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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Application and Evaluation of Bismuth Sulfide (Bi2s3) Metal Nanoparticles as Nanocarriers for Poorly Soluble Class II Drug Clarithromycin Mustafa R. Abdulbaqi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objective: The aim of this study was to evaluate the effect of bismuth sulfide Bi2S3 metalnanoparticles as carries on the pharmaceutical properties and biologic activity of Biopharmaceutical Classification System (BCS) class II drug clarithromycin (CLA). Methods: Bismuth sulfide (Bi2S3) nanoparticles synthesized by chemical co-precipitation technique, during which CLA loaded (incorporation method). Characterizations techniques including atomic force microscopy (AFM), X-ray diffraction (XRD) and fourier transform infra-red spectroscopy (FTIR) were used for particle size and particle size distribution, crystal lattice and compatibility, respectively. USP puddle apparatus type II (in phosphate buffer solution pH 7.4) was used for in-vitro release study. Disc diffusion method was the technique used to test the antibacterial activity of blank Bi2S3 nanoparticles; free CLA (as control) and CLA loaded metal nanoparticles. Results: CLA was loaded successfully with synthesized Bi2S3 nanoparticles by physical interaction without any chemical modification, as approved by FTIR. Particle size of CLA was reduced from 116.17 to 95.5 nm after loading process with uniform particle size distribution (as measured by AFM). In vitro release study demonstrated complete release of CLA from Bi2S3 nanoparticles after 120 min, indicating significant*increase in the solubility and dissolution profile of CLA after loading process. XRD spectrum showed lattice transition from crystalline into amorphous structure. Susceptibility test displayed significant*potentiation of antibacterial activity at all tested concentrations against gram +ve bacteria Staphylococcus aureus and Bacillus subtilis after loading of CLA with Bi2S3 nanoparticles, while gram –ve bacteria E. coli showed no response for CLA before and after loading process. Bi2S3 nanoparticles showed no antibacterial activity against all tested bacterial cultures. Conclusion: The use of synthesized metal Bi2S3 nanoparticles, as nanocarriers, was applied successfully as an attractive delivery system for the improvement in the solubility, dissolution profile and biologic activity of BCS class II drug CLA.Keywords: Class II drug; Clarithromycin (CLA); Bismuth sulfide (Bi2S3)nanoparticles.
Effect of Topical Phytosterol Fraction of Chenopodium murale on Induced Hypertrophic Scar in Rabbits Aya Ashraf Ahmed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: The present study aimed to evaluate the role of phytosterol fraction of Chenopodium murale in experimentally induced hypertrophic scar in rabbits. Methods: Surgical wound was performed on day 1 with an 8‑mm biopsy punch four wounds were created on the ventral surface of the rabbit ear (in vivo) down to cartilage. Triamcinolone acetonide (TAC) and phytosterol extracts of Chenopodium murale are administered topically to established scars on day 31. The outcome measures include the study of histopathology of skin section, transforming growth factor beta-1(TGF-β1) level and collagen III alpha in skin tissue. Results: The treatment groups produced high significant reduction in inflammatory scores, height, index of scar and in immunological scores of TGFβ1 and scores of collagen III in comparison with induced hypertrophic scar group (P≤0.001). Significant reduction was observed also in fibroblast count as compared with induced hypertrophic scar control group (P<0.05).Conclusion. Phytosterol extract of Chenopodium murale was effective in treatment of induced hypertrophic scar through its ability to produce reduction in inflammation, fibroblast count; height and thickness of hypertrophic scar in addition to decrease in immunological scores and the results were nearly comparable to that of topical triamcinolone acetonide.Keywords: Chenopodium murale; Rabbits; Topical phytosterol.
Sequencing of Phospholipase and Enterotoxin Genes of B. Fragilis Isolated from Women with BV Zahraa Kais Salman
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

One of the most common genital infections among women in the childbearing age is Bacterial vaginosis (BV). Many novel, fastidious and uncultivated bacterial species are related with BV. These are called bacterial vaginosis associated bacteria (BVAB), present in trace amount and have a significant role in the infection. A total of 300 high vaginal swabs were obtained from 150 non-pregnant women with bacterial vaginosis depending on Amsel criteria. Two swabs where taken for each patient, 150 of these swabs were cultivated on selective media, Bacteroides Bile Esculin agar and the remaining samples were used for direct DNA detection. Samples were collected from a patient who’s admitted to the out-patient clinics of Gynecology and Obstetrics in Babylon Maternity and Pediatrics teaching hospital Hospital, and Al-Hillah General Teaching Hospital. Cultivated swabs were gave 31(21%) positive results for Gram negative, anaerobic Bacteroides fragilis.  Specific primers used for detection and study  two of virulence factors .The direct molecular detection revealed 39 (26 %)  of sample positive for detection by nan H  gene where gave band with a molecular weight of (842 bp) and all of these samples where revealed 39 (100 %) positive result for enterotoxin gene and 35 (89.7%) of them gave positive result for phospholipase gene, by produced  (367 bp) PCR prodcut    for amplification of enterotoxin gene and (400 bp) PCR product for amplification of phospholipase gene. Sequencing of enter toxin and phospholipase genes gave similar identity in percentages (100 and 99) respectively with the standard strains in NCBI web site.Keywords: Bacterial vaginosis, Selective media, Molecular detection, PCR-technique, Sequencing.     
The Effect of Special Exercises in the Development of Some Visual Abilities and the Accuracy of Some Basic Skills of the Young in the Handball Thaerah Abdul Jabbar Saleh
Journal of Global Pharma Technology .
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Abstract

The problem of research is the lack of use of some trainers for visual exercises during the training modules and do not have great importance in their training curriculum as it is for the physical, skill and planning aspects, and thus the objectives of the research are as follows:Develop special exercises to develop some visual abilities and the accuracy of some of the basic skills of beginner's handball.Knowing the impact of special exercises in developing some of the visual abilities of the emerging handball players.Knowing the effect of special exercises in developing the accuracy of some of the basic skills of beginner's handball.Either Research HypothesesThere is a significant impact of special training in developing some visual abilities of the emerging handball players. There is a significant effect of special exercises in developing the accuracy of some of the basic skills of beginner's handball.  The researchers adopted the experimental approach in the design of the two equal groups with Pre and Post testing through the research society represented by the players of the specialized center of handball at Al-Qasim Sports Club. The number of (40) player was randomized. The random number of 16 players was divided into two equal groups, And the tests used in the visual abilities and skill handball were conducted Pretests, and then applied visual exercises for the experimental group by combining them with the curriculum prepared by the trainer (3) units per week for a period of (8) weeks, and then conducted After the data were obtained from the Pre and Posttests where the researcher treated them statistically to extract the results. The results were presented, analyzed and discussed according to research objectives, the most important conclusions reached by the researchers in:There is an evolution of the experimental group in all visual and technical tests of the hand pulley except the test (Perception of the depth of vision) as well as the control group, except for the Perception of the depth of vision and the test of the accuracy of handling from the head level by the field of vision. Visual training is futile in the latest development in the Perception of the depth of vision and accuracy of the performance of the correction of the jump field of vision of the two groups.Keywords: Special exercises, Visual abilities and accuracy.
Isolation and Identification of Pathogenic Fungi from Cyprinus carpio L. (1758) in Al-Nasiriya City Ihsan Flayyih Hasan AI-Jawhari
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Thirty  samples  of  Cyprinus  carpio  were   collected  from Al-Nasiriya fish  ponds  during  the  period  from  March   until  Novmber  2017 . Seventeen  fish  samples  showed  fungal  infection .In this study eight species were identified and the most common were Aspergillus  niger, Saplolegnia sp., Achyla  prolifera, Alternaria  alternate , Penicillium funigulosum, Rhizopus  stolinifer, Aspergillus  fumigatus and  Aspergillus  flavus . Aspergillus Niger and Saplolegnia sp. were the most prevalent fungi infecting all the organs of Cyprinus carpio. Gills  and  abdomen   had  higher  infection  than  rest  of  the  organs .Keywords: Contaminnet, Disease, Environment, Fishes, Fungi, Ponds.
The Effect of Interpersonal on the Use of Traditional Medicine in Hypertension Patients with Health Promotion Model Approach Ronal Surya Aditya
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

ABSTRACT: Hypertension is a disease that requires compliance with drug consumption, but many people are affected by using traditional medicine. Interpersonal influences affect them in the choice of treatment. This study aims to determine the interpersonal influence on traditional drug use in hypertensive patients with a theoretical approach to health promotion models. The subjects of this study were 148 hypertension people in Posyandu, Jenggolo Village, Kepanjen Regency. The design of this research is Cross-Sectional with the sampling technique uses purposive sampling to get a sample of 108 people. Retrieval of data using questionnaire sheets and multiple linear regression statistical tests. The results of the study using multiple linear regression test showed that family support had a B value of 0.111 with sig = 0.036, support of health workers had a value of B 0.156 with sig = 0.028, and peer support had a value of B 0.233 with sig = 0.002. The beta coefficient value on family support is 0.203, health worker support is 0.212, and peer support is 0.297. It can be concluded that the three supporters, namely family, health workers and peers, influence the use of traditional medicine. The most dominant influence in this study was on peer support. The results of this study are expected to provide input for other researchers about providing interventions to peers in patients with hypertension.
The Impact of Small Games use in Reducing Psychological Pollution and the Development of Psychological Skills and the Most Important Physical Abilities and Learn the Effectiveness of Running 100 Meter Mohammed Abdulreda Salman
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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The research problem is that there is a weakness in the technical performance of jogging efficiency 100 meters for students aged 11-12 years. The researchers found that the use of teachers for specific and non-varied methods in the education of students in addition to the lack of focus in developing the physical abilities of students, Pupils for this event. This has prompted researchers to study the problem to find appropriate solutions. Where the researchers saw the development of a program of motor education in the style of small games and include exercises to reduce the psychological pollution and develop psychological skills and the most physical capabilities as well as technical performance in the effectiveness of running 100 meters relay to ensure the level of performance of students to this event and the goal of the research to: Preparation exercises small games in reducing pollution and psychological development of psychological skills and the most important physical abilities of students aged (11-12 years). Find out the effect of small games in the style of artistic performance development ran 100 meters for students aged (11-12 years). The researchers used the experimental approach to design the equal groups to suit the nature of the study. The research community consisted of 6 primary pupils in Al-Farahidi Primary School for Boys in Babil Governorate (ages 11-12). The research society was the sixth primary pupils (28).Small games contributed to reducing the psychological pollution of the pupils by 11-12 years. The small games that have been used within the physical exercise capacity in the development of its effectiveness ran (100 m) and psychological skills for pupils Reconstruction (11-12 years).The approach taken by the teacher contributed to the reduction of pollution and psychological development of physical abilities and mental skills for pupils Reconstruction (11-12 years).Keywords: Small games, Psychological pollution and physical abilities.
Determination of Valproic Acid without Derivatization in Human Plasma using High Performance Liquid Chromatography-Photodiode Array Yahdiana Harahap
Journal of Global Pharma Technology .
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Abstract

Objective: To develop and validate a simple and sensitive HPLC method without derivatization for determination of valproic acid in human plasma. Methods: Nonanoic acid as internal standard was added to 500 mL of plasma sample prior to liquid-liquid extraction using n-hexane and 0.5% triethylamine. Chromatographic separation was achieved on C-8 Symmetry® column (5µm; 150 x 3.9mm) in isocratic mode at 45°C. The mobile phase was 40 mM sodium dihydrogen phosphate pH 3.5 – acetonitrile (56:44 %v/v) with flow rate of 1.00 mL/min and was detected at 210 nm. Method validation referred to EMA Guideline 2011 for bioanalytical method validation in term of parameters lower limit of quantification (LLOQ), selectivity, calibration curve and linearity, carry over, recovery and stability. The valid method was applied in pharmacokinetic study of one healthy subject after administration of 500mg extended release caplet of valproic acid. The blood was collected as much as 7mL for twelve spots, which are predose, 1, 2, 3, 4, 5, 8, 10, 24, 36, 48, and 72 hours after drug administration. Results: The calibration curve valproic acid was linear over the concentration range of 2.0 – 200.0 µg/mL (r = 0.9992). Within-run and between-run precision and accuracy were studied at four concentrations and RSDs were less than 1.8 % and 5.4 %, while the bias (accuracy values) were less than 17.9 % and 13.1 %, respectively. Conclusion: The developed method provides sensitivity, linearity, precision, accuracy and is suitable for analysis of valproic acid in plasma samples for pharmacokinetic studies.Keywords: Valproic acid, Nonanoic acid, HPLC, Validation, Liquid-liquid extraction.
Synthesis, Characterization and Antimicrobial Activity of Novel Symmetrical and Unsymmetrical Thiadiazole Derivatives as Potential Carbonic Anhydrase Inhibitor in E. Coli Ammar H. Al-Dujaili
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Ten compounds of 2, 5-disubstitutedamido-1, 3, 4-thiadiazole, 3, 5-disubstituted-amido-1, 2, 4-thiadiazole and a Schiff base of 1, 3, 4-thiadiazole derivatives were synthesized. The structures were characterized by elemental analysis and different spectroscopic techniques and their biological activities were evaluated. All the synthesized compounds were screened for their antimicrobial activity against Staphylococcus aureus and Escheriochia coli, and antifungal activity against Candida albicans and a clinical isolate of Candida albicans. Most of the compounds have shown significant antibacterial and antifungal activity. When compared with the standard antimicrobial agents. The induced fit study of Schiff base derivative showed that the compound has potential inhibitory effect on bacterial β carbonic anhydrase with binding score of (-33.681 kJ/mol).Keywords: Thiadiazole;  Antibactrial activity;  Antifungl activity; Amid; Coli.
Effectiveness of Intravenous Subanesthetic Dose of Ketamine on the Subarachnoid Block to Attenuate Inflammation Response in Transurethral Resection of the Prostate Surgeries Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Background: Perioperative anesthesia and surgery can induce a stress response in the body. Regional anesthesia with local anesthetic drugs in the transurethral Resection of the Prostate (TUR-P), has been proven to minimize inflammation. Patients and Methods: Forty-eight patients of ASA I-II, scheduled for TUR-P with spinal subarachnoid anesthesia were randomly divided into two groups, group A with ketamine and group B without ketamine. The blood level of interleukin (IL)-10, IL-8, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and IL-10/IL-8 ratio were measured in both groups at 1 hour before operation, also at 1 and 24 hours after operation. Results: Blood level of IL-10 (p<0.001) and IL-10/IL-8 Ratio (p<0.05) were significantly different with higher values on group A. Other parameters were not found to be different. Conclusion: Subanesthetic dose of ketamine on spinal subarachnoid anesthesia technique done for TUR-P operation was found able to control inflammation and prevent the deterioration of immune system perioperatively.Keywords: IL-10, IL-8, CRP, NLR, Benign prostatic hyperplasia.

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