg reduction with α = 0.05. The most significant reduction in average Pb occurs in processing with a 20 volt electricity voltage and 60 minutes contact time. Meanwhile, the most significant decrease in Hg levels occurs in processing with a 24 volt electricity voltage and contact time for 30 minutes. Discussion and Conclusion: The reduction in Pb and Hg levels using the electrocoagulation method with aluminum electrodes comes from a redox reaction process where the anode (in acidic pH) will form the Al(s) → Al3+ (aq)¬ + 3e and the cathode will form 3H+ (aq) + 3e- → 1,5H2 (g)¬. After the anode and cathode react, there will be a floc formation which functions as a coagulant that will bind Pb. The conclusion of this study is that the most significant decrease in the average Pb level occurs in processing with a power supply of 20 volts and a contact time of 60 minutes. Meanwhile, the most significant decrease in Hg levels occurred in the treatment with 24 volt electricity and the contact time was 30 minutes. Keywords: Electro-coagulation, Voltage, Contact time, Heavy metals.
The Relationship between Three (Human, Perceptual, and Technical) Skills of Financial Managers and Their Effectiveness in Manufacturing Companies with the Intermediate Role of Empowering Managers Hossein Azimi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

The aim of this study is to investigate the effect of three (human, perceptual, and technical) skills of financial managers on their effectiveness in Gilan province's manufacturing companies with the mediating role of empowering managers. The research method was descriptive-correlational and the statistical population included managers and financial experts of 193 manufacturing companies in Rasht industrial town. Data collection tool was a researcher-made questionnaire which was distributed among 30 active companies by random sampling method. The reliability of the questionnaire was confirmed. Additionally, the content validity of questionnaire was confirmed by the opinion of the experts and its construct validity was confirmed by factor analysis. The results of the correlation test using spss16 software showed that there is a statistically significant effect between the studied variables. Moreover, structural equation modeling and path analysis technique were used to investigate the interactions of research variables. The results obtained from the seven examined hypotheses confirmed the impact of three (human, perceptual, and technical) skills of financial managers on their empowerment in manufacturing companies of Gilan province (P <0.05). Also, the results of this study indicated that the empowerment of managers affects the financial management effectiveness (planning, budgeting, control and assessment) in manufacturing companies of Gilan province (P <0.05).Keywords: Triple skills (Human, Perceptual, and Technical), Effectiveness of managers, Empowerment of managers.
Attitude and Performance of Nurses in Oral Care in Intensive Care Unit Patients Elham Niknejad
Journal of Global Pharma Technology .
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Abstract

Introduction: Prevention of respiratory tract infections in intensive care units is an important aspect of patient safety and oral care as nursing intervention plays an important role in reducing the risk of infection so the present study was aimed to determine attitude and performance of nurses in oral care in intensive care unit patients. Materials and Methods A descriptive study in which105nurses working in special educational- therapeutic centers affiliated to Uremia University of Medical Sciences were selected by available sampling method. For data collection a part of rello et al. questionnaire was used. Data analysis was performed using descriptive statistics and Chi-square test. Results showed that the majority of nurses (87.5% and72.8%), respectively had moderate attitude and performance about their oral care, but based on chi-square tests there is no significant relationship between attitude and performance of the staff. The majority of nurses (85.3%) are not using protocol and the standard tool for the assessment of oral healthcare. Conclusion Education of basic concepts of health care is necessary in order to enhance employee attitude and performance and improve the patient's status in intensive care units and should be taken into consideration by the authorities’ and directors of nursing.Keywords: Attitude, Performance, Nurses, Oral Care, Intensive care unit.
Correlation between AMH and Polycystic Ovarian Syndrome Phenotypes among Iraqi Population Fatin Shallal Farhan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Anti-Mullerian hormone is considered as a marker with has an important function in ovarian folliculogenesis besides the steroidogenesis. Anti-mullerian hormone with ovarian stimulation may guide the treatment plan in infertility. Objective:  To evaluate the anti-Mullerian hormone role in identification and diagnosis of polycystic ovarian syndrome phenotypes in Iraqi population. Patients and Methods: This retrospective cohort study was carried at Al-Yarmuk Teaching Hospital in Baghdad from the 1st January 2016 to the 1st of December 2018. Ninety-nine women were enrolled in the study. Anti-Mullerian hormone was obtained from those women, those who had high AMH above 5 ng/ml were enrolled in the study, then they classified based on the level of AMH into three groups: First group, their AMH 5-10 ng/ml, the second group, the AMH level was 10-14 ng/ml, the third group their AMH was more than 14 ng /ml. Then the comparison between these groups was done according to their polycystic ovary syndrome phenotype, and their endocrine parameters. Results: The percentages of Hyperandrogenimia were not statistically significant except for that between group 3 and 2 (78.8% vs. 50% respectively; the P value was= 0.014). The polycystic ovaries by ultrasound was significantly higher in group 3 (as the P value was= 0.001). PCOS diagnosis was significantly more prevalent in group 2 (91.2%) and group 3 (100%) in comparison with group 1 (50%). The difference  was statistically significant for women with polycystic ovary syndrome who had  regular period and the percentages were (65.6% vs. 26.5% vs. 3% for group 1 vs. 2 and 3 respectively )while there was a significant higher percentages for  oligomenorrrhea in group 2 (67.6%) ,and group 1 (31.3%), Whereas proportion of amenorrhea was significantly higher  in group 2 (5.9%) , and group 3 (24.2%) in comparisons to  group 1 (3.1%). Conclusion: Antimullerian hormone levels might be used for polycystic ovary syndrome diagnosis and determine its severity. The majority of women with Antimullerian hormone >10 ng/mL will have severe type of PCOS.Keywords: (PCOS), Antimullerian hormone, Polycystic phenotype.
A Study of the Effect of the Use of Magnetised Water Technology to Increase the Hatching Rate of Common Carp (Cyprinuscarpio) in Hatching Incubators Abdulhusein Hamzah Jawdhari
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

This study was conducted in the fish hatchery of the Middle Euphrates Fish Production Company in Babylon Governorate on 1/4/2017 and used in three different strengths of magnetised water, known as tensile (700, 1400. 200) gauss, respectively, for five days, using four glass incubators (Zucker). The fertilised fish eggs were placed in four treatments with 100 g in each incubator. 1-2-3-4 The first incubator contained normal non-magnetised water. The second buffer was highly magnetised water 700, the third was 1400, and the fourth was 2000 gauss. Measure Percentage of oxygen, Electrical conduction, and Salinity by using a device YIS (conductivity meter) and Use the mercurial thermometer to measure the temperature. Was noticed that the incubator exposed to an intensity of 1400 gauss increased the proportion of oxygen in it and reached 10 while the lack of electrical conduction rate reached 40 and achieved a hatch rate 90% higher than those of the other treatments, with the hatching time beginning about8 hours before the others.Keywords: Magnetised Water, Hatching, Fish eggs, Magnetism intensity.

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