cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 198   199   200   201   202 
Wharton’s Jelly Derived Mesenchymal Stem Cells: A Comparison Study in Preterm vs. Term Deliveries and in FBS vs. PRP vs Mesencult Culture Media Gita Pratama
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Use of human mesenchymal stem cells (MSCs) for therapy in the field of degenerative medicine has been extensively studied. One of the potential sources of MSC which is easily available is from the human umbilical cords Wharton’s jelly of the newborn baby. Wharton's jelly derived MSCs (WJ-MSCs) from full-term labor has been isolated and differentiated, but very limited data came from preterm labor. This study aimed to compare the proliferation and differentiation characteristics between human WJ-MSCs from preterm and term labor using xeno-free culture media, particularly platelet rich plasma (PRP). Methods: WJ-MSCs from preterm and term deliveries was cultured using culture medium supplemented with 10% PRP or MSC or FBS culture media. Cells were cultured until the fifth passages. Cumulative cell numbers and differentiation capacity of the MSCs was tested according to International Society for Cellular Therapy (ISCT) criteria. Results: The preterm WJ-MSCs grown in culture media is not significant differences with WJ-MSCs derived from full-term labor, but have higher number of cell populations. WJ-MSCs are able to differentiate into osteocyte, chondrocyte and adipocyte., and xeno-free media can be used to replace FBS. WJ J-MSCs from preterm labor can be used as a source for mesenchymal stem cells. Conclusion: WJ-MSCs collected from preterm samples to have a better proliferation rate compared to term samples, while possessing equal differentiation capacity. In addition, PRP can replace FBS as it a xeno-free material for WJ-MSCs production that required for regenerative medicine. Keywords: Mesenchymal stem cells, Wharton’s jelly, Preterm labor, Proliferation, Differentiation.
New Flow Injection Method for Determination of Glutathione Using Merging Zone Technique Muthana Salih Mashkoor
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

New flow injection were designed for the determination of glutathione by Iodate and Iodide at λmax=350 nm with high efficiency and distinction, with new innovative design included tri-valve in one level. The best manifold and optimum conditions were managed at λ max=350nm. The calibration curve was fabricated   with linear range (1-80) ppm. The linearity (R2) value was 0.9990.The limit of detection value was 0.256 ppm. The limit of quantification value was 0.853 ppm. The dispersion coefficient value was 1.45 and 1.35 for the two concentrations 10 and 30 ppm respectively. Sampling rate was over the range 80sample per hour for every run cycle. The arrival time of sample/reagent zone from injection unit to flow cell was 20 seconds. Determination of GSH was applied on standard solutions, which gave high precision and accuracy with recovery in well worthily.Key words: Flow injection analysis, Glutathione, Iodate.
The Effect of N-Acetylcysteine on Serum Malon Di Aldehyde in Chronic Hemodialysis Patients Ali Javaherforoush Zadeh
Journal of Global Pharma Technology Volume 08 Issue 03
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Among patients with chronic kidney diseases, oxidative stress and reactive oxygen species induce inflammatory responses, which in turn, intensify uremic complications, atherosclerosis and cardiovascular events. This study assesses the effect of N-Acetylcysteine on serum Malon Di Aldehyde (MDA) level as an oxidative stress marker in patients undergoing chronic hemodialysis (HD). Methods: The study was a double blind, and randomized clinical trial which performed on sixty ESRD patients undergoing maintenance HD at the Imam hospital, Ahvaz, Iran that randomly divided in the two groups (NAC and placebo groups).Thirty patients in the NAC group were received 600 mg of NAC tablet, twice a day for six weeks and other was received placebo at the same time. At the beginning and the end of the study, blood samples were obtained prior to the initiation of the HD session for check of serum MDA levels in two groups. Results: The mean serum MDA level in the NAC group significantly decreased from 1.95±0.86 mmol/lit to 0.92±0.4 mmol/lit (p value <0.05). In the placebo group, the mean serum MDA level before and after intervention were 1.98±1.12 and 1.5±0.91 respectively and there was no significant difference between them (p value=0.899). The mean differences in NAC group and placebo group were 1.03±0.99 and 0.48±1.05 respectively (p value<0.001).Conclusion: According to the results of our study, N-Acetylcysteine decreases serum MDA level in chronic hemodialysis patients. So, oral N-Acetylcysteine supplement may be a promising therapy for decrease of serum MDA level in these patients. Keywords: N-Acetylcysteine; Hemodialysis; Malon Di Aldehyde.
Analysis on Advantages and Disadvantages GAP 43 as Neuroregenaration Marker Examination in Rat Sciatic Nerve Injury Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Analysis focuses on the advantages as well as the disadvantages of using Growth Associated Protein 43 (GAP-43) as a neuroregeneration marker examination tool in a rat sciatic nerve injury examination. The sources of this research were attained from past scientific publications that had been published on the NCBI website. The research is unique because no past researches have ever been performed to ascertain the advantages and disadvantages of GAP-43 as a neuroregeneration marker examination tool in a rat sciatic nerve injury examination. The analysis will focus mostly on a research that was published on September 10, 2016. It focused on the GAP-43, a growth associated protein used in the treatment of a sciatic nerve injury in a Norway rat. The keywords used to attain the access the publication included GAP-43, neuroregeneration marker and sciatic nerve injury. The results of the search yielded a total of twenty-six full journal articles from PubMed Central and one scientific and medical abstract citation from PubMed. These are all publications that contain information pertaining GAP-43 and its applications. The materials for inclusion in the research were all journals summarizing the effects of GAP-43 on a sciatic rat. The participants of this review were program professor and myself. The materials for exclusion in the research included all publications with the exception of peer-reviewed scientific journals and publications from the PubMed or NCBI website. The conclusion of the study revealed that although GAP-43 has a few disadvantages, it is an effective neurogenerational marker in a rat sciatic nerve injury examination.Keywords: GAP 43, Neuroregenaration marker, Sciatic nerve injury
Animal Model of Pancytopenia and Bone Marrow Function Diagnosis of Domestic Rabbits Mohammed E. Mansur
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The present research aims at showing the effects of extracts of some plants seeds (Nigella sativa, Medicago sativa, Eruca sativa, Ocimum basilicum, Vitis vinifera, Portulaca oleracea) in animals that are induced by a type of drug Azathioprine as animal model of pancytopenia. Several reports have shown that plant extracts are used as an alternative to chemotherapy in many cases of diseases. The research was conducted on forty white rabbit (five weeks old), after weaning, weighing between 500-700 grams, the method of work included eight groups, the numbers of blood cell types that indicate the effectiveness of bone marrow were measured ( RBC, WBC, Thrombocytes, IRF, IPF,IGs, Schistocytes, reticulocyte and ANC),the extracts showed different effects in terms of their ability to improve or re-develop bone marrow to produce blood cells, Ocimum basilicum extract showed a higher effect than the rest of the extracts in pancytopenia treatment, which gave a clear effect on improving bone marrow efficiency.
The Study of Human Physiological Aspect; The Implementation of Clean Production Technology Through Participatory Ergonomic Decreases Workers’ Musculoskeletal Disorders Wahyu Susihono; I Putu Gede Adiatmika
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Metal manufacturing industries in Bali are spread in Klungkung Regency, Bali. The position of the metal manufacturing industries is in buffer sector of Bali tourism development, so that the stability of sales and production in each period continues to increase. Demand for product quality assurance is carrying out by exporters, including guaranteeing environmentally friendly process. There are many high-quality products are rejected in international market due to the fact that metal manufacturing industries have not consideredhuman and environmental factors (eco-labeling) in their production activity. Companies are switched from Industrial Systems Type I to Closed Loop Industrial System. Various environmental management and industrial management approaches have been carried out, but the current literature review has not reached human physiological aspect. This research is experimental research using treatment by subject design. The result shows that the implementation of clean production technology through participatory ergonomic is able toincrease work performance, in the form of the decrease of musculoskeletal disorders as much as 34.66%.Keywords: Physiological, Musculoskeletal disorders, Metal industry.
The Effects of Purified Hepatotoxins, Microcystin-LR from Anabaena Circinalis on Some Biochemical Markers of Common Carp (Cyprinus carpio) Maher M. Khadairi
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Determination the effects of purified microcrystal-LR from Anabaena sp on biochemical markers in liver of C. carpio, Microcrystal-LR was purification by using silica gel, and highly purified and collected by preparative high performance liquid chromatography and concentration of purified hepatotoxins reached to 74.832 µg/ml. fish was intraperitoneally injection with different concentration of microcrystal-LR (3, 6, 9) µg/ kg per day body weight for 30 days. The fish oxidative status was determined through measuring the lipid per oxidation levels MDA, reactive oxygen species ROS and antioxidants activities such as superoxide dismutase SOD, catalase CAT, and glutathione per oxidase GPx and glutathione GSH. The results of presents shown concentration of MDA as well as  ROS and activities of antioxidants such as SOD, CAT and GPx were significantly increased (P<0.05) with increased microcrystal-LR concentration but glutathione activities was significantly decreased with increasing concentration as compared with control groups.Keywords: Hepatotoxins, Microcystin-LR, Purification, Biochemical markers.
Comparative Analysis of Pharmacopeial Requirements to Extem-poraneous Medicines Galyna Melnik
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract. The article presents a comparative analysis of pharmacopoeial requirements for extemporaneous medicines on the example of the articles of State Pharmacopoeia of Ukraine 2.0 “Nonsterile medicines made in pharmacies” and Guide for the Compounding Practitioner USP on Compounding “795” “Pharmaceutical Compounding – Nonsterile Preparations”. These articles have been shown to differ in structure and title, but many sections are close in content. It is established that State Pharmacopoeia of Ukraine contains, to date, a very limited list of general pharmacopoeial articles for individual extemporaneous dosage forms unlike USP. In this regard, it is necessary to expand and improve the basic regulatory documentation, including general articles of State Pharmacopoeia of Ukraine, in order to improve the quality of extemporaneous medicines.
Levels of IL-6 and TNF-α among Type 2 Diabetic Patients with Dyslipidemia and Insulin Resistance Najlaa Jabaar Wasmi
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study was aimed to investigate the effect of type2 diabetes mellitus in Iraqi male patients on the levels of IL-6 and TNF-α and their relationship with IR and dyslipidemia. The study included (80) individual (males), (60) were diagnosed with type2 diabetic patients and (20) as healthy control group.IL-6 and TNF-α biomarkers were assessed in both control and diabetic groups.  Results showed increasing levels of IL-6 in diabetic group ((9.065 ± 0.504) in comparison with healthy control group (4.186 ± 0.509), TNF-α was increased significantly (p<0.05) in diabetic group (44.222 ± 7.336) in comparison with control group (11.082 ± 1.204). FBG level was increased significantly (p < 0.01) in diabetic groups (233.90±11.12) in comparison with control group (92.90±240).HbA1cin diabetic group (7.59 ± 0.21) showed significant increase (p < 0.01) in comparison with control group (4.59 ± 0.11).Insulin showed high significant (p < 0.01) increase in diabetic group (18.24 ± 2.27) when compared with control group (6.74 ± 0.86).IR value was increased significantly (p < 0.01) in diabetic group (11.58 ± 1.89) when  compared with control group (1.56 ± 0.21).Total cholesterol showed non- significant (p> 0.05) difference in diabetic group (188.83 ± 5.46) in comparison with control group (186.40 ± 7.47). Triglycerides value was increased significantly (p < 0.01) in diabetic group (208.05 ± 11.41) when compared with control group (125.55 ± 11.18).LDL showed non-significant (p> 0.05) difference in diabetic group (102.23 ± 4.29) in comparison with control group (111.85 ± 7.24).VLDL was increased significantly (p < 0.01) in diabetic group (41.95 ± 2.33) when compared with control group (23.99 ± 2.47).HDL showed non-significant difference (p> 0.05) in diabetic group (47.15 ± 1.15) in comparison with control group (50.46 ± 1.86).Key words: IL-6, TNF-α, Diabetes type2, insulin resistance (IR), Dyslipidemia.
Evaluation of Phylogenetic Tree of blaCTX-M Gene in Pseudomonas earugenosa Isolated form Corneal Scraping Specimens in Baghdad Ali Mhana Sabeeh Zirjawi
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Nosocomial infections caused by Pseudomonas earugenosa (P. earugenosa) presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. earugenosa isolates that isolated form Ibn-Al Haitham teaching hospital for eyes diseases had carried blaCTX-M gene which have the highest clinical impact. Hence, this study was designed to investigate the presence of genes codifying for bla CTX-M among beta-lactam resistant P. earugenosa isolated in one of Baghdad hospitals. Antibiotic sensitivity was carried out using Kirby-Bauer method, and polymerase chain reaction was carried out in addition to the gell electrophoresis, the genotypic and the sequencing in aadtion the phylogetic tree were done. Thirteen P. aerogenosa isolates were isolated from corneal scraping specimens and the results of antibiotic sensitivity showed that the most effective antibiotic on P. aerogenosa isolates was impeniem with 13(100%) sensitivity rate while the highest resistance was to cefozlen 13(100%) resistance rate. The investigation of the blaCTX-M gene via polymerase chain reaction showed the presence of blaCTX gene (544bp) in 3(23.1%) P. aerogenosa isolates. The sequencing of blaCTX-M amplicons confirmed the correct identification of blaCTX-M gene among P. aerogenosa isolates and the data obtained from the sequencing of blaCTX-Mgene was submitted to the GenBank of National Center for Biotechnology Information (NCBI) under the accession number (KY966041). Molecular phylogenetic analyses were based on the sequences of blaCTX gene and closest relatives (100% identity) with closely related blaCTX-M gene of some bacterial isolates in the GenBank by using MEGA6 software.Keywords: Pseudomonas aerogenosa, blaCTX M gene and phylogetic tree.

Page 200 of 244 | Total Record : 2439

 198   199   200   201   202 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue